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Researchers identify protein essential in transmission of Ebola virus

Researchers identified a novel small molecule that inhibits EboV entry into cells by more than 99 percent; they found that the target of the inhibitor is the cell protein Niemann-Pick C1

2011-08-25
(Press-News.org) This research was funded by a grant from the New England Regional Center of Excellence for Biodefense and Emerging Infectious Diseases (NERCE) at Harvard Medical School.

Brigham and Women's Hospital (BWH) is a 793-bed nonprofit teaching affiliate of Harvard Medical School and a founding member of Partners HealthCare, an integrated health care delivery network. BWH is the home of the Carl J. and Ruth Shapiro Cardiovascular Center, the most advanced center of its kind. BWH is committed to excellence in patient care with expertise in virtually every specialty of medicine and surgery. The BWH medical preeminence dates back to 1832, and today that rich history in clinical care is coupled with its national leadership in quality improvement and patient safety initiatives and its dedication to educating and training the next generation of health care professionals. Through investigation and discovery conducted at its Biomedical Research Institute (BRI), BWH is an international leader in basic, clinical and translational research on human diseases, involving more than 900 physician-investigators and renowned biomedical scientists and faculty supported by more than $537 M in funding. BWH is also home to major landmark epidemiologic population studies, including the Nurses' and Physicians' Health Studies and the Women's Health Initiative. For more information about BWH, please visit www.brighamandwomens.org

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[Press-News.org] Researchers identify protein essential in transmission of Ebola virus
Researchers identified a novel small molecule that inhibits EboV entry into cells by more than 99 percent; they found that the target of the inhibitor is the cell protein Niemann-Pick C1