(Press-News.org) PHILADELPHIA — Researchers at Kaiser Permanente have found that patients with a very early form of breast cancer (ductal carcinoma in situ or DCIS) who have higher mammographic density may be at increased risk for subsequent breast cancer, especially in the breast opposite to the one with the initial cancer.
These study results are published in Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research.
Mammographic density refers to the proportion of the breast that appears dense on a mammogram; it is one of the strongest risk factors for primary invasive breast cancer. On a mammogram, dense tissue looks white while non-dense tissue looks dark grey. The dense area consists primarily of breast ducts and connective tissue, while the non-dense tissue is mostly fat.
Results of a previous study showed that patients with DCIS who had higher mammographic density had about two to three times increased risk for a second breast cancer.
To confirm her earlier findings, Laurel A. Habel, Ph.D., research scientist at Kaiser Permanente's Division of Research, and colleagues conducted a larger cohort study that consisted of 935 women diagnosed with DCIS who were treated with breast-conserving surgery (i.e., not a mastectomy) between 1990 and 1997 at Kaiser Permanente of Northern California.
After reviewing medical records, evaluating mammograms at diagnosis and then calculating the risk of subsequent breast cancer events during follow-up, the researchers found that risk of second breast cancer appeared to be elevated among the women with higher density.
"While risk was elevated for both breasts, the increase was greatest and most consistent for the breast opposite to the one with the initial cancer," Habel said.
Of the patients, 164 had a subsequent ipsilateral breast cancer (breast cancer on the original cancer-affected breast) and 59 had a new primary cancer in the other breast during follow-up. The researchers anticipated finding an increased risk of a subsequent cancer in the breast with the initial cancer, as well as in the opposite breast.
Habel stressed that additional studies will be needed to confirm these risk estimates and determine whether information on density can aid in risk assessment and treatment options.
"Information on mammographic density may help with treatment decisions for ductal carcinoma in situ patients," she said. "While it's not a strong enough risk factor on its own, it may be possible to combine it with other factors to improve risk assessment and inform treatment decisions."
###
The mission of the American Association for Cancer Research is to prevent and cure cancer. Founded in 1907, the AACR is the world's oldest and largest professional organization dedicated to advancing cancer research. The membership includes 32,000 basic, translational and clinical researchers; health care professionals; and cancer survivors and advocates in the United States and more than 90 other countries. The AACR marshals the full spectrum of expertise from the cancer community to accelerate progress in the prevention, diagnosis and treatment of cancer through high-quality scientific and educational programs. It funds innovative, meritorious research grants, research fellowships and career development awards. The AACR Annual Meeting attracts more than 18,000 participants who share the latest discoveries and developments in the field. Special Conferences throughout the year present novel data across a wide variety of topics in cancer research, treatment and patient care. The AACR publishes six major peer-reviewed journals: Cancer Research; Clinical Cancer Research; Molecular Cancer Therapeutics; Molecular Cancer Research; Cancer Epidemiology, Biomarkers & Prevention; and Cancer Prevention Research. The AACR also publishes CR, a magazine for cancer survivors and their families, patient advocates, physicians and scientists, providing a forum for sharing essential, evidence-based information and perspectives on progress in cancer research, survivorship and advocacy.
Breast density linked to increased risk of subsequent breast cancer
2010-10-07
ELSE PRESS RELEASES FROM THIS DATE:
Half-time gamblers give stock market insight
2010-10-07
Computer-modelled comparison of online football gamblers' behaviour during play and during half-time shows distinct real-time differences, begging the question what motivates betting behaviour when play is not underway?
Research published today, Thursday 7 October 2010, in New Journal of Physics (co-owned by the Institute of Physics and German Physical Society), details how researchers from Trinity College Dublin have analysed data and identified betting trends during the 2007-08 Champions' League Tournament.
Using a complete dataset from Betfair.com, drawn from bets ...
Study shows faith-based interventions can encourage exercise in older African-American women
2010-10-07
In a randomized controlled study based in Los Angeles, California, encouraging African-American women aged 60 or over to exercise, in conjunction with scripture reading and group prayer, led to a 78% increase in steps per week, equivalent to about three extra miles. This increase was four times greater than in the control group who were also encouraged to exercise but with no faith based interventions. The results are published today in the Journal of the American Geriatrics Society.
Older African-American women are the least physically active race-sex subgroup in the ...
Poverty grows in suburbs, but social services don't keep up
2010-10-07
VIDEO:
University of Chicago Professor Scott Allard talks about the problems the poor face in getting help in the suburbs.
Click here for more information.
Poverty has grown in America's suburbs during the recent economic downturn, but poor people in many suburban communities are finding it hard to get the help they need, a report by University of Chicago researchers shows.
"Many suburbs have seen significant expansion in the number of poor persons over the last several years, ...
Study links large waist size to higher diabetes rates among Americans
2010-10-07
A higher rate of diabetes seen among adult Americans when compared to peers in England is explained primarily by a larger waist size rather than conventional risk factors such as obesity, according to a new study by researchers from the RAND Corporation, University College London and the Institute for Fiscal Studies in London.
Researchers say the findings offer more evidence that accumulating fat around the mid-section poses a health risk and suggests that studies of diabetes risk should emphasize waist size along with traditional risk factors.
"Americans carry more ...
Americans' life expectancy continues to fall behind other countries'
2010-10-07
New York, NY, October 7, 2010—The United States continues to lag behind other nations when it comes to gains in life expectancy, and commonly cited causes for our poor performance—obesity, smoking, traffic fatalities, and homicide—are not to blame, according to a Commonwealth Fund-supported study published today as a Health Affairs Web First. The study, by Peter Muennig and Sherry Glied at Columbia University, looked at health spending; behavioral risk factors like obesity and smoking; and 15-year survival rates for men and women ages 45 and 65 in the U.S. and 12 other ...
On September 23, 2010 DVDLink.ca Shipped Its 300,000 Disc
2010-10-07
G.Sran is pleased to announce the http://www.DVDLink.ca shipped its 300,000 disc on September 23, 2010. The phenomenal popularity and growth of DVDLink since its inception in 2008, has made it one of the largest online Movies and Games rental providers in Canada.
When interviewed Mr. G.Sran stated, "I am extremely proud that we have shipped 300,000 discs today! DVDLink.ca serves over 11,000 customers all over Canada. I want to thank our 11,000+ and growing customers for making us one of the top rental company in Canada. Our goal remains focused on the needs and desires ...
What is Roxy Offering for Spring- 2011?
2010-10-07
Roxy, today is a way of life for many. The brand has always been associated with surf culture. This year, we saw Roxy take advantage of its successful surfing clothes and come up with a number of products that included flip flops and even bed linen. The fall/winter collection also saw the latest in hoodies and sweaters. Their clothes as we all know range from the basic surf wear for sport and style to even vintage inspired sport wear.
"This year's surf expo was a huge success. We're super excited about the upcoming surf clothing lines for 2011. The Roxy clothing ( http://www.ripyard.com/m-11-roxy.aspx ...
Australia Online Pet Store to Launch New Designs of Dog Kennel, Rabbit Hutch and Chicken Coop
2010-10-07
As part of its commitment to providing high quality yet affordable pet products, Petitude, the FUN and VALUE online pet store is off to launch fresh selections of dog kennels, rabbit hutches and chicken coops that Australia-based pet owners will surely love.
One of the best ways that pet owners can show their love to their pets is to provide them the best shelter. For dog owners, being able to find the most comfortable and secured dog kennel for their precious pooch is a must. Not only can they ensure the safety of their dog buddy but they can also make their "best friend" ...
New Mirror Invention Revolutionizes Safe Driving
2010-10-07
Maxi View, the world's best blind spot mirror offers a solution to a problem we all face; the dangerous blind spot.
Maxi View Mirrors, as featured on QVC, experienced rave reviews and over 1 million dollars in mirror sales! Maxi View Mirrors dramatically increase driving safety to fleets, passenger cars, SUV's, trucks, and motorcycles.
More than 400,000 vehicle accidents occur each year due to vehicle blind spot related mishaps. Lane change accidents damage more than 800,000 vehicles and injure or kill more than 160,000 people each and every year! Maxi View Mirrors ...
InSomnis Enterprises announces the launch of the Infinity Windows of Long Islands new state-of-the-art CMS driven website.
2010-10-07
InSomnis Enterprises today unveiled the newly designed CMS driven infinityli.com. Infinity Windows of Long Island provides state-of the-art replacement windows, doors, siding and expert installation. They offer top quality products that make homes more energy efficient. Serving all of Long Island, New York and New York City they are the premier replacement window, door and siding contractor.
Infinity Windows of Long Island came to InSomnis looking for an updated, clean and stylish redesign of their existing site, as well as a complete restructuring of their content and ...