AMP reports on possibilities, challenges, and applications of next-generation sequencing
Timely report provides a detailed and compelling overview of the landscape of next generation sequencing (NGS) technology and its clinical relevance and impact on improving patient care
2012-10-19
(Press-News.org) Bethesda, MD, October 18, 2012 The Association for Molecular Pathology (AMP) published the
report of the Whole Genome Analysis (WGA) Working Group of the AMP Clinical Practice Committee
in the November 2012 issue of The Journal of Molecular Diagnostics (JMD). Titled "Opportunities and
Challenges Associated with Clinical Diagnostic Genome Sequencing," the timely report provides a
detailed and compelling overview of the landscape of next generation sequencing (NGS) technology
and its clinical relevance and impact on improving patient care. The issues addressed in the report
are comprehensive, including "…current technical, bioinformatic, and clinical implementation
considerations, as well as medical applications, clinical utility, and ethical, legal, and education issues
presented by genome-level diagnostic testing."1
NGS-related technologies and instrumentation introduced over the past decade have significantly
alleviated the amount of resources required to conduct complex genomic analysis. "The possibilities
of these technologies are numerous," noted, Iris Schrijver, AMP President and lead author of the
report. "As the only Association whose members are experts specifically dedicated to the field of
molecular pathology, AMP has the responsibility to initiate and lead the discussion on safe, effective
and practical applications of next-generation sequencing."
The report illuminates the current state of NGS by calling out and highlighting the issues to be
addressed in greater depth moving forward. "The next phase of reporting will include detailed studies
of the validation, interpretation, and bioinformatics elements of NGS. We are excited to collaborate
with other organizations to develop guidelines for application and quality assessment," said Jane
Gibson, WGA Working Group Chair. "While this report is comprehensive, there is much yet to be
done."
INFORMATION:
A full copy of the report is available online at: http://bit.ly/QVQSqt
ABOUT AMP:
The Association for Molecular Pathology (AMP) is an international medical professional association
dedicated to the advancement, practice, and science of clinical molecular laboratory medicine and
translational research based on the applications of molecular biology, genetics, and genomics. The
Annual Meeting will be held in Long Beach, CA, October 25-27, 2012. For more information, please
visit www.amp.org.
CONTACT:
Mary Steele Williams
mwilliams@amp.org
(301) 634-7921
1 Schrijver, I, et al: Opportunities and Clinical Challenges Associated with Clinical Diagnostic Genome Sequencing. The
Journal of Molecular Diagnostics 2012, 14: 541-549.
END
ELSE PRESS RELEASES FROM THIS DATE:
2012-10-19
Boston, MA— Excitement around the potential for targeted nanoparticles (NPs) that can be controlled by stimulus outside of the body for cancer therapy has been growing over the past few years. More specifically, there has been considerable attention around near-infrared (NIR) light as an ideal method to stimulate nanoparticles from outside the body. NIR is minimally absorbed by skin and tissue, has the ability to penetrate deep tissue in a noninvasive way and the energy from NIR light can be converted to heat by gold nanomaterials for effective thermal ablation of diseased ...
2012-10-19
We live in a human-dominated world. For many of our fellow creatures, this means a fragmented world, as human conduits to friends, family, and resources sever corridors that link the natural world. Our expanding web of highways, cities, and intensive agriculture traps many animals and plants in islands and cul-de-sacs of habitat, held back by barriers of geography or architecture from reaching mates, food, and wider resources.
A team of researchers, managers, and ecological risk assessors review the current state-of-the-art in landscape connectivity planning, offering ...
2012-10-19
People are more likely to install a solar panel on their home if their neighbors have one, according to a Yale and New York University study in the journal Marketing Science.
The researchers studied clusters of solar installations throughout California from January 2001 to December 2011 and found that residents of a particular zip code are more likely to install solar panels if they already exist in that zip code and on their street.
"We looked at the influence that the number of cumulative adoptions—the number of people who already installed solar panels in a zip ...
2012-10-19
It's fall football season, when fight songs and shouted play calls fill stadiums across the country. Another less rousing sound sometimes accompanies football games: the sharp crack of helmet-to-helmet collisions. Hard collisions can lead to player concussions, but the physics of how the impact of a helmet hit transfers to the brain are not well understood. A research team from the U.S. Naval Academy in Annapolis, Md., has created a simplified experimental model of the brain and skull inside a helmet during a helmet-to-helmet collision. The model illustrates how the fast ...
2012-10-19
Global temperatures directly affect the acidity of the ocean, which in turn changes the acoustical properties of sea water. New research suggests that global warming may give Earth's oceans the same hi-fi sound qualities they had more than 100 million years ago, during the Age of the Dinosaurs.
The reason for this surprising communication upgrade is that whales vocalize in the low-frequency sound range, typically less than 200 hertz, and the new research predicts that by the year 2100, global warming will acidify saltwater sufficiently to make low-frequency sound near ...
2012-10-19
Noise can be distracting, especially to a person trying to concentrate on a difficult task. Studying annoying noises helps architects design better building environments and policy makers choose effective noise regulations. To better understand how short noise bursts affect humans' mental state, researchers from the University of Nebraska – Lincoln played quarter-second-long white noise clips to test subjects as they worked on arithmetic problems. The researchers noticed a slight general trend toward lower performance when louder noises were played, and also identified ...
2012-10-19
Miss hitting the "sweet spot" on a baseball bat and the resulting vibrations can zing your hands. Bat companies have tried for decades to reduce these painful shocks with limited success. But Daniel Russell, a professor in the graduate program in acoustics at Pennsylvania State University in University Park, has figured out that bat vibrations between 600 and 700 hertz (Hz) cause the most pain and that specifically tuned vibration absorbers are the best at combatting the sting. He will present the results of his damping technique comparisons at the 164th meeting of the ...
2012-10-19
Earthquakes sway buildings, buckle terrain, and rumble – both audibly and in infrasound, frequencies below the threshold of human hearing. New computer modeling by a team of researchers indicates that most of the low-frequency infrasound comes from an unexpected source: the actual "pumping" of the Earth's surface. The researchers confirmed their models by studying data from an actual earthquake.
"It's basically like a loudspeaker," said Stephen Arrowsmith, a researcher with the Geophysics Group at Los Alamos National Laboratory in Santa Fe, N.M., who presents his team's ...
2012-10-19
VIDEO:
Einstein predicted gravity waves in his general theory of relativity, but to date these ripples in the fabric of space-time have never been observed. Now a scientific research technique called...
Click here for more information.
A pioneering technology capable of atomic-level precision is now being developed to detect what so far has remained imperceptible: gravitational waves or ripples in space-time caused by cataclysmic events including even the Big Bang itself.
A ...
2012-10-19
Tropical Storm Maria is moving away from Japan and strong wind shear is pushing its rainfall east of the storm's center, according to NASA satellite imagery.
On Oct. 18 at 0845 UTC (4:45 a.m. EDT), NASA's Tropical Rainfall Measuring Mission (TRMM) satellite saw that rain associated with Tropical Storm Maria was limited to the east of the storm's center. Rainfall was also light to moderate, falling at a rate between .78 to 1.57 inches/20 to 40 mm per hour. There were no areas of heavy rain remaining in the tropical cyclone. The low-level center of the storm is now exposed ...
LAST 30 PRESS RELEASES:
[Press-News.org] AMP reports on possibilities, challenges, and applications of next-generation sequencing
Timely report provides a detailed and compelling overview of the landscape of next generation sequencing (NGS) technology and its clinical relevance and impact on improving patient care
