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2012-12-28
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Prompt Proofing Blog Post: Book Review - The Secret Keeper by Kate Morton
2012-12-28
Kate Morton's The Secret Keeper takes you back in time to the early 1960s, where we meet 16-year-old Laurel, who witnesses her mother commit an unspeakable act at her baby brother's birthday party.
Opening with such a strong plot point could make you wonder if the book will succeed in maintaining momentum, but there isn't any concern of that when Morton then plunges us back in time even further, to the unique period of World War II, when relationships, lives and decisions were all dictated by the harsh living conditions resulting from years of ongoing war. Here we get ...
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2012-12-27
If the sinful excess of holiday eating sends your system into butter-slathered, brandy-soaked overload, you are not alone: People who are jet-lagged, people who work graveyard shifts and plain-old late-night snackers know just how you feel.
All these activities upset the body's "food clock," a collection of interacting genes and molecules known technically as the food-entrainable oscillator, which keeps the human body on a metabolic even keel. A new study by researchers at the University of California, San Francisco (UCSF) is helping to reveal how this clock works on ...
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2012-12-27
Children suspected of having appendicitis are more likely to receive CT scans, which involve radiation, if they are evaluated at a general hospital, a new study by Washington University School of Medicine in St. Louis has shown.
Similar patients who went to St. Louis Children's Hospital were more often evaluated with an ultrasound scan, a safer option that uses sound waves instead of radiation to confirm or rule out the need for surgery to remove the appendix.
Use of either scanning technique can potentially reduce the occurrence of unnecessary surgeries and expedite ...
Liquid crystal research, future applications advance
2012-12-27
AMHERST, Mass. – Contributing geometric and topological analyses of micro-materials, University of Massachusetts Amherst mathematician Robert Kusner aided experimental physicists at the University of Colorado (UC) by successfully explaining the observed "beautiful and complex patterns revealed" in three-dimensional liquid crystal experiments. The work is expected to lead to creation of new materials that can be actively controlled.
Kusner is a geometer, an expert in the analysis of variational problems in low-dimensional geometry and topology, which concerns properties ...
Benefits of higher oxygen, breathing device persist after infancy
2012-12-27
By the time they reached toddlerhood, very preterm infants originally treated with higher oxygen levels continued to show benefits when compared to a group treated with lower oxygen levels, according to a follow-up study by a research network of the National Institutes of Health that confirms earlier network findings. Moreover, infants treated with a respiratory therapy commonly prescribed for adults with obstructive sleep apnea fared as well as those who received the traditional therapy for infant respiratory difficulties, the new study found.
In the original 2010 ...
Development of new corneal cell line provides powerful tool
2012-12-27
Human corneal endothelial cells (HCEnCs) form a monolayer of hexagonal cells whose main function is to maintain corneal clarity by regulating corneal hydration. Cell loss due to aging or corneal endothelial disorders, such as Fuchs dystrophy, can lead to cornea edema and blindness, resulting in the need for cornea transplants.
Studying human corneal endothelium has been difficult for cell biologists because limited cellular model systems exist and have significant drawbacks. The major drawback is that HCEnC cells do not divide and there is a limited source of these cells ...
New technique catalogs lymphoma-linked genetic variations
2012-12-27
As anyone familiar with the X-Men knows, mutants can be either very good or very bad — or somewhere in between. The same appears true within cancer cells, which may harbor hundreds of mutations that set them apart from other cells in the body; the scientific challenge has been to figure out which mutations are culprits and which are innocent bystanders. Now, researchers at Johns Hopkins Medicine have devised a novel approach to sorting them out: they generated random mutations in a gene associated with lymphoma, tested the proteins produced by the genes to see how they ...
Ability to metabolize tamoxifen affects breast cancer outcomes, Mayo Clinic-led study confirms
2012-12-27
ROCHESTER, Minn. -- For nearly a decade, breast cancer researchers studying the hormone therapy tamoxifen have been divided as to whether genetic differences in a liver enzyme affect the drug's effectiveness and the likelihood breast cancer will recur. A new study by researchers from the Mayo Clinic Cancer Center and the Austrian Breast and Colorectal Cancer Study Group provides evidence that genetic differences in the enzyme CYP2D6 play a key role in how well tamoxifen works.
"Our findings confirm that, in early breast cancer treated with tamoxifen, genetic alterations ...
Immune system changes may drive aggressiveness of recurrent tumors
2012-12-27
PHILADELPHIA – Nearly half of the 700,000 cancer patients who undergo surgical removal of a primary tumor each year suffer a recurrence of their disease at some point, and many of those patients will eventually die from their disease. The traditional view of recurrent tumors is that they are resistant to therapy because they've acquired additional genetic mutations that make them more aggressive and impervious to drugs. Now, however, researchers at the Perelman School of Medicine at the University of Pennsylvania show in an animal model that the enhanced aggressiveness ...
Piranha kin wielded dental weaponry even T. rex would have admired
2012-12-27
Taking into consideration its size, an ancient relative of piranhas weighing about 20 pounds delivered a bite with a force more fierce than prehistoric whale-eating sharks, the four-ton ocean-dwelling Dunkleosteus terrelli and – even – Tyrannosaurus rex.
Besides the force of the bite, Megapiranha paranensis appears to have had teeth capable of shearing through soft tissue the way today's piranhas do, while also being able to pierce thick shells and crack armoring and bones, according to Stephanie Crofts, a University of Washington doctoral student in biology.
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