PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Bone marrow cells used in bladder regeneration

2013-02-19
(Press-News.org) A new approach to bladder regeneration is capitalizing on the potential of two distinct cell populations harvested from a patient's healthy bone marrow, a new study reports.

The Northwestern Medicine® research, which will be published February 18 in the Proceedings of the National Academy of Sciences by lead author Arun K. Sharma, research assistant professor in urology at Northwestern University Feinberg School of Medicine and colleagues, is an alternative to contemporary tissue-engineering strategies. The bone marrow cells are being used to recreate the organ's smooth muscle, vasculature, and nerve tissue.

"We are manipulating a person's own disease-free cells for bladder tissue reformation," said Sharma, a member of the Institute for BioNanotechnology in Medicine and the Ann & Robert H. Lurie Children's Hospital of Chicago Research Center. "We have used the spina bifida patient population as a proof of concept model because those patients typically have bladder dysfunction. However, this regeneration approach could be used for people suffering from a variety of bladder issues where the bone marrow microenvironment is deemed normal."

In end-stage neurogenic bladder disease – an illness often associated with spinal cord diseases like spina bifida – the nerves which carry messages between the bladder and the brain do not work properly, causing an inability to pass urine. The most common surgical option, augmentation cystoplasty, involves placing a "patch" derived from an individual's bowel over a part of the diseased organ in order to increase its size. The current "gold standard," the procedure remains problematic because the bowel tissue introduces long-term complications like the development of electrolyte imbalance and bladder cancer.

Because Sharma's procedure does not use bowel tissue, it offers the benefits of augmentation without the association of long-term risks. His technique combines stem and progenitor cells from a patient's bone marrow with a synthetic scaffold created in the lab of Guillermo Ameer, ScD, professor of biomedical engineering at McCormick School of Engineering and Applied Science and of surgery at Feinberg. The scaffold takes the place of the traditional patch.

"We decided to use material that has the ability to be tailored to simulate mechanical properties of the bladder," said Sharma, director of pediatric urological regenerative medicine at Lurie Children's. "Using the elastomer created by Dr. Ameer and the bone marrow stem and progenitor cells, I believe that we have developed a technique that can potentially be used in lieu of current bladder augmentation procedures. However, further study is needed."

###Sharma's initial research was supported in part by an Excellence in Academic Medicine grant funded by the Illinois Department of Healthcare and Family Services.


ELSE PRESS RELEASES FROM THIS DATE:

Data on novel IL-1 inhibitor protein for topical treatment of dry eye disease published

2013-02-19
Cambridge, MA, February xx, 2013 – Eleven Biotherapeutics, a biopharmaceutical company creating novel and differentiated protein-based biotherapeutics, has published preclinical data in Proceedings of the National Academy of Sciences (PNAS) showing beneficial effects of EBI-005, the first rationally-designed topically administered IL-1 protein for the treatment of ocular diseases. In the paper entitled "Design of a superior cytokine antagonist for topical ophthalmic use," the scientists, including drug developers from Eleven Biotherapeutics and collaborators from Howard ...

New study on Hepatitis C drug treatment in vivo and in vitro

2013-02-19
Hepatitis C virus (HCV) infection affects about 4.1 million in the United States and is the primary cause of liver cirrhosis and liver cancer. Current therapy against HCV is suboptimal. Daclatasvir, a direct acting antiviral (DAA) agent in development for the treatment of HCV, targets one of the HCV proteins (i.e., NS5A) and causes the fastest viral decline (within 12 hours of treatment) ever seen with anti-HCV drugs. An interdisciplinary effort by mathematical modelers, clinicians and molecular virologists has revealed that daclatasvir has two main modes of action against ...

Lake-effect snow sometimes needs mountains

Lake-effect snow sometimes needs mountains
2013-02-19
SALT LAKE CITY, Feb. 19, 2013 – University of Utah researchers ran computer simulations to show that the snow-producing "lake effect" isn't always enough to cause heavy snowfall, but that mountains or other surrounding topography sometimes are necessary too. The study is relevant not only to forecasting lake-effect storms near the Great Salt Lake, Sea of Japan, Black Sea and other mountainous regions, but also sheds light on how even gentle topography near the Great Lakes helps enhance lake-effect snowstorms, says the study's senior author, Jim Steenburgh, a professor ...

CT angiography helps predict heart attack risk

2013-02-19
OAK BROOK, Ill. – Coronary computed tomography angiography (CCTA) is an effective tool for determining the risk of heart attacks and other adverse cardiac events in patients with suspected coronary artery disease but no treatable risk factors, such as high cholesterol or high blood pressure, according to a new study published online in the journal Radiology. "CCTA should be considered as an appropriate first- line test for patients with atypical chest pain and suspected but not confirmed coronary artery disease," said the study's lead author, Jonathon Leipsic, M.D., ...

Fibromyalgia prevalence at 2.1 percent of general German population

2013-02-19
Researchers have determined that fibromyalgia prevalence is 2.1% of the general population in Germany. Results appearing in Arthritis Care & Research, a journal published by Wiley on behalf of the American College of Rheumatology (ACR), suggest that fibromyalgia is a spectrum disorder rather than a categorical illness. Additionally, a number of fibromyalgia cases in the general population satisfy proposed criteria for physical symptom disorder—the presence of one or more physical symptoms that impair function, which cannot be explained by another clinical or psychiatric ...

Novel coronavirus well-adapted to humans, susceptible to immunotherapy

2013-02-19
The new coronavirus that has emerged in the Middle East is well-adapted to infecting humans but could potentially be treated with immunotherapy, according to a study to be published on February 19 in mBio®, the online open-access journal of the American Society for Microbiology. The study indicates that the virus HCoV-EMC can penetrate the lining of the passageways in the lung and evade the innate immune system as easily as a cold virus can, signs that HCoV-EMC is well-equipped for infecting human cells. The study also reveals that the virus is susceptible to treatment ...

The SWIBA Awards Connect Veteran Thought Leaders With Emerging Change Makers to Elevate Women in Business

2013-02-19
The advancement of women in leadership has fundamentally shaped the business landscape, and Stiletto Woman Media celebrates this evolving influence. The company's mission to empower women in business has flourished into an effort that cultivates leaders and contributes to the progression of business owners and independent professionals. Stiletto Woman In Business Awards (SWIBA) is a nationally recognized comprehensive awards program that exclusively honors women in the micro business sector. Known for its influential reach, this initiative commemorates prolific leaders ...

Famous Italian Tenor, Joseph Spinella, Opens Mystical Magic and Music Show in Venice, Florida

2013-02-19
Joseph Spinella, international tenor sensation, performs a special music and magic show in Venice, Florida for 16 shows starting on March 7, 2013. Returning from his recording sessions with the Macedonian Radio Symphonic Orchestra, Spinella sings classic Neapolitan songs from his latest album and performs exhilarating magic illusions on-stage. The show starts out with a spot-on impersonation of Luciano Pavarotti and goes into a quick-change to a Venetian gondola. He sings in this magnificent tenor voice and performs magic as his assistant comes on stage and then disappears ...

Rod Hubbard to Speak at GTC Drug Design Conference, May 8-10, 2013 in Boston, MA

2013-02-19
Roderick Hubbard, long-time expert in the field of drug design, will deliver the keynote address at GTC's 7th Drug Design & Medicinal Chemistry Conference, to be held May 8-10, 2013 in Boston, MA. Professor Hubbard, who divides his time between academic research at the York Structural Biology Laboratory and applied research at the pharmaceutical company Vernalis, has a unique and balanced perspective of drug discovery in both academia and industry. He will review recent developments in the field during his presentation, "Current Perspectives in Fragment-Based ...

Veteran College Basketball Coach Bobby Cremins Named 2013 NC Beautiful Golf Classic Honorary Chair

2013-02-19
NC Beautiful has announced that Bobby Cremins will serve as Honorary Chair of the 28th NC Beautiful Golf Classic. The environmental non-profit's fundraiser will be held from July 19-21 at Pinehurst Resort & Spa, one of the world's finest golf resorts located among the Sandhills of North Carolina. Cremins is a veteran of 31 seasons as a college basketball head coach. Cremins graduated from the University of South Carolina in 1970 and played professional basketball in Ecuador before beginning his collegiate coaching career at Point Park College in Pittsburgh, PA in ...

LAST 30 PRESS RELEASES:

3D printing breakthrough: Scientists create functional human islets for type 1 diabetes treatment

Malnutrition in children rises when economy drops

New model enables the study of how protein complex influences mitochondrial function

Device study offers hopes for spinal cord injuries

How urea forms spontaneously

Mayo Clinic’s AI tool identifies 9 dementia types, including Alzheimer’s, with one scan

Gene therapy improves blood flow in the brain in patients with sickle cell disease

Building breast tissue in the lab to better understand lactation

How gut bacteria change after exposure to pesticides

Timepoint at which developing B-cells become cancerous impacts leukemia treatment

Roberto Morandotti wins prestigious IEEE Photonics Society Quantum Electronics Award 

New urine-based tumor DNA test may help personalize bladder cancer treatment

How a faulty transport protein in the brain can trigger severe epilepsy

Study reveals uneven land sinking across New Orleans, raising flood-risk concerns

Researchers uncover novel mechanism for regulating ribosome biogenesis during brain development

RNA codon expansion via programmable pseudouridine editing and decoding

Post-diagnosis emergency department presentation and demographic factors in malignant skin cancers

A new genetic tuner for embryo development

Insurance churn and the COVID-19 pandemic

Postpartum Medicaid use in birthing parents and access to financed care

Manufacturing chemicals via orthogonal strategy, making full use of waste plastic resources in real life

Study overturns long-held belief about shape of fish schools

Precision oncology Organ Chip platform accurately and actionably predicts chemotherapy responses of patients suffering from esophageal adenocarcinoma

Verify the therapeutic effect of effective components of lycium barbarum on hepatocellular carcinoma based on molecular docking

Early intervention changes trajectory for depressed preschoolers

HonorHealth Research Institute presents ‘monumental’ increase in survivability for patients suffering ultra-low blood pressure

Mitochondrial dynamics in breast cancer metastasis: From metabolic drivers to therapeutic targets

Removing out-of-pocket fee improves access to 3D mammography

Does reducing exposure to image and video content on messaging apps reduce the impact of misinformation? Yes and no

A global microbiome preservation effort enters its growth phase

[Press-News.org] Bone marrow cells used in bladder regeneration