(Press-News.org) The first-in-human study of the NeuroBlate™ Thermal Therapy System finds that it appears to provide a new, safe and minimally invasive procedure for treating recurrent glioblastoma (GBM), a malignant type of brain tumor. The study, which appears April 5 in the Journal of Neurosurgery online, was written by lead author Andrew Sloan, MD, Director of Brain Tumor and Neuro-Oncology Center at University Hospitals (UH) Case Medical Center and Case Comprehensive Cancer Center, who also served as co-Principal Investigator, as well as Principal Investigator Gene Barnett, MD, Director of the Brain Tumor and Neuro-Oncology Center at Cleveland Clinic and Case Comprehensive Cancer Center, and colleagues from UH, Cleveland Clinic, Cleveland Clinic Florida, University of Manitoba and Case Western Reserve University.
NeuroBlate™ is a device that "cooks" brain tumors in a controlled fashion to destroy them. It uses a minimally invasive, MRI-guided laser system to coagulate, or heat and kill, brain tumors. The procedure is conducted in an MRI machine, enabling surgeons to plan, steer and see in real-time the device, the heat map of the area treated by the laser and the tumor tissue that has been coagulated.
"This technology is unique in that it allows the surgeon not only to precisely control where the treatment is delivered, but the ability to visualize the actual effect on the tissue as it is happening," said Dr. Sloan. "This enables the surgeon to adjust the treatment continuously as it is delivered, which increases precision in treating the cancer and avoiding surrounding healthy brain tissue."
The study was a Phase I clinical trial investigating the safety and performance of NeuroBlate™ (formerly known as AutoLITT™), a specially-designed laser probe system. The FDA gave the system's developer Monteris Medical and the Case Comprehensive Cancer Center, (comprised of the UH Case Medical Center, Cleveland Clinic, and Case Western Reserve University School of Medicine), an investigatory device exemption (IDE) to study the system in patients with GBMs. The device has recently been cleared by the FDA due, in part, to the results of the study.
The paper describes the treatment of the first10 patients with this technology. These patients, who had a median age of 55, had tumors which were diagnosed to be inoperable or "high risk" for open surgical resection because of their location close to vital areas in the brain, or difficult to access with conventional surgery.
"Overall the NeuroBlate™ procedure was well-tolerated," said Dr. Sloan. "All 10 patients were alert and responsive within one to two hours post-operatively and nine out of the 10 patients were ambulatory within hours. Response and survival was also nearly 10 ½ months, better than expected for patients with such advanced disease."
"Previous attempts using less invasive approaches such as brachytherapy and stereotactic radiosurgery have proven ineffective in recent meta-analysis and randomized trials," said Dr. Barnett. "However, unlike therapies using ionizing radiation, NeuroBlate™ therapy results in tumor death at the time of the procedure. A larger national study will be developed, as a result of this initial success."
INFORMATION:
Dr. Sloan and Dr. Barnett are paid consultants for Monteris Medical and members of the company's Medical Advisory Board.
About the Cleveland Clinic
Cleveland Clinic, located in Cleveland, Ohio, is a not-for-profit multispecialty academic medical center that integrates clinical and hospital care with research and education. Cleveland Clinic was founded in 1921 by four renowned physicians with a vision of providing outstanding patient care based upon the principles of cooperation, compassion and innovation. U.S. News & World Report consistently names Cleveland Clinic as one of the nation's best hospitals in its annual "America's Best Hospitals" survey. Approximately 1,800 full-time salaried physicians and researchers at Cleveland Clinic and Cleveland Clinic Florida represent more than 100 medical specialties and subspecialties. In 2007, there were 3.5 million outpatient visits to Cleveland Clinic and 50,455 hospital admissions. Patients came for treatment from every state and from more than 80 countries. Cleveland Clinic's Web site address is http://www.clevelandclinic.org.
About University Hospitals
University Hospitals serves the needs of patients through an integrated network of hospitals, outpatient centers and primary care physicians. At the core of our health system is University Hospitals Case Medical Center. The primary affiliate of Case Western Reserve University School of Medicine, University Hospitals Case Medical Center is home to some of the most prestigious clinical and research centers of excellence in the nation and the world, including cancer, pediatrics, women's health, orthopedics and spine, radiology and radiation oncology, neurosurgery and neuroscience, cardiology and cardiovascular surgery, organ transplantation and human genetics. Its main campus includes the internationally celebrated UH Rainbow Babies & Children's Hospital, ranked among the top children's hospitals in the nation; UH MacDonald Women's Hospital, Ohio's only hospital for women; and UH Seidman Cancer Center, part of the NCI-designated Case Comprehensive Cancer Center at Case Western Reserve University. University Hospitals Case Medical Center is the 2012 recipient of the American Hospital Association – McKesson Quest for Quality Prize for its leadership and innovation in quality improvement and safety.
For more information, go to http://www.uhhospitals.org
END
Researchers at the University of East Anglia (UEA) have made a discovery in neuroscience that could offer a long-lasting solution to eating disorders such as obesity.
It was previously thought that the nerve cells in the brain associated with appetite regulation were generated entirely during an embryo's development in the womb and therefore their numbers were fixed for life.
But research published today in the Journal of Neuroscience has identified a population of stem cells capable of generating new appetite-regulating neurons in the brains of young and adult rodents.
Obesity ...
A research team led by Professor Makoto Fujita of the University of Tokyo, Japan, and complemented by Academy Professor Kari Rissanen of the University of Jyväskylä, Finland, has made a fundamental breakthrough in single-crystal X-ray analysis, the most powerful method for molecular structure determination. The team's breakthrough was reported in Nature on 28 March 2013 (published online 27 March 2013).
X-ray single-crystal diffraction (SCD) analysis has the intrinsic limitation that the target molecule must be obtained as single crystals. Now, Professor Fujita's team ...
Researchers of the Max Delbrück Center for Molecular Medicine (MDC) and the Leibniz Institute of Molecular Pharmacology (FMP) in Berlin-Buch, Germany, have now detected a substance that can prevent the accumulation of fluid in body tissue and thus edema formation. The results of Dr. Jana Bogum (MDC/FMP) from the MDC research group led by Professor Walter Rosenthal and PD Dr. Enno Klußmann could be important in the future for the treatment of excessive fluid retention in patients with chronic heart failure. Using a novel approach, the researchers have also discovered a new ...
A study led by Dr Akash Sinha has shown that muscle function improves with Vitamin D supplements which are thought to enhance the activity of the mitochondria, the batteries of the cell.
A hormone normally produced in the skin using energy from sunlight, Vitamin D can also be found in a few foods – including fish, fish liver oils, egg yolks and fortified cereals but it can also be effectively boosted with Vitamin D supplements.
It is thought around 60% of people in the UK are vitamin D deficient, with children under five, people with dark skin and the elderly being ...
HOUSTON -- (April 5, 2013) -- Rice University physicists on the hunt for the origins of high-temperature superconductivity have published new findings this week about a material that becomes "schizophrenic" -- simultaneously exhibiting the characteristics of both a metallic conductor and an insulator.
In a theoretical analysis this week in Physical Review Letters (PRL), Rice physicists Qimiao Si and Rong Yu offer an explanation for a strange series of observations described earlier this year by researchers at the Stanford Linear Accelerator Center in Menlo Park, Calif. ...
Scientists have shed light on a common bleeding disorder by growing and analysing stem cells from patients' blood to discover the cause of the disease in individual patients.
The technique may enable doctors to prescribe more effective treatments according to the defects identified in patients' cells.
In future, this approach could go much further: these same cells could be grown, manipulated, and applied as treatments for diseases of the heart, blood and circulation, including heart attacks and haemophilia.
The study focused on von Willebrand disease (vWD), which ...
This press release is available in German.
For animals, prevailing in a fight affects their likelihood of winning future conflicts. The opposite is true of losing a fight. The sex hormone testosterone is often believed to mediate this "winner effect". Researchers from the Max Planck Institute for Ornithology in Seewiesen have examined whether the presence of an audience influences the behaviour and the testosterone changes of Japanese quails (Coturnix japonica) after a fight. The evidence shows that both winners and losers exhibit raised testosterone levels after a ...
Amsterdam, NL, April 5, 2013 – Each year more than three million Americans are living with traumatic brain injury (TBI), a condition that is associated with physical, cognitive, and emotional problems that often affect their sexuality, and subsequently their marital stability, identity, and self-esteem. Taking an in-depth look at the impact of TBI on sexuality, an investigative team critically reviews fourteen studies representing a collective study sample of nearly 1,500 patients, partners, spouses, control individuals, and rehabilitation professionals to examine brain ...
The Djehuty Project, led by the Spanish National Research Council (CSIC), has discovered on the hill of Dra Abu el-Naga in Luxor (ancient Thebes), the burials of four personages belonging to the elite of the 17th Dynasty of Ancient Egypt, who lived about 3.550 years ago. These findings, discovered during the 12th campaign of archeological excavations of the project, shed light on a little-known historical period in which Thebes becomes the capital of the kingdom and the empire's foundations become established with the dominance of Egypt over Palestine and Syria to the ...
DURHAM, N.C. -- The cost of complying with tougher EPA air-quality standards could spur an increased shift away from coal and toward natural gas for electricity generation, according to a new Duke University study.
The stricter regulations on sulfur dioxide, particulate matter, nitrogen oxide and mercury may make nearly two-thirds of the nation's coal-fired power plants as expensive to run as plants powered by natural gas, the study finds.
"Because of the cost of upgrading plants to meet the EPA's pending emissions regulations and its stricter enforcement of current ...
