INDIANAPOLIS — Drug-drug interactions causing adverse effects are common and can cause significant patient harm and even death. A new study is one of the first to examine how clinicians become aware of and process information about potential interactions and subsequently make their real-world decisions about prescribing. Based on these findings, the research team makes specific recommendations to aid clinician decision-making to improve patient safety. “Drug-drug interactions are very common, more common than a lot of people outside the healthcare system expect. In the U.S., these interactions lead to hundreds of thousands of hospitalizations ...

A type of immune cell can help predict which patients may benefit most from cancer immunotherapies, researchers from King’s College London, Guy’s and St Thomas’ Hospital Trust, and the Francis Crick Institute have found. The study, published today in Nature Cancer, found that a rare type of T cells (a type of immune cell), can help predict the likelihood of whether a patient with advanced skin cancer will be responsive to immunotherapy treatments. The results could also lead to the development of new and more effective treatments for patients with melanoma who do not benefit from current ...

Mutations of the tumor suppressor p53 not only have a growth-promoting effect on the cancer cells themselves, but also influence the cells in the tumor's microenvironment. Scientists at the German Cancer Research Center (DKFZ) and the Weizmann Institute in Israel have now shown that p53-mutated mouse breast cancer cells reprogram fat cells. The manipulated fat cells create an inflammatory microenvironment, impairing the immune response against the tumor and thus promoting cancer growth. No other gene is mutated as frequently in human tumors as the gene for the tumor suppressor p53. In around 30 percent of all cases of breast cancer, the cancer cells show mutations or losses ...

Primates – and this includes humans – are thought of as highly social animals. Many species of monkeys and apes live in groups. Lemurs and other Strepsirrhines, often colloquially referred to as “wet-nosed” primates, in contrast, have long been believed to be solitary creatures, and it has often been suggested that other forms of social organization evolved later. Previous studies have therefore attempted to explain how and when pair-living evolved in primates. More recent research, however, indicates that many nocturnal Strepsirrhines, which are more challenging to investigate, are not in fact solitary but live in pairs of males and females. But ...

Research team draws up criteria for PET-based examinations of malignant brain tumors Diffuse gliomas are malignant brain tumors that cannot be optimally examined by means of conventional MRI imaging. So-called amino acid PET scans are better able to image the activity and spread of gliomas. An international team of researchers (RANO Working Group), led by scientists from LMU and the Medical University of Vienna, has now drawn up the first ever international criteria for the standardized imaging of gliomas using amino acid PET. It has published its results ...

The mini-halos of dark matter scattered throughout the Cosmos could function as highly sensitive probes of primordial magnetic fields. This is what emerges from a theoretical study conducted by SISSA and published in Physical Review Letters. Present on immense scales, magnetic fields are found everywhere in the Universe. However, their origin are still subjects of debate among scholars. An intriguing possibility is that magnetic fields originated near the birth of the universe itself, that is they are primordial magnetic fields. In the study, researchers showed that if magnetic fields are indeed primordial then it could cause an increase in dark matter density perturbations ...

Perovskite materials are still attracting a lot of interest in solar cell applications. Now, the nanostructures of perovskite materials are being considered as a new laser medium. Over the years, light amplification in perovskite quantum dots has been reported, but most of the works present inadequate quantitative analysis. To assess the light amplification ability, “gain coefficient” is necessary, whereby the essential characteristic of a laser medium is revealed. An efficient laser medium is one that has a large gain. Scientists have been exploring ways to boost this gain. Now, in a recent study, a team of researchers, led by Professor ...

Scientific researchers draw inspiration from nature’s brilliance as they seek to develop transformative solutions to unresolved challenges. Prof. WANG Zuankai, Associate Vice President (Research and Innovation) and Chair Professor of the Department of Mechanical Engineering of The Hong Kong Polytechnic University (PolyU), has meticulously explored the intricacies of nature and made remarkable findings with very significant real-world applications. His recently published research on cooling ceramic successfully translates novel discovery into sustainable applications.   Findings from his research project “Hierarchically structured passive radiative cooling ceramic with high ...

CHAMPAIGN, Ill. — Acetaminophen is considered the safest over-the-counter pain reliever and fever reducer available during pregnancy. Studies have shown that 50%-65% of women in North America and Europe take acetaminophen during pregnancy. A new study from researchers at the University of Illinois Urbana-Champaign explored the relationship between acetaminophen use during pregnancy and language outcomes in early childhood. It found that increasing acetaminophen use was associated with language delays. The findings are reported in the journal Pediatric ...

Hydrothermal vents are an unlikely environment for animals to flourish, characterized by rapid changes in temperature and a challenging chemistry: acidic pH, rich in sulfur and methane. Not to mention the high hydrostatic pressure and the darkness of the deep sea. A team of scientists at the Sanya Institute of Deep-sea Science and Engineering (China) have now sequenced the full genome of a particularly unusual inhabitant of the hydrothermal vent environment: the sea cucumber Chiridota heheva. The research has been published in the Open Science ...

A UC Riverside study to motivate your new year’s resolutions: it demonstrates that high-fat diets affect genes linked not only to obesity, colon cancer and irritable bowels, but also to the immune system, brain function, and potentially COVID-19 risk. While other studies have examined the effects of a high-fat diet, this one is unusual in its scope. UCR researchers fed mice three different diets over the course of 24 weeks where at least 40% of the calories came from fat. Then, they looked not only at the microbiome, but also at genetic changes in all four parts of the intestines.  One group of ...

PULLMAN, Wash. – As more states require employers to list compensation on job ads, a trending strategy to use very wide pay ranges could potentially harm recruitment, according to a Washington State University study. The study, published in the Journal of Applied Psychology, found that participants in three different experiments were more likely to respond negatively to job ads with very wide pay ranges, viewing those employers as less trustworthy. Prior surveys have found that most people report they would trust organizations that include pay ranges in ...

Researchers at the University of Maryland and National Institutes of Health have identified the microbial enzyme responsible for giving urine its yellow hue, according to a new study published in the journal Nature Microbiology on January 3, 2024. The discovery of this enzyme, called bilirubin reductase, paves the way for further research into the gut microbiome’s role in ailments like jaundice and inflammatory bowel disease.  “This enzyme discovery finally unravels the mystery behind urine’s yellow color,” said the study’s lead author Brantley Hall, an assistant ...

Invisible to our eyes, shortwave infrared (SWIR) light can enable unprecedented reliability, function and performance in high-volume, computer vision first applications in service robotics, automotive and consumer electronics markets. Image sensors with SWIR sensitivity can operate reliably under adverse conditions such as bright sunlight, fog, haze and smoke. Furthermore, the SWIR range provides eye-safe illumination sources and opens up the possibility of detecting material properties through molecular imaging.   Colloidal quantum ...

CAMBRIDGE, MA -- With help from an artificial language network, MIT neuroscientists have discovered what kind of sentences are most likely to fire up the brain’s key language processing centers. The new study reveals that sentences that are more complex, either because of unusual grammar or unexpected meaning, generate stronger responses in these language processing centers. Sentences that are very straightforward barely engage these regions, and nonsensical sequences of words don’t do much for them either. For ...

New York, NY [January 3, 2024]—Driven by the need for a better way to prioritize targets for drug development, the Icahn School of Medicine at Mount Sinai has led the development of a novel “genetic priority score” (GPS) that will integrate various types of human genetic data into a single easy-to-interpret score. The findings were described in the January 3 online issue of Nature Genetics [DOI: 10.1038/s41588-023-01609-2]. Studies have shown that drugs have an increased likelihood of success in clinical trials when ...

Alaska is on the front lines of climate change, experiencing some of the fastest rates of warming of any place in the world. And when temperatures rise in the state’s interior—a vast high-latitude region spanning 113 million acres—permafrost there not only thaws, releasing significant amounts of its stored carbon back into the atmosphere where it further accelerates rising temperatures, but it decays. This decomposition has the potential to infuse above- and belowground food webs with carbon, which can affect ...

Disease-causing bacteria of the genus Salmonella or Yersinia can use tiny injection apparatuses to inject harmful proteins into host cells, much to the discomfort of the infected person. However, it is not only with a view to controlling disease that researchers are investigating the injection mechanism of these so-called type III secretion systems, also known as "injectisomes". If the structure and function of the injectisome were fully understood, researchers would be able to hijack it to deliver specific drugs into cells, such as cancer cells. In fact, the structure of the injectisome has already been elucidated. ...

MAGs, predominantly in 1(3)-MAG form, and DAGs, with 1,3-DAGs as the more stable isomer, are crucial in food, cosmetic, and other industries. While MAGs are vital emulsifiers, comprising 75% of global production, DAGs are known as functional cooking oils that can reduce body fat and serum TAGs. However, their natural concentration in oils is low, prompting extensive research into their chemical and environmentally-friendly enzymatic production. Recently, a review published in the Grain & Oil Science and Technology journal on 2 November 2023, has shed light on the advancements in enzymatic production methods with special efforts on practical and ...

In Hawaiʻi and across much of Oceania, Pacific Islanders celebrate the connections between their islands and the ocean that surrounds them. “As descendants of the ocean, the dearth of Native Hawaiians and Pacific Islanders (NHPI) in ocean science seems inconsonant,” writes a team of authors that includes University of Hawai‘i (UH) at Mānoa faculty, students, and alumni in an article in a special issue of the journal Oceanography, “Building Diversity, Equity, and Inclusion in the Ocean Sciences. The authors ask, “Where are all our island people in the ...

In China, national parks represent the country’s most unique natural landscapes. Scientific evaluation of landscape resources is significant for preserving the authenticity and integrity of national parks. Taking Qianjiangyuan National Park System Pilot Zone as an example, this research investigated the willingness of internal group (residents and administrative staff) and external group (tourists) to pay for a hypothetical market project based on the pilot zone via Contingent Valuation Method to acquire the monetized value of landscape resources in the national park, and applied Logistic Regression to analyze the influencing factors. The results show ...

In 2022, the insurance industry made a whopping USD 6 trillion globally—more than the entire economy of big countries like Japan and Germany. A new study, published in The Journal of Finance and Data Science, looked at how technology, especially big data, is shaking things up in insurance. Big data means using a lot of information to make better decisions. The study found that by using big data, insurance companies can understand risks better, offer fair prices and keep customers happier. “What's surprising is how fast insurance companies are jumping on the big data bandwagon,” says first ...

Light, as an electromagnetic field, has two essential components: amplitude and phase. However, optical detectors, usually relying on photon-to-electron conversion (such as charge-coupled device sensors and the human eye), cannot capture the phase of the light field because of their limited sampling frequency. Fortunately, as the light field propagates, the phase delay also causes changes in the amplitude distribution; therefore, we can record the amplitude of the propagated light field and then calculate the corresponding phase, called phase recovery. Some common phase ...

A University of Queensland-led study has found humans can tell if chickens are excited or displeased, just by the sound of their clucks.   Professor Joerg Henning from UQ’s School of Veterinary Science said researchers investigated whether humans could correctly identify the context of calls or clucking sounds made by domestic chickens, the most commonly farmed species in the world. “In this study, we used recordings of chickens vocalising in all different scenarios from a previous experiment,” ...

A previously unidentified genetic mutation in a small protein provides significant protection against Parkinson’s disease and offers a new direction for exploring potential treatments, according to a new USC Leonard Davis School of Gerontology study. The variant, located in a mitochondrial microprotein dubbed SHLP2, was found to be highly protective against Parkinson’s disease; individuals with this mutation are half as likely to develop the disease as those who do not carry it. The variant form of the protein is relatively rare and is found primarily in people of European descent. The findings appear on January 3, 2024, in the journal Molecular Psychiatry. First ...