Reston, VA—PET imaging with 68Ga-FAPI can more effectively detect and stage pancreatic cancer as compared with 18F-FDG imaging or contrast-enhanced CT, according to new research published in the December issue of The Journal of Nuclear Medicine. In a head-to-head study, 68Ga-FAPI detected more pancreatic tumors on a per-lesion, per-patient, or per-region basis and led to major and minor changes to clinical management of patients. In addition to enhancing precise detection of pancreatic cancer, 68Ga-FAPI ...

Understanding Climate Mobilities: New study examines perspectives from South Florida practitioners As climate change continues to impact people across South Florida, the need for adaptive responses becomes increasingly important. A recent study led by researchers at the University of Miami Rosenstiel School of Marine, Atmospheric, and Earth Science, assessed the perspectives of 76 diverse South Florida climate adaptation professionals. The study titled, “Practitioner perspectives on climate mobilities in South Florida” was published in the December issue of the Journal Oxford Open Climate Change, and explores the expectations and concerns of practitioners from the ...

Major cities on the U.S. Atlantic coast are sinking, in some cases as much as 5 millimeters per year – a decline at the ocean’s edge that well outpaces global sea level rise, confirms new research from Virginia Tech and the U.S. Geological Survey. Particularly hard hit population centers such as New York City and Long Island, Baltimore, and Virginia Beach and Norfolk are seeing areas of rapid “subsidence,” or sinking land, alongside more slowly sinking or relatively stable ground, increasing the risk to roadways, runways, building foundations, rail ...

Reston, VA—A novel PET imaging tracer has been proven to safely and effectively detect a common cancer gene mutation that is an important molecular marker for tumor-targeted therapy. By identifying this mutation early, physicians can tailor treatment plans for patients to achieve the best results. This research was published in the December issue of The Journal of Nuclear Medicine. Kirsten rat sarcoma (KRAS) is a commonly mutated oncogene that is present in approximately 20-70 percent of cancer cases. Patients with KRAS mutations usually respond poorly to standard therapies. As such, the National Comprehensive ...

Central features of human evolution may stop our species from resolving global environmental problems like climate change, says a new study led by the University of Maine. Humans have come to dominate the planet with tools and systems to exploit natural resources that were refined over thousands of years through the process of cultural adaptation to the environment. University of Maine evolutionary biologist Tim Waring wanted to know how this process of cultural adaptation to the environment might influence the goal of solving global environmental problems. ...

WASHINGTON, D.C., Jan 2, 2024 — The latest issues of three American Psychiatric Association journals, The American Journal of Psychiatry, Psychiatric Services and The American Journal of Psychotherapy are now available online.   The January issue of The American Journal of Psychiatry features studies focusing on improving clinical outcomes and informing new interventions. Highlights include: Predicting Acute Changes in Suicidal Ideation and Planning: A Longitudinal Study of Symptom Mediators and the Role of the Menstrual ...

In a world grappling with the complexities of mental health conditions like anxiety, depression, and PTSD, new research from Boston University neuroscientist Dr. Steve Ramirez and collaborators offers a unique perspective. The study, recently published in the Journal of Neuroscience, delves into the intricate relationship between fear memories, brain function, and behavioral responses. Dr. Ramirez, along with his co-authors Kaitlyn Dorst, Ryan Senne, Anh Diep, Antje de Boer, Rebecca Suthard, Heloise ...

New York, NY (January 2, 2024)—Researchers at the Icahn School of Medicine at Mount Sinai have uncovered insights into the potential mechanism of action of the antipsychotic medication asenapine, a possible therapeutic target for substance use and neuropsychiatric disorders. This discovery may pave the way for the development of improved medications targeting the same pathway. Their findings, detailed in the January 2 online issue of Nature Communications https://doi.org/10.1038/s41467-023-44601-4, show that a brain protein known as the TAAR1 receptor, a drug target known to regulate dopamine signaling in key reward pathways in the brain, differs ...

St. Jude Children’s Research Hospital scientists found that cytonemes (thin, long, hair-like projections on cells) are important during neural development. Cytonemes connect cells communicating across vast distances but are difficult to capture with microscopy in developing vertebrate tissues. The researchers are the first to find a way to visualize how cytonemes transport signaling molecules during mammalian nervous system development. The findings were published in Cell.  “We showed cytonemes are a direct express route for signal transport,” said corresponding author ...

Philadelphia, January 2, 2024 – Findings from a pioneering study in The American Journal of Pathology, published by Elsevier, reveal that administration of the neuropeptide α-melanocyte–stimulating hormone (α-MSH) promotes corneal healing and restores normal eye function to an otherwise degenerating and diseased cornea by providing protection against cell death and promoting cell regeneration. Due to a lack of currently available medical therapy, patients suffering from corneal endothelial disease, ...

At night in the Cerrado, Brazil’s savanna and second-largest biome, larvae of the click beetle Pyrearinus termitilluminans, which live in termite mounds, display green lanterns to capture prey attracted by the bright light. In more than 30 years of expeditions with his students to Emas National Park and farms around the conservation unit in Goiás state to collect specimens, the phenomenon has never been so rare, said Vadim Viviani, a professor at the Federal University of São Carlos’s Science and Technology for Sustainability Center (CCTS-UFSCar) in Sorocaba, São Paulo state. “In the 1990s, we ...

Binghamton University, State University of New York Distinguished Professor and Nobel Laureate M. Stanley Whittingham has been chosen as the joint winner of the $3 million 2023 VinFuture Grand Prize in recognition of his contributions to the invention of lithium-ion batteries. The prize recognized how the combination of solar energy and lithium battery storage is overcoming climate change and was recently presented by the Prime Minister of Vietnam. “I am truly honored to be chosen for this prestigious honor,” said Whittingham. “VinFuture’s efforts to recognize green and sustainable energy is a noble cause, and ...

ITHACA, NY: In a significant advancement in the field of biochemistry, scientists at the Boyce Thompson Institute (BTI) and Cornell University have uncovered new insights into a family of metabolites, acylspermidines, that could change how we understand aging and fight diseases. The study, recently published in Nature Chemical Biology, presents an unexpected connection between spermidine, a long-known compound present in all living cells, and sirtuins, an enzyme family that regulates many life-essential functions. Sirtuins ...

COLUMBUS, Ohio – The number of Americans who watch or follow girls’ and women’s sports goes well beyond those who view TV coverage of women’s athletic events, a new study suggests.   In fact, just over half of American adults spent some time watching or following female sports in the past year, the results showed.   U.S. adults spend about one hour a week consuming female sports content, which may seem higher than expected, according to the researchers.  Still, it is only a small fraction of Americans’ overall sports consumption.   The study was ...

New research has identified the specific biological mechanism behind the muscle dysfunction found in myotonic dystrophy type 1 (DM1) and further shows that calcium channel blockers can reverse these symptoms in animal models of the disease. The researchers believe this class of drugs, widely used to treat a number of cardiovascular diseases, hold promise as a future treatment for DM1. “The main finding of our study is that combined calcium and chloride channelopathy is highly deleterious and plays a central role in the function impairment of muscle found in the disease,” said John Lueck, Ph.D., an assistant professor at the University of Rochester Medical Center (URMC) in the Departments ...

Throughout the day and night, cerebrospinal fluid (CSF) pulses through small fluid-filled channels surrounding blood vessels in the brain, called perivascular spaces, to flush out neuroinflammation and other neurological waste. A disruption to this vital process can lead to neurological dysfunction, cognitive decline, or developmental delays. For the first time, researchers Dea Garic, PhD, and Mark Shen, PhD, both at the UNC School of Medicine’s Department of Psychiatry, discovered that infants with abnormally enlarged perivascular spaces have a 2.2 times greater chance of developing autism ...

Growth hormone (GH) acts on many tissues throughout the body, helping build bones and muscles, among other functions. It is also a powerful anxiolytic. A study conducted by researchers at the University of São Paulo (USP) in Brazil has produced a deeper understanding of the role of GH in mitigating anxiety and, for the first time, identified the population of neurons responsible for modulating the influence of GH on the development of neuropsychiatric disorders involving anxiety, depression and post-traumatic stress. An article on the study is published in the Journal of Neuroscience. In ...

ITHACA, N.Y. – New Cornell University-led research finds that social media platforms and the metrics that reward content creators for revealing their innermost selves to fans open creators up to identity-based harassment. “Creators share deeply personal – often vulnerable – elements of their lives with followers and the wider public,” said Brooke Erin Duffy, associate professor of communication. “Such disclosures are a key way that influencers build intimacy with audiences and form communities. There’s a pervasive sense that internet users clamor for less polished, less idealized, ...

Imagine blasting off on a multiyear voyage to Mars, fueled by a diet of bland, prepackaged meals. As space agencies plan for longer missions, they’re grappling with the challenge of how to best feed people. Now, researchers reporting in ACS Food Science & Technology have designed the optimal “space meal”: a tasty vegetarian salad. They chose fresh ingredients that meet male astronauts’ specialized nutritional needs and can be grown in space. Astronauts in space burn ...

Perceived time has a significant impact on the actual time it takes to heal physical wounds, according to new research by Harvard psychologists Peter Aungle and Ellen Langer. Their study, published late last month in Nature Scientific Reports, challenges conventional beliefs about psychological influences on physical health. The findings suggest a broader range of psychological influences than is currently appreciated. To complete their study, the authors used a standardized procedure to mildly wound volunteer subjects. Perceived time was then manipulated in the lab, with each study participant completing three ...

About The Study: This study of 67,000 freezing cycles among 47,000 patients reveals a distinct pattern in the utilization of cryopreserved oocytes among patients undergoing planned oocyte cryopreservation in the U.S. Despite the increase in number of patients pursuing oocyte cryopreservation, there is a notably low rate of return to utilize previously vitrified oocytes; notably, patients with poor ovarian response are more likely to return, although the time to return is similar to those with normal ovarian response.  Authors: Yuval Fouks, M.D., M.P.H., of Boston IVF-The Eugin Group in Waltham, Massachusetts, is the corresponding ...

About The Study: The findings of this systematic review and meta-analysis of 23 randomized clinical trials including 3,100 parents suggest that problem-solving skills training for parents of children with chronic health conditions may improve the psychosocial well-being of the parents, their children, and their families. Further high-quality randomized clinical trials with longer follow-up times and that explore physical and clinical outcomes are encouraged to generate adequate evidence.  Authors: Yuanhui Luo, Ph.D., of Central South University in Changsha, Hunan, China, is the corresponding ...

In a report just published in the journal Nature Climate Change, researchers argue that tackling inequality is vital in moving the world towards Net-Zero – because inequality constrains who can feasibly adopt low-carbon behaviours. They say that changes are needed across society if we are to mitigate climate change effectively. Although wealthy people have very large carbon footprints, they often have the means to reduce their carbon footprint more easily than those on lower incomes. The researchers say there is ...

Synthetic biology offers the opportunity to build biochemical pathways for the capture and conversion of carbon dioxide (CO2). Researchers at the Max-Planck-Institute for Terrestrial Microbiology have developed a synthetic biochemical cycle that directly converts CO2 into the central building block Acetyl-CoA. The researchers were able to implement each of the three cycle modules in the bacterium E.coli, which represents a major step towards realizing synthetic CO2 fixing pathways within the context of living cells. Developing new ways for the capture and conversion of CO2 is key to tackle ...

Monitoring glucose levels is one of the key elements in health monitoring. A research team has now developed a battery-independent fluorescent nanosensor based on single-wall carbon nanotubes and an inactive form of the enzyme glucose oxidase (GOx). Because the enzyme is not in its active form, the analyte is not consumed during the measurement, and continuous, reversible, and non-invasive bioimaging of glucose levels in body fluids and tissues is possible, the team reports in the journal Angewandte Chemie. Blood glucose levels are typically measured using GOx-based electrochemical sensors. However, these sensors ...