A new method to cure HIV—by transplanting HIV-resistant stem cells from umbilical cord blood—has yielded long-term successful results, say scientists. The approach was successfully used to treat the “New York patient,” a middle-aged woman with leukemia and HIV who self-identifies as mixed race, who has been without HIV since 2017. Using stem cells from cord blood rather than from compatible adult donors, as has been done previously, increases the potential to cure HIV via stem cell transplantation ...

The Ashaninka are the most numerous Indigenous people living in the rainforests of Peru and Brazil where they inhabit a crucial area between the Andes and sources of the Amazon River. And yet, despite the size of the population and their importance in the past and present, their genetic history has remained understudied. Now a team of researchers reporting in the journal Current Biology on March 16 has analyzed the genomes of more than 50 individuals to clarify the group’s interactions with nearby South American regions, including Central America and the Caribbean. ...

Geneticists have written new chapters in the reconstruction of pre-colonial Americas history after using DNA from the indigenous Ashaninka people from Amazonian Peru. They have discovered previously unexpected levels of genetic variation in this group and uncovered a strong hint that these people were involved in a South-to-North migration that led to the transition from an archaic to ceramic culture in the Caribbean islands.  The dramatic impact of European colonisation during the second half of the last millennium has strongly influenced the genetic history of the Americas, making the reconstruction ...

About The Study: This survey study found that people with disabilities were more likely to report household employment loss and financial hardship during the initial COVID-19 pandemic, which are especially pronounced among racial and ethnic minority respondents. These findings suggest people with disabilities may be disproportionately affected by the initial pandemic and may require additional resources and policy strategies (e.g., training programs, workplace accommodations) as several labor markets adapt to the pandemic (e.g., shifting to remote working).  Authors: Kea Turner, Ph.D., M.P.H., M.A., of the H. Lee Moffitt Cancer Center ...

About The Study: In this study of 722,000 hospitalization episodes, patients with Alzheimer disease and related dementias (ADRD) had higher readmission rates and overall readmission and episode costs than their counterparts without ADRD. Hospitals may need to be better equipped to care for patients with ADRD, especially in the post-discharge period. Considering that any type of hospitalization may put patients with ADRD at a high risk of 30-day readmission, judicious preoperative assessment, postoperative discharge, and ...

Preterm infants do not get used to repeated pain in the way that full-term infants, children and adults do habituate to pain, finds a study led by UCL (University College London) researchers. The authors of the new Current Biology paper say that if preterm infants have not yet developed the mechanism that enables people to get used to moderate pain, medical procedures in their first few weeks of life could potentially impact their development. Lead author Dr Lorenzo Fabrizi (UCL Neuroscience, Physiology & Pharmacology) said: “The way that we can get used to things can be seen as the simplest example of behavioural and brain plasticity, and it is ...

Ikoma, Japan – The generation and maintenance of tissue boundaries are fundamental to the development of functional organs in both plants and animals. In general, tissue boundaries are initially set among primordial cells, and their shapes and arrangements are refined during subsequent organ growth. In this process, cell migration plays a curtail role for boundary refinement in animal systems, however, plant tissue lacks such cell fluidity due to its cell walls. Despite significant progress in understanding the initial patterning of tissue boundaries in several ...

A recent study makes it clear: Countries like Sweden that can link data from different areas - such as the labor market and health care - have a decisive advantage when it comes to setting targeted actions. A research team from the Complexity Science Hub, together with scientists from Sweden, Denmark and the Netherlands, investigated the extent to which mental and somatic illnesses influence integration into the labor market and whether there is a difference here between refugee and Swedish-born young adults. "In total, we analyzed ...

Coal-fired power plants have been in place for a long time to meet the global demands for power generation. Needless to say, there are environmental and human health concerns to be addressed on this front. While there are ongoing efforts to transition to renewable energy resources, coal-fired power plants may not become obsolete just yet. Against this backdrop, it is pertinent to explore how the efficiency of these coal-fired boilers can be improved while mitigating their harmful effects on the environment, namely greenhouse gas emissions, acid rain, and photochemical smog generation, and the human health. To this end, various ...

The rapidly-growing bottled water industry can undermine progress towards a key sustainable development goal: safe water for all, says a new United Nations report.   Based on an analysis of literature and data from 109 countries, the report says that in just five decades bottled water has developed into “a major and essentially standalone economic sector,” experiencing 73% growth from 2010 to 2020. And sales are expected to almost double by 2030, from US$ 270 billion to $500 billion. Released ...

(WASHINGTON, March 16, 2023) – While research has long established disparities in health outcomes among individuals living with sickle cell disease (SCD), few studies have quantified these gaps. A new study published in Blood Advances finds that the average life expectancy of publicly insured patients living with SCD is roughly 52.6 years. In contrast, the CDC reports that the average life expectancy in the United States is 73.5 years for men and 79.3 years for women, demonstrating the considerable ...

The western chimpanzees of Guinea are threatened by mining activities. Using a novel genetic approach, UZH researchers and an international team have collected information on population size and community structure of the endangered species. These data provide an important baseline to assess the impact of mining. The western chimpanzee is listed as “Critically Endangered” on the Red List of the International Union for the Conservation of Nature. The Mount Nimba Strict Nature Reserve, a UNESCO World Heritage site, located on the borders of Guinea, Liberia and Côte ...

The future of wireless communications is set to take a giant leap with the advent of sixth-generation (6G) wireless technology. A research team at City University of Hong Kong (CityU) invented a groundbreaking tunable terahertz (THz) meta-device that can control the radiation direction and coverage area of THz beams. By rotating its metasurface, the device can promptly direct the 6G signal only to a designated recipient, minimizing power leakage and enhancing privacy. It is expected to provide a highly adjustable, directional and secure means for future 6G communications systems. The potential of THz band technology ...

New Orleans, Louisiana – Ochsner Health is leading the way for precision medicine nationwide by becoming one of the first hospital systems to standardize genomic testing, significantly advancing ways in which care teams can treat cancer patients. This change helps providers determine individualized treatment by understanding how patients will react to certain drugs, thereby lowering risk of adverse side effects, improving patient experience, and bettering patient outcomes. Pharmacogenomics, or PGx, testing guides physicians how patients metabolize certain drugs and warns of possible side effects so they may ...

  Photos There's been a well-documented shift toward earlier springtime flowering in many plants as the world warms. The trend alarms biologists because it has the potential to disrupt carefully choreographed interactions between plants and the creatures—butterflies, bees, birds, bats and others—that pollinate them.   But much less attention has been paid to changes in other floral traits, such as flower size, that can also affect plant-pollinator interactions, at a time when many insect pollinators are in global decline.   In ...

B lymphocytes – also known simply as B cells – play a central role in the immune system. If pathogens enter the body, B cells are activated and develop into plasma cells, which then release antibodies. One important step in this process is the germinal center reaction. If the B cells’ maturation into plasma cells is disrupted, multiple myeloma can develop – one of the most common blood cancers. This disease has a variety of subtypes and is not yet curable. Multiple myelomas develop very slowly and in several stages. The process is initiated by spontaneous genetic aberrations that occur ...

What are the key research priorities that will help tackle the global challenges of climate change, the biodiversity crises and feed a growing population in a sustainable way? Ten years after these priorities were first debated and summarised by a panel of scientists and published in New Phytologist, the panel reflects on the changes to plant science and the progress made to address these research areas, published on 16 March in a Letter in New Phytologist. To re-evaluate research priorities, a new panel was formed in 2022 to provide an international perspective on the important areas for plant science research. This project, ...

LOS ANGELES — More than 37 million Americans have diabetes, and approximately 90-95% have Type 2 diabetes. Diabetes is a chronic condition where the body does not produce or effectively use insulin. A lack of insulin leads to raised blood glucose (sugar) levels, which can cause heart disease and stroke, kidney disease, nerve damage and other severe complications. Keck Medicine of USC has launched a Phase 2 clinical trial investigating the effectiveness of a new outpatient, nonsurgical endoscopic procedure in stabilizing blood glucose levels for patients.  “Currently, the only treatment for diabetes ...

New UC Riverside research makes it likely that proteins responsible for activating mosquito sperm can be shut down, preventing them from swimming to or fertilizing eggs. The study could help control populations of Culex, the common house mosquito that transmits brain-swelling encephalitis and West Nile Virus.  “During mating, mosquitoes couple tail to tail, and the males transfer sperm into the female reproductive tract. It can be stored there awhile, but it still has to get from point A to point B to complete fertilization,” said Cathy Thaler, UCR cell biologist and the study’s first author.  Key to completing that journey are the specialized proteins secreted ...

Arlington, Va., March 16, 2023 – Findings from a new study published in the American Journal of Infection Control (AJIC), highlight perceptions of and barriers to reliable hand hygiene among specific clinician subgroups. The results, from the first study of its kind, provide insights that can be used to design and implement future, targeted interventions to optimize hand hygiene reliability among medical professionals. “While prior studies focused on challenges to hand hygiene reliability by healthcare role, we believe our study is the first to highlight key differences in perceived barriers ...

Many people keen to reduce their meat consumption are turning to substitutes made of legumes packed with protein, vitamins, and fiber. But allergies to legumes like soy or peanuts are both common and dangerous. Are patients allergic to particular legumes at risk from meat-free proteins made of legumes even if they contain different legumes? Dr Mark Smits and a team of scientists at University Medical Center Utrecht set out to investigate. “Both protein consumption and the world’s population are increasing which leads to an urgent demand for sustainable ...

A small nucleus in the brainstem called locus coeruleus (literally the “blue spot,”) is the primary source of a major neuromodulator, norepinephrine (NE), an important mediator of the ‘fight or flight’ response in animals. However, very little is known about the local connections of this small albeit critically important group of neurons. A recent pioneering study published in eLife from the laboratory of Dr. Xiaolong Jiang, investigator at the Jan and Dan Duncan Neurological Research Institute (Duncan NRI) ...

More donated hearts could be suitable for transplantation if they are kept functioning within the body for a short time following the death of the donor, new research has concluded. The organs are kept functioning by restarting local circulation to the heart, lungs and abdominal organs – but, crucially, not to the brain – of patients whose hearts have stopped beating for five minutes or longer and have been declared dead by circulatory criteria (donation after circulatory death, or DCD). It is hoped that this technique could increase the number of usable donated hearts by as much as 30% in the future, helping address ...

**Note: the release below is a special early release from the European Congress of Clinical Microbiology & Infectious Diseases (ECCMID 2023, Copenhagen, 15-18 April). Please credit the congress if you use this story** Embargo – 2301H UK time Wednesday 15 March A review from WHO on the number of new antibiotics currently in the pipeline shows that just 12 new antibiotics have entered the market in the five years from 2017-21.  And there are far too few (just 27) under development in clinical trials against pathogens considered critical* by WHO such as Acinetobacter baumannii and Pseudomonas aeruginosa. ...

Sophia Antipolis, 16 March 2023:  Sleeping less than five hours a night is associated with a 74% raised likelihood of developing peripheral artery disease (PAD) compared with seven to eight hours. That’s the finding of a study published today in European Heart Journal – Open, a journal of the ESC.1   “Our study suggests that sleeping for seven to eight hours a night is a good habit for lowering the risk of PAD,” said study author Dr. Shuai Yuan of the Karolinska Institute, Stockholm, ...