CORVALLIS, Ore. - A team of Oregon State University scientists has discovered a new class of anti-cancer compounds that effectively kill liver and breast cancer cells. The findings, recently published in the journal Apoptosis, describe the discovery and characterization of compounds, designated as Select Modulators of AhR-regulated Transcription (SMAhRTs). Edmond Francis O'Donnell III and a team of OSU researchers conducted the research in the laboratory of Siva Kolluri, a professor of cancer research at Oregon State. They also identified the aryl hydrocarbon receptor (AhR) as a new molecular target ...

Researchers looking to help people suffering from addiction, depression, and pain are studying how certain brain neurons operate to see if they can be controlled. In a paper published May 11 in Neuron, researchers at the University of Washington School of Medicine and Washington University in St. Louis, along with several other universities, successfully used a protein called parapinopsin to turn off brain circuits. This protein is found in lamprey - an ancient lineage of jawless fish similar to eel. Reserachers said the ability to inhibit neurons could eventually lead to turning ...

BUFFALO, N.Y. - Americans are in chronic pain, and a comprehensive new study exploring trends in this major public health concern reveals that what has been a long-standing and under-acknowledged problem is getting substantially worse. The findings, published in the latest issue of the journal Demography, suggest blanket increases across multiple measures, with pain rising in every adult age group, in every demographic group, and at every site of pain for which data exists. People today are experiencing more pain than individuals of the same age in earlier decades. In fact, each subsequent birth group is in greater pain than the one that came before it. "We ...

BOSTON - It's a real-life plot worthy of a classic spy novel: Researchers at Massachusetts General Hospital (MGH), the Dana-Farber Cancer Institute and other Boston-area research centers are turning the tables on glioblastomas, the most devastating and aggressive form of brain cancer, by transforming a type of cell that normally protects tumors and inhibits effective drug therapy into a stone-cold glioblastoma killer. Glioblastoma, a type of brain tumor, is rapidly fatal: Most patients die within two years of diagnosis despite aggressive therapies such as brain surgery, whole-brain radiation and chemotherapy. Despite hopes that a class of drugs known as immune checkpoint blockers (ICBs) - drugs that have revolutionized the treatment ...

DURHAM, N.C. -- With mosquito season upon us, people are stocking up on repellents to prevent itchy bites. Bug repellents are important because they don't just protect against the buzzing, blood-sucking little pests -- they also safeguard against the diseases they carry, which kill some 700,000 people worldwide each year. Surprisingly, despite widespread use, no one understood exactly how most mosquito repellents keep the insects away. Now researchers are starting to uncover the first pieces of the puzzle. A new study has identified a scent receptor in mosquitoes that helps them sniff out and avoid trace amounts of pyrethrum, a plant extract used for centuries to repel biting insects. One ...

INFORMS Journal Manufacturing & Service Operations Management Study Key Takeaways: The study looked at archival data on 240 U.S. federal government technology programs across 24 federal agencies. Researchers found that the practice of moving baseline targets is a key driver in continually increasing budgets for federal government technology programs. The componentization of a program into smaller work units and increasing the level of competency in program management can dampen this increase, resulting in significant cost savings. CATONSVILLE, MD, May 11, 2021 ...

HERSHEY, Pa. -- Over the past year, studies have revealed that certain pre-existing conditions, such as cancer, diabetes and high blood pressure, can increase a person's risk of dying from COVID-19. New research shows that individuals living with human immunodeficiency virus (HIV) and acquired immune deficiency syndrome (AIDS) -- an estimated 38 million worldwide, according to the World Health Organization -- have an increased risk of SARS-CoV-2 infection and fatal outcomes from COVID-19. In a new study, published in Scientific Reports, Penn State College of Medicine researchers found that people living ...

A newly described horned dinosaur that lived in New Mexico 82 million years ago is one of the earliest known ceratopsid species, a group known as horned or frilled dinosaurs. Researchers reported their find in a publication in the journal PalZ (Paläontologische Zeitschrift). Menefeeceratops sealeyi adds important information to scientists' understanding of the evolution of ceratopsid dinosaurs, which are characterized by horns and frills, along with beaked faces. In particular, the discovery sheds light on the centrosaurine subfamily of horned dinosaurs, of which Menefeeceratops is believed to be the oldest member. Its remains offer a clearer picture of the group's evolutionary path ...

Researchers have developed a global earthquake monitoring system that uses the Global Navigational Satellite System (GNSS) to measure crustal deformation. The monitoring system within seconds can rapidly assess earthquake magnitude and fault slip distribution for earthquakes of magnitude 7.0 and larger, making it a potentially valuable tool in earthquake and tsunami early warning for these damaging events, Central Washington University geophysicist Timothy Melbourne and colleagues report in the Bulletin of the Seismological Society of America. GNSS can potentially characterize a large earthquake much more rapidly than the global seismic network, ...

Covid-19 patients who receive oxygen therapy or experience fever show reduced gray matter volume in the frontal-temporal network of the brain, according to a new study led by researchers at Georgia State University and the Georgia Institute of Technology. The study found lower gray matter volume in this brain region was associated with a higher level of disability among Covid-19 patients, even six months after hospital discharge. Gray matter is vital for processing information in the brain and gray matter abnormality may affect how well neurons function and communicate. The study, published in the May 2021 issue of Neurobiology ...

A new approach to road safety that relies on design and engineering principles--the "Safe System" approach--could lead to dramatic reductions in vehicle-related deaths and injuries if implemented in the U.S., according to a report from a consortium of experts convened by researchers at Johns Hopkins Bloomberg School of Public Health and the Institute of Transportation Engineers. The Safe System approach engineers road systems so that they are safe when used intuitively, the way people tend to use them. A Safe System minimizes the chances for mistakes by drivers, pedestrians, and bicyclists, and reduces the intensity ...

Marie-Claude Bourgeois-Daigneault and her team at the CRCHUM are using mice to show how a combination of peptides and oncolytic viruses, used as an adjuvant, can provide effective immunization against cancer. In her laboratoryat the University of Montreal Hospital Research Centre (CRCHUM), Marie-Claude Bourgeois-Daigneault and a team of scientists usually modify viruses to make them specific to the cells of a tumour. Once in the patient's body, these viruses, called oncolytic viruses, infect and specifically destroy the cancer cells without touching healthy cells. These viruses can even stimulate the immune system so that it is better armed to recognize and kill malignant cells. This is immunotherapy. In a study published in Nature Communications, the scientific team at the University ...

NEW YORK (May 11, 2021) - A group of scientists say now is the time to talk about reintroducing jaguars (Panthera onca) into the U.S. In a study published today in the journal Conservation Science and Practice, the authors provide a prospective framework for this effort and describe "righting a wrong" done to "America's Great Cat" in the Southwest more than 50 years ago. The big cats lived for hundreds of years in the central mountains of Arizona and New Mexico but were driven to local extinction by the mid-20th century, in part because of killing by government hunters. Authors of the study include a diverse set ...

Amsterdam, May 11, 2021 - It is projected that up to 152 million people worldwide will be living with Alzheimer's disease (AD) by 2050. To date there are no drugs that have a substantial positive impact on either the prevention or reversal of cognitive decline. A growing body of evidence finds that targeting lifestyle and vascular risk factors have a beneficial effect on overall cognitive performance. A new review in the Journal of Alzheimer's Disease, published by IOS Press, examines research that finds spiritual fitness, a new concept in medicine that centers on psychological and spiritual wellbeing, and Kirtan Kriya, a simple 12-minute meditative practice, may reduce multiple risk factors for AD. "The key point of this review is that making a commitment ...

DNA is composed of nucleobases represented by the letters A, T, G and C. They form the basis of the genetic code and are present in all living beings. But in a bacteriophage, another base, represented by the letter Z, exists. This exception, the only one observed to date, has long remained a mystery. Scientists from the Institut Pasteur and the CNRS, in collaboration with the CEA, have now elucidated the biosynthesis pathway of this base. This work has been published in the April 30th, 2021 issue of Science. DNA, or deoxyribonucleic acid, is a molecule ...

Study Take-Aways: Different African populations were genetically interrelated suggesting abundant gene flow across Africa such that all African population should be considered together as single subspecies. There appeared a striking genomic distance between leopards living in Asia vs. leopards in Africa. Asian leopards are more genetically separated from African leopards than brown bear species are from polar bear species, the researchers found. The two leopard groups actually diverged around the same time as Neanderthals split apart from modern humans. The genetic differences between African and Asian leopards have been maintained ...

It took an unlikely food innovation -- earth-friendly vegetarian patties, made to taste and "bleed" like the familiar meaty ones -- to make people aware of heme. But heme is an essential part of proteins found in most life forms, from tiny bacteria to soy plants to the human body. Heme plays a crucial role in supplying cells with the energy needed to carry out chemical reactions. In human cells, iron-containing heme is the essential cofactor of two types of molecules. One is the hemoglobin molecules that bind oxygen in the lungs and ferry it around the body. More than half ...

ALBUQUERQUE, N.M. -- Two groups of researchers at Sandia National Laboratories have published papers on the droplets of liquid sprayed by coughs or sneezes and how far they can travel under different conditions. Both teams used Sandia's decades of experience with advanced computer simulations studying how liquids and gases move for its nuclear stockpile stewardship mission. Their findings reinforce the importance of wearing masks, maintaining social distancing, avoiding poorly ventilated indoor spaces and washing your hands frequently, especially with ...

Trinity study finds people homeless in their 20s, 30s and 40s are physically comparable to those housed in their 70s and 80s A Trinity College study published today (Monday, 10th May 2021) demonstrates an extremely high burden of physical and mobility problems experienced by people who are homeless and were admitted for inpatient care to an acute hospital in Dublin. The study found that only one third of participants could climb a hospital stairs and there was a very common presentation of geriatric conditions such as frailty, falls and needing a mobility aid on a long term basis, despite a low median participant age of 45 years. The study is published in the journal Scientific Reports here: http://www.nature.com/articles/s41598-021-88590-0 Overall ...

Dental and orthopedic implants are widely used around the world. Common causes for implant failure are the immune response against oral bacteria and titanium particles shed by the implant. These and other phenomena can generate an inflammatory response, activating the osteoclasts (bone resorbing cells), and ultimately leading to osteolysis (destruction of bone tissue) around the implants. After this process begins, it is almost impossible to control, eventually leading to loss of the implant. A similar process occurs around natural teeth, with bacteria as the main cause, and bone resorption triggered by the immune response and inflammatory cells. Researchers from Tel Aviv University have developed ...

LAWRENCE -- The COVID-19 pandemic has presented a new world of challenges for education. But a new study from the University of Kansas shows the voices and experiences of students who are already among the most marginalized can help lead the way in making young people's strengths the focus of education. Students with disabilities already faced a disproportionate amount of inequities in the American educational system before the pandemic. Researchers interviewed students in this population about their experiences during the pandemic and found that students relied on their own strengths, resilience and self-determination. The findings not only highlight the importance ...

Extreme weather is harming UK agriculture - but many farmers have not yet made adapting to the effects of the climate emergency a priority, a new study shows. All farmers who took part in the research said they had experienced or witnessed issues caused by extreme weather such as heavy rain or prolonged dry spells in recent years, and expected these to intensify further. Many were concerned about the impact of heat and drought on crop and grass growth, with knock-on impacts for yield and winter animal feed, and the implications of heavy rainfall/flooding for soil run-off and erosion and for field operations such as drilling and harvesting. ...

Greater Presence of Family Physicians, Midwives May Be Key Component to Decreasing Cesarean Delivery Rates Surgical cesarean births can expose new mothers to a range of health complications, including infection, blood clots and hemorrhage. As part of Healthy People 2020 and other maternal health objectives, the state of California exerted pressure to reduce cesarean deliveries, and statewide organizations established quality initiatives in partnership with those goals. In this study, researchers from Stanford University and the University of Chicago examined unit culture and provider mix differences on hospital and delivery units to identify characteristics of units that successfully reduced their cesarean delivery rates. The mixed-methods study surveyed ...

SALT LAKE CITY - Today in Nature Communications, researchers at Huntsman Cancer Institute at the University of Utah report critical new insights into how cells mount an attack against melanoma tumors. Melanoma is an aggressive type of skin cancer that can arise from excess exposure to sun, frequent sunburns, genetics, and other environmental factors. Melanoma, like all cancers, begins within cells. Specially designed and refined over billions of years, cells are experts at working to root out and fix routine errors that arise. A tumor begins when a cell makes faulty copies of itself over and over again. If left unchecked, these faulty cell copies ...

A new Dartmouth Engineering study shows that integrating renewable energy into the American Electric Power System (AEPS) would enhance the grid's resilience, meaning a highly resilient and decarbonized energy system is possible. The researchers' analysis is based upon the incremental incorporation of architectural changes that would be required to integrate renewable energy into AEPS. The paper, "A Hetero-functional Graph Resilience Analysis of the Future American Electric Power System," was recently published by IEEE Access. "We concluded that there are no structural trade-offs between grid sustainability and resilience enhancements, meaning these strategic goals can be pursued ...