LOS ANGELES — There are currently few effective treatment options for patients with recurrent ovarian cancer and other solid tumors, but City of Hope researchers are trying to change that.  Researchers with City of Hope, one of the largest cancer research and treatment organizations in the nation, have published preclinical research in Nature Communications demonstrating that a chimeric antigen receptor (CAR)-engineered T cell therapy worked against ovarian cancer in the laboratory and in preclinical models.  “City of Hope’s ...

SAN DIEGO (AUG. 10, 2023) — A new study on gray-necked rockfowl has found a much smaller range of suitable habitat for this elusive African bird than was previously assumed, and may warrant a downgrade in its conservation status. Scientists from the Cameroon Biodiversity Association (CAMBIO) in Cameroon, in partnership with San Diego Zoo Wildlife Alliance, set out to better understand how much suitable habitat remains for the rockfowl, and where the birds can still be found. Understanding suitable habitat and its extent is crucial for protecting species. However, scientists have limited knowledge ...

Physicians, psychologists, advanced practice providers, dietitians, and others who are committed to treating and preventing obesity in Louisiana have come together to formally launch the Louisiana Obesity Society, a new statewide professional organization. The Louisiana Obesity Society will be hosting its inaugural annual conference in conjunction with the Louisiana Chapter of American Society of Metabolic and Bariatric Surgery on Saturday, Aug. 12, at the Renaissance New Orleans Arts Warehouse District Hotel in New Orleans. The Louisiana Obesity Society was created to support providers treating obesity through education and networking. The society will also advocate ...

Although millions are spent each year on entrepreneurship training that is intended to help alleviate poverty and elevate the quality of life of entrepreneurs in developing nations, these programs often fail to make an impact. Brigham Young University professors Shad Morris and Chad Carlos, along with three other colleagues, were invited by the Tanzania Social Action Fund (“TASAF”) to see if they could help figure out why TASAF’s entrepreneurship trainings were not producing the results they were hoping for. In order to assist TASAF, Morris, Carlos, and colleagues Geoff Kistruck, Elly Tumsifu and Bob Lount, carried out an extensive ...

For now, cyborgs exist only in fiction, but the concept is becoming more plausible as science progresses. And now, researchers are reporting in ACS’ Nano Letters that they have developed a proof-of-concept technique to “tattoo” living cells and tissues with flexible arrays of gold nanodots and nanowires. With further refinement, this method could eventually be used to integrate smart devices with living tissue for biomedical applications, such as bionics and biosensing. Advances in electronics have enabled manufacturers ...

Long COVID can persist for at least a year after the acute illness has passed, or appear months later, according to the most comprehensive look yet at how symptoms play out over a year.     The multicenter study, a collaboration between UC San Francisco, the Centers for Disease Control and Prevention (CDC) and seven other sites, expands knowledge of post-COVID-19 conditions, describing trends in more detail than previous research and highlighting significant impacts the epidemic has had on the U.S. health care system.     The study appears Aug. 10, 2023, in Morbidity and Mortality Weekly Report (MMWR), ...

Open Access publisher PeerJ have announced their second Editor-in-Chief partnership for the Open Advances series of journals. Professors Ute Roessner and Luis E. Eguiarte have agreed to take on the leadership of PeerJ Open Advances in Plant Science as Co-Editors-in-Chief.  Professors Roessner and Eguiarte are highly respected, award-winning scientists working at the forefront of their fields. As Co-Editors-in-Chief they will provide the scientific leadership for the journal, starting with recruiting an Editorial Board who will ...

A microscopy image created by National Institutes of Health researchers is part of the “Life Magnified” stamp panel issued today by the United States Postal Service (USPS®). The NIH zebrafish image, which was taken to understand lymphatic vessel development in the brain, merges 350 individual images to reveal a juvenile zebrafish with a fluorescently tagged skull, scales and lymphatic system.  “Zebrafish are used as a model for typical and atypical human development. It is surprising how much we have in common with ...

Brazilian researchers combined environmental physical, social and economic indicators to create an index that measures a region’s vulnerability and used it to analyze the basins of the Parnaíba River and São Francisco River in the Northeast of Brazil. The index is named SEVI (for Socio-Environmental Vulnerability). The Parnaíba and São Francisco basins are considered crucial to agricultural expansion and biodiversity conservation. They contain more than 780 municipalities and part of the semi-arid Caatinga and savanna-like Cerrado biomes, which are threatened ...

ROCHESTER, Minn. — Using human "mini-brain" models known as organoids, Mayo Clinic and Yale University scientists have discovered that the roots of autism spectrum disorder may be associated with an imbalance of specific neurons that play a critical role in how the brain communicates and functions. The specific cells are known as excitatory cortical neurons. The new study is published in Nature Neuroscience. Findings The team found an abnormal imbalance of excitatory ...

Batavia, Ill., Aug. 10, 2023 – Physicists now have a brand-new measurement of a property of the muon called the anomalous magnetic moment that improves the precision of their previous result by a factor of 2. An international collaboration of scientists working on the Muon g-2 experiment at the U.S. Department of Energy’s Fermi National Accelerator Laboratory announced the much-anticipated updated measurement on Aug. 10. This new value bolsters the first result they announced in April 2021 and sets up a showdown between theory and experiment over 20 years in the making. “We’re really probing new territory. We’re determining ...

Bringing ultrafast physics to structural biology has revealed the dance of molecular ‘coherence’ in unprecedented clarity. How molecules change when they react to stimuli such as light is fundamental in biology, for example during photosynthesis. Scientists have been working to unravel the workings of these changes in several fields, and by combining two of these, researchers have paved the way for a new era in understanding the reactions of protein molecules fundamental for life. The large international research team, led by Professor ...

CHAPEL HILL, N.C. – Over the past decade, the gut microbiome has gained significant interest by scientists and non-scientists alike. Recent research has shown that the bacteria and other microbes in our gut play a supporting role in immunity, metabolism, digestion, and the fight against "bad bacteria" that try to invade our bodies. However, new research published in Nature Biotechnology by Angela Wahl, PhD, Balfour Sartor, MD, J. Victor Garcia, PhD, and UNC School of Medicine colleagues others has revealed that the microbiome may not as always be protective against human pathogens. Using a first-of-its-kind ...

New Haven, Conn. — Two distinct neurodevelopmental abnormalities that arise just weeks after the start of brain development have been associated with the emergence of autism spectrum disorder, according to a new Yale-led study in which researchers developed brain organoids from the stem cells of boys diagnosed with the disorder. And, researchers say, the specific abnormalities seem to be dictated by the size of the child’s brain, a finding that could help doctors and researchers to diagnosis and treat autism in the future. The findings were ...

Mountain ranges play a key role in global climate, altering weather and shaping the flora and fauna that inhabit their slopes and the valleys below. As warm air rises windward grades and cools, moisture condenses into rain and snow. On the leeward side, it’s quite the opposite. Deserts prevail, a phenomenon known as rain shadow. Thus, the way mountain ranges form is a matter of intense interest among those who study and model climates of the past. That debate will soon grow more heated with a new paper in the journal Nature Geoscience. A team of researchers ...

Francis Crick Institute press release Under strict embargo: 16:00hrs BST 10 August 2023 Peer reviewed Observational study Cells Researchers at the Francis Crick Institute and UCL Queen Square Institute of Neurology, working with technology company Faculty AI, have shown that machine learning can accurately predict subtypes of Parkinson’s disease using images of patient-derived stem cells. Their work, published today in Nature Machine Intelligence, has shown that computer models can accurately classify four subtypes of Parkinson’s disease, with one reaching an accuracy of 95%. This could pave the way for personalised medicine and targeted drug discovery. Parkinson’s ...

Random Telegraph Noise (RTN), a type of unwanted electronic noise, has long been a nuisance in electronic systems, causing fluctuations and errors in signal processing. However, a team of researchers from the Center for Integrated Nanostructure Physics within the Institute for Basic Science (IBS), South Korea has made an intriguing breakthrough that can potentially harness these fluctuations in semiconductors. Led by Professor LEE Young Hee, the team reported that magnetic fluctuations and their gigantic RTN signals can be generated in a vdW-layered semiconductor by introducing vanadium in ...

Boston – Researchers from Dana-Farber Cancer Institute have found a way to use artificial intelligence (AI) to diagnose muscle wasting, called sarcopenia, in patients with head and neck cancer. AI provides a fast, automated, and accurate assessment that is too time-consuming and error-prone to be made by humans. The tool, published in JAMA Network Open, could be used by doctors to improve treatment and supportive care for patients. “Sarcopenia is an indicator that the patient is not doing well. A real-time tool that tells us when a patient is losing muscle mass would trigger us to intervene and do something supportive ...

About The Study: The findings of this study of 15,000 adults suggest that alcohol consumption and risky drinking behaviors were common among cancer survivors, even among individuals receiving treatment. Given the adverse treatment and oncologic outcomes associated with alcohol consumption, additional research and implementation studies are critical in addressing this emerging concern among cancer survivors.  Authors: Yin Cao, Sc.D., M.P.H., of the Washington University in St. Louis School of Medicine, is the corresponding author.  To ...

About The Study: The results of this study of 3.4 million adults suggest that most individuals commencing treatment with prescription opioids had relatively low and time-limited exposure to opioids over a 5-year period. The small proportion of individuals with sustained or increasing use was older with more comorbidities and use of psychotropic and other analgesic drugs, likely reflecting a higher prevalence of pain and treatment needs in these individuals.  Authors: Natasa Gisev, ...

The study, carried out by scientists from Navarrabiomed, the Institute of Neurosciences CSIC-UMH, and IRB Barcelona, has been published in Nature Metabolism. In 2022, 7,500 new cases of melanoma—the most aggressive type of skin cancer—were diagnosed in Spain. A collaborative study undertaken by the Navarrabiomed Biomedical Research Center (Pamplona, ​​Navarre), the Institute of Neurosciences CSIC-UMH (Sant Joan d’Alacant, Valencian Community) and IRB Barcelona (Barcelona, ​​Catalonia) shows that the administration of ranolazine, a drug currently used to treat heart conditions, improves the ...

Legal restrictions placed on the amount of time young people in China can play video games may be less effective than originally thought, a new study has revealed. To investigate the effectiveness of the policy, a team of researchers led by the University of York, analysed over 7 billion hours of playtime data from tens of thousands of games, with data drawn from over two billion accounts from players in China, where legal restrictions on playtime for young people have been in place since 2019.  The research team, however, did not find evidence of a decrease in heavy play of games after these ...

Researchers from Tokyo Medical and Dental University (TMDU) identify lipids stimulating self-repair mechanisms in the brain after ischemic stroke Tokyo, Japan – Patients often experience functional decline after an ischemic stroke, especially due to the brain’s resistance to regenerate after damage. Yet, there is still potential for recovery as surviving neurons can activate repair mechanisms to limit and even reverse the damage caused by the stroke. How is it triggered though?  In a study published ...

The researchers also identified three proteins that are needed for the virus to carry out the invasion and have in turn synthesized molecules (potential drugs) that can target one of the proteins, potentially leading to new treatments for AIDS. “We have revealed a protein pathway that appears to have a direct impact on diseases, which opens up a new area for potential drug development,” says the study’s senior author Aurelio Lorico, MD PhD, Professor of Pathology and interim Chief Research Officer at Touro University Nevada College of Osteopathic Medicine. HIV infection requires the virus to enter a cell and gain access to the well-guarded nucleus in order ...

New research from Memorial Sloan Kettering Cancer Center (MSK) and the Sloan Kettering Institute — a hub for basic science and translational research within MSK — found a potential target against neuroendocrine transformation in lung and prostate cancers; discovered new clues about why donor T cells attack certain tissues in graft-versus-host disease; shed light on why T cells let go of their prey; and used CRISPR interference and dynamic cell-state transitions to discover enhancers that affect early human development. Targeting exportin 1 may help prevent neuroendocrine transformation in lung and prostate cancers Over time, some lung and prostate ...