LOS ALAMOS, N.M., June 17, 2021 -- A research team from Los Alamos National Laboratory and Purdue University have developed bio-inks for biosensors that could help localize critical regions in tissues and organs during surgical operations. "The ink used in the biosensors is biocompatible and provides a user-friendly design with excellent workable time frames of more than one day," said Kwan-Soo Lee, of Los Alamos' Chemical Diagnostics and Engineering group. The new biosensors allow for simultaneous recording and imaging of tissues and organs during surgical procedures. "Simultaneous recording and imaging could be useful during heart surgery in localizing critical regions and guiding surgical interventions such as a procedure for restoring normal ...

Nanodecoys made from human lung spheroid cells (LSCs) can bind to and neutralize SARS-CoV-2, promoting viral clearance and reducing lung injury in a macaque model of COVID-19. By mimicking the receptor that the virus binds to rather than targeting the virus itself, nanodecoy therapy could remain effective against emerging variants of the virus. SARS-CoV-2 enters a cell when its spike protein binds to the angiotensin-converting enzyme 2 (ACE2) receptor on the cell's surface. LSCs - a natural mixture of lung epithelial stem cells and mesenchymal cells - also express ACE2, making them a perfect vehicle ...

Current approaches for planning relocation for potentially millions of people affected by climate change and related risks are "woefully inadequate" and risk worsening societal inequities, experts wrote in a policy perspective on June 17 in Science. Policymakers and scientists need to rethink how they work together to develop, communicate and carry out relocation plans. "Relocation involves moving people away from risk and into totally new settings," said the team of experts led by Richard Moss. Moss is a Gerhard R. Andlinger Visiting Fellow at Princeton's Andlinger Center ...

The Yellow fever mosquito (scientific name, Aedes aegypti) spreads multiple untreatable viruses in humans and is primarily controlled using a pesticide called permethrin. However, many mosquitoes are evolving resistance to the pesticide. A new study by Karla Saavedra-Rodriguez of Colorado State University and colleagues, published in the journal PLOS Genetics, identifies mutations linked to different permethrin resistance strategies, which threaten our ability to control disease outbreaks. When treated mosquitoes encounter permethrin in the wild, they will do one of the following: immediately die, be knocked out but recover, or be unaffected. Saavedra-Rodriguez and her colleagues decided to investigate the genetic variations that lead to these ...

A new treatment approach focused on fixing cell damage, rather than fighting the virus directly, is effective against SARS-CoV-2 in lab models. Combination of two drugs reduces spread of SARS-CoV-2 infection in cells by up to 99.5%. If found safe for human use, this anti-viral treatment would make COVID-19 symptoms milder and speed up recovery times. When a person is infected with SARS-CoV-2, the virus that causes COVID-19, it invades their cells and uses them to replicate - which puts the cells under stress. Current approaches to dealing with infection target the virus itself with antiviral drugs. But ...

Patents with all-female inventor teams are more likely than all-male teams to address problems that specifically or disproportionately affect women, according to a new study. The findings, derived from an analysis of more than 440,000 U.S. biomedical patents filed from 1976 to 2010, suggest that who benefits most from innovation largely depends on who gets to invent. While the gender gap in research and innovation is well known, its broader impact on what gets invented - and for whom - isn't well understood. To address this question, Rembrand Koning and colleagues used machine learning text analysis to evaluate all U.S. biomedical patents filed from 1976 to 2010. They found that patents ...

Daunting and uncertain is the future for people who must decide whether, where, when, and how to vacate their homes as the climate changes. Communities who will absorb this influx of uprooted people also face challenges. In a special issue of Science, "Fallback Strategies: Planning for Climate-Induced Relocation," experts examine ways in which interdisciplinary basic and applied research can - and must - engage with and support communities and governments navigating this landscape. As this work is done, "we must consider not only what science can do, but how science ...

Using LIGO's suspended mirrors, researchers have demonstrated the ability to cool a large-scale object - the 10-kilogram optomechanical oscillator the suspended mirrors form - to nearly the motional quantum ground state. Upgrading LIGO (Laser Interferometer Gravitational-Wave Observatory) with such a modification would not only increase the device's sensitivity and range in detecting gravitational waves but could also provide new insights into large-scale quantum phenomena. For most mechanical objects to be coaxed into a quantum state, they need to be cooled to exceedingly low temperatures to overcome the thermal vibrations, or phonons, that mask the signature of quantum motion. This brings the ...

Marine-terminating glaciers may be less vulnerable to rapid and irreversible collapse than previously suggested, according to a new study, which finds that ice cliff collapse is limited by upstream thinning of the ice sheet and how quickly calved icebergs and sea-ice float away. The glaciers of Greenland and Antarctica slowly flow to the sea, terminating in massive vertical ice cliffs. Occasionally, these partially submerged margins can collapse under their own weight and trigger rapid disintegration of ice sheets. It's thought that this process, called marine ice cliff instability (MICI), could lead to the catastrophic retreat of some of the planet's largest ice sheets, substantially contributing to global sea level rise. However, current ...

CAMBRIDGE, MA -- To the human eye, most stationary objects appear to be just that -- still, and completely at rest. Yet if we were handed a quantum lens, allowing us to see objects at the scale of individual atoms, what was an apple sitting idly on our desk would appear as a teeming collection of vibrating particles, very much in motion. In the last few decades, physicists have found ways to super-cool objects so that their atoms are at a near standstill, or in their "motional ground state." To date, physicists have wrestled small objects such as clouds of millions of atoms, or nanogram-scale objects, into such pure quantum states. Now for the first time, scientists at MIT and elsewhere have cooled a large, human-scale object to close to its motional ground state. The object ...

Research conducted by Qiang et al has discovered a link between a protein in red blood cells and age-related decline in cognitive performance. Published in the open access journal PLOS Biology on 17th June 2021, the study shows that depleting mouse blood of the protein ADORA2B leads to faster declines in memory, delays in auditory processing, and increased inflammation in the brain. As life expectancies around the world increase, so are the number of people who will experience age-related cognitive decline. Because the amount of oxygen in the blood also declines with age, the team hypothesized that ...

CLEVELAND--Case Western Reserve University researchers studying prions--misfolded proteins that cause lethal incurable diseases--have identified for the first time surface features of human prions responsible for their replication in the brain. The ultimate goal of the research is to help design a strategy to stop prion disease in humans--and, ultimately, to translate new approaches to work on Alzheimer's and other neurodegenerative diseases. Scientists have yet to discover the exact cause of Alzheimer's disease, but largely agree that protein issues play a role in its emergence and progression. Alzheimer's disease afflicts more than 6 million people in the U.S., and the Alzheimer's Association ...

UTICA, NY -- More than 2 million coronary artery stents are implanted each year to help protect or restore normal blood flow to the heart, to treat patients suffering from angina or a heart attack due to coronary artery disease (CAD). While stents are highly effective and safe devices, scarring or clotting of unhealed stents can occur in a small percentage of subjects, leading to complications such as stent restenosis or thrombosis, which can be life-threatening. At present, approaches to understand stent healing based on their biological clotting status is unavailable in patients. To devise a potential solution to this problem, Dr. Jason McCarthy, an Associate Professor at the Masonic Medical Research Institute (MMRI), and his team have developed a fluorescent probe that binds ...

A long-term passive rewilding study has shown that natural woodland regeneration could make a significant contribution to meeting the UK's ambitious tree planting targets - potentially at no cost and within relatively short timescales. The research, led by the UK Centre for Ecology & Hydrology (UKCEH), found natural growth due to seed dispersal by birds, mammals and wind can produce biodiverse and resilient woodland. Woodland development can be rapid, while avoiding the cost, management and plastic tubing involved in planting schemes. The study - published in the journal PLOS ONE - found that after just 15 years, previously bare agricultural ...

Physicists at Ludwig-Maximilian University in Munich (LMU) and the Max Planck Institute for Quantum Optics (MPQ) have used ultrashort laser pulses to probe the dynamics of photoelectron emission in tungsten crystals. Almost a century ago, Albert Einstein received the Nobel Prize for Physics for his explanation of the photoelectric effect. Published in 1905, Einstein's theory incorporated the idea that light is made up of particles called photons. When light impinges on matter, the electrons in the sample respond to the input of energy, and the interaction gives rise to what is known as the photoelectric effect. Light quanta (photons) are absorbed by the ...

Lugano, Switzerland, 17 June 2021 - Adding an immune checkpoint inhibitor to anti-HER2 treatment in breast cancer does not improve pathological complete response (pCR), according to the primary analysis of the IMpassion050 trial presented today during the ESMO Virtual Plenary. (1) The phase III trial is the first to report data comparing a neoadjuvant anti-HER2 based regimen with or without the anti-PD-L1 antibody atezolizumab in patients with high-risk, HER2-positive early breast cancer. The standard treatment for high-risk, HER2-positive early breast cancer is dual anti-HER2 blockade plus chemotherapy. While antibody therapy may enhance innate and adaptive immunity and activate cellular cytotoxicity, there is evidence ...

(Boston)--An intrauterine fracture is a rare finding during routine prenatal imaging. This condition can be due to maternal trauma, genetic disorders of the skeleton, as well as other predisposing maternal metabolic and vascular disorders. Genetic disorders that have previously been reported to cause intrauterine fracture include brittle bone disease (osteogenesis imperfecta or OI), osteopetrosis, hypophosphatasia and Ehlers-Danlos syndrome (EDS). Now for the first time, researchers from Boston University School of Medicine (BUSM) report a new genetic cause, unrelated to OI, for the 23 fractures that occurred in-utero to a mother with EDS hypermobility type. EDS is a disease that weakens the bones and connective tissues ...

New study challenges long-standing assumptions about disease severity in infants, and suggests that standard qPCR interpretations underestimate the true burden of other highly contagious diseases, such as COVID-19 and influenza. Pertussis, also known as "whooping cough," remains a significant cause of death in infants and young children around the world and, despite global vaccination programs, many countries are experiencing a resurgence of this highly contagious disease. A new study by Boston University School of Public Health and the University of Georgia's Odum School of Ecology presents evidence that could help explain this ...

Bottom Line: Genetic mutations indicative of DNA damage were associated with high red meat consumption and increased cancer-related mortality in patients with colorectal cancer. Journal in Which the Study was Published: Cancer Discovery, a journal of the American Association for Cancer Research Author: Marios Giannakis, MD, PhD, an assistant professor of medicine at Harvard Medical School and a physician at Dana-Farber Cancer Institute Background: "We have known for some time that consumption of processed meat and red meat is a risk factor for colorectal cancer," said Giannakis. The International Agency for Research on Cancer declared that processed meat was carcinogenic and that red meat was probably carcinogenic to humans in 2015. Experiments ...

HOUSTON ? Preclinical research from The University of Texas MD Anderson Cancer Center finds that although glioblastoma stem cells (GSCs) can be targeted by natural killer (NK) cells, they are able to evade immune attack by releasing the TFG-β signaling protein, which blocks NK cell activity. Deleting the TFG-β receptor in NK cells, however, rendered them resistant to this immune suppression and enabled their anti-tumor activity. The findings, published today in the Journal of Clinical Investigation, suggest that engineering NK cells to resist immune suppression may be a feasible path ...

The energy density of traditional lithium-ion batteries is approaching a saturation point that cannot meet the demands of the future - for example in electric vehicles. Lithium metal batteries can provide double the energy per unit weight when compared to lithium-ion batteries. The biggest challenge, hindering its application, is the formation of lithium dendrites, small, needle-like structures, similar to stalagmites in a dripstone cave, over the lithium metal anode. These dendrites often continue to grow until they pierce the separator membrane, causing the battery to short-circuit and ultimately destroying ...

Nitrogen from agriculture, vehicle emissions and industry is endangering butterflies in Switzerland. The element is deposited in the soil via the air and has an impact on vegetation - to the detriment of the butterflies, as researchers at the University of Basel have discovered. More than half of butterfly species in Switzerland are considered to be at risk or potentially at risk. Usually, the search for causes focuses on intensive agriculture, pesticide use and climate change. A research team led by Professor Valentin Amrhein from the University of Basel, however, has been investigating another factor - the depositing ...

Living beings are continuously exposed to harmful agents, both exogenous (ultraviolet radiation, polluting gases, etc.) and endogenous (secondary products of cellular metabolism) that can affect DNA integrity. That's why cells are endowed with a series of molecular mechanisms whose purpose is to identify and signpost possible damage to the genetic material for speedy repair. These mechanisms are precisely regulated because they are key to cell survival. In extreme situations of massive and irreparable damage, cells enter a phase of controlled dismantling called "programmed cell death". Among the events that take place during this process is the massive delivery to the cytoplasm of a mitochondrial protein called cytochrome C. Under homeostatic conditions, this protein plays a role in energy ...

The 2018 Nobel Prize in Physics was shared by researchers who pioneered a technique to create ultrashort, yet extremely high-energy laser pulses at the University of Rochester. Now researchers at the University's Institute of Optics have produced those same high-powered pulses--known as chirped pulses--in a way that works even with relatively low-quality, inexpensive equipment. The new work could pave the way for: Better high-capacity telecommunication systems Improved astrophysical calibrations used to find exoplanets Even more accurate atomic clocks Precise devices for measuring chemical contaminants in the atmosphere In a paper in Optica, the researchers describe the first demonstration ...

Peatlands are an important ecosystem that contribute to the regulation of the atmospheric carbon cycle. A multidisciplinary group of researchers, led by the University of Helsinki, investigated the climate response of a permafrost peatland located in Russia during the past 3,000 years. Unexpectedly, the group found that a cool climate period, which resulted in the formation of permafrost in northern peatlands, had a positive, or warming, effect on the climate. The period studied, which began 3,000 years ago, is known as a climate period of cooling temperatures. The climate-related effect of permafrost formation brought about by the cooling was investigated particularly by analysing the ancient plant communities of the peatland, using similarly analysed peatland data from elsewhere in ...