Researchers at Queen Mary University of London’s Precision Healthcare Research Institute (PHURI) and the Berlin Institute of Health (BIH) at Charité – Universitätsmedizin Berlin have identified the genetic causes of Raynaud’s phenomenon. Their findings, published today in Nature Communications, could lead to the first effective treatments for people with Raynaud’s. Raynaud’s phenomenon (RP) is a heritable condition that affects blood circulation. It’s a vasopastic condition, which means ...

Between 7% and 15% of people in North America, between 5% and 9% of people in Europe, and between 1% and 5% of people in Asia suffer from kidney stones. Common symptoms are severe pain, nausea, vomiting, fever, chills, and bloody urine. But kidney stones don’t just reduce the quality of life: in the long run, they may lead to infections, swollen kidneys (hydronephrosis), renal insufficiency, and end-stage renal disease. Known risk factors for developing kidney stones include being an adult male, obesity, chronic diarrhea, dehydration, and having inflammatory bowel disease, diabetes, or gout. Now, a ...

Obesity, a major risk factor for various lifestyle diseases such as diabetes and hypertension has become widespread worldwide, inherently demanding innovative solutions to combat it. A multi-institutional research group led by Associate Professor Akiko Kojima of the Graduate School of Human Life and Ecology at Osaka Metropolitan University, has made significant progress in the fight against obesity. The group had previously conducted a study on the effects of the extract of Mallotus furetianus (MFE), a tropical plant native to Hainan Island, China, on the prevention of fatty liver, but the antiobesity effects of MFE and its mechanisms had not been ...

In a study published today in Cell, one of the most prominent peer-reviewed scientific journals in the field of Biochemistry & Molecular Biology, scientists from the National University of Singapore (NUS) and Imperial College London have discovered a new way by which bacteria transmit their genes, enabling them to evolve much faster than previously understood. Led by Assistant Professor John Chen from the Department of Microbiology and Immunology and the Infectious Diseases Translational Research Programme at the NUS Yong Loo Lin School of Medicine (NUS Medicine), ...

Understanding the ionosphere high in the Earth's atmosphere is important due to its effects on communications systems, satellites and crucial chemical features including the ozone layer. New insights into the activity of high energy electrons have come from a simulation study led by geophysicist Yuto Katoh at Tohoku University, reported in the journal Earth, Planets and Space. "Our results clarify the unexpected role of the geomagnetic field surrounding the Earth in protecting the atmosphere from high energy electrons," says Katoh. The ionosphere is a wide region between roughly ...

Function and form are deeply intertwined in biology. Knowing how organisms grow, adapt and reproduce requires understanding their physical structures. Hence the transformative power of the microscope across the past four centuries of science. Microscopy, or the field of microscope use, can now reveal the tiniest of structures through techniques such as microcrystal electron diffraction, or MicroED. Instead of passing light through a cell like an optical microscope, MicroED bombards crystalline samples with a stream of electrons to produce detailed information about their atomic configuration. “The method was developed ...

Korean researchers have unveiled a novel signaling pathway that fosters aging-related chronic metabolic disorders.   A research team led by Professor Jong Kyoung Kim from the Department of Life Sciences at POSTECH along with Professor Seung-Hoi Koo from the Division of Life Sciences at Korea University and principal researcher Geum-Sook Hwang from Korea Basic Science Institute (KBSI)   announced the discovery of a new mechanism where BCAA metabolic pathway becomes impaired due to aging, resulting in dysfunctions of adipose cells and chronic metabolic disorders. The research findings were published in Nature Aging (IF=16.6) ...

Leesburg, VA, August 4, 2023—An accepted manuscript published in the American Journal of Roentgenology (AJR) found that deploying a radiomic-based model with T2-weighted MRI data could increase diagnostic accuracy for pediatric Crohn disease (CD). Noting that ileal-wall radiomic features were strongly predictive of CD—and that model performance improved when ensembled with clinical data—“a radiomic machine learning model predicted CD diagnosis with better performance than two of three expert radiologists,” wrote corresponding author and AJR Pediatric Imaging Section Editor Jonathan R. Dillman, MD, MSc. Dillman et al.’s manuscript ...

Childhood trauma, such as abuse, emotional neglect, and exposure to domestic violence, may heighten a woman’s subsequent risk of pregnancy complications, and of giving birth to a low birthweight or premature baby, finds a pooled data analysis of the available evidence, published in the open access journal BMJ Open.  The risks of pregnancy related diabetes, high blood pressure, depression/anxiety and of giving birth to underweight and or premature babies may all be significantly higher, the analysis suggests. While previously ...

The use of essential peppermint oil aromatherapy may ease pain severity after open heart surgery and enhance sleep quality as well, suggest the results of a small comparative clinical trial, published online in the journal BMJ Supportive & Palliative Care. Heart surgery is a major procedure, necessitating the separation of the breastbone (sternum) as well as mechanical breathing support, both of which are associated with a high risk of severe pain, stress, and sleeplessness, note the researchers. Effective pain relief allows patients to recover more quickly and may reduce the risk of postoperative complications, ...

SEATTLE, Wash. August 3, 2023 – An analysis of 19 causes of death in the United States revealed persistent disparities and a familiar pattern across five racial-ethnic groups and 3,110 counties from 2000 to 2019. That’s according to the most comprehensive peer-reviewed research published today in The Lancet.   The mortality rates among American Indian or Alaska Native (AIAN) and Black populations were substantially higher than among White populations nationally and in most counties. For example, mortality was higher among the AIAN population than the White population in nearly all counties for skin and ...

As little as 25 minutes a day of slow walking seems to be enough to counter the detrimental physical effects of bedrest on older hospital patients, finds a pooled data analysis of the available evidence, published online in the British Journal of Sports Medicine. And for optimal improvements in physical function, around 50 mins/day of slow walking or  around 40 mins of combined physical activities, such as 20 mins of resistance bands with around 20 mins of aerobic activity, are the most effective, the analysis indicates. But there may be a threshold effect, with no clear benefit for ‘doses’ of more than 90 mins/day ...

An international team of scientists have discovered an unusual Jupiter-sized planet orbiting a low-mass star called TOI-4860, located in the Corvus constellation. The newly discovered gas giant, named TOI-4860 b, is an unusual planet for two reasons: stars of such low mass are not expected to host planets like Jupiter, and the planet appears to be particularly enriched by heavy elements. The study, led by University of Birmingham astronomers, is published today (Friday 4th August) in a letter published within the Monthly Notices of the Royal Astronomical Society. The planet was initially identified using NASA’s Transiting Exoplanet ...

Novel blood testing technology being developed by researchers at the Johns Hopkins Kimmel Cancer Center that combines genome-wide sequencing of single molecules of DNA shed from tumors and machine learning may allow earlier detection of lung and other cancers. The test, called GEMINI (Genome-wide Mutational Incidence for Non-Invasive detection of cancer), looks for changes to DNA throughout the genome. First, a blood sample is collected from a person at risk for developing cancer. Then, cell-free DNA (cfDNA) shed by tumors is extracted from the plasma and sequenced using cost-efficient ...

Kamaʻehuakanaloa (formerly Lōʻihi Seamount), a submarine Hawaiian volcano located about 20 miles off the south coast of the Big Island of Hawai‘i, has erupted at least five times in the last 150 years, according to new research led by Earth scientists at the University of Hawai‘i at Mānoa. For the first time, scientists were able to estimate the ages of the most recent eruptions of Kamaʻehu, as well as the ages of eight additional older eruptions at this volcano going back about 2,000 years. Their findings were published recently in Geology.  Hawaiian volcanoes are thought to transition through a series of growth stages. ...

Research from the Max Planck Florida Institute for Neuroscience has identified a mechanism through which insulin-like growth factors facilitate brain plasticity. The insulin superfamily of hormones, including insulin, insulin-like growth factor 1 (IGF1), and insulin-like growth factor 2 (IGF2), play a crucial role not only in regulating blood sugar, metabolism, and growth, but also in healthy brain development and function, including learning and memory. These hormones can enter the brain through the bloodstream from the liver or can be synthesized directly in neurons and glial cells within the brain. They bind to receptors, ...

Mothers who eat apples and herbs in early pregnancy could be protecting the brain health of their children and grandchildren, a Monash University study using genetic models has found. The discovery is part of a project that found a mother’s diet can affect not just her child’s brain but also those of her grandchildren. Published in Nature Cell Biology, the Monash Biomedicine Discovery Institute study found that certain foods could help protect against the deterioration of brain function. More specifically, the study used roundworms (Caenorhabditis elegans) as the genetic model because many of ...

In a new study published in Nature Geosciences, researchers, led by a Tulane University sedimentologist , investigated why the paths of meandering rivers change over time and how they could be affected by climate change. Chenliang Wu, PhD, a postdoctoral researcher at Tulane University School of Science and Engineering, began this research by looking at the Mississippi River before adding other rivers on Earth and ancient riverbeds on Mars to the study. The study specifically looks at river sinuosity, or how much rivers curve. The sinuosity of rivers changes over time, depending on the age of the river and environmental changes. Some of these changes ...

EAST LANSING, Mich. – Sometimes, the best place to hide a secret is in broad daylight. Just ask the sun. “The sun is more surprising than we knew,” said Mehr Un Nisa, a postdoctoral research associate at Michigan State University. “We thought we had this star figured out, but that’s not the case.” Nisa, who will soon be joining MSU’s faculty, is the corresponding author of a new paper in the journal Physical Review Letters that details the discovery of the highest-energy ...

Key points: A cohort study of millions of Medicare beneficiaries found that chronic exposures to PM2.5 and NO2 over a 10-year period increased the risk of developing colorectal and prostate cancers. Even in areas with low pollution levels, researchers found substantial associations between exposures to these pollutants and the risk of developing colorectal and prostate cancers, in addition to breast and endometrial cancers. For immediate release: August 3, 2023 Boston, MA—Chronic exposure to fine particulate air pollutants (PM2.5) ...

MINNEAPOLIS/ST. PAUL (08/03/2023) — Published in the International Journal of Obesity, University of Minnesota Medical School and School of Public Health researchers led a study on the relationship between dietary intake and cardiovascular disease risk factors.  Over 20 years, the research team examined people's regular dietary intake, paying particular attention to non-nutritive sweeteners commonly found in artificial sweeteners. They found that long-term consumption of aspartame, saccharin and diet beverages were linked to increased fat stores in the abdomen and fat within muscle. However, ...

The key to understanding proteins — such as those that govern cancer, COVID-19, and other diseases — is quite simple.  Identify their chemical structure and find which other proteins can bind to them. But there’s a catch. “The search space for proteins is enormous,” said Brian Coventry, a research scientist with the Institute for Protein Design, University of Washington and The Howard Hughes Medical Institute.  A protein studied by his lab typically is made of 65 amino acids, and ...

AUGUST 3, 2023, NEW YORK – A Ludwig Cancer Research study has identified a pair of genes whose expression by a type of immune cell within tumors is predictive of outcomes for cancer patients and is linked to a vast network of gene expression programs, engaged by multiple cell types in the tumor microenvironment, that control human cancers. Researchers led by Ludwig Lausanne’s Mikaël Pittet report in the current issue of Science that patients with higher expression of the gene CXCL9 in their tumor-associated macrophages had far better clinical outcomes than those with higher expression of a gene named SPP1 by the immune cells. Macrophages expressing the former ...

After decades of decline, fatal coronary heart disease may rise again unless Americans modify three major risk factors: smoking, drinking, and obesity. A Rutgers study just published in American Heart Journal found that deaths from coronary heart disease among people ages 25 to 84 dropped to 236,953 in 2019 from 397,623 in 1990, even though Americans’ median age increased to 38 from 33 over the last three decades. Between 1990 and 2019, the US age-standardized coronary heart disease mortality rate per 100,000 fell from 210.5 to 66.8 for females (4 percent decline per year) and from 442.4 to 156.7 for males (3.7 percent decline per year). However, the decline has slowed significantly ...

UCF, MIT Designing Technology To Fight Bacterial Infections, Improve Aquaculture Farming    BY SUHTLING WONG | AUGUST 3, 2023 11:11 AM UCF and MIT researchers are using farm-raised seafood as a model to create new technologies that fight pathogenic bacteria. University of Central College of Medicine microbiologist Dr. Salvador Almagro-Moreno and Massachusetts Institute of Technology's Dr. Otto Cordero were recently awarded a grant from the National Science Foundation  to create synthetic microbiomes –  communities of microorganisms – that will better protect aquatic environments from bacteria.  The team ...