A new study from Vanderbilt University Medical Center researchers finds that new mothers who receive opioids after uncomplicated vaginal births face an increased risk of serious opioid-related events regardless of the opioid dosage, a finding that could significantly impact care delivery. Andrew Wiese, PhD, MPH, assistant professor of Health Policy in the Division of Pharmacoepidemiology, authored the paper published online April 15 in Women's Health Issues, with Sarah Osmundson, MD, MPH, associate professor of Obstetrics and Gynecology, and other researchers in the departments of Biostatistics and Health Policy. The study examined roughly 147,000 women enrolled in TennCare -- Tennessee's Medicaid program -- between ...

COLUMBUS, Ohio - A new study of advanced small-cell lung cancer (SCLC) led by researchers at The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC - James) has identified molecular patterns linked to patients developing resistance to certain therapies. This study, published in the journal JTO Clinical and Research Reports, examined more than 60 tumors from five patients. OSUCCC - James researchers identified distinct mutational and molecular changes in four SCLC subtypes. The findings provide new insights into the patterns treatment resistance and could offer new targets for the development of more effective ...

LEXINGTON, Ky. (April 20, 2021) - A new study from University of Kentucky Markey Cancer researchers shows that Artemisia annua, a plant that has been traditionally used for its anti-malaria components, shows promise in treating ovarian cancer. The study, recently published in Diagnostics, demonstrates that artesunate, a drug synthesized from Artemisia annua, kills ovarian cancer cells in multiple preclinical model systems. Despite accounting for only 1.3% of all new cancer cases, 2.3% of cancer deaths in 2021 are predicted to be caused by ovarian cancer. The current ...

Wild blueberry fields in Down East Maine are warming faster than the state as a whole, according to a new University of Maine study on the effects of climate change on the barrens over the past 40 years. The difference in rising temperature rates suggests the need to develop specific wild blueberry management strategies, such as irrigation and fertilizer use, to mitigate the effects of climate change on Down East fields, rather than using tactics devised from statewide climate patterns, according to researchers. Rafa Tasnim, a Ph.D. student of ecology and environmental sciences, led the study that explored changes in climate change patterns, particularly in temperature and precipitation, ...

The aquatic animal known as the sponge is often described as entirely sessile: once they've settled in a spot and matured, they aren't generally thought of as moving around. But, according to a new study in the journal Current Biology on April 26--in which researchers describe mysterious trails of light brown sponge spicules (spike-like support elements in sponges) across the Arctic seafloor--that isn't always so. "We observed trails of densely interwoven spicules connected directly to the underside or lower flanks of sponge individuals, suggesting these trails are traces of motility of the sponges," the researchers, led ...

DURHAM, N.C. - A digital app successfully detected one of the telltale characteristics of autism in young children, suggesting the technology could one day become an inexpensive and scalable early screening tool, researchers at Duke University report. The research team created the app to assess the eye gaze patterns of children while they watched short, strategically designed movies on an iPhone or iPad, then applied computer vision and machine learning to determine whether the child was looking more often at the human in the video, or objects. "We know that babies who have autism pay attention ...

Monday, April 26, 2021, CLEVELAND: Since the start of the COVID-19 pandemic, mutations of SARS-CoV-2 - the virus that causes COVID-19 - have spread to the U.S. and a host of other countries worldwide. Recent studies suggest that current COVID-19 variants are up to 70% more contagious than the pandemic's original strains. A multidisciplinary team of scientists at Cleveland Clinic and Case Western Reserve University used genomic sequencing to track SARS-CoV-2 as it mutated in Northeast Ohio from March 11 to April 22, 2020. The research findings, published in JAMA Network Open, demonstrated that initial strains and subgroups of virus strains (called ...

What The Study Did: COVID-19 rates in children and teenagers to age 19 before and after reopening schools in Israel are examined in this observational study. Authors: Eli Somekh, M.D., of the Mayanei Hayeshuah Medical Center in Bnei Brak, Israel, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2021.7105) Editor's Note: The article includes conflicts of interest and funding/support disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support. INFORMATION: Media advisory: The full study is linked to this news release. Embed ...

Women who have preeclampsia during pregnancy are at least three times more likely to have strokes later in life than women who do not have a history of this condition, according to University of Utah Health scientists. Based on this finding, the researchers recommend that women who have had preeclampsia should be carefully monitored in the years after it occurs. "Our study strongly suggests that, for women who have a history of preeclampsia, physicians should consider aggressive treatment of midlife vascular risk factors, including high blood pressure and elevated cholesterol and glucose levels," says Adam de Havenon, M.D., lead author of the study and an assistant professor of neurology at U of U Health. "Doing this could potentially reduce the risk of these women ...

What The Study Did: In this quality improvement study, hand hygiene compliance rates in a hospital with an automated hand hygiene monitoring system during the COVID-19 pandemic were assessed. Authors: Rachel Marrs, D.N.P., R.N., C.I.C., of University of Chicago Medicine, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamainternmed.2021.1429) Editor's Note: The article includes conflict of interest and funding/support disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support. INFORMATION: Media advisory: The full study is ...

What The Study Did: The association of identified SARS-CoV-2 variants and virus groupings with disease severity and patient outcomes is evaluated in this study. Authors: Frank P. Esper, M.D., of Cleveland Clinic Children's in Ohio, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2021.7746) Editor's Note: The article includes conflict of interest and funding/support disclosures. Please see the article for additional information, including ...

What The Study Did: The risk of stroke in later life among women with and without a history of preeclampsia in pregnancy was assessed in this study. Authors: Adam de Havenon, M.D., of the University of Utah in Salt Lake City, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2021.5077) Editor's Note: The article includes conflicts of interest and funding/support disclosures. Please see the article for additional information, including other ...

What The Study Did: This survey study looked at how common is the use of marijuana in e-cigarettes among students in grades 6 to 12 and also changes in use by racial and ethnic groups from 2017 to 2020. Authors: Christina V. Watson, Dr.P.H., M.P.H., of the Centers for Disease Control and Prevention in Atlanta, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamapediatrics.2021.0305) Editor's Note: The article includes funding/support disclosures. Please see the article for additional information, including other authors, author contributions ...

WHAT: A mobile app was successful at distinguishing toddlers diagnosed with autism spectrum disorder (ASD) from typically developing toddlers based on their eye movements while watching videos, according to a study funded by the National Institutes of Health. The findings suggest that the app could one day screen infants and toddlers for ASD and refer them for early intervention, when chances for treatment success are greatest. The study appears in JAMA Pediatrics and was conducted by Geraldine Dawson, Ph.D., director of the NIH Autism Center of Excellence at Duke University, and colleagues. Funding was provided by NIH's Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) and National Institute of ...

Scientists have made a promising step towards developing a new drug for treating acute myeloid leukaemia, a rare blood disorder. In a study published today in Nature, Cambridge researchers report a new approach to cancer treatment that targets enzymes which play a key role in translating DNA into proteins and which could lead to a new class of cancer drugs. Our genetic code is written in DNA, but in order to generate proteins - molecules that are vital to the function of living organisms - DNA first needs to be converted into RNA. The production of proteins is controlled by enzymes, which make chemical changes to RNA. Occasionally these enzymes become mis-regulated, being produced in over-abundance. In a study published in 2017, a team led by Professor Tony Kouzarides from the Milner ...

DURHAM, N.C. - Engineers at Duke University have developed the world's first fully recyclable printed electronics. By demonstrating a crucial and relatively complex computer component -- the transistor -- created with three carbon-based inks, the researchers hope to inspire a new generation of recyclable electronics to help fight the growing global epidemic of electronic waste. The work appears online April 26 in the journal Nature Electronics. "Silicon-based computer components are probably never going away, and we don't expect easily recyclable electronics like ours to replace the technology and devices that are already widely used," ...

A new way to identify tumours that could be sensitive to particular immunotherapies has been developed using data from thousands of NHS cancer patient samples sequenced through the 100,000 Genomes Project. The MMRDetect clinical algorithm makes it possible to identify tumours that have 'mismatch repair deficiencies' and then improve the personalisation of cancer therapies to exploit those weaknesses. The study, led by researchers from the University of Cambridge's Department of Medical Genetics and MRC Cancer Unit, identified nine DNA repair genes that are critical guardians of the human genome from damage caused by oxygen and water, as well as errors during cell division. The team used ...

Australian scientists have unlocked another mystery of the class of microorganisms believed to be among Earth's oldest of life forms, throwing new light on the study of cell division and the evolution of life. In a newly published paper in Nature Microbiology a research team from the iThree Institute at the University of Technology Sydney describes the cell division process used by the microorganism Haloferax volcanii from the archaea realm of single-celled life, which is distinct from bacteria. Archaea make up the third major grouping, or domain, of life on the planet, alongside eukaryotes (including all plants and animals) and bacteria, but were only recognised ...

Earthquakes and volcanoes in subduction zones may cause great human catastrophe. Previous studies on subduction zone structure and causal mechanisms of giant megathrust earthquakes (M ≥ 9.0) have mainly focused on aspects like subducting plates and plate interfaces. In contrast, the oceanic asthenosphere structure beneath the subducting slab (at depths of 100-250 km) and its influence on the nucleation of giant megathrust earthquakes have not been well studied. Recently, Dr. FAN Jianke from the Institute of Oceanology of the Chinese Academy of Sciences (IOCAS) and Prof. ZHAO Dapeng from Tohoku University ...

Weight loss surgery is more effective than dieting to reduce brain pressure that can cause blindness in patients with a neurological condition, finds a study led by the University of Birmingham and University Hospitals Birmingham NHS Foundation Trust (UHB). Idiopathic Intracranial Hypertension (IIH) is a debilitating condition that raises pressure in the brain and can lead to chronic headaches and even permanent sight loss. The illness, which often leaves patients with a reduced quality of life, predominately affects women aged 25 to 36 and weight gain is a major risk factor of developing IIH and relapses of the disease. Weight ...

Sponges: They are considered to be one of the most primitive forms of animal life, because they have neither locomotion organs nor a nervous system. A team around deep-sea scientist Antje Boetius has now discovered that sponges leave trails on the sea floor in the Arctic deep sea. They conclude that the animals might move actively - even if only a few centimetres per year. They are now publishing these unique findings in the journal Current Biology. The surprise was great when researchers looked at high-resolution images of the sea floor of the Arctic deep sea in detail: Path-like tracks across the sediments ended where sponges were located. These trails were observed to run in all directions, ...

Monday, 26 April 2021: A national study of 20,000 patients conducted by RCSI University of Medicine and Health Sciences and the HSE Health Protection Surveillance Centre (HPSC) has identified the underlying conditions that are associated with more severe outcomes from COVID-19 in an Irish setting. The research, which has been published in The Lancet Regional Health - Europe, will help inform national public health policies and assist in future treatment and prevention strategies for people at most risk from the virus. The study, which took place during the first wave of the pandemic between March and July 2020, is the first national surveillance study in Ireland that captures data from both hospital ...

MINNEAPOLIS/ST.PAUL (04/26/2021) -- A new study by five doctoral students in neuroscience at the University of Minnesota Medical School calls attention to a lack of regulation and unknown long-term health effects of tear gas. Based on their research, the group recommends changing the protocols around the use of tear gas as a crowd control measure at both the local and national level. "Following the murder of George Floyd and the protests in our city, we felt compelled to dig into the police force used during those protests. We are trained to look at data and ...

A NUST MISIS professor was part of an international research team that has found evidence for the existence of the Zeeman spin-orbit coupling in antiferromagnetic conductors. This work may pave the way for the next generation of electronics. The study was published in npj Quantum Materials. The electron possesses two fundamental properties: charge and spin. Conventional electronic devices use only the charge of electron for information processing. In recent years, an enormous research effort has been focused on building fundamentally new electronic devices (often called "spintronic devices") that would specifically exploit spin properties in addition to charge degrees of freedom. Transfer from conventional electronics to spintronics technology opens the possibilities to construct devices ...

BROOKLYN, New York, Thursday, April 22, 2021 - Rising sea levels and more powerful cyclonic storms, phenomena driven by the warming of oceans due to climate change, puts at immediate or potential risk an estimated 680 million people living in low-lying coastal zones (a number projected to reach more than one billion by 2050). In nations like Bangladesh these populations are already moving to escape sea-level rise. In a new study, "Modeling human migration under environmental change: a case study of the effect of sea level rise in Bangladesh," researchers led by Maurizio Porfiri, an engineer at ...