Immune checkpoint inhibitor (ICI) therapies used to treat cancer come with the risk of adverse autoimmune responses, including arthritis that can persist for years and require joint replacement surgery. Little is known about the specific cells responsible for these events. Researchers at Brigham and Women’s Hospital, a founding member of the Mass General Brigham healthcare system, and collaborators led a study to investigate these immune adverse events and identified a specific type of CD8 T cell that characterizes inflammatory arthritis induced by ICI therapies. Researchers ...

Even vulnerable people, who are at risk of severe Covid-19, achieved good antibody levels after three doses of mRNA vaccine. This is shown by a study from the University of Gothenburg on patients having undergone a bone marrow transplant or with liver disease, including cirrhosis. The aim of the study, which has been published in the journal Infectious Diseases, was to investigate the effects of repeated vaccinations and hybrid immunity against Covid-19 among particularly vulnerable individuals. Hybrid immunity refers to the protection provided by vaccination in combination with SARS-CoV-2 ...

UCSF Medical Center Is Among Nation’s Top Hospitals for 2023-24  U.S. News & World Report ranks UCSF Health adult care among nation’s top 10 hospitals in 7 specialties, Best in the West for neurology/neurosurgery and rheumatology UCSF Medical Center has been named to the Honor Roll of the nation’s top hospitals for adult care in U.S. News & World Report’s 2023-24 Best Hospitals rankings, representing the highest quality of care and safety standards in the country.  The distinction was earned by only 22 medical ...

COLUMBIA, Mo. -- When assessing the skills and competencies or “human capital” of long-term care registered nurses in the United States, studies often focus solely on years of experience and traditional educational backgrounds. However, a new study conducted by a nurse scientist now at University of Missouri found that by incorporating additional criteria, such as ability to speak multiple languages, additional certificates or trainings and licenses to practice in multiple states, immigrant nurses often represent far more human capital than their American-born counterparts. Roy Thompson, a postdoctoral fellow in the MU Sinclair School of Nursing ...

In a new study published on 21 July 2023 by the journal Bone Research, a team of researchers from Johns Hopkins University, using a combination of lineage tracing and single-cell RNA sequencing (scRNA-seq), delved into the contribution of synovial/tendon sheath progenitor cells to heterotopic bone formation. The researchers identified a distinct population of Tppp3+ tendon progenitor cells that actively participated in the formation of ectopic bone in vivo. Their findings provide new insights into the intricate cellular processes driving heterotopic ossification and offer potential therapeutic targets to prevent and ...

It’s easy to imagine that growing up in a neighborhood with safe and clean parks, little to no discrimination, and where people are not struggling financially makes for a lower-stress childhood. In contrast, neighborhoods with few community spaces, violence, and poverty create a higher-stress environment for a child to live in. Unfortunately, systemic and structural issues such as wealth inequality, residential segregation, barriers to home ownership, and environmental injustice in neighborhoods where Black American adolescents disproportionately reside make ...

A type of soil called terra preta da Amazônia, or Amazon dark earth (ADE), promotes faster growth of trees and enhances their development in qualitative terms, according to an article published in the journal Frontiers in Soil Science.  The findings reported in the article resulted from studies supported by FAPESP (projects 20/08927-0, 18/19000-4 and 14/50320-4) under the aegis of its Biodiversity, Characterization, Conservation, Restoration and Sustainable Use Program (BIOTA).  “ADE is rich in nutrients and supports communities of microorganisms that help plants grow, among other things. Native people of the Amazon have ...

Irvine, Calif., Aug. 1, 2023 — When a fragrance wafted through the bedrooms of older adults for two hours every night for six months, memories skyrocketed. Participants in this study by University of California, Irvine neuroscientists reaped a 226% increase in cognitive capacity compared to the control group. The researchers say the finding transforms the long-known tie between smell and memory into an easy, non-invasive technique for strengthening memory and potentially deterring dementia.   The team’s study appears in Frontiers in Neuroscience. ...

Almost half of patients who experienced a stroke in the right cerebral hemisphere later develop a very unusual symptom: they lose the ability to perceive what is happening in the left side of space. As a result, they tend to eat only the right side of their plate, ignore people on their left, and have great difficulty finding their way around. This disorder, known as hemispatial neglect, does not involve basic visual abilities, which remain intact. “These patients see very well. The problem ...

PHILADELPHIA—A Penn Medicine and Children’s Hospital of Philadelphia (CHOP) team will seek to develop treatments for three rare, incurable genetic diseases with the help of a $26 million grant from the National Institutes of Health (NIH). The research will focus on three genetic diseases that impact newborns in the first weeks and months after birth: Phenylketonuria (PKU), hereditary tyrosinemia type 1 (HT1), and mucopolysaccharidosis type 1 (MPSI), commonly known as Hurler’s Syndrome. PKU causes an amino acid—called phenylalanine—to build up in the body, and as long as treatment begins at birth, PKU is ...

False claims and disinformation, especially in a social media-driven society, have become major problems with potentially severe consequences. Kash Barker, Ph.D., principal investigator and the Anadarko Presidential Professor in the School of Industrial and Systems Engineering, Gallogly College of Engineering at the University of Oklahoma, is leading a team of researchers examining indirect attacks targeting infrastructure systems via unwitting users, supported by a $599,947 grant from the National Science Foundation's Secure ...

Despite this prevailing negative sentiment, results showed the public generally think the most suitable punishment for disruptive, non-violent protesters is a fine or lesser penalty than imprisonment. The research, led by the University of Bristol, suggests public opinion may not be supportive of the Government’s recent legislative changes, through The Public Order Act 2023, which introduce harsher sentences for disruptive protesters. The online poll, conducted by YouGov this month, surveyed 2,069 adults of all political viewpoints across Britain. ...

HAMILTON, ON, Aug. 1, 2023 – Based on decades of work to uncover the underlying mechanisms of asthma and other respiratory conditions, researchers at McMaster University and St. Joseph’s Healthcare Hamilton have produced a simple, rapid test that can identify the presence of a key driver of severe asthma. John Brennan, director of McMaster’s Biointerfaces Institute, and Parameswaran Nair, a respirologist at the St. Joseph’s-based Firestone Institute for Respiratory Health, led the creation of a new rapid test that can quickly and accurately identify white blood cells known as eosinophils, even when they are present in complex biological samples ...

WASHINGTON, Aug. 1, 2023 – Since ancient times, gemstones have been mined and traded across the globe, sometimes traveling continents from their origin. Gems are geologically defined as minerals celebrated for beauty, strength, and rarity. Their unique elemental composition and atomic orientation act as a fingerprint, enabling researchers to uncover the stones’ past, and with it, historical trade routes. In AIP Advances, from AIP Publishing, Khedr et al. employed three modern spectroscopic techniques to rapidly analyze gems found in the Arabian-Nubian Shield and compare them with similar gems from around the world. Using ...

Birds can be electrocuted if they come into contact with two energized parts of a power line at once—which can happen when they spread their wings to take off from or land on a power pole. Because of this, energy companies invest substantial time and money into making sure power lines are avian safe, installing safe perches and insulating energized elements. However, a recent study published on August 1 in the journal iScience presents a new priority for conservation, as it suggests that electrocution is no longer the only leading cause of death for ...

Media contacts:     Coby Schal, coby@ncsu.edu Mick Kulikowski, News Services, 919.218.5937 or mick_kulikowski@ncsu.edu                          Aug 1, 2023              Male Moth ‘Aphrodisiac’ Revealed  EMBARGOED FOR RELEASE UNTIL 11 A.M. EDT ON TUESDAY, AUG.1 North Carolina State University researchers have identified the specific blend of pheromone chemicals – including a newly revealed aphrodisiac – used by male moths during courtship as they attempt to entice females to mate. The findings provide more detail ...

Bottom Line: The U.S. Preventive Services Task Force (USPSTF) recommends that all persons planning to or who could become pregnant take a daily supplement containing 0.4 to 0.8 mg (400 to 800 μg) of folic acid. Neural tube defects are among the most common congenital malformations in the U.S., with an estimated 3,000 pregnancies affected each year. Many of these neural tube defects are caused by low folate levels in the body. The USPSTF routinely makes recommendations about the effectiveness ...

About The Study: The results of this study suggest that providing fair and equal access to health care may reduce the disparities in treatment outcomes between Black and white patients with advanced prostate cancer. Authors: Neeraj Agarwal, M.D., of the University of Utah in Salt Lake City, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/  (doi: 10.1001/jamanetworkopen.2023.26546) Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, ...

About The Study: The findings of this secondary analysis of a randomized clinical trial suggest that exercise is a promising treatment for chemotherapy-induced peripheral neuropathy (CIPN) and incorporating exercise program referrals into the standard oncology care may reduce CIPN symptoms and increase quality of life for survivors of ovarian cancer. Authors: Anlan Cao, M.B.B.S., of the Yale School of Public Health in New Haven, Connecticut, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/  (doi: 10.1001/jamanetworkopen.2023.26463) Editor’s ...

LOS ANGELES — Researchers at City of Hope, one of the largest cancer research and treatment organizations in the United States, today published a new study explaining how they took a protein once thought to be too challenging for targeted therapy, proliferating cell nuclear antigen (PCNA), and developed a targeted chemotherapy that appears to annihilate all solid tumors in preclinical research. As the scientists continue to investigate the foundational mechanisms that make this cancer-stopping pill work in animal models, they note that ...

Millions of Americans with tobacco-related lung disease have symptoms that do not fit any existing tobacco-related disease criteria – including the most common of those, chronic obstructive pulmonary disease (COPD) – according to a new study led by researchers at UC San Francisco. In a study publishing Aug. 1, 2023, in the Journal of the American Medical Association (JAMA), the research team found that half of the participants with extensive tobacco exposure had a persistently high level of respiratory symptoms, including shortness of breath, daily cough and ...

Para-cresol is an aromatic compound with a strong horse stable-like odor. It contributes to the off-flavor of some foods, but it is also detectable as a characteristic odorant in whiskey and tobacco, as well as in the urine of various mammals. A research team led by the Leibniz Institute of Food Systems Biology at the Technical University of Munich has now discovered which odorant receptor humans use to perceive para-cresol. Para-cresol (4-methylphenol) is formed during the microbial degradation of certain amino acids, but also during thermal ...

A large natural experiment in Catalonia shows that moving to areas with higher levels of air pollution is associated with weight gain in young children. The study, led by the Barcelona Institute for Global Health (ISGlobal), an institution supported by ”la Caixa Foundation”, in collaboration with the IDIAP Jordi Gol, provides further evidence to support efforts to reduce air pollution. Overweight and obesity in childhood result from the interaction of genes, lifestyle behaviours, physiological and social factors. Environmental exposures such as air pollution may ...

Aug. 1, 2023 Contact: Derek Smith, 734-546-3632, smitdere@umich.edu                  Katherine McAlpine, 734-647-7087, kmca@umich.edu    Images  Cracking in lithium-ion batteries speeds up electric vehicle charging Cracks in predominant lithium-ion electrodes shorten battery lifespans, but a neuroscience-inspired technique shows that they have an upside ANN ARBOR—Rather than being solely detrimental, cracks in the positive electrode of lithium-ion batteries reduce battery charge time, research done at the University of Michigan shows. This runs counter to the view of many ...

INDIANAPOLIS – Periodontal disease is a growing public health issue in the United States as the nation’s population ages, yet it’s underdiagnosed and undertreated. According to the U.S. Centers for Disease Control and Prevention (CDC), 47 percent of adults aged 30 years and older and 79 percent of adults 65 years and older have some form of periodontal disease. Researchers from Regenstrief Institute and Indiana University School of Dentistry have developed computer algorithms to track periodontal disease change, which could help dentists and periodontists follow disease progression. They also have developed tools to ...