Announcing a new article publication for BIO Integration journal. In this review article the authors Yue Li, Zhiyi Chen and Shuping Ge from First Affiliated Hospital of University of South China, Hengyang, China and Tower Health and Drexel University, Philadelphia, PA, USA summarize current state of the art applications of microbubble-cell interactions and sonoporation effects to cellular functions. Ultrasound combined with microbubble-mediated sonoporation has been applied to enhance drug or gene intracellular delivery. Sonoporation leads to the formation of openings in the cell membrane, triggered by ultrasound-mediated oscillations and destruction of microbubbles. Multiple mechanisms are involved in the occurrence ...

Announcing a new article publication for BIO Integration journal. In this review article the authors Xiuling Li, Shunung Liang, Chee Hwee Tan, Shuwen Cao, Xiaoding Xu, Phei Er Saw and Wei Tao from Sun Yat-sen University, Guangzhou, China, Guangzhou University of Chinese Medicine, Guangzhou, China and Center for Harvard Medical School, Boston, MA, USA discuss the potential benefits of four plants endogenous to China and the enhancement of their therapeutic efficacy by nanotechnology intervention. Plant derived natural products have been used for the treatment of various human diseases long before the intervention of modern medicine. The basis of modern medicine is still inspired by traditional medicine and therapies. However, ...

LA JOLLA, CA--As new COVID-19 variants begin to throw vaccine efficacy in question, two leading scientists are calling for health agencies to invest in the development of vaccines that would be broadly effective against many different variants and strains of potential pandemic viruses. In a END ...

Researchers at the University of Campinas's Chemistry Institute (IQ-UNICAMP) in the state of São Paulo, Brazil, have developed a template-free technique to fabricate cilia of different sizes that mimic biological functions and have multiple applications, from directing fluids in microchannels to loading material into a cell, for example. The highly flexible cilia are based on polymer-coated iron oxide nanoparticles, and their motion can be controlled by a magnet. In nature, cilia are microscopic hairlike structures found in large numbers on the surface of certain cells, causing currents ...

Photoplethysmography (PPG) is a simple optical technique used to detect volumetric changes in peripheral blood circulation. It's used in smart watches, for example, to monitor pulse and heart rate, but PPG biosensors are also found in millions of smartphones, but without any current clinical applications. In a study published online in the February 2021 issue of Chest, researchers at University of California San Diego School of Medicine, with industry collaborators, found that already embedded PPG in smartphones, in tandem with application software, could be used for remote clinical pulse oximetry to manage chronic cardiopulmonary disease and perhaps initial treatment and monitoring of persons affected in respiratory viral pandemics, such as COVID-19. "Pulse oximetry monitoring ...

As governments try to mitigate the spread of COVID-19, many are turning to contact tracing, including apps that track your location and electronic check-in QR codes. But with that technology come questions of personal safety, privacy, trust, control and collective action. So what can be done to improve these large-scale technological system roll-outs without infringing on a citizen's right to privacy? "These systems are logging your physical social network," said Katina Michael, an Arizona State University professor at the School for the Future of Innovation in Society in the College of Global Futures and the School of Computing, Informatics and Decision Systems Engineering in the Ira A. Fulton Schools of Engineering. "The physical has become more ...

Beyond the environmental benefits and lower electric bills, it turns out installing solar panels on your house actually benefits your whole community. Value estimations for grid-tied photovoltaic systems prove solar panels are beneficial for utility companies and consumers alike. For years some utility companies have worried that solar panels drive up electric costs for people without panels. Joshua Pearce, Richard Witte Endowed Professor of Materials Science and Engineering and professor of electrical and computer engineering at Michigan Technological University, has shown the opposite is true -- grid-tied solar photovoltaic (PV) owners are actually subsidizing their non-PV ...

ALBUQUERQUE, N.M. -- The huge forces generated by the Z machine at Sandia National Laboratories are being used to replicate the gravitational pressures on so-called "super-Earths" to determine which might maintain atmospheres that could support life. Astronomers believe that super-Earths -- collections of rocks up to eight times larger than Earth -- exist in the millions in our galaxy. "The question before us is whether any of these super planets are actually Earthlike, with active geological processes, atmospheres and magnetic fields," said Sandia physicist Joshua Townsend. The current ...

Energy efficiency or carbon intensity (defined as CO2 emissions per transport work, ed.) is a possible point of convergence between the International Maritime Organization (IMO) and EU regulations to cut GHG emissions and decarbonize shipping. Short term measures to increase energy efficiency and achieve carbon intensity savings include voyage optimization. A new study led by the CMCC Foundation, realized in the framework of the Interreg Italy-Croatia END ...

New research by Morgan Philbin, PhD, at Columbia University Mailman School of Public Health and colleagues looks at why Black young men who have sex with men (YMSM) are disproportionately subject to high rates of arrest and incarceration. They find that perceived racial discrimination, sexual orientation discrimination, and HIV-status discrimination are all associated with risk for criminal justice involvement in this population. The research appears in the journal Stigma and Health. Various studies have shown that Black men are imprisoned at nearly seven times the rate of white men; sexual minority young adults are nearly three times more likely to report being criminally sanctioned compared to their heterosexual ...

An electrocardiogram (ECG) is an examination that records the electrical activity of the heart during the cardiac cycle. It is non-invasive and usually involves placing electrodes on the subject's skin. It is a most indicated type of examination when there is suspected heart disease and also in routine preventive health check-ups. The cardiac cycle entails the emptying of blood from the atria to the ventricles ("P" wave, red in the image), the contraction of the ventricles to propel blood to the different tissues and organs of the body ("QRS" wave, green in the image), and ...

ATLANTA--ProAgio, a drug developed by Georgia State University biology professor Zhi-Ren Liu and his team, is effective at treating pancreatic cancer and prolonging survival in mice, according to a study published in the journal Cellular and Molecular Gastroenterology and Hepatology. A second study, published in the Journal of Experimental Medicine, shows the drug is also effective against triple-negative breast cancer, a fast-growing and hard-to-treat type of breast cancer that carries a poor prognosis. ProAgio, created from a human protein, targets the cell surface receptor integrin αVβ?, which is expressed on cancer-associated fibroblasts. Fibroblasts are cells ...

HOUSTON - (Feb. 9, 2021) - Rice University researchers have created a "defective" catalyst that simplifies the generation of hydrogen peroxide from oxygen. Rice scientists treated metal-free carbon black, the inexpensive, powdered product of petroleum production, with oxygen plasma. The process introduces defects and oxygen-containing groups into the structure of the carbon particles, exposing more surface area for interactions. When used as a catalyst, the defective particles known as CB-Plasma reduce oxygen to hydrogen peroxide with 100% Faradaic efficiency, a measure of charge transfer in electrochemical reactions. The process shows promise to replace the complex anthraquinone-based production ...

With the COVID-19 pandemic entering its second year, the challenges faced both by individuals and nations remain substantial. While notable medical advancements in the treatment of COVID-19 have been made, a host of questions about how to live with it and how to work to end it remain active. Carnegie Mellon University researchers David Rode and Paul Fischbeck explore these questions in a new article, "On ambiguity reduction and the role of decision analysis during the pandemic," published in a special issue of the journal END ...

Wintertime outbreaks of COVID-19 have been largely driven by whether people adhere to control measures such as mask wearing and social distancing, according to a study published Feb. 8 in Nature Communications by Princeton University researchers. Climate and population immunity are playing smaller roles during the current pandemic phase of the virus, the researchers found. The researchers -- working in summer 2020 -- ran simulations of a wintertime coronavirus outbreak in New York City to identify key factors that would allow the virus to proliferate. They found that relaxing control measures in the summer months led to an outbreak in the winter regardless of climate factors. "Our results implied that lax control measures -- and likely ...

Ancient Amazonian communities fortified valuable land they had spent years making fertile to protect it from conflict, excavations show. Farmers in Bolivia constructed wooden defences around previously nutrient-poor tropical soils they had enriched over generations to keep them safe during times of social unrest. These long-term soil management strategies allowed Amazonians to grow nutrient demanding crops, such as maize and manioc and fruiting trees, and this was key to community subsistence. These Amazonian Dark Earths, or Terra Preta, were created through burning, mulching, and the deposition of organic waste. It was known that some communities built ditches ...

An ecologist from RUDN University suggested a method to evaluate and reduce the effect of animal farms on climate change and developed a set of measures for small farms that provides for the complete elimination of greenhouse gas emissions. The results of the study were published in the Journal of Cleaner Production. Crop and animal farming and other agricultural activities account for almost a quarter of all greenhouse gases produced by humanity and therefore add a lot to climate change. On the other hand, the soils and biomass accumulate a lot of carbon, thus preventing it from getting into the atmosphere as a part of carbon dioxide and slowing climate change down. An ecologist from RUDN University suggested ...

Ithaca, NY--Love them or hate them, there's no doubt the European Starling is a wildly successful bird. A new study from the Cornell Lab of Ornithology examines this non-native species from the inside out. What exactly happened at the genetic level as the starling population exploded from just 80 birds released in New York City's Central Park in 1890, peaking at an estimated 200 million breeding adults spread all across North America? The study appears in the journal Molecular Ecology. "The amazing thing about the evolutionary changes among starling populations ...

The term "algae" is used to refer to over 72,500 identified aquatic species. The size of algae is up to tens of meters, however, most (about 80%) of the species are much smaller - they comprise the microalgae group. Microalgae are rich in nutrients and biologically active substances such as proteins, carbohydrates, lipids, vitamins, pigments and others. These components are widely used in food, cosmetic, chemical and energy industries. Biotechnology of microalgae has multiple advantages: they are a renewable and sustainable resource, more productive than terrestrial plants due to their high growth rate and lack of seasonality ...

LAWRENCE -- Traditional burial in a graveyard has environmental costs. Graves can take up valuable land, leak embalming chemicals and involve nonbiodegradable materials like concrete, as well as the plastic and steel that make up many caskets. But the other mainstream option -- cremation -- releases dangerous chemicals and greenhouse gasses into the environment. So, what's an environmentalist to do when making plans for the end of life? A new study from the University of Kansas in the journal Mortality details how older environmentalists consider death care and how likely they are to choose "green" burials and other eco-friendly options. "This article is specifically asking if older adult environmentalists consider how their bodies are going to ...

GAINESVILLE, Fla. --- A ruler and scale can tell archaeologists the size and weight of a fragment of pottery - but identifying its precise color can depend on individual perception. So, when a handheld color-matching gadget came on the market, scientists hoped it offered a consistent way of determining color, free of human bias. But a new study by archaeologists at the Florida Museum of Natural History found that the tool, known as the X-Rite Capsure, often misread colors readily distinguished by the human eye. When tested against a book of color chips, the machine failed to produce correct color scores in 37.5% of cases, even though its software system included the same set of chips. In an analysis of fired ...

Individually, California blackworms live an unremarkable life eating microorganisms in ponds and serving as tropical fish food for aquarium enthusiasts. But together, tens, hundreds, or thousands of the centimeter-long creatures can collaborate to form a "worm blob," a shape-shifting living liquid that collectively protects its members from drying out and helps them escape threats such as excessive heat. While other organisms form collective flocks, schools, or swarms for such purposes as mating, predation, and protection, the Lumbriculus variegatus worms are unusual in their ability to braid themselves together to accomplish tasks that unconnected individuals cannot. A new study reported by researchers at ...

HOUSTON - (Feb. 9, 2021) - Finding a needle in a haystack is hard enough. But try finding a specific molecule on the needle. Rice University researchers have achieved something of the sort with a new genome editing tool that targets the supporting players in a cell's nucleus that package DNA and aid gene expression. Their work opens the door to new therapies for cancer and other diseases. Rice bioengineer Isaac Hilton, postdoctoral researcher and lead author Jing Li and their colleagues programmed a modified CRISPR/Cas9 complex to target specific histones, ubiquitous epigenetic proteins that keep DNA in order, ...

RIVERSIDE, Calif. -- A team led by astronomers at the University of California, Riverside, has found that some dwarf galaxies may today appear to be dark-matter free even though they formed as galaxies dominated by dark matter in the past. Galaxies that appear to have little to no dark matter -- nonluminous material thought to constitute 85% of matter in the universe -- complicate astronomers' understanding of the universe's dark matter content. Such galaxies, which have recently been found in observations, challenge a cosmological model used by astronomers called Lambda Cold Dark Matter, or LCDM, where all galaxies are surrounded by a massive and extended dark matter halo. Dark-matter-free galaxies are not well understood in the astronomical community. ...

UCLA RESEARCH ALERT FINDINGS In a study of mice, researchers at the UCLA Jonsson Comprehensive Cancer Center have identified a new approach that combines an anti-psychotic drug, a statin used to lower high cholesterol levels, and radiation to improve the overall survival in mice with glioblastoma. Glioblastoma is one of the deadliest and most difficult-to-treat brain tumors. Researchers found the triple combination extended the median survival 4-fold compared to radiation alone. BACKGROUND Radiation therapy is part of the standard-of-care treatment regimen for glioblastoma, often helping prolong the survival of patients. However, survival times have not improved significantly over the past two decades and attempts to improve the efficacy ...