To effectively fight off SARS-CoV-2, the immune system depends on both antibodies and T cells, a type of white blood cell, which work together to eradicate the virus. However, little was known about virus-specific T cells in asymptomatic patients. "We now know that many people are getting infected with SARS-CoV-2 without realising it, as they stay healthy and don't develop any symptoms. These asymptomatic infections may provide the key to understanding how the immune system can control the virus without triggering pathological processes," explained Dr Nina Le Bert, Senior Research Fellow ...

A Korean research group has developed a technology that allows for the differentiation of stem cells into desired cell types, such as vascular mural cells or osteoblasts, without special pretreatment. This technology is expected to facilitate the production of artificial organs for preclinical studies or artificial tissues for transplants such as artificial skin and cardiac patches. The Korea Institute of Science and Technology (KIST) announced that the research group led by Dr. Youngmee Jung of the Center for Biomaterials has developed a new cell co-culture platform ...

In recent years there has been an increased focus on the circular economy and a heightened demand for products made of recyclable materials, however many materials can only be recycled so many times before they begin to wear out. This is the case with carbon fibre reinforced polymer (CFRP) composites, non-biodegradable materials which, until now, have lacked a viable recycling method. CRFP composites are present in products such as wind turbines, aeroplane parts, vehicles such as cars and ships, and everyday technology such as laptops and mobile ...

FOR IMMEDIATE RELEASE Physicians understand frailty as a dysregulation among multiple systems in the body that make it less resilient and unable to recover completely when faced with a physical challenge such as injury or illness. "Defining frailty on a scientific level, however, has been a challenging task," explains END ...

SPOKANE, Wash. - New clues as to why night shift workers are at increased risk of developing certain types of cancer are presented in a new study conducted at Washington State University Health Sciences Spokane. ...

It is well-known that patients who undergo Fontan surgery slowly develop liver fibrosis for years post-operatively. In the past decade, these incidences have been steadily increasing and this is due partly to the need for an accurate diagnostic method. A research group led by Dr. Daisuke Tokuhara, Associate Professor of Pediatrics, Osaka City University Graduate School of Medicine and Dr. Yuki Cho have found that the conventional methods of ultrasound elastography and biomarkers via blood tests do not show the actual status of postoperative liver ...

INDIANAPOLIS -- In a study conducted shortly before COVID-19 vaccines became available in the U.S., more than two-thirds of nursing home and assisted living staff in Indiana indicated willingness to receive a vaccine immediately or in the future. The study was led by researchers from Regenstrief Institute, Indiana University and the State of Indiana. Vaccine uptake by front-line staff is important because it will help protect against serious illness and death for the high-risk people who receive care in these facilities. "The vaccines offer the opportunity to return to a more normal life within the nursing ...

Native to the southeastern United States, a weedy grass has spread northward to Canada and also made its way to Australia and Japan. Andropogon virginicus grows densely packed and up to seven feet tall, disrupting growth patterns of other plants and competing for resources. When burned, it grows back stronger. There is no way to effectively remove the weed once it has invaded. But there might be a way to use it to human advantage. An international team of researchers has found that A. virginicus extracts appear to be effective against several human diseases, including diabetes and cancer. The results were published on Dec. 31, 2020, in a special issue of Plants, titled ...

Hydrogen has been hailed as the 'fuel of the future' owing to several reasons. First, compared to the conventionally used hydrocarbons, hydrogen exhibits higher energy yield. Second, the commercial use of hydrogen fuel, which yields only water as a byproduct product, would help mitigate the imminent global warming crisis by reducing the use of exhaustible and polluting fossil fuels. Thus, ongoing research has been focusing on efficient and environment-friendly ways to produce of hydrogen fuel. Solar hydrogen production through photoelectrochemical (PEC) water-splitting reaction is an attractive "green" method of ...

Research from the University of Kent predicts an end to deregulated competitive pubic transport in the UK as a consequence of Covid-19 social distancing measures leading to drastically reduced ridership, requiring a major rethinking of the provision of public transport. This paper, published in Transport Policy, argues that the situation will require a fundamental approach to long-term policy for transport as a whole. This is an opportunity to reconstruct the system whilst addressing such problems as the environmental impact of transport, congestion and questions of transport justice such as accessibility ...

A new substance could improve the treatment of persistent cancers. Researchers at Martin Luther University Halle-Wittenberg (MLU) and the University of Greifswald have developed a new inhibitor that makes drug-resistant tumour cells respond again to chemotherapy. The new substance blocks a protein in the cancer cells that normally transports the cancer drugs back out of the cells. The results were published in the scientific journal Molecules. In addition to radiation therapy, cytotoxic agents, also known as chemotherapy, are frequently used to treat cancer. They prevent cells from dividing and thus cancer cells are unable to multiply unchecked. "Cytotoxic agents remain a very important form ...

In 1952, Alan Turing, the father of computer science and artificial intelligence, proposed that certain repetitive natural patterns may be produced by the interaction of two specific substances through the "reaction-diffusion" process. In this system, activator promotes the reaction and inhibitor inhibits the reaction. When the two meet, the reaction diffuses. When the difference in diffusion coefficient between the two reaches a certain level, the high diffusion ratio between them will cause the system imbalance and induce the formation of periodic complex patterns. "Turing structure" exists widely in nature, such as the body patterns of zebras, the phyllotaxis of sunflowers, the follicle spacing of ...

The precise choice of treatment for breast cancer depends upon the status of the hormone receptors (for oestrogen and progesterone). Their conventional determination by means of immunohistochemistry (IHC) is associated with a certain error rate, which can be reduced by adding genomic data. Even conventional statistics can bring about a notable improvement but now it is possible to use decision theory to optimally combine diagnostic findings, particularly where they are contradictory. This is the finding of a recent study conducted by MedUni Vienna under the leadership of Wolfgang Schreiner from the Center for Medical Statistics, Informatics and Intelligent Systems (CeMSIIS). The methodology has applications way beyond breast cancer and can be deployed ...

Recently, research group, led by Prof. FU Yao and associate research fellow LU Xi From Hefei National Laboratory for Physical Sciences at the Microscale and School of Chemistry and Materials Science of the University of Science and Technology of China (USTC), has made significant achievements in the field of synthesis of chiral amines. They developed a mild and general nickel-catalysed asymmetric reductive hydroalkylation and realized the modular synthesis of chiral aliphatic amines. Results were published in Nature Communications on Feb. 26, 2021. Chiral amines are important chiral auxiliaries and key synthetic intermediates of pharmaceuticals and natural products. ...

With the help of the European Southern Observatory's Very Large Telescope (ESO's VLT), astronomers have discovered and studied in detail the most distant source of radio emission known to date. The source is a "radio-loud" quasar -- a bright object with powerful jets emitting at radio wavelengths -- that is so far away its light has taken 13 billion years to reach us. The discovery could provide important clues to help astronomers understand the early Universe. Quasars are very bright objects that lie at the centre of some galaxies and are powered by supermassive black holes. As the black hole consumes the surrounding gas, energy is released, allowing astronomers to ...

Astronomers using the National Science Foundation's Karl G. Jansky Very Large Array (VLA) and Very Long Baseline Array (VLBA) have found and studied the most distant cosmic jet discovered so far -- a jet of material propelled to nearly the speed of light by the supermassive black hole in a quasar some 13 billion light-years from Earth. The quasar is seen as it was when the universe was only 780 million years old, and is providing scientists with valuable information about how galaxies evolved and supermassive black holes grew when the universe was that young. The studies indicate that the quasar -- a galaxy harboring a black hole 300 million times more massive than the Sun -- has a jet of fast-moving particles only about 1,000 years ...

COLUMBUS, Ohio - Multinational companies headquartered in countries with tougher environmental policies tend to locate their polluting factories in countries with more lax regulations, a new study finds. While countries may hope their regulations will reduce emissions of carbon dioxide and other greenhouse gases, these results show that these policies can lead to "carbon leakage" to other nations, said Itzhak Ben-David, co-author of the study and professor of finance at The Ohio State University's Fisher College of Business. "Firms decide strategically where to locate their production based ...

North Carolina State University engineers continue to improve the efficiency of a flexible device worn on the wrist that harvests heat energy from the human body to monitor health. In a paper published in npj Flexible Electronics, the NC State researchers report significant enhancements in preventing heat leakage in the flexible body heat harvester they first reported in 2017 and updated in 2020. The harvesters use heat energy from the human body to power wearable technologies - think of smart watches that measure your heart rate, blood oxygen, glucose and other health parameters - that never need to have their batteries recharged. The technology relies on the same principles ...

Rome, Italy, March 8, 2021 - Allelica, a leading genomics software company specialising in developing polygenic risk scores (PRS) for personalised medicine, today announced publication of a study in Circulation (Vol. 143, Issue 10) showing that the effect of LDL cholesterol on a person's risk of having a heart attack depends on their genes. Using Allelica's proprietary PRS analysis software, the data showed that combining information on an individual's genetic risk of heart attack with their LDL level helps determine those at most risk from heart attack, including those potentially in need of treatment with statins or PCSK9 inhibitors. The PRS was also able to identify individuals eligible for therapeutic intervention based on current ...

To avoid a substantial increase in water scarcity, biomass plantations for energy production need sustainable water management, a new study shows. Bioenergy is frequently considered one of the options to reduce greenhouse gases for achieving the Paris climate goals, especially if combined with capturing the CO2 from biomass power plants and storing it underground. Yet growing large-scale bioenergy plantations worldwide does not just require land, but also considerable amounts of freshwater for irrigation - which can be at odds with respecting Earth's ...

Diphtheria - a relatively easily-preventable infection - is evolving to become resistant to a number of classes of antibiotics and in future could lead to vaccine escape, warn an international team of researchers from the UK and India. The researchers, led by scientists at the University of Cambridge, say that the impact of COVID-19 on diphtheria vaccination schedules, coupled with a rise in the number of infections, risk the disease once more becoming a major global threat. Diphtheria is a highly contagious infection that can affect the nose and throat, and sometimes the skin. If left untreated it can prove fatal. In the UK and other high-income countries, babies are vaccinated against ...

DALLAS, March 8, 2021 -- Out-of-hospital cardiac arrests triggered by opioid overdose are a significant cause of death among adults 25 to 64, according to a scientific statement from the American Heart Association, the nation's largest voluntary health organization focused on heart and brain health for all. The statement published today in the Association's flagship journal Circulation. In the U.S., opioid use disorder affects an estimated 2 million people each year and costs more than $78 billion in health care expenses. The opioid epidemic, ...

DALLAS, March 8, 2021 - While most people think of strokes affecting the brain, they can also affect the eye. Central retinal artery occlusion (CRAO) is a rare form of acute ischemic stroke that occurs when blood flow is blocked to the main artery of the eye. It typically causes painless, immediate vision loss in the impacted eye, with fewer than 20% of people regaining functional vision in that eye. Today, the American Heart Association published a new scientific statement, "Management of Central Retinal Artery Occlusion," in Stroke, an American Heart Association ...

The analysis of immune cells infiltrating cerebrospinal fluid enables the characterization of the tumor microenvironment in brain metastases. Findings reported today in Nature Communications* confirm that these cells recapitulate the characteristics of those detected in brain metastases, and could act as novel and non-invasive biomarkers to predict patient responsiveness to immune-based therapies. Results from a study led by Joan Seoane, Director of Preclinical and Translational Research co-program at VHIO and ICREA Professor, show that immune cells accessing cerebrospinal fluid faithfully recapitulate the characteristics of cells identified in brain metastasis, and could therefore constitute novel ...

Philadelphia, March 8, 2021 - Virtual reality avatar-based coaching shows promise to increase access to and extend the reach of nutrition education programs to children at risk for obesity, according to a new study in the Journal of Nutrition Education and Behavior, published by Elsevier. Researchers introduced 15 adult-child dyads to a virtual avatar-based coaching program that incorporated age-specific information on growth; physical, social, and emotional development; healthy lifestyles; common nutrition concerns; and interview questions around eating behaviors and food resources and counseling. "We developed a virtual reality avatar computer program ...