COLUMBUS, Ohio - We know that what happens in the mouth doesn't stay in the mouth - but the oral cavity's connection to the rest of the body goes way beyond chewing, swallowing and digestion. The healthy human oral microbiome consists of not just clean teeth and firm gums, but also energy-efficient bacteria living in an environment rich in blood vessels that enables the organisms' constant communication with immune-system cells and proteins. A growing body of evidence has shown that this system that seems so separate from the rest of our bodies is actually highly influential on, and influenced by, our overall health, said Purnima Kumar, professor of periodontology at The Ohio State University, speaking at a science conference this week. For example, type 2 diabetes has long ...

New research finds caffeine consumed during pregnancy can change important brain pathways that could lead to behavioral problems later in life. Researchers in the Del Monte Institute for Neuroscience at the University of Rochester Medical Center (URMC) analyzed thousands of brain scans of nine and ten-year-olds, and revealed changes in the brain structure in children who were exposed to caffeine in utero. "These are sort of small effects and it's not causing horrendous psychiatric conditions, but it is causing minimal but noticeable behavioral issues that should make us consider long term effects ...

One of humanity's biggest challenges right now is reducing our emissions of greenhouse gases into the atmosphere. Research groups worldwide are trying to find ways to efficiently separate carbon dioxide (CO2) from the mixture of gases emitted from industrial plants and power stations. Among the many strategies for accomplishing this, membrane separation is an attractive, inexpensive option; it involves using polymer membranes that selectively filter CO2 from a mix of gases. Recent studies have focused on adding low amounts of metal-organic frameworks (MOFs) into polymer matrices to enhance their properties. MOFs are compounds made of a metallic center bonded to organic molecules in a very orderly fashion, producing porous crystals. When added to polymer ...

DURHAM, N.C. -- The world's most technologically advanced robots would lose in a competition with a tiny crustacean. Just the size of a sunflower seed, the amphipod Dulichiella cf. appendiculata has been found by Duke researchers to snap its giant claw shut 10,000 times faster than the blink of a human eye. The claw, which only occurs on one side in males, is impressive, reaching 30% of an adult's body mass. Its ultrafast closing makes an audible snap, creating water jets and sometimes producing small bubbles due to rapid changes in water pressure, a phenomenon known ...

Bark beetle outbreaks and wildfire alone are not a death sentence for Colorado's beloved forests--but when combined, their toll may become more permanent, shows new research from the University of Colorado Boulder. It finds that when wildfire follows a severe spruce beetle outbreak in the Rocky Mountains, Engelmann spruce trees are unable to recover and grow back, while aspen tree roots survive underground. The study, published last month in Ecosphere, is one of the first to document the effects of bark beetle kill on high elevation forests' recovery from wildfire. "The fact that Aspen is regenerating prolifically after wildfire is not a surprise," said Robert Andrus, who conducted ...

A team of engineers and scientists has developed a method of 'multiplying' organoids: miniature collections of cells that mimic the behaviour of various organs and are promising tools for the study of human biology and disease. The researchers, from the University of Cambridge, used their method to culture and grow a 'mini-airway', the first time that a tube-shaped organoid has been developed without the need for any external support. Using a mould made of a specialised polymer, the researchers were able to guide the size and shape of the mini-airway, grown from adult mouse stem cells, and then remove it from the mould when it reached ...

DANVILLE, Pa. - Researchers at Geisinger have found that a computer algorithm developed using echocardiogram videos of the heart can predict mortality within a year. The algorithm--an example of what is known as machine learning, or artificial intelligence (AI)--outperformed other clinically used predictors, including pooled cohort equations and the Seattle Heart Failure score. The results of the study were published in Nature Biomedical Engineering. "We were excited to find that machine learning can leverage unstructured datasets such as medical images and videos to improve on a wide range of clinical prediction models," said Chris Haggerty, Ph.D., co-senior author and assistant ...

A type of cell derived from human stem cells that has been widely used for brain research and drug development may have been leading researchers astray for years, according to a study from scientists at Weill Cornell Medicine and Columbia University Irving Medical Center. The cell, known as an induced Brain Microvascular Endothelial Cell (iBMEC), was first described by other researchers in 2012, and has been used to model the special lining of capillaries in the brain that is called the "blood-brain barrier." Many brain diseases, including brain cancers as well as degenerative ...

Older adults who are classified as having "prediabetes" due to moderately elevated measures of blood sugar usually don't go on to develop full-blown diabetes, according to a study led by researchers at Johns Hopkins Bloomberg School of Public Health. Doctors still consider prediabetes a useful indicator of future diabetes risk in young and middle-aged adults. However, the study, which followed nearly 3,500 older adults, of median age 76, for about six and a half years, suggests that prediabetes is not a useful marker of diabetes risk in people of more advanced age. The results were published February 8 in JAMA ...

Ask anyone from an NFL quarterback scanning the field for open receivers, to an air traffic controller monitoring the positions of planes, to a mom watching her kids run around at the park: We depend on our brain to hold what we see in mind, even as we shift our gaze around and even temporarily look away. This capability of "visual working memory" feels effortless, but a new MIT study shows that the brain works hard to keep up. Whenever a key object shifts across our field of view--either because it moved or our eyes did--the brain immediately transfers a memory of it by re-encoding it among neurons in the opposite brain hemisphere. The finding, published in Neuron by neuroscientists at The Picower Institute for Learning and Memory, explains via experiments in animals how we can keep ...

The snapping claws of male amphipods--tiny, shrimplike crustaceans--are among the fastest and most energetic of any life on Earth. Researchers reporting in the journal Current Biology on February 8 find that the crustaceans can repeatedly close their claws in less than 0.01% of a second, generating high-energy water jets and audible pops. The snapping claws are so fast, they almost defy the laws of physics. "What's really amazing about these amphipods is that they're sitting right on the boundary of what we think is possible in terms of how small something can be and how fast it can move without self-destructing," says senior author Sheila Patek, a Professor of Biology at Duke University. "If they accelerated any faster, their bodies would break." While amphipods are ...

What The Study Did: The National Health Service in Italy provides universal coverage to citizens but because no approved drug was available for COVID-19, patients received potentially effective drugs, participated in clinical trials, accessed compassionate drug use programs or self-medicated. This study evaluated changes in drug demand during the early phase of the COVID-19 outbreak in Italy compared with the period before the outbreak. Authors: Adriana Ammassari, M.D., of the Italian Medicines Agency in Rome, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2020.37060) Editor's ...

Philadelphia, February 8, 2021--Adding to a growing body of research affirming the benefits of fetal surgery for spina bifida, new findings show prenatal repair of the spinal column confers physical gains that extend into childhood. The researchers found that children who had undergone fetal surgery for myelomeningocele, the most severe form of spina bifida, were more likely than those who received postnatal repair to walk independently, go up and down stairs, and perform self-care tasks like using a fork, washing hands and brushing teeth. They also had stronger leg muscles and walked faster than children who had their spina bifida surgery ...

What The Study Did: This observational study compared different measures of prediabetes and the risk of progression to diabetes among adults age 71 to 90. Authors: Mary R. Rooney, Ph.D., M.P.H., of the Johns Hopkins Bloomberg School of Public Health in Baltimore, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamainternmed.2020.8774) Editor's Note: The article includes conflicts of interest and funding/support disclosures. Please see the article for additional information, including other authors, author contributions and ...

What The Study Did: Researchers assessed what percentage of the Virginia population had been exposed to SARS-CoV-2 after the first wave of COVID-19 infections in the U.S. Authors: Eric R. Houpt, M.D., of the University of Virginia in Charlottesville, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2020.35234) Editor's Note: The article includes conflict of interest and funding/support disclosures. Please see the article for ...

If temperature varies strongly from day to day, the economy grows less. Through these seemingly small variations climate change may have strong effects on economic growth. This shows data analyzed by researchers from the Potsdam Institute for Climate Impact Research (PIK), Columbia University and the Mercator Research Institute on Global Commons and Climate Change (MCC). In a new study in Nature Climate Change, they juxtapose observed daily temperature changes with economic data from more than 1,500 regions worldwide over 40 years - with startling results. "We ...

Negishi cross-coupling reactions have been widely used to form C-C bonds since the 1970s and are often perceived as the result of two metals (i.e zinc and palladium/nickel) working in synergy. But like all relationships, there is more under the surface than what we first expected. PhD student Craig Day and Dr. Rosie Somerville from the Martin group at ICIQ have delved into the Negishi cross-coupling of aryl esters using nickel catalysis to understand how this reaction works at the molecular level and how to improve it. The results have been published in Nature Catalysis. Compared to palladium, nickel has the advantage of being readily available transition metal, ...

It's clear that rising greenhouse gas emissions are the main driver of global warming. But on a regional level, several other factors are at play. That's especially true in the Arctic - a massive oceanic region around the North Pole which is warming two to three times faster than the rest of the planet. One consequence of the melting of the Arctic ice cap is a reduction in albedo, which is the capacity of surfaces to reflect a certain amount of solar radiation. Earth's bright surfaces like glaciers, snow and clouds have a high reflectivity. As snow and ice decrease, albedo decreases and more radiation is absorbed by the Earth, leading to a rise in ...

What The Study Did: Researchers investigated the association between the use of proton pump inhibitors among children and adolescents in Sweden and the risk of asthma. Authors: Yun-Han Wang, M.Sc., B.Pharm., of the Karolinska Institutet in Stockholm, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamapediatrics.2020.5710) Editor's Note: The article includes conflict of interest and funding/support disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, conflict ...

What The Article Says: In this essay, the authors describe a 97-year-old patient who learned to titrate condensed chicken soup like a medicine during the COVID-19 pandemic. Authors: Yuenting Diana Kwong, M.D., M.A.S., University of California, San Francisco, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamainternmed.2020.8897) Editor's Note: The article includes conflicts of interest disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, ...

What The Study Did: Salary information from faculty at U.S. medical schools was used to examine the association between the percentage of female clinicians in a medical specialty and the average and median salaries for that specialty. Authors: Terrill Bravender, M.D., M.P.H., of the University of Michigan in Ann Arbor, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamapediatrics.2020.5683) Editor's Note: The article includes conflict of interest disclosures. Please see the article for additional information, including other authors, author ...

Coral reefs are beautiful and diverse ecosystems that power the economies of many coastal communities. They're also facing threats that are driving their decline, including the planet's warming waters. This threat hit extreme levels in 2015, when high temperatures were turning corals white around the globe. Kaneohe Bay in Hawaii was hit hard; nearly half of its corals bleached. Hidden in the aftermath of this extreme event, however, were biochemical clues as to why some corals bleached while others were resistant, information that could help reefs better weather warming waters in the future. These clues have now been uncovered by researchers at Michigan State University and the University of Hawaii at Manoa. "It was kind of horrifying," said coral biologist Crawford Drury, who witnessed ...

Researchers at the University of Massachusetts Amherst have gained new insight into the biological processes of a chytrid fungus responsible for a deadly skin infection devastating frog populations worldwide. Led by cell biologist Lillian Fritz-Laylin, the team describes in a paper published Feb. 8 in Current Biology how the actin networks of Batrachochytrium dendrobatidis (Bd) also serve as an "evolutionary Rosetta Stone," revealing the loss of cytoskeletal complexity in the fungal kingdom. "Fungi and animals seem so different, but they are actually pretty closely related," says Fritz-Laylin, whose lab studies how cells move, which is a central ...

The findings are published in the prestigious journal, Nature Climate Change, and calls on businesses, the financial services industry and regulators to work more closely with climate scientists. Regulators and governments - both domestic and international - are increasingly requiring that businesses assess and disclose their vulnerability to the physical effects of climate change, for example, increased drought, bushfires and sea level rise. "People are making strategically material decisions on a daily basis, and raising debt or capital to finance these, but the decisions may not have properly considered climate risk," said lead author Dr Tanya Fiedler from the University of Sydney Business School. ...

Under increasing global warming, tropical fish are escaping warmer seas by extending their habitat ranges towards more temperate waters. But a new study from the University of Adelaide, published in Nature Climate Change, shows that the ocean acidification predicted under continuing high CO2 emissions may make cooler, temperate waters less welcoming. "Every summer hundreds of tropical fish species extend their range to cooler and temperate regions as the waters of their natural habitat become a little too warm for comfort," says lead author Ericka Coni, PhD student in the University's School of Biological Sciences. "For at least two decades, Australian temperate reefs have been receiving new guests ...