The development of scanning probe microscopes in the early 1980s brought a breakthrough in imaging, throwing open a window into the world at the nanoscale. The key idea is to scan an extremely sharp tip over a substrate and to record at each location the strength of the interaction between tip and surface. In scanning force microscopy, this interaction is -- as the name implies -- the force between tip and structures on the surface. This force is typically determined by measuring how the dynamics of a vibrating tip changes as it scans over objects deposited on a substrate. A common analogy is tapping a finger across a table and sensing objects placed ...

A new study by Indiana University found women, younger individuals, those with lower levels of formal education, and people of color are being hit hardest by the COVID-19 pandemic. The study, published in the Proceedings of the National Academy of Sciences journal, found that Black adults were three times as likely as whites to report food insecurity, being laid off, or being unemployed during the pandemic. Additionally, residents without a college degree were twice as likely to report food insecurity (compared to those with some college) while those not completing high school are four times as likely to report it, compared ...

Cases of symptomatic COVID-19 were extremely low among children and staff at a network of YMCA summer camps held last year in North Carolina that took precautions like masking and physical distancing, with close to zero transmissions occurring at the camps, according to researchers at Duke Health, Weill Cornell Medicine and NewYork-Presbyterian. In the camps' 2020 sessions, there were 19 cases of COVID-19 among 5,344 staff and 1,486 youth, only two of which were linked to possible on-site transmission at a group of YMCA of the Triangle camps, at a time ...

The modern world is powered by electrical circuitry on a "chip"--the semiconductor chip underpinning computers, cell phones, the internet, and other applications. In the year 2025, humans are expected to be creating 175 zettabytes (175trillion gigabytes) of new data. How can we ensure the security of sensitive data at such a high volume? And how can we address grand-challenge-like problems, from privacy and security to climate change, leveraging this data, especially given the limited capability of current computers? A promising alternative is emerging quantum communication and computation technologies. For this to happen, however, it will require the widespread ...

Enterocytes, which line the epithelium of the small intestine, are the sites of absorption and metabolism of most orally consumed medications. For this reason, studies on the absorption of novel oral drugs rely on in vitro or animal models to accurately recreate the environment of the small intestine. Currently, scientists widely use the human colon cancer cell line Caco-2 as a model of the intestinal epithelium. However, this has its drawbacks: Caco-2 cells have been derived from the colon; therefore, they more closely resemble the colon than the small intestine. For example, these cells do not express cytochrome P450 3A4 (CYP3A4), a protein critical for drug metabolism that is abundantly expressed in the small intestine. Moreover, Caco-2 ...

Fresno, CA - A recent human study published in the Journal of the American Academy of Dermatology found that consuming grapes protected against ultraviolet (UV) skin damage.1 Study subjects showed increased resistance to sunburn and a reduction in markers of UV damage at the cellular level. 2 Natural components found in grapes known as polyphenols are thought to be responsible for these beneficial effects. The study, conducted at the University of Alabama, Birmingham and led by principal investigator Craig Elmets, M.D., investigated the impact of consuming whole grape powder - equivalent to 2.25 cups of grapes ...

DALLAS - Feb. 5, 2021 - The COVID-19 pandemic is having a detrimental impact on substance use, mental health, and weight-related health behaviors among people with obesity, according to a new study by researchers at UT Southwestern and the END ...

Health care and education systems are two main pillars of a community's stability. How well and how quickly a community recovers following a natural disaster depends on the resilience of these essential social services. New research from the Colorado State University Department of Civil and Environmental Engineering, published in Nature Scientific Reports, has found hospitals and schools are interdependent, suggesting their collective recovery must be considered in order to restore a community in the wake of disaster. Because hospitals and schools are so integral to a community's well-being, Associate Professor Hussam Mahmoud and Ph.D. graduate student Emad Hassan wanted to determine the correlation between them to understand their overall influence on community ...

UCLA materials scientists and colleagues have discovered that perovskites, a class of promising materials that could be used for low-cost, high-performance solar cells and LEDs, have a previously unutilized molecular component that can further tune the electronic property of perovskites. Named after Russian mineralogist Lev Perovski, perovskite materials have a crystal-lattice structure of inorganic molecules like that of ceramics, along with organic molecules that are interlaced throughout. Up to now, these organic molecules appeared to only serve a structural function and could not directly contribute to perovskites' electronic performance. Led by UCLA, a new study shows that when the organic molecules ...

Gene expression is a highly regulated process, which involves several steps. These include transcription of DNA instructions into RNA, removal of non-coding segments from the RNA message, and its subsequent translation into proteins. All these steps involve specific molecular machineries responsible for conducting each process with high accuracy. The Galej group, based at EMBL Grenoble, studies the structure and function of the RNA-protein complexes that are involved in the regulation of gene expression. During transcription, genetic information contained in the DNA is used to create a precursor messenger RNA (pre-mRNA) thanks to the action of an enzyme, RNA Polymerase II. To maintain only the necessary coding segments ...

All life on earth evolved multiple layers and networks of ensuring survival upon catastrophic events. Even cells have their emergency plan: the heat shock response. Triggered by multiple stress stimuli such as heat, toxins, or radiation, this cellular safety program tries to prevent permanent damage to the organism. The response resembles an overall adopted "lockdown" strategy witnessed during the global corona virus pandemic. During a lockdown, only essential activities are permitted and resources were diverted towards measures ensuring minimizing the impact of a pandemic. Under normal conditions, RNA polymerase II rushes down the DNA. At the correct places, the DNA is transcribed into mRNA, which is then translated into proteins. In a crisis, ...

SARS-CoV-2 mutations similar to those in the B1.1.7 UK variant could arise in cases of chronic infection, where treatment over an extended period can provide the virus multiple opportunities to evolve, say scientists. Writing in Nature, a team led by Cambridge researchers report how they were able to observe SARS-CoV-2 mutating in the case of an immunocompromised patient treated with convalescent plasma. In particular, they saw the emergence of a key mutation also seen in the new variant that led to the UK being forced once again into strict lockdown, though there is no suggestion that the variant originated from this patient. Using a synthetic version of the virus Spike protein created in the ...

Scientists at the Francis Crick Institute have found important structural similarities between SARS-CoV-2 and a pangolin coronavirus, suggesting that a pangolin coronavirus could infect humans. While SARS-CoV-2 is thought to have evolved from a bat coronavirus, its exact evolutionary path is still a mystery. Uncovering its history is challenging as there are likely many undiscovered bat coronaviruses and, due to differences between bat coronaviruses and SARS-CoV-2, it is thought that the virus may have passed to humans via at least one other species. In their study, published in Nature Communications, the scientists compared the structures of the spike proteins found on ...

A banking crisis is often seen as a self-fulfilling prophecy: The expectation of bank failure makes it happen. Picture people lining up to withdraw their money during the Great Depression or customers making a run on Britain's Northern Rock bank in 2007. But a new paper co-authored by an MIT professor suggests we have been missing the bigger picture about banking crises. Yes, there are sometimes panics about banks that create self-reinforcing problems. But many banking crises are quieter: Even without customers panicking, banks can suffer losses serious enough to create subsequent economy-wide downturns. "Panics are not needed for banking crises to have severe economic consequences," says Emil Verner, the MIT professor who helped lead the study. "But ...

Plastics made from crops such as maize or sugarcane instead of fossil fuels are generally considered sustainable. One reason is that plants bind CO2, which compensates for the carbon released into the atmosphere when plastics are disposed. However, there is a catch: With increasing demand for raw materials for bioplastic production, the areas under cultivation may not be sufficient. As a result, natural vegetation is often converted to agricultural land and forests are cut down. This in turn releases large amounts of CO2. The assumption that more bioplastics does not necessarily lead to more climate protection has now been confirmed by researchers at the University of Bonn ...

A study from the Center for Phage Technology, part of Texas A&M's College of Agriculture and Life Sciences and Texas A&M AgriLife Research, shows how the "hidden" genes in bacteriophages -- types of viruses that infect and destroy bacteria -- may be key to the development of a new class of antibiotics for human health. The study has been published in Nature Communications and Current Science Daily, as well as featured in a recent Nature Research Microbiology Community blog post. The need for new antibiotics Antibiotic-resistant bacteria pose ...

Primeval forests are of great importance for biodiversity and global carbon and water cycling. The three-dimensional structure of forests plays an important role here because it influences processes of gas and energy exchange with the atmosphere, whilst also providing habitats for numerous species. An international research team led by the University of Göttingen has investigated the variety of different complex structures that can be found in the world's forests, as well as the factors that explain this diversity. The results have been published in Nature Communications. The researchers investigated the structure of primeval ...

A vegan diet is more effective for weight loss than a Mediterranean diet, according to a groundbreaking new study that compared the diets head to head. The randomized crossover trial, which was END ...

Rain falls lightly on the ocean's surface. Marine mammals chirp and squeal as they swim along. The pounding of surf along a distant shoreline heaves and thumps with metronomic regularity. These are the sounds that most of us associate with the marine environment. But the soundtrack of the healthy ocean no longer reflects the acoustic environment of today's ocean, plagued with human-created noise. A global team of researchers set out to understand how human-made noise affects wildlife, from invertebrates to whales, in the oceans, and found overwhelming evidence that marine fauna, and their ecosystems, are negatively ...

In the framework of the Chlorella microalgae cultivation process, the researchers from Peter the Great St.Petersburg Polytechnic University (SPbPU) obtained microalgae biomass with a high content of carotenoid pigments, which is suitable for the food industry. The research results were published Nov. 2020 in the scientific journal "Agronomy Research". The deterioration of the ecological status of urban areas and the industrialization of the food industry requires the additional enrichment of the diet with biologically valuable food substances. Such pigments as carotenoids, from which vitamin A is synthesized in the body, are ...

Astronomers have for the first time used distant galaxies as 'scintillating pins' to locate and identify a piece of the Milky Way's missing matter. For decades, scientists have been puzzled as to why they couldn't account for all the matter in the universe as predicted by theory. While most of the universe's mass is thought to be mysterious dark matter and dark energy, 5 percent is 'normal matter' that makes up stars, planets, asteroids, peanut butter and butterflies. This is known as baryonic matter. However, direct measurement has only accounted for about half ...

Using AI and computer automation, Technion researchers have developed a "conjecture generator" that creates mathematical conjectures, which are considered to be the starting point for developing mathematical theorems. They have already used it to generate a number of previously unknown formulas. The study, which was published in the journal Nature, was carried out by undergraduates from different faculties under the tutelage of Assistant Professor Ido Kaminer of the Andrew and Erna Viterbi Faculty of Electrical Engineering at the Technion. The project deals with one of the most fundamental elements of mathematics - mathematical constants. ...

When treating cancer, researchers are always searching for ways to remove cancer cells while minimizing damage to the rest of the body. One possible approach is to find processes unique to cancer cells, and which would allow specific targeting. If such a process can be disrupted, only those cells would be affected. A process (or absence thereof) can be unique to some types of cancer, and not be present in others. In such a case, we would want a simple way to recognize whether a particular tumor possesses the unique trait or not. The implication of this question is whether the tumor would respond to ...

Researchers from the HSE Institute for Cognitive Neuroscience have proposed a new method to process magnetoencephalography (MEG) data, which helps find cortical activation areas with higher precision. The method can be used in both basic research and clinical practice to diagnose a wide range of neurological disorders and to prepare patients for brain surgery. The paper describing the algorithm was published in the journal NeuroImage. Magnetoencephalography (MEG) is a method based on measuring very weak magnetic fields (several orders of magnitude weaker than the Earth's magnetic field) induced by the brain's electrical activity. When using MEG, researchers face the complicated task ...

Professionalisation in any field requires long-term experience and training. In the past decades, studies have demonstrated that the professionalisation of athletes and artists create differences in the behaviour of the brain while carrying out activities related to their area of expertise. To detect the effects of media professionalisation in the brain, a research team from the Universitat Autònoma de Barcelona, the Instituto Ràdio Televisió Espanyola and the Universidad Pablo de Olavide in Seville conducted a study published in Frontiers in Systems Neuroscience in which audiovisual contents were presented to a group of media ...