Targeting part of an antiviral pathway triggered by the accumulation of a key pathogen shared in Alzheimer’s disease and frontotemporal dementia may one day offer a new therapeutic approach to deterring or delaying cognitive decline, according to preclinical research led by Weill Cornell Medicine scientists. The study, published April 24 in Nature Neuroscience, demonstrates that inhibiting an innate immune system enzyme called cyclic GMP–AMP synthase (cGAS) helps neurons become resilient to the build-up of the protein tau into bundles known as fibrils, a hallmark of Alzheimer’s and some forms of frontotemporal dementia, the two most ...

Organic solar cells have a photoactive layer that is made from polymers and small molecules. The cells are very thin, can be flexible, and are easy to make. However, the efficiency of these cells is still much below that of conventional silicon-based ones. Applied physicists from the University of Groningen have now fabricated an organic solar cell with an efficiency of over 17 percent, which is in the top range for this type of material. It has the advantage of using an unusual device structure that is produced using a scalable technique. The design involves a conductive layer of tin oxide that is grown ...

The 25th International Conference on Redox Medicine will take place on June 21-23 in Paris. Redox Medicine 2023 will provide a glimpse into the role of redox in tomorrow’s medicine. What to Expect in Redox Medicine 2023? Reactive oxygen species (ROS) have been studied for decades, but the results remain controversial. ROS are beneficial to biological mechanisms, acting as signaling molecules and enhancing immune defense. However, they also have harmful effects, such as causing tissue and organ damage. Dr. Carole Nicco, stated that “The work and results presented at the Redox Medicine Congress will give ...

Key takeaways A study by researchers from UCLA, Australia, Ecuador, Germany, the Netherlands and the U.K. found that people around the world signal others for assistance every couple of minutes. The research, which examined behaviors in towns and rural areas in several different countries, revealed that people comply with these small requests for help far more often than they decline them. The findings suggest that people from all cultures have more similar cooperative behaviors than prior research has established. A new study by UCLA sociologist Giovanni Rossi and an international team of collaborators finds that people rely on ...

WASHINGTON, DC – The Department of Energy’s (DOE’s) Office of Science will sponsor the participation of 999 undergraduate students and 79 faculty members in three STEM-focused workforce development programs at 16 DOE national laboratories and a national fusion facility during summer 2023. Collectively, these programs ensure DOE and our nation have a strong, sustained workforce trained in the skills needed to address the energy, environment, and national security challenges of today and tomorrow. “Our future depends on the next generation ...

“One of the great mysteries of biology,” says Eric Libby, former SFI Postdoctoral Fellow, now an associate professor at the Integrated Science Lab (IceLab), Umeå University in Sweden, “is eukaryogenesis, or how eukaryotes arose.” Scientists consider this to be a period of major evolutionary transition, critical to our understanding of the history and evolution of life on Earth.  In a new study published on April 21, 2023, in PNAS, Libby worked with SFI Professor Christopher Kempes and Jordan ...

The U.S. Department of Energy’s (DOE) Argonne National Laboratory has awarded its newest cohort of named fellowships, providing five early-career scientists with additional support as they pursue pivotal discoveries that will make Americans safer and better off and increase our understanding of the universe.   For 2023, the laboratory has named four Maria Goeppert Mayer Fellows and one Walter Massey Fellow. Maria Goeppert Mayer was a pioneering nuclear physicist who received the 1963 Nobel Prize in physics for discovering, at Argonne, the shell model of the atomic nucleus. Walter Massey ...

Laguerre-Gaussian (LG) modes are a type of light wave that can carry the external torque of photons as they move through space. They are useful in many fields, from optical communications to super-resolution imaging. Advanced developments in these and other applications demand reliable and color-tunable LG mode laser sources, which do not yet exist. An optical parametric oscillator (OPO) is a device that can generate a wavelength-tunable laser beam, so it has been used to realize a color-tunable LG laser source — generally, in one of two ways. One way is to change a regular beam into an LG beam using a phase component ...

Every giant was once a baby, though you may never have seen them at that stage of their development. NASA’s James Webb Space Telescope has begun to shed light on formative years in the history of the universe that have thus far been beyond reach: the formation and assembly of galaxies. For the first time, a protocluster of seven galaxies has been confirmed at a distance that astronomers refer to as redshift 7.9, or a mere 650 million years after the big bang. Based on the data collected, astronomers calculated the nascent cluster’s future development, finding that it will likely grow in size and mass to resemble the Coma Cluster, ...

Ithaca, NY--Mountain Quail are an under-studied but recreationally-valued management indicator species in California's Sierra Nevada. They are notoriously difficult to study due to their penchant for impenetrable, dense, shrubby habitats, high elevations, and steep slopes. In this study, researchers used 1,636 autonomous recording units across about 22,000 square kilometers to conduct the first ever systematic and comprehensive study of Mountain Quail habitat associations and fire ecology in the Sierra Nevada. Researchers from the Cornell Lab of Ornithology, the University of Minnesota, Univesity of Wisconsin-Madison, and the ...

SAN ANTONIO (April 24, 2023) — Intensive blood pressure treatment significantly reduces the risk of adverse cerebrovascular events such as stroke. New research from The University of Texas Health Science Center at San Antonio (UT Health San Antonio) shows evidence of how the brain benefits from consistently lower blood pressure. The study, published March 1 in JAMA Network Open, is a follow-up analysis of the Systolic Blood Pressure Intervention Trial (SPRINT), a multicenter clinical trial that compared intensive systolic blood pressure control ...

Deadlines are part and parcel of modern knowledge work. Journalists must serve their weekly columns, managers must turn in their monthly reports, and researchers must submit their papers and proposals on time. Despite their ubiquity, deadlines conjure up negative feelings and are perceived as challenging events. Accordingly, there has been a trend to do away with deadlines, where possible. For instance, the National Science Foundation (NSF) in the United States introduced no-deadline submissions in some of its funding programs. Critics, however, have been arguing that although deadlines may be painful, they are necessary, because they motivate people to act. Researchers from the University ...

URBANA, Ill. – As Corn Belt states seek ways to curb nitrogen flow from farms into the Gulf of Mexico, new University of Illinois research adds evidence for winter cover crops as an important part of the solution. A simulation study published in Science of the Total Environment finds widespread planting of cereal rye in Illinois could reduce nitrate in the state’s tile drainage water by 30%. The research team, part of the College of Agricultural, Consumer and Environmental Sciences (ACES) and The Grainger ...

Regenerative medicine—the process of replacing, engineering or regenerating human cells, tissues or organs—holds exciting potential for the field of health care. It could someday make it possible to grow a new kidney in a petri dish, repair damaged nerve cells, or reverse memory loss. Continuing a commitment to advance medicine through forward-thinking approaches and groundbreaking discoveries, the Icahn School of Medicine at Mount Sinai is announcing the creation of the Institute for Regenerative Medicine to foster innovative research into new pathways to cure ...

BINGHAMTON, N.Y. -- Researchers at Binghamton University partnered with the Center for Functional Nanomaterials (CFN) — a U.S. Department of Energy Office of Science User Facility at Brookhaven National Laboratory — to get a better look at how peroxides on the surface of copper oxide promote the oxidation of hydrogen but inhibit the oxidation of carbon monoxide, allowing them to steer oxidation reactions. They were able to observe these quick changes with two complimentary spectroscopy methods that have not been used in this way. The results of this work have been published in the journal Proceedings ...

A new Technology from Sage report sheds light on challenges in the librarian-patron relationship, including the need for greater digital literacy and more tailored support for students, and recommends methods to support the student experience. “The Knowledge Gap Between Librarians and Students: Contrasting Librarian and Student Perspectives on the Undergraduate Workflow” report is the second in the Librarian Futures series. A survey of nearly 600 students in the US, UK, and Canada highlights key findings for librarians across the undergraduate workflow — specifically ...

Over the past few decades, it has become obvious that climate change, and consequent extreme weather events, can wreak havoc on crop yields. Concerningly, there is a large disparity in agricultural vulnerability between developed and developing countries. In a new study, researchers have looked at major food grains in India to understand the long- and short-term effects of climate change on crop yields. “Most studies that measure the effects of climate change are looking at year-to-year changes, which are representative of variations in weather and not climate,” said Madhu Khanna (CABBI), a professor of agriculture ...

Plant diseases pose a significant threat to nations across the globe, owing to the financial burden they impose and the impact they have on food security. Healthy crops sustain millions of livelihoods, and accurate diagnosis of plant diseases allows for timely interventions to ensure sufficient crop production with minimal yield loss. Traditional approaches to disease recognition typically follow two paths. The first relies on crop inspection by trained experts, while the second leverages neural networks ...

Researchers have developed a new method to distinguish between cancerous and healthy stem cells and progenitor cells from samples of patients with acute myeloid leukaemia (AML), a disease driven by malignant blood stem cells that have historically been difficult to identify. The findings, published today in the journal Cell Stem Cell, pave the way for the development of new techniques to predict whether patients will respond to chemotherapy. AML is a type of cancer characterised by the rapid growth and accumulation of abnormal white blood cells. ...

Kamaljeet Sanghera, Executive Director, Institute for Digital InnovAtion (IDIA), Research and Innovation Initiatives; Professor, Information Sciences and Technology, received funding to design and deliver a pilot of a summer, hands-on experience for 20 high school students.  Sanghera will leverage IBM artificial intelligence (AI) kits to help the students gain technical skills, knowledge, and abilities in AI and an understanding of its ethical and social impact.  Sanghera received $150,000 from Trenchant Analytics, LLC, on a subaward from the ...

(Toronto, April 24, 2023) JMIR Publications and the Society of Digital Psychiatry (SODP) have announced a new partnership aimed at advancing research in the field of digital mental health. This collaboration will focus on supporting education and knowledge sharing in the fast moving world of digital psychiatry and establishing priorities for the space, including identifying current gaps in knowledge and determining areas for future study, with particular emphasis on addressing disparities in access to care.  The partnership brings together JMIR Publications, a leading open-access publisher of scholarly journals on digital health, ...

Exploring the upstream transcription factors or proteins interacting with MdMYB10 is an important way to enrich the complex network of anthocyanin synthesis. In this study, the upstream regulatory gene MdNAC1 of MdMYB10 was selected through yeast one hybridization experiments, and EMSA and LUC experiments showed that MdNAC1 can transcriptionally activate MdMYB10. The transformation experiments in apple callus and apple fruit showed that MdNAC1 significantly promoted the accumulation of anthocyanins. At the same time, researchers have found that MdNAC1 can interact with MdbZIP23 ...

Problems with the brain’s ability to ‘prune’ itself of unnecessary connections may underlie a wide range of mental health disorders that begin during adolescence, according to research published today. The findings, from an international collaboration, led by researchers in the UK, China and Germany, may help explain why people are often affected by more than one mental health disorder, and may in future help identify those at greatest risk. One in seven adolescents (aged 10-19 years old) worldwide experiences mental health disorders, according to the World Health Organization (WHO). Depression, anxiety and behavioural disorders, such as ...

About The Study: In this study that included 167,000 non-hospitalized patients, neutralizing monoclonal antibody (nMAb) treatment for COVID-19 was safe and associated with reductions in emergency department visits, hospitalization, and death, although it was not associated with reduced risk of hospitalization during the Omicron BA.1 epoch. These findings suggest that targeted risk stratification strategies may help optimize future nMAb treatment decisions.  Authors: Brian Anderson, M.D., of the MITRE Corporation in Bedford, Massachusetts, is the corresponding author.  To access the embargoed study: Visit our For The Media website ...

Researchers at Karolinska Institutet in Sweden have investigated how preterm birth and foetal growth are related to the risk of atrial fibrillation up to middle-age. The study, which is published in JAMA Pediatrics, shows that being born preterm or large for gestational age was associated with increased risks of atrial fibrillation later in life. Being small for gestational age at birth was only associated with an increased risk of atrial fibrillation up to the age of 18.  The incidence of atrial fibrillation in the young has increased over the past few decades, from low levels. “Atrial fibrillation at a young age may involve a heavy socioeconomic burden for the affected ...