Traumatic brain injury (TBI) is a major cause of disability and a risk factor for early-onset dementia. The injury is characterized by a physical insult followed acutely by complement driven neuroinflammation. Complement, a part of the innate immune system that functions both in the brain and throughout the body, enhances the body's ability to fight pathogens, promote inflammation and clear damaged cells. Complement plays a role in the brain, regardless of infection or injury, as it influences brain development and synapse formation. In TBI, complement- induced inflammation partially determines the outcome in the weeks immediately following injury. However, more research is needed to define a role for the complement system in neurodegeneration ...

For cancer cells to metastasize, they must first break free of a tumor's own defenses. Most tumors are sheathed in a protective "basement" membrane -- a thin, pliable film that holds cancer cells in place as they grow and divide. Before spreading to other parts of the body, the cells must breach the basement membrane, a material that itself has been tricky for scientists to characterize. Now MIT engineers have probed the basement membrane of breast cancer tumors and found that the seemingly delicate coating is as tough as plastic wrap, yet surprisingly elastic like a party balloon, able to inflate to twice its original size. But while a balloon becomes much easier to blow up after some initial effort, the team found that a basement membrane becomes stiffer as it expands. ...

Found around the world, powdery mildew is a fungal disease especially harmful to plants within the sunflower family. Like most invasive pathogens, powdery mildew is understudied and learning how it affects hosts can help growers make more informed decisions and protect their crops. Scientists at the University of Washington and the University of Central Florida inoculated 126 species of plants in the sunflower family with powdery mildew, growing 500 plants from seeds that were collected from the wild and provided from the USDA germplasm network. Through this ...

BOSTON - The higher rates of obesity in Black, Indigenous and People of Color (BIPOC) compared with other groups in the United States can be attributed in large part to systemic racism, according to a new perspective article published in the Journal of Internal Medicine. The authors offer a 10-point strategy to study and solve the public health issues responsible for this disparity. "First, it is important to recognize that the interplay of obesity and racism is real. Once persons recognize this, they can begin to appropriately address and treat obesity in BIPOC communities," says co-author Fatima Cody ...

Women who experienced hypertensive disorders of pregnancy (HDPs) but did not develop chronic hypertension have a greater risk of premature mortality, specifically cardiovascular disease (CVD)-related deaths, according to a study published in the Journal of the American College of Cardiology (JACC). A separate JACC study examined the cardiovascular health risks associated with pregnancy in obese women with heart disease. HDPs, which occur in approximately 10% of all pregnancies worldwide, are among the most common health issues during pregnancy. There are four types of HDPs: chronic hypertension, gestational hypertension (GHTN), preeclampsia and ...

Other senses re-routed during evolution, but not sense of smell Loss of smell linked to depression and poor quality of life Smell research can help treatments for loss in COVID-19 CHICAGO ---Odors evoke powerful memories, an experience enshrined in literature by Marcel Proust and his beloved madeleine. A new Northwestern Medicine paper is the first to identify a neural basis for how the brain enables odors to so powerfully elicit those memories. The paper shows unique connectivity between the hippocampus--the seat of memory in the brain--and olfactory areas in humans. This new research suggests a neurobiological basis for privileged access by olfaction to memory areas in the brain. The study compares connections between primary sensory areas--including ...

Researchers have developed a spectroscopic microscope to enable optical measurements of molecular conformations and orientations in biological samples. The novel measurement technique allows researchers to image biological samples at the microscopic level more quickly and accurately. The new instrument is based on the discrete frequency infrared spectroscopic imaging technique developed by researchers at the Beckman Institute for Advanced Science and Technology at the University of Illinois Urbana-Champaign. "This project is about bringing the study ...

DALLAS - March 8, 2021 - A study led by UT Southwestern and Children's Health researchers defines parameters for the number of white blood cells that must be present in children's urine at different concentrations to suggest a urinary tract infection (UTI). The findings, published recently in Pediatrics, could help speed treatment of this common condition and prevent potentially lifelong complications. UTIs account for up to 7 percent of fevers in children up to 24 months old and are a common driver of hospital emergency room visits. However, says study leader Shahid Nadeem, M.D., assistant professor of pediatrics at UTSW as well as an emergency department physician and pediatric nephrologist at Children's Medical Center Dallas, these bacterial infections ...

Boston, MA - Financial pollution arises when exorbitant or unnecessary healthcare spending depletes resources needed for the wellbeing of the population. This is the subject of a JAMA Health Forum Insight co-authored by researchers in the Department of Population Medicine at Harvard Pilgrim Health Care Institute and Harvard Medical School. The Insight was published in the March 8, 2021 issue of JAMA Health Forum. The authors lay out the rationale for "financial pollution" as a metaphor to express the urgency of addressing wasteful health care spending and to guide innovative policymaking. Akin to environmental pollution, financial ...

When a coastline undergoes massive erosion, like a hurricane flattening a beach and its nearby environments, it has to rebuild itself - relying on the resilience of its natural coastal structures to begin piecing itself back together in a way that will allow it to survive the next large phenomena that comes its way. Drs. Orencio Duran Vinent, assistant professor, and Ignacio Rodriguez-Iturbe, Distinguished University Professor and Wofford Cain Chair I Professor, in the Department of Ocean Engineering at Texas A&M University, are investigating the resilience of barrier ...

You're going at the speed limit down a two-lane road when a car barrels out of a driveway on your right. You slam on the brakes, and within a fraction of a second of the impact an airbag inflates, saving you from serious injury or even death. The airbag deploys thanks to an accelerometer -- a sensor that detects sudden changes in velocity. Accelerometers keep rockets and airplanes on the correct flight path, provide navigation for self-driving cars, and rotate images so that they stay right-side up on cellphones and tablets, among other essential tasks. Addressing the increasing ...

Forecasting changes in stock prices may be possible with the help of brain activity in regions associated with how people feel before making investment choices. Scientists could accurately forecast market price changes based on the average brain activity among a group but failed when using only prior stock trends or people's investment choices, according to new research published in JNeurosci. Scientists have used the average brain activity among a group to predict which videos will go viral and which crowdfunding campaigns will receive funding. In a new study, Stallen et al. investigated if this relationship extends to a more ...

Irvine, CA - March 8, 2021 - A new study from the University of California, Irvine shows that compounds in both green and black tea relax blood vessels by activating ion channel proteins in the blood vessel wall. The discovery helps explain the antihypertensive properties of tea and could lead to the design of new blood pressure-lowering medications. Published in Cellular Physiology and Biochemistry, the discovery was made by the laboratory of Geoffrey Abbott, PhD, a professor in the Department of Physiology and Biophysics at the UCI School of Medicine. Kaitlyn Redford, a graduate student in the Abbott Lab, was first author of the study titled, "KCNQ5 potassium channel activation underlies vasodilation by tea." Results from the research revealed that two catechin-type ...

HOUSTON - (March 8, 2021) - Health care teams must prepare for anything, including the unconventional work environments brought about by a global pandemic and social unrest. Multiracial medical team having a discussion as they stand grouped together around a tablet computer on a stair well, overhead view Open communication and trust are essential for successful teamwork in challenging health care situations, as detailed in "Building effective healthcare team development interventions in uncertain times: Tips for success." The paper was authored by researchers at Rice University, the University of Texas MD Anderson ...

Squids have long been a source of fascination for humans, providing the stuff of legend, superstition and myth. And it's no wonder -- their odd appearances and strange intelligence, their mastery of the open ocean can inspire awe in those who see them. Legends aside, squids continue to intrigue people today -- people like UC Santa Barbara professor Daniel Morse -- for much the same, albeit more scientific, reasons. Having evolved for hundreds of millions of years to hunt, communicate, evade predators and mate in the vast, often featureless expanses of open water, squids have developed some of the most sophisticated skin in the animal kingdom. "For centuries, people have been amazed at the ability of squids to change the color and patterns of their skin -- which they ...

The perils of machine learning - using computers to identify and analyze data patterns, such as in facial recognition software - have made headlines lately. Yet the technology also holds promise to help enforce federal regulations, including those related to the environment, in a fair, transparent way, according to a new study by Stanford researchers. The analysis, published this week in the proceedings of the Association of Computing Machinery Conference on Fairness, Accountability and Transparency(link is external), evaluates machine learning techniques designed to support a U.S. Environmental Protection Agency (EPA) initiative to reduce ...

GAINESVILLE, Fla. --- Evolutionary arms races between marine animals overhauled ocean ecosystems on scales similar to the mass extinctions triggered by global disasters, a new study shows. Scientists at Umeå University in Sweden and the Florida Museum of Natural History used paleontological databases to build a multilayered computer model of the history of marine life over the last 500 million years. Their analysis of the fossil record closely echoed a seminal 1981 study by paleontologist J. John Sepkoski - with one key difference. Sepkoski's ground-breaking statistical work showed abrupt ocean-wide changes in biodiversity about 490 and 250 ...

Oncotarget published "Chemotherapy sensitivity testing on ovarian cancer cells isolated from malignant ascites" which reported that the authors aim is to determine the feasibility of cell proliferation assays of tumor cells isolated from malignant ascites to predict in vitro chemotherapy sensitivity, and to correlate these results with clinical outcome. Cell samples were enriched for tumor cells and EOC origin was confirmed by intracellular staining of CK7, surface staining of CA125 and EpCAM, and HE4 gene expression. In vitro sensitivity to chemotherapy was determined in cell proliferation assays using intracellular ATP content as an indirect measure of cell number. In twelve of ...

Oncotarget published "High-fat diet-fed ovariectomized mice are susceptible to accelerated subcutaneous tumor growth potentially through adipose tissue inflammation, local insulin-like growth factor release, and tumor associated macrophages" which reported that the association between obesity and colorectal cancer (CRC) risk has been well established. This relationship appears to be more significant in men than in women, which may be attributable to sex hormones - controlled animal studies to substantiate these claims and the mechanisms involved are lacking. MC38 murine colon adenocarcinoma ...

Oncotarget recently published "Estrogen receptor α polymorphism is associated with dementia in a Brazilian cohort" which reported that the growth of the elderly population is a worldwide phenomenon and it is associated with chronic diseases, including dementia. In this scenario, the present study aimed to evaluate a possible association of estrogen receptor α polymorphisms with dementia in a Brazilian cohort. The genotyping for the ERα PvuII and XbaI polymorphisms were performed by polymerase chain reaction-restriction fragment length polymorphism. The ERα PvuII pp genotype was associated with a higher odds ratio for dementia (OR = 3.42, 95% CI = 1.33-8.77, p = 0.01, ...

Here is a link to a free Altmetric Report on this Research Output Aging-US published "Hyperbaric oxygen therapy increases telomere length and decreases immunosenescence in isolated blood cells: a prospective trial" which reported that the aim of the current study was to evaluate whether hyperbaric oxygen therapy (HBOT) affects telomere length (TL) and senescent cell concentrations in a normal, non-pathological, aging adult population. Thirty-five healthy independently living adults, aged 64 and older, were enrolled to receive 60 daily HBOT exposures. Whole blood samples were collected at baseline, at the 30th and 60th session, and 1-2 weeks following the last HBOT session. Telomeres ...

Aging-US published "In search of preventive strategies: novel high-CBD Cannabis sativa extracts modulate ACE2 expression in COVID-19 gateway tissues" which reported that Cannabis sativa, especially those high in the anti-inflammatory cannabinoid cannabidiol, has been found to alter gene expression and inflammation and harbour anti-cancer and anti-inflammatory properties. Working under a Health Canada research license, the Aging-US authors developed over 800 new C. sativa cultivars and hypothesized that high-CBD C. sativa extracts may be used to down-regulate ...

Aging-US published "DNA- and telomere-damage does not limit lifespan: evidence from rapamycin" which reported that failure of rapamycin to extend lifespan in DNA repair mutant and telomerase-knockout mice, while extending lifespan in normal mice, indicates that neither DNA damage nor telomere shortening limits normal lifespan or causes normal aging. Dr. Mikhail V. Blagosklonny said, "As a provocative title has recently announced, 'rapamycin fails to extend lifespan in DNA repair -deficient mice' [1]. The word 'fails' implies bad news. Rapamycin tried but failed. Yet, it is expected that the anti-aging ...

East Hanover, NJ. March 8, 2021. Kessler Foundation researchers have demonstrated changes in the functional connectivity within the 'fatigue network' in response to cognitive fatigue. This finding, the first of its kind, was reported in Scientific Reports on December 14, 2020 in the open access article, "Using functional connectivity changes associated with cognitive fatigue to delineate a fatigue network" (doi: 10.1038//s41598-020-78768-3). The authors are Glenn Wylie, DPhil, Brian Yao, PhD, Helen M. Genova, PhD, Michele H. Chen, PhD, and John DeLuca, PhD, of Kessler Foundation. All have faculty appointments at Rutgers New Jersey Medical School. Dr. Wylie is also a research scientist at The Department of Veterans' Affairs War-related Injury and Illness ...

A new study of the U.K. and South Africa variants of SARS-CoV-2 predicts that current vaccines and certain monoclonal antibodies may be less effective at neutralizing these variants and that the new variants raise the specter that reinfections could be more likely. The study was published in Nature on March 8, 2021. A preprint of the study was first posted to BioRxiv on January 26, 2021. David Ho (Credit: Columbia University Irving Medical Center) The study's predictions are now being borne out with the first reported results of the Novavax vaccine, says the study's lead author David ...