ITHACA, N.Y. - For the first time, Cornell University researchers have developed a technique for studying the neuroscience of motor control in mice ¬- by focusing on a mouse's tongue when it licks a water spout. The technique incorporates high-speed cameras and machine learning in a tractable experimental setup that opens the door for revealing mysteries of how the motor cortex works, understanding the neural basis of related disorders like Parkinson's disease, and informing robots. "We now have an approach in a mouse where we can bring all the tools of modern neuroscience to bear on this really classic problem of motor control," said senior author Jesse Goldberg, associate professor of neurobiology and behavior. The field of motor control neuroscience has made advancements ...

Updated Criteria Also Released for Legius Syndrome and Mosaic NF NF2 and Schwannomatosis Diagnostic Criteria to Be Released Later This Year The Children's Tumor Foundation (CTF) today announced the publication of updated diagnostic criteria for the genetic disorder neurofibromatosis type 1 (NF1) in Genetics in Medicine, the official journal of the American College of Medical Genetics and Genomics. The new publication is the result of an extensive, multi-year collaborative effort of over 90 leading neurofibromatosis (NF) experts from around the globe, and is aimed at improving the accuracy and earlier diagnosis of NF1 in patients, thus ultimately leading to improved care and quality of life for those patients. ...

Open up Scott Roy's Twitter bio and you'll see a simple but revealing sentence: "The more I learn the more I'm confused." Now the rest of the scientific world can share in his confusion. The San Francisco State University associate professor of Biology's most recent research, published earlier this month in one of the scientific world's most prestigious journals, catalogues a strange and confounding system of genes in a tiny rodent that scientists have ignored for decades. "This is basically the weirdest sex chromosome system known to science," Roy said. "Nobody ordered this." But he's serving it anyway. The owner of those chromosomes is the creeping vole, a burrowing rodent native to the Pacific Northwest. Scientists ...

In recent years, foresters have been able to observe it up close: First, prolonged drought weakens the trees, then bark beetles and other pests attack. While healthy trees keep the invaders away with resin, stressed ones are virtually defenseless. Freiburg scientist Sylvie Berthelot and her team of researchers from the Faculty of Environment and Natural Resources and the Faculty of Biology are studying the importance of tree diversity on bark beetle infestation. They are investigating whether the composition of tree species affects bark beetle feeding behavior. The team recently published their findings in the Journal of Ecology. In a 1.1 hectare experimental set-up in Freiburg, six native deciduous and coniferous tree species from Europe and six deciduous and coniferous ...

SAN ANTONIO (May 19, 2021) -- Four months of multi-drug therapy that included rifapentine and moxifloxacin treated active tuberculosis (TB) as effectively as the standard six-month regimen in a multinational study, cutting treatment time by a third. Coauthors including Marc Weiner, MD, of The University of Texas Health Science Center at San Antonio, reported the findings May 6 in the New England Journal of Medicine. "Shorter treatment would be easier for people to complete without missing doses, and ultimately may be cost-effective," said Dr. Weiner, associate professor in the health science center's Joe R. and Teresa Lozano END ...

A team of researchers at the Centre Spatial de Liège (CSL) of the University of Liège has just developed a method to identify the contributors and origins of stray light on space telescopes. This is a major advance in the field of space engineering that will help in the acquisition of even finer space images and the development of increasingly efficient space instruments. This study has just been published in the journal Scientific Reports. Space telescopes are becoming more and more powerful. Technological developments in recent years have made it possible, for example, to observe objects further and further into the universe or to measure the composition of the Earth's atmosphere with ever greater precision. However, there is still one factor limiting the performance ...

HAMILTON, ON (May 19, 2021) - Researchers have found that the inclusion of a third drug to commonly used dual-drug inhalers can reduce asthma exacerbations and improve control over the disease in children, adolescents, and adults with moderate-to-severe asthma. A team from McMaster University and The Research Institute of St. Joe's Hamilton announced their findings from a systematic review and meta-analysis. Data from 20 randomized controlled trials, which included a total of almost 12,000 patients, were analyzed in the study. Dual-drug inhalers used to treat asthma typically contain an inhaled corticosteroid (ICS) to reduce inflammation, as well as a long-acting beta-adrenoceptor agonist (LABA) that acts as a bronchodilator. High-certainty evidence showed that the inclusion of a third ...

Leesburg, VA, May 19, 2021--According to an open-access article in ARRS' American Journal of Roentgenology (AJR), increased axillary lymph node or ipsilateral deltoid uptake is occasionally observed on FDG or 11C-choline PET performed after Pfizer-BioNTech or Moderna COVID-19 vaccination. "Recognition of occasional abnormal axillary lymph node or deltoid uptake on PET examinations performed after COVID-19 vaccination will aid interpreting physicians and reduce unnecessary biopsies," wrote corresponding author Jason R. Young from the department of radiology at Mayo Clinic in Rochester, MN. Young and colleagues' retrospective study included ...

For the first time, geological records have been used to reconstruct the history of Larsen C Ice Shelf in Antarctica. The ice shelf is the largest remaining remnant of a much more extensive area of ice on the Antarctic Peninsula that began to break up during the 1990s (Larsen A), and saw a huge collapse in 2002 (Larsen B). This new reconstruction enables scientists to better understand if and when the remaining ice shelf could collapse in the future. Publishing this month in the journal Geology an international team describes how the largest remaining ice shelf on the Antarctic ...

By mapping its genetic underpinnings, researchers at University of California San Diego School of Medicine have identified a predictive causal role for specific cell types in type 1 diabetes, a condition that affects more than 1.6 million Americans. The findings are published in the May 19, 2021 online issue of Nature. Type 1 diabetes is a complex autoimmune disease characterized by the impairment and loss of insulin-producing pancreatic beta cells and subsequent hyperglycemia (high blood sugar), which is damaging to the body and can cause other serious health problems, such as heart disease and vision loss. Type 1 is less common than type 2 diabetes, but its prevalence is growing. The U.S. Centers for Disease ...

Boulder, Colo., USA: Deep pools below waterfalls are popular recreational swimming spots, but sometimes they can be partially or completely filled with sediment. New research showed how and why pools at the base of waterfalls, known as plunge pools, go through natural cycles of sediment fill and evacuation. Beyond impacting your favorite swimming hole, plunge pools also serve important ecologic and geologic functions. Deep pools are refuges for fish and other aquatic animals in summer months when water temperatures in shallow rivers can reach lethal levels. Waterfalls also can liquefy sediment within the pool, potentially triggering debris flows that can damage property and threaten ...

Florida State University researchers have more insight into a strange sea creature found in oceans around the world and what their presence means for the health of a marine ecosystem. Scientists have thought that salps -- small marine organisms that look like clear, gelatinous blobs -- competed for resources with krill, shrimp-like creatures that are an important food source for many marine animals. But new research published in Limnology and Oceanography suggests that salps are actually competing for food with an organism known as a protist. An image of a salp taken during research. New research published in Limnology and Oceanography suggests that salps are actually competing for food with an organism known as a protist. (Courtesy of ...

A heart surgeon doesn't need to grasp quantum mechanics to perform successful operations. Even chemists don't always need to know these fundamental principles to study chemical reactions. But for Kang-Kuen Ni, the Morris Kahn associate professor of chemistry and chemical biology and of physics, quantum spelunking is, like space exploration, a quest to discover a vast and mysterious new realm. Today, much of quantum mechanics is explained by Schrödinger's equation, a kind of master theory that governs the properties of everything on Earth. "Even though ...

The amount of nutrients people get from the crops that they eat is a type of 'postcode lottery', according to new research that has analysed thousands of cereal grains and soils as part of a project to tackle hidden hunger in Malawi and Ethiopia. A global team led by the University of Nottingham and its Future Food Beacon including academics and researchers from Addis Ababa University (AAU) in Ethiopia and Lilongwe University of Agriculture and Natural Resources (LUANAR) in Malawi, working on the GeoNutrition project, have discovered more about the relation between soils, crops and micronutrient deficiencies among people living there. Their ...

HERSHEY, Pa. -- Parkinson's disease is the second most common neurodegenerative disease and affects more than 10 million people around the world. To better understand the origins of the disease, researchers from Penn State College of Medicine and The Hebrew University of Jerusalem have developed an integrative approach, combining experimental and computational methods, to understand how individual proteins may form harmful aggregates, or groupings, that are known to contribute to the development of the disease. They said their findings could guide the development of new therapeutics to delay or even halt the progression of neurodegenerative diseases. Alpha-synuclein ...

A new study by a Belgian team using data from the European Southern Observatory's Very Large Telescope (ESO's VLT) has shown that iron and nickel exist in the atmospheres of comets throughout our Solar System, even those far from the Sun. A separate study by a Polish team, who also used ESO data, reported that nickel vapour is also present in the icy interstellar comet 2I/Borisov. This is the first time heavy metals, usually associated with hot environments, have been found in the cold atmospheres of distant comets. "It was a big surprise to detect iron and nickel atoms in the atmosphere of all the comets ...

Where you live may predict your long-term survival after experiencing a first heart attack. Socioeconomic factors -- such as income, education, employment, community safety and more -- have long been associated with cardiovascular health, but less is known about how neighborhood factors impact outcomes after myocardial infarction (MI), particularly among younger individuals. In an article published in JAMA Cardiology, researchers from Brigham and Women's Hospital and colleagues studied the health records of 2,002 patients who experienced an MI at or before age 50. They found that even after adjusting ...

What The Study Did: Researchers evaluated racial and ethnic diversity among obstetrics and gynecology, surgical and nonsurgical residents in the United States from 2014 to 2019. Authors: Claudia L. Lopez, M.D., of the University of California, Davis, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2021.9219) Editor's Note: The article includes funding/support disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support. #  ...

What The Study Did: Registry data were used to examine the association between living in a socioeconomically disadvantaged area and long-term survival among patients who had their first heart attack at or before age 50. Authors: Ron Blankstein, M.D., of Brigham and Women's Hospital in Boston, is the corresponding author. To access the embargoed study:  Visit our For The Media website at this link https://media.jamanetwork.com/  (doi:10.1001/jamacardio.2021.0487) Editor's Note: The article includes conflict of interest disclosures. Please see the articles for additional information, including other authors, author contributions and affiliations, conflicts of interest and financial ...

What The Study Did: This study looked at the use of consumer digital information for COVID-19 control U.S. adults consider to be acceptable and the factors associated with higher or lower approval of using this information. Authors: David Grande, M.D., M.P.A., of the University of Pennsylvania, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2021.10918) Editor's Note: The article includes conflict of interest and funding/support disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support. #  #  # Media advisory: ...

What The Study Did: SARS-CoV-2 seropositivity wasn't associated with low levels of vitamin D independently of other risk factors. Authors: Yonghong Li, Ph.D., of Quest Diagnostics in San Juan Capistrano, California, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2021.11634) Editor's Note: The article includes funding/support disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, ...

What The Study Did: Clinical characteristics and outcomes of patients with multisystem inflammatory syndrome among adults with laboratory-confirmed SARS-CoV-2 infection at a single U.S. medical center are described in this study. Authors: Giovanni E. Davogustto, M.D., of the Vanderbilt University Medical Center in Nashville, Tennessee, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2021.10323) Editor's Note: The article includes conflicts of interest and funding/support disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, ...

What The Study Did: Racial and ethnic representation among departmental chairs and faculty in academic medicine in the United States from 1980 to 2019 was examined in this study. Authors: Darrion Mitchell, M.D., Ph.D., of the Ohio State University James Cancer Center in Columbus, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2021.10726) Editor's Note: The article includes conflicts of interest disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and ...

Philadelphia, May 19, 2021 - A multidisciplinary team of researchers from Children's Hospital of Philadelphia (CHOP) and the Perelman School of Medicine at the University of Pennsylvania (Penn) showed how the "batteries" of cells are highly implicated in whether patients with the chromosome 22q11.2 deletion syndrome develop schizophrenia. The results of the study may eventually lead to targeted prevention and treatment strategies for patients with the condition. The findings were published today in JAMA Psychiatry. 22q11.2 deletion syndrome (22q) is ...

The common skin disease atopic eczema (AE) impacts heavily on the life quality and general health of sufferers. Researchers at Karolinska Institutet in Sweden have now evaluated its treatment with internet-delivered cognitive behavioural therapy (iCBT). The study suggests that patients feel better after iCBT compared with a control group who received only traditional treatment. The results, which are published in JAMA Dermatology, might eventually make important care available to a large patient group. "We've carried out a promising pilot study but were still surprised at how effective internet-delivered CBT ...