CAMBRIDGE, MA -- Cryo-electron microscopy (cryo-EM) allows scientists to produce high-resolution, three-dimensional images of tiny molecules such as proteins. This technique works best for imaging proteins that exist in only one conformation, but MIT researchers have now developed a machine-learning algorithm that helps them identify multiple possible structures that a protein can take. Unlike AI techniques that aim to predict protein structure from sequence data alone, protein structure can also be experimentally determined using cryo-EM, which produces hundreds of thousands, or even millions, of two-dimensional images of protein samples frozen in a thin layer of ice. Computer algorithms then piece together these images, taken from different angles, into a three-dimensional ...

The next time you tuck in to a tikka masala you might find yourself asking a burning question: are spices used in dishes to help stop infection? It's a question many have chewed the fat over. And now thanks to new research from The Australian National University (ANU) we have an answer. The quick takeaway is: probably not. Professor Lindell Bromham and her colleagues asked why hot countries across the world tend to have spicy food? This pattern has led to what some have termed "Darwinian gastronomy" - a tummy-led cultural evolutionary process in countries with hotter climates. To find out the answer to their question, the researchers feasted on a true ...

You might remember you ate cereal for breakfast but forget the color of the bowl. Or recall watching your partner put the milk away but can't remember on which shelf. A new Northwestern Medicine study improved memory of complex, realistic events similar to these by applying transcranial magnetic stimulation (TMS) to the brain network responsible for memory. The authors then had participants watch videos of realistic activities to measure how memory works during everyday tasks. The findings prove it is possible to measure and manipulate realistic types of memory. "On a day-to-day basis we must remember complex events that involve many elements, such as different locations, people and objects," said lead author Melissa Hebscher, a postdoctoral fellow ...

New tools and methods have been described by WEHI researchers to study an unusual protein modification and gain fresh insights into its roles in human health and disease. The study - about how certain sugars modify proteins - was published today in Nature Chemical Biology. Led by WEHI researcher Associate Professor Ethan Goddard-Borger, this work lays a foundation for better understanding diseases like muscular dystrophy and cancer. At a glance WEHI researchers have developed new tools and methods to determine how 'tryptophan C-mannosylation', an unusual protein modification, impacts the stability and function ...

In order to produce tiny electronic memories or sensors in future, it is essential to be able to arrange individual metal atoms on an insulating layer. Scientists at Bielefeld University's Faculty of Chemistry have now demonstrated that this is possible at room temperature: molecules of the metal-containing compound molybdenum acetate form an ordered structure on the insulator calcite without jumping to other positions or rotating. Their findings have been presented in the Nature Communications journal. The work was done in cooperation with researchers from the universities of Kaiserslautern, Lincoln (UK) and Mainz. 'Until now, it has been difficult ...

A healthy person has a general balance of good and bad bacteria. But that balance is thrown off when someone gets sick. So, to help boost their levels of good bacteria, many people take probiotic supplements -- live bacteria inside of a pill. Various commercial probiotic supplements are available for consumer purchase, and while health experts generally agree about their overall safety, controversy surrounds their efficacy. Inside the human body lives a large microscopic community called the microbiome, where trillions of bacteria engage in a constant "tug of war" to maintain optimal levels of good and bad bacteria. Most of this struggle takes place within the body's gastrointestinal tract, as bacteria help with digesting food and support the immune system. Although ...

New research carried out by City data scientist, Dr Andrea Baronchelli, and colleagues, into the dark web marketplace (DWM) trade in products related to COVID-19, has revealed the need for the continuous monitoring of dark web marketplaces (DWMs), especially in light of the current shortage and availability of coronavirus vaccines. In their paper, Dark Web Marketplaces and COVID-19: before the vaccine published in the EPJ Data Science journal, Dr Baronchelli and his colleagues analysed 851,199 listings extracted from 30 DWMs between January 1, 2020 and November 16, 2020 before the advent of the availability of the coronavirus vaccine. They identify 788 listings directly related to COVID-19 products and monitor the temporal evolution of product categories including Personal Protective ...

Researchers from the University of Missouri School of Medicine have discovered that children who receive a seasonal flu shot are less likely to suffer symptoms from a COVID-19 infection. The finding comes from a review of more than 900 children diagnosed with COVID-19 in 2020. "It is known that the growth of one virus can be inhibited by a previous viral infection," said Anjali Patwardhan, MD, professor of pediatric rheumatology and child health. "This phenomenon is called virus interference, and it can occur even when the first virus invader is an inactivated virus, such as the case with the flu vaccine." Patwardhan reviewed records from 905 pediatric patients diagnosed with COVID-19 between February and August 2020 to determine each patient's influenza vaccination history. ...

Cardiac patients who also have diabetes will be able to do their rehabilitation exercises more safely, thanks to the world's first guidance on the subject, which has been published by international experts including a Swansea University academic. The guidance will be a crucial resource for healthcare professionals, so they can help the growing number of cardiac rehabilitation patients who also have diabetes. The guidance, approved by international diabetes organisations, was drawn up by a team including Dr. Richard Bracken of the School of ...

Scientists at Bielefeld University's Faculty of Physics have succeeded for the first time in imaging the SARS-CoV-2 coronavirus with a helium ion microscope. In contrast to the more conventional electron microscopy, the samples do not need a thin metal coating in helium ion microscopy. This allows interactions between the coronaviruses and their host cell to be observed particularly clearly. The scientists have published their findings, obtained in collaboration with researchers from Bielefeld University's Medical School OWL and Justus Liebig University Giessen, in the Beilstein Journal of Nanotechnology. 'The study shows that the helium ion microscope is suitable for imaging coronaviruses - so precisely that the interaction between virus ...

People undergoing long-term dialysis are almost 4 times more likely to die from COVID-19 and should be prioritized for vaccination, found a new Ontario study published in CMAJ (Canadian Medical Association Journal). "As the COVID-19 pandemic proceeds, focused efforts should be made to protect this population from infection including prioritizing patients on long-term dialysis and the staff treating them for SARS-CoV-2 vaccination," writes Dr. Peter Blake, provincial director, Ontario Renal Network, Ontario Health, and professor, Schulich School of Medicine and Dentistry, Western University, ...

It is necessary to develop additional COVID-19 vaccines, as different vaccine approaches have their advantages and disadvantages and may work synergistically. Researchers at Karolinska Institutet in Sweden now report that they have developed a prototype vaccine against SARS-CoV-2 using a DNA vaccine platform that is inexpensive, stable, easy to produce, and shows a good safety profile. A study published in Scientific Reports shows that the vaccine induces potent immune responses in mice. The vaccine, called DREP-S, is administered as DNA and is based on a DNA-launched self-amplifying RNA (DREP) platform developed at Karolinska ...

Between chemistry classes, gemstones, and electronics, the idea of crystals, substances with an ordered and periodic arrangement of atoms is quite common. But about 40 years ago, a strange particle was discovered by scientists that hasn't become commonplace in our world yet: quasicrystals. These are structures with curious atomic arrangements, which, while superficially similar to crystals, lack periodicity despite being ordered. Because of their structures, quasicrystals exhibit symmetries forbidden to crystals and are endowed with interesting properties that crystals cannot show, ...

The unmet HIV prevention and treatment needs of female sex workers and especially their male clients could contribute substantially to ongoing HIV transmission in South Africa, according to a new study led by researchers at the University of Bristol, UK. The researchers used mathematical modelling to look at the contribution of commercial sex, sex between men, and other heterosexual partnerships to HIV transmission in South Africa. They found that, over a ten-year period (2010-19), sex between female sex workers and their paying clients contributed 6.9 per cent of new HIV infections, while ...

In order to fight pathogens, mast cells regulate inflammatory reactions of the immune system. Both mast cells and neutrophils are white blood cells and are critical for the body's immune defense. A team of scientists around the immunologist Prof. Dr. Anne Dudeck and the bioengineer Jan Dudeck has discovered a crucial aspect of the communication between mast cells and neutrophils. These new findings may allow for developing innovative, targeted therapeutic strategies to dampen allergic responses and inflammatory reactions. The results have been published ...

ADELPHI, Md. -- A new quantum sensor can analyze the full spectrum of radio frequency and real-world signals, unleashing new potentials for soldier communications, spectrum awareness and electronic warfare. Army researchers built the quantum sensor, which can sample the radio-frequency spectrum--from zero frequency up to 20 GHz--and detect AM and FM radio, Bluetooth, Wi-Fi and other communication signals. The Rydberg sensor uses laser beams to create highly-excited Rydberg atoms directly above a microwave circuit, to boost and hone in on the portion of the spectrum being measured. The Rydberg atoms are sensitive to the circuit's voltage, enabling the device to be used as a sensitive probe for the wide range of signals in the RF spectrum. "All ...

People traditionally think that lungs and limbs are key innovations that came with the vertebrate transition from water to land. But in fact, the genetic basis of air-breathing and limb movement was already established in our fish ancestor 50 million years earlier. This, according to a recent genome mapping of primitive fish conducted by the University of Copenhagen, among others. The new study changes our understanding of a key milestone in our own evolutionary history. There is nothing new about humans and all other vertebrates having evolved from fish. The conventional understanding has been that certain fish shimmied landwards roughly ...

A global team of researchers has developed a new strategy for fast and reliable antibody tests, which can quantify the immune response induced by vaccination and reveal the timeline and stage of pathogen infection. Led by Professor Martin Hegner, Principal Investigator in CRANN and Trinity College Dublin's School of Physics, the team's one-step quantitative antibody tests are conducted using (blood) serum and are on a par with the gold-standard, enzyme-linked immunosorbent assay (ELISA) technique. The major advantage of the newly developed nano technique with respect to ELISA tests is that it is equally ...

ATLANTA - Researchers at Yerkes National Primate Research Center, Emory University, have developed a COVID-19 vaccine that has proven safe and effective in mice and monkeys. Results from this National Institute of Allergy and Infectious Diseases (NIAID)-funded study are published online today in Immunity. The Emory MVA COVID-19 vaccine approaches inducing protective immunity via modified vaccinia Ankara (MVA), a harmless version of a poxvirus that is well-known for its use in HIV/AIDS vaccines. Like the Moderna and Pfizer COVID-19 vaccines, the Emory MVA COVID-19 vaccine ...

New research carried out by City, University of London data scientist, Dr Andrea Baronchelli, and colleagues into the dark web marketplace (DWM) trade in products related to COVID-19, has revealed the need for the continuous monitoring of dark web marketplaces (DWMs) especially in light of the current shortage and availability of coronavirus vaccines. In their paper, Dark Web Marketplaces and COVID-19: before the vaccine published in the EPJ Data Science, Dr Baronchelli and his colleagues analysed 851,199 listings extracted from 30 DWMs between January 1, 2020 and November 16, 2020 before the advent of the availability of the coronavirus vaccine. They identify 788 listings directly related to COVID-19 ...

In data gathered and analyzed over 13 years, the North American Nanohertz Observatory for Gravitational Waves (NANOGrav) Physics Frontiers Center (PFC) has found an intriguing low-frequency signal that may be attributable to gravitational waves. NANOGrav researchers - including a number from West Virginia University's (WVU's) Department of Physics and Astronomy and the Center for Gravitational Waves and Cosmology - measure the times of arrival of radio pulses from exotic stars called pulsars with large radio telescopes, including the Green Bank Telescope (GBT) in Pocahontas County, ...

Researchers have developed a new technique to protect rice seeds against fungal infections that can ruin up to half of all rice crops in the world. The biocontrol method, which involves inoculation of flowers with a different fungus that doesn't cause disease and using seeds harvested from the flower to grow crops, is even better at protecting rice plants from diseases than existing fungicide approaches, and could also be used against similar pathogens that affect other staple crops. The extremely destructive seedborne bakanae disease, which affects rice plants everywhere in the world that the staple crop is grown, is currently typically combatted with either chemical fungicides or ...

The new therapeutic approach is based on shutting down the viral hepatitis B genome located in the nucleus of infected liver cells. Upon infection of the liver cell, the viral genome is transformed inside the nucleus into a closed circular DNA molecule. This deoxyribonucleic acid is a stable molecule known as covalently closed circular DNA (cccDNA) and serves as the template for the production of new viruses. The cccDNA represents the central reservoir of the hepatitis B viruses and enables their persistence in the liver. The virologist Prof. Dr. Maura Dandri and her team at the UKE managed to prevent the HBV-cccDNA from producing further viruses in the animal model. The point of attack of their ...

Treating equine donor stem cells with a growth factor called TGF-β2 may allow them to avoid "tripping" the immune response in recipients, according to new research from North Carolina State University. The work could simplify the stem cell treatment process for ligament and tendon injuries in horses, and may also have implications for human stem cell therapies. Mesenchymal stem cell therapy is a promising avenue for treating musculoskeletal injuries - particularly tendon and ligament injuries - in horses. Mesenchymal stem cells are adult stem cells found in bone marrow that act as repair directors, producing secretions that recruit paracrine, or healing, factors to the site of injury. Just as blood cells have "types," ...

Gels are formed by mixing polymers into fluids to create gooey substances useful for everything from holding hair in place to enabling contact lenses to float over the eye. Researchers want to develop gels for healthcare applications by mixing in medicinal compounds, and giving patients injections so that the gel releases the active pharmaceutical ingredient over a period of months to avoid weekly or daily needle sticks. But standing in the way is a problem that's as easily understandable as the difference between using hair gel on a beach versus in a ...