Scientists have developed a new biomaterial that regrows blood vessels and bone, potentially providing a single-stage approach when repairing large bone defects. The study, led by researchers from RCSI University of Medicine and Health Sciences and SFI AMBER Centre, is published in the Journal of Controlled Release. Previous RCSI-led research had found that activating a mechanosensitive gene, called placental growth factor (PGF), at different doses promoted bone regeneration and grew new blood vessels. Using this knowledge, the researchers developed a biomaterial that delivers PGF at different concentrations. Inspired by the natural way in ...

ROCHESTER, Minn. -- A new Mayo Clinic study bolsters evidence that colorectal cancer is often imprinted in family genes and passed on from one generation to the next. In the study, published in Clinical Gastroenterology and Hepatology, researchers within the Mayo Clinic Center for Individualized Medicine found 1 in 6 patients with colorectal cancer had an inherited cancer-related gene mutation, which likely predisposed them to the disease. In addition, the researchers discovered that 60% of these cases would not have been detected if relying on a standard guideline-based approach. "We found that 15.5% of the 361 patients with colorectal cancer had an inherited mutation in a gene associated with the development of their cancer," says Niloy Jewel Samadder, M.D., a Mayo ...

Nearly a decade ago, global news outlets reported vast ice melt in the Arctic as sapphire lakes glimmered across the previously frozen Greenland Ice Sheet, one of the most important contributors to sea-level rise. Now researchers have revealed the long-term impact of that extreme melt. Using a new approach to ice-penetrating radar data, Stanford University scientists show that this melting left behind a contiguous layer of refrozen ice inside the snowpack, including near the middle of the ice sheet where surface melting is usually minimal. Most importantly, the formation of the melt layer changed the ice sheet's behavior by reducing its ability to store future meltwater. The research appears in Nature Communications ...

PHILADELPHIA-- Researchers at Penn Medicine have identified more genetic mutations that strongly predispose younger, otherwise healthy women to peripartum cardiomyopathy (PPCM), a rare condition characterized by weakness of the heart muscle that begins sometime during the final month of pregnancy through five months after delivery. PPCM can cause severe heart failure and often leads to lifelong heart failure and even death. The study is published today in Circulation. PPCM affects women in one out of every 2,000 deliveries worldwide, with about a third of those women developing heart failure for life, and about five percent of them ...

A myriad of genetic factors can influence the onset of diseases like high blood pressure, heart diseases, and type 2 diabetes. If we were to know how the DNA influences the risk of developing such diseases, we, we could shift from reactive to more preventive care, not only improving patients' quality of living but also saving money in the health system. However, tracing the connections between the DNA and disease onset requires solid statistical models that reliably work on very large datasets of several hundred thousand patients. Matthew Robinson, Assistant Professor at the Institute ...

Our guts may not provide long-lasting systemic immunity from COVID-19, which is where immune cells circulate through the body to provide protection to other organs, finds a new study published in Frontiers in Immunology. An analysis of blood samples from patients infected with SARS-CoV-2 revealed that immune cells circulating in the blood, which were triggered by the gut's response to infection, were limited in number when compared to immune cells that had been triggered elsewhere in the body. "Although the gut is considered an important portal of entry for the virus, the immune response in the blood of COVID-19 patients is dominated by ...

Philadelphia, April 20, 2021 - American artisan cheese has become increasingly popular over the past few decades. Understanding spoilage concerns and the financial consequences of defects can improve quality, profitability, and sustainability in the American artisan cheesemaking industry. In an article appearing in the END ...

Some Himalayan glaciers are more resilient to global warming than previously predicted, new research suggests. Rock glaciers are similar to "true" ice glaciers in that they are mixtures of ice and rock that move downhill by gravity - but the enhanced insulation provided by surface rock debris means rock glaciers will melt more slowly as temperatures rise. Rock glaciers have generally been overlooked in studies about the future of Himalayan ice. The new study, led by Dr Darren Jones at the University of Exeter, shows rock glaciers already account for about one twenty-fifth of Himalayan ...

A new mathematical model for the interaction of bacteria in the gut could help design new probiotics and specially tailored diets to prevent diseases. The research, from Chalmers University of Technology in Sweden, was recently published in the journal PNAS. "Intestinal bacteria have an important role to play in health and the development of diseases, and our new mathematical model could be extremely helpful in these areas," says Jens Nielsen, Professor of Systems Biology at Chalmers, who led the research. The new paper describes how the mathematical model performed when making predictions ...

Newly published research contained in the Special Issue of the Journal of Marketing features fourteen global author teams focused on the topic of Better Marketing for a Better World. Edited by Rajesh Chandy (London Business School), Gita Johar (Columbia University), Christine Moorman (Duke University), and John Roberts (University of New South Wales), this Special Issue brings together wide-ranging research to assess, illuminate, and debate whether, when, and how marketing contributes to a better world. The Special Issue is built on the thesis that marketing has the power to improve lives, sustain livelihoods, strengthen societies, and benefit the world at large. It calls for a renewed ...

PORTLAND, Ore. - Policies designed to prevent the misuse of opioids may have the unintended side effect of limiting access to the pain-relieving drugs by terminally ill patients nearing the end of their life, new research led by the Oregon State University College of Pharmacy suggests. A study of more than 2,500 hospital patients discharged to hospice care over a nine-year period showed a decreasing trend of opioid prescriptions as well as an increase in the prescribing of less powerful, non-opioid analgesics, meaning some of those patients might have been undertreated for their pain compared to similar patients in prior years. The findings, published in the Journal of Pain and Symptom Management, are an important step toward optimizing ...

Philadelphia, April 20, 2021 - A collaborative study from the Center for Injury Research and Prevention (CIRP) and the Center for Autism Research (CAR) at Children's Hospital of Philadelphia (CHOP) identified clear strengths and a series of specific challenges autistic adolescents experience while learning to drive. The findings were recently published by the American Journal of Occupational Therapy. Researchers conducted in-depth interviews with 17 specialized driving instructors who were trained as occupational therapists, driving rehabilitation specialists, or licensed driving instructors and who had completed additional training related ...

Flushing a toilet can generate large quantities of microbe-containing aerosols depending on the design, water pressure or flushing power of the toilet. A variety of pathogens are usually found in stagnant water as well as in urine, feces and vomit. When dispersed widely through aerosolization, these pathogens can cause Ebola, norovirus that results in violent food poisoning, as well as COVID-19 caused by SARS-CoV-2. Respiratory droplets are the most prominent source of transmission for COVID-19, however, alternative routes may exist given the discovery of small numbers of viable viruses in urine and stool samples. Public restrooms are especially cause for concern for transmitting COVID-19 because they are ...

A new UCLA study finds that the proportion of physicians who are Black in the U.S. has increased by only 4 percentage points over the past 120 years, and that the share of doctors who are Black men remains unchanged since 1940. The research also spotlights a significant income gap between white and Black male physicians -- a disparity, the researcher writes, that could reflect a combination of pay discrimination and unequal access for physicians to pursue careers in more lucrative specialties. The paper will be published April 19 in the peer-reviewed Journal of General Internal Medicine. "These findings demonstrate how slow progress has been, and how far and fast we have to go, if we care about the diversity of the physician workforce and the health benefits such diversity brings ...

COLUMBUS, Ohio - A high daily dose of an omega-3 supplement may help slow the effects of aging by suppressing damage and boosting protection at the cellular level during and after a stressful event, new research suggests. Researchers at The Ohio State University found that daily supplements that contained 2.5 grams of omega-3 polyunsaturated fatty acids, the highest dose tested, were the best at helping the body resist the damaging effects of stress. Compared to the placebo group, participants taking omega-3 supplements produced less of the stress hormone cortisol and lower levels of a pro-inflammatory protein during a stressful event in the lab. And while levels of protective compounds sharply declined in the placebo group after the stressor, there were ...

A Monash University study has uncovered for the first time a way to prevent and reverse damage caused by broken-heart syndrome, also known as Takotsubo cardiomyopathy. Using mouse models, the pre-clinical study published in the acclaimed journal Signal Transduction and Targeted Therapy, has shown the cardioprotective benefit of a drug called Suberanilohydroxamic acid, or SAHA, dramatically improved cardiac health and reversed the broken-heart. The landmark study used SAHA to target genes and is a world first for Takotsubo cardiomyopathy. SAHA, currently used for cancer treatment, is approved by the US Food and Drug Administration (FDA) and Australian Therapeutic Goods Administration (TGA), works by providing a protective benefit to genes and ...

For the first time, a study has shown a clear link between the frequency and duration of unconscious wakefulness during night-time sleep and an increased risk of dying from diseases of the heart and blood vessels, and death from any cause, particularly in women. The study of 8001 men and women, which is published today (Tuesday) in the European Heart Journal [1], found that women who experienced unconscious wakefulness most often and for longer periods of time had nearly double the risk of dying from cardiovascular disease during an average of between 6 and 11 years' ...

Taking multivitamins, omega-3, probiotics or vitamin D supplements may lessen the risk of testing positive for SARS-CoV-2, the virus responsible for COVID-19 infection--at least among women--indicates a large population study, published online in the journal BMJ Nutrition Prevention & Health. But taking any of vitamin C, zinc, or garlic supplements wasn't associated with a lower risk of testing positive for the virus, the findings show. There has been plenty of celebrity endorsement of the use of dietary supplements to both ward off and treat COVID-19 infection since the start of the pandemic, note the researchers. In the UK alone, market share ...

Nanochannels have important applications in biomedicine, sensing, and many other fields. Though engineers working in the field of nanotechnology have been fabricating these tiny, tube-like structures for years, much remains unknown about their properties and behavior. Now, University of Maryland mechanical engineering associate professor Siddhartha Das and a group of his Ph.D. students have published surprising new findings in the journal ACS Nano. Using atomic-level simulations, Das and his team were able to demonstrate that charge properties as well as charge-induced fluid flow within a functionalized nanochannel does not always behave as expected. "We've discovered a new context for nanochannels functionalized by grafting ...

One of the marks of a successful idea in science is how quickly it can develop and evolve. In the case of the Anthropocene, the conceptual evolution has taken place with extraordinary speed. The strikingly influential hypothesis launched by the late Nobel laureate Paul Crutzen (Obituary, 24th Feb 2021) in 2000, was that the actions of an industrialised humanity has impacted the Earth so greatly as to trigger a new geological epoch. Originally developed within the Earth System science community in charting global environmental change, the Anthropocene then began ...

April 19, 2021 -- Ensuring COVID-19 vaccine access for refugee and displaced populations, and addressing health inequities, is vital for an effective pandemic response. Yet, vaccine allocation and distribution has been neither equitable nor inclusive, despite that global leaders have stressed this as a critical aspect to globally overcoming the pandemic, according to a paper published by Columbia University Mailman School of Public Health. Read "Leave No-one Behind: Ensuring Access to COVID-19 vaccines for Refugee and Displaced Populations" in the journal Nature Medicine. As of April 1st, high and upper-middle-income countries received 86 percent of the vaccine doses delivered worldwide, while ...

Tools that allow neuroscientists to record and quantify functional activity within the living brain are in great demand. Traditionally, researchers have used techniques such as functional magnetic resonance imaging, but this method cannot record neural activity with high spatial resolution or in moving subjects. In recent years, a technology called optogenetics has shown considerable success in recording neural activity from animals in real time with single neuron resolution. Optogenetic tools use light to control neurons and record signals in tissues that are genetically modified ...

A group of scientists have just made a key discovery that could prevent and eradicate immune responses that lead to treatment failure in about one-third of people with severe hemophilia A. Hemophilia is the most common severe inherited bleeding disorder in men. The disease affects 1 in 10,000 males worldwide and results from deficiency of blood clotting factor VIII (FVIII). Both children and adults with hemophilia A (80 percent of all hemophilia) receive treatment that involves infusing FVIII protein into the bloodstream. However, about 30 percent ...

Our planet's worst mass extinction event happened 252 million years ago when massive volcanic eruptions caused catastrophic climate change. The vast majority of animal species went extinct, and when the dust settled, the planet entered the early days of the Age of Dinosaurs. Scientists are still learning about the patterns of which animals went extinct and which ones survived, and why. In a new study in PNAS, researchers found that while extinctions happened rapidly in the oceans, life on land underwent a longer, more drawn-out period of extinctions. "People assumed that because the marine extinction happened over a short period of time, life on land should have followed the same pattern, but we found that the marine extinction ...

Professor Nicole Boivin, Director of the Department of Archaeology at the Max Planck Institute for the Science of Human History in Jena, Germany, is part of an international initiative to examine the implications of past land use for contemporary conservation efforts. The multi-disciplinary team, which includes archaeologists, ecologists, anthropologists and conservation managers, has reconstructed ancient population and land use to show that already by 12,000 years ago, humans had re-shaped much of the terrestrial biosphere. Their data challenge the idea that conservation ...