Studies on cancer are limited by the threshold at which cellular transformations become clinically detectable. However, the very initial phase on the way to malignancy is histologically invisible, as the process originates from one single cell. In this early phase, a so-called "seeding cell" acquires an initial pro-cancerous mutation, also known as the "first oncogenic hit", while being completely surrounded by normal tissue. To overcome the detection barrier, a team of researchers around IMBA group leader Bon-Kyoung Koo and University of Cambridge group leader Professor Benjamin D. Simons developed a laboratory system to dissect the pre-cancerous steps that remained under the radar ...

A team of researchers led by the University of Cambridge and University of Utrecht examined trends in daily crime counts before and after COVID-19 restrictions were implemented in major metropolitan areas such as Barcelona, Chicago, Sao Paulo, Tel Aviv, Brisbane and London. While both stringency of lockdowns and the resulting crime reductions varied considerably from city to city, the researchers found that most types of crime - with the key exception of homicide - fell significantly in the study sites. Across all 27 cities, daily assaults fell ...

Clinical trials published in high-profile medical journals rarely report on income or other key sociodemographic characteristics of study participants, according to a new study that suggests these gaps may create blind spots when it comes to health care, especially for disadvantaged populations. The study, publishing June 2 in JAMA Network Open, analyzed 10 per cent of 2,351 randomized clinical trials published in New England Journal of Medicine, JAMA, The BMJ, The Lancet and Annals of Internal Medicine between Jan. 1, 2014 and July 31, 2020. The most commonly reported sociodemographic variables were sex and gender (in 98.7 per cent of trials) and race/ethnicity (in 48.5 per cent). All other sociodemographic ...

Experts at the Alfred Wegener Institute have, for the first time, experimentally measured the release of iron from the fecal pellets of krill and salps under natural conditions and tested its bioavailability using a natural community of microalgae in the Southern Ocean. In comparison to the fecal pellets of krill, Antarctic phytoplankton can more easily take up the micronutrient iron from those produced by salps. Observations made over the past 20 years show that, as a result of climate change, Antarctic krill are increasingly being supplanted by salps in the Southern Ocean. In the future, salps could more effectively stimulate the fixation of the greenhouse gas carbon dioxide in Antarctic microalgae than krill, as the team of researchers report ...

Peer reviewed Experimental study / Meta-analysis Animals / Human data Protein disguise could be new target for cancer immunotherapy Researchers at the Francis Crick Institute have identified a protein that helps tumours evade the immune system and, in certain types of cancers, is linked to a poorer chance of survival. The protein could become a target for future cancer treatments. A crucial part of the immune system's response to cancer is a group of white blood cells, called CD8+ T-cells, which kill tumour cells. Before they launch their anti-tumour response, these cells must be told who to attack by another immune cell, ...

They studied the extent to which cirrus clouds caused by aircraft occurred during the global hard lockdown between March and May 2020, and compared the values with those during the same period in previous years. The study was led by Johannes Quaas, Professor of Theoretical Meteorology at Leipzig University, and has now been published in the renowned journal "Environmental Research Letters". Cirrus clouds, known for their high, wispy strands, contribute to warming the climate. When cirrus clouds occur naturally, large ice crystals form at an altitude of about 36 kilometres, in turn reflecting sunlight back into space - albeit ...

What drives the feasibility of climate scenarios commonly reviewed by organizations like the Intergovernmental Panel on Climate Change (IPCC)? And can they actually be achieved in practice? A new systematic framework can help understand what to improve in the next generation of scenarios and explore how to make ambitious emission reductions possible by strengthening enabling conditions. While the IPCC is in the midst of the drafting cycle of the Sixth Assessment Report, whose publication will start in the second half of 2021, there is an ongoing debate ...

ITHACA, N.Y. - Influencing millions of people on social media and being paid handsomely is not as easy as it looks, according to new Cornell University research. Algorithm vagaries are just one of several challenges social media content creators face, according to study author Brooke Erin Duffy, associate professor of communication at Cornell. "I think [our research] is a cautionary tale for aspiring creators as well as the broader public," Duffy said. "The people hoping to work as full-time YouTubers, Instagrammers, and TikTokers are led to believe it's easy and democratic. ...

One-quarter of people who take the drug methotrexate for common immune system disorders -- from rheumatoid arthritis to multiple sclerosis -- mount a weaker immune response to a COVID-19 vaccine, a new study shows. Published (online May 25) recently in Annals of the Rheumatic Diseases, the study addressed disorders that result when the immune system, meant to fight disease and drive healing, is triggered abnormally. This in turn causes inflammation, the pain and swelling that come as immune cells rush into damaged or infected tissue, but often in the wrong amount or context. Called immune-mediated inflammatory disorders, they are typically treated ...

The pollution of the world's oceans with plastic waste is one of the major environmental problems of our time. However, very little is known about how much plastic is distributed globally in the ocean. Models based on ocean currents have so far suggested that the plastic mainly collects in large ocean gyres. Now, researchers at the University of Bern have calculated the distribution of plastic waste on a global scale while taking into account the fact that plastic can get beached. In their study, which has just been published in the "Environmental Research Letters" scientific journal, ...

Zebrafish exposed to the leading cannabinoids found in cannabis in the earliest stages of development suffer a significant drop in neural activity later in life, according to a University of Alberta study that has implications for prenatal development in humans. Richard Kanyo, the lead author on the study and post-doctoral fellow in the Faculty of Medicine & Dentistry, said despite the popular narrative that the health benefits of cannabis are many, it turns out there is a surprisingly large knowledge gap. "Once the legalization happened, people got really excited about it and there's a lot of bias in the media about positive ...

The number of specialty behavioral health establishments, their workforce and their wages have increased steadily between 2011 and 2019, according to a new study by Indiana University and University of Michigan researchers. The largest increases were found in the number of outpatient establishments and the size of their workforce, as well as an increase in the average wage at residential health establishments. Researchers say while these increases are important in closing the gaps in needed treatment, more work needs to be done to increase behavioral health workforce deficits, especially in areas with an elevated drug overdose mortality rate. At ...

By Karina Toledo  |  Agência FAPESP - The novel coronavirus is transmitted mainly via inhalation of saliva droplets or respiratory secretions suspended in air, so that face covering and social distancing are the most effective ways to prevent COVID-19 until enough vaccines are available for all. In Brazil, fabric masks are among the most widely used because they are cheap, reusable and available in several colors or designs. However, this type of face covering's capacity to filter aerosol particles of a size equivalent to the novel coronavirus can vary between 15% and 70%, according to a study conducted in Brazil by the University of São Paulo (USP). The study was supported by FAPESP, and the principal investigator was Paulo Artaxo, a professor in the university's ...

(10 a.m. EDT, June 2, 2021--Denver) - New research published in the Journal of Thoracic Oncology (JTO) suggests the method used to calculate how obesity is measured may affect whether it is considered a risk factor for lung cancer. The JTO is an official journal of the International Association for the Study of Lung Cancer. Although the association between measures of obesity and both cancer incidence and outcome are clear in some solid tumor types such as breast, esophageal, and colon cancer, the relationship between obesity and lung cancer is more nuanced. Now, a group of researchers led by Sai Yendamuri, M,D, from Rosewell Comprehensive ...

Fluorinated compounds are an important group of compounds that are widely used in pharmaceuticals, agricultural chemicals, functional resins, and organic electronic materials. In particular, perfluorinated compounds with multiple carbon-fluorine bonds are attracting attention because of their high thermal and chemical stability and various excellent properties such as water and oil repellency and chemical resistance. "C-F bonds are extremely strong; hence, their transformation under mild conditions is difficult, and the selective activation of a specific C-F bond from among multiple C-F bonds in perfluorinated compounds has not been achieved," explains Prof. Makoto Yasuda, corresponding author of the study. The research team led by Prof. Makoto Yasuda has discovered ...

What makes cheetah the fastest land mammal? Why aren't other animals, such as horses, as fast? While we haven't yet figured out why, we have some idea about how--cheetahs, as it turns out, make use of a "galloping" gait at their fastest speeds, involving two different types of "flight": one with the forelimbs and hind limbs beneath their body following a forelimb liftoff, called "gathered flight," while another with the forelimbs and hind limbs stretched out after a hind limb liftoff, called "extended flight" (see Figure 1). Of these, the extended flight is what enables cheetahs to accelerate to high ...

Developing vaccines against bacteria is in many cases much more difficult than vaccines against viruses. Like virtually all pathogens, bacteria are able to sidestep a vaccine's effectiveness by modifying their genes. For many pathogens, such genetic adaptations under selective pressure from vaccination will cause their virulence or fitness to decrease. This lets the pathogens escape the effects of vaccination, but at the price of becoming less transmissible or causing less damage. Some pathogens, however, including many bacteria, are extremely good at changing in ways that allow them to escape the effects of vaccination while remaining highly ...

The white-tailed sea eagle is known for reacting sensitively to human disturbances. Forestry and agricultural activities are therefore restricted in the immediate vicinity of the nests. However, these seasonal protection periods are too short in the German federal States of Brandenburg (until August 31) and Mecklenburg-Western Pomerania (until July 31), as a new scientific analysis by a team of scientists from the Leibniz Institute for Zoo and Wildlife Research (Leibniz-IZW) suggests. Using detailed movement data of 24 juvenile white-tailed sea eagles with GPS transmitters, they were able to track when they fledge and when they leave the parental territory: on average, a good 10 and ...

Materials have a variety of properties that can be used to solve computational problems, according to studies in substrate-based computing. BZ computers, slime mould computers, plant computers, and collision-based liquid marbles computers are just a few examples of prototypes produced for future and emergent computing devices. Modelling the computational processes that exist in such systems, however, is a difficult task in general, and determining which part of the embodied system is doing the computation is still somewhat ill-defined. Claiming that fungi are the most intelligent living organisms in the world sounds like an exaggeration. However, a recent study by Mohammad Mahdi Dehshibi, a UOC researcher who is contributing to a growing body of knowledge on the use of fungal materials, ...

Eating at least two serves of fruit daily has been linked with 36 percent lower odds of developing type 2 diabetes, a new Edith Cowan University (ECU) study has found. The study, published today in the Journal of Clinical Endocrinology and Metabolism, revealed that people who ate at least two serves of fruit per day had higher measures of insulin sensitivity than those who ate less than half a serve. Type 2 diabetes is a growing public health concern with an estimated 451 million people worldwide living with the condition. A further 374 million people are at increased risk of developing type 2 diabetes. The study's lead author, Dr Nicola ...

Researchers at Linköping University in Sweden have developed an app to help women achieve a healthy weight gain and lifestyle during a pregnancy. The results from an evaluation of the app have now been published in two scientific articles. Using the app contributed to a better diet. Pregnant women with overweight or obesity who received the app also gained less weight during pregnancy. "Pregnancy is a phase in life when many people try to do what is best for themselves and their baby. We think it's important to be able to offer a tool that has ...

Good acoustics in the workspace improve work efficiency and productivity, which is one of the reasons why acoustic materials matter. The acoustic insulation market is already expected to hit 15 billion USD by 2022 as construction firms and industry pay more attention to sound environments. Researchers at Aalto University, in collaboration with Finnish acoustics company Lumir, have now studied how these common elements around us could become more eco-friendly, with the help of cellulose fibres. 'Models for acoustic absorption are based on tests done with synthetic fibres, and ...

An international research team determined that ancestors of modern domestic horses and the Przewalski horse moved from the territory of Eurasia (Russian Urals, Siberia, Chukotka, and eastern China) to North America (Yukon, Alaska, continental USA) from one continent on another at least twice. It happened during the Late Pleistocene (2.5 million years ago - 11.7 thousand years ago). The analysis results are published in the journal. The findings and description of horse genomes are published in the journal Molecular Ecology. "We found out that the Beringian Land Bridge, or the area known as Beringia, influenced genetic ...

All the cells of an organism share the same DNA sequence, but their functions, shapes or even lifespans vary greatly. This happens because each cell "reads" different chapters of the genome, thus producing alternative sets of proteins and embarking on different paths. Epigenetic regulation--DNA methylation is one of the most common mechanisms--is responsible for the activation or inactivation of a given gene in a specific cell, defining a secondary cell-specific genetic code. Researchers led by Dr. Modesto Orozco, head of the Molecular Modelling and Bioinformatics lab at IRB Barcelona, have described how methylation has a protein-independent regulatory role by increasing the stiffness of DNA, which affects the 3D structure ...

Autistic people's ability to accurately identify facial expressions is affected by the speed at which the expression is produced and its intensity, according to new research at the University of Birmingham. In particular, autistic people tend to be less able to accurately identify anger from facial expressions produced at a normal 'real world' speed. The researchers also found that for people with a related disorder, alexithymia, all expressions appeared more intensely emotional. The question of how people with autism recognise and relate to emotional expression has been debated by scientists for more than three decades and it's only in the past 10 years ...