The iconic X-shaped organization of metaphase chromosomes is frequently presented in textbooks and other media. The drawings explain in captivating manner that the majority of genetic information is stored in chromosomes, which transmit it to the next generation. “These presentations suggest that the chromosome ultrastructure is well-understood. However, this is not the case”, says Dr. Veit Schubert from IPK’s research group “Chromosome structure and function”. Several models have been proposed to describe the higher-order structure of metaphase chromosomes based on data obtained using a range of molecular and microscopy methods. These models ...

New insights into the importance of early-life factors on lung health have been unveiled in the most comprehensive study of its kind, led by the Universities of Essex and Bristol. The researchers hope the findings, published today in the European Respiratory Journal, will pave the way to developing predictive tools for respiratory health and reduce healthcare inequality by targeting early-life interventions for people at higher risk. The study analysed data collected from 7,545 participants of Bristol’s Children of the 90s ...

Today, the Academic Freedom Index (AFI) project presents its Update 2023, providing an overview of the state of academic freedom in 179 countries. The decline in academic freedom affects over 50% of the world's population, approximately 4 billion people. The Index identifies 22 countries where universities and scholars experience significantly less academic freedom today than they did ten years ago. This includes democratic systems as well as autocratic countries. During the same period, academic freedom levels have only ...

A new paper in The Quarterly Journal of Economics, published by Oxford University Press, measures the overall impact of electoral campaigns and finds that televised debates have little effect on the formation of voter choice. Information received from other sources such as the media, political activists, and other citizens, matters more. Researchers and pundits have long debated the impact of political campaigns. One view is that the weeks immediately preceding elections are a crucial period. Campaign information can help voters assess the performance of incumbent politicians, compare the qualities and positions of all candidates, and perhaps even reconsider their policy preferences. But ...

Embargoed for Use Until: 3:30 p.m. PT/6:30 p.m. ET on Wednesday, March 1, 2023   Older Black men are likelier to die after surgery than others, particularly following elective procedures, new UCLA research suggests   Older Black men have a higher chance of dying within 30 days of surgery than do Black women and white men and women – with their odds of death 50% higher after elective surgery compared with white men.   The researchers suspect that the “especially high cumulative amounts of stress and allostatic load” that Black men face the U.S. may significantly contribute to declines in their physical health, they write.   “While ...

Black men have a higher death rate within 30 days of surgery compared with any other subgroup of race and sex, finds a study of adults in the United States published in The BMJ. This inequality in death rate was mainly observed for elective, or planned, surgeries, where the death rate for Black men was 50% higher than that of White men.  The researchers say further research is needed to understand better the “factors contributing to this higher mortality rate among Black men after elective surgery.” In previous studies, racial inequities in surgical care and outcomes, including a higher death rate following surgery for Black patients, have been well documented.  However, ...

In the 35 years before the covid-19 pandemic, the US government invested at least $337 million into critical research that led to the mRNA covid-19 vaccines, finds a study published by The BMJ today. The US government also paid $31.6 billion during the pandemic to support vaccine research, production, and to purchase vaccines for all Americans and for global donation. These public investments saved millions of lives - and mRNA vaccine technology also has the potential to address future pandemics and treat other diseases. But the researchers ...

Moderna and Pfizer-BioNTech have recently announced plans to increase the price of their respective mRNA COVID-19 vaccines, thrusting them into the spotlight of debates around drug price hikes. A new study, led by investigators from Brigham and Women’s Hospital, a founding member of the Mass General Brigham health care system, analyzed the role of public funding in the development of mRNA vaccines. In a systematic assessment, the team found that over the last 35 years, three federal agencies—the National Institutes of Health, the Department ...

New research from the Work Foundation at Lancaster University reveals that while two thirds of senior business leaders (66%) agree that employers have a ‘substantial role’ to play in supporting staff through the rising cost of living, only 40% have introduced new support measures since the start of 2022.  At the same time, four in ten business leaders (41%) also report increases in production costs in their organisation. Pressures that are likely to increase, the Work Foundation ...

Tucked away in a small, dark room at UPMC Hillman Cancer Center, Brittani Schnable is on a fishing expedition. Wielding a joystick similar to those used by video gamers, she casts microscopic beads into an ocean of molecules, pushing and pulling the beads apart until they eventually catch a strand of DNA. After a few taps of the keyboard, a lightshow begins. A burst of colors flashes across the black screen like fireworks exploding in the night sky. Although these colors seem random at first, a pattern starts to emerge. Lines of blue and red light streak across the screen: A DNA repair protein has bound to the site of damage. Schnable, a Ph.D. student in Dr. Bennett ...

Loss of muscle strength can be one of the most damaging outcomes when someone is unable to move a part of their body for a long period of time.   But a new Edith Cowan University (ECU) study may have found a way to offset or even protect against this — and it doesn’t even involve the affected body part at all.   Injury or illness may see a part of the body incapacitated for weeks or even months, causing unused muscles to weaken and lose their mass and strength, which can have ...

Regular physical activity can improve adolescents’ mental health and help with behavioural difficulties, research suggests. Engaging in regular moderate to vigorous physical activity at age 11 was associated with better mental health between the ages of 11 and 13, the study found. Physical activity was also associated with reduced hyperactivity and behavioural problems, such as loss of temper, fighting with other children, lying, and stealing, in young people. Researchers from the Universities of Edinburgh, Strathclyde, Bristol, and Georgia in the United States explored data from the Children of the 90s study (also known as the Avon Longitudinal Study of ...

Diabetes mellitus, simply called diabetes, is a metabolic disorder characterized by the presence of abnormally high concentrations of glucose in blood. Existing methods for the diagnosis of diabetes rely on traditional techniques of detecting glucose in blood serum samples—a process that is typically tedious and expensive. Molecular recognition is the science of accurately detecting specific compounds by exploiting their binding properties. Here, a receptor molecule–a kind of sensor–selectively binds to a target molecule. This process triggers some reaction, say, a change ...

A good night’s sleep can solve all sorts of problems – but scientists have now discovered new evidence that sleeping well may make you less vulnerable to infection. Scientists at the University of Bergen recruited medical students working in doctors’ surgeries to hand out short questionnaires to patients, asking about sleep quality and recent infections. They found that patients who reported sleeping too little or too much were more likely also to report a recent infection, and patients ...

Study Suggests EHR-Focused Interventions Can Significantly Reduce Unnecessary Urine Cultures Among Hospital Patients Initiative highlighted in AJIC provides model for resource-limited institutions to decrease overdiagnosis and overtreatment of asymptomatic bacterial infections Arlington, Va., March 2, 2023 – Physicians in the largest safety-net hospital system in the United States used two electronic health record (EHR)-focused interventions to significantly reduce inappropriate urine cultures among hospitalized patients. Findings from their study, published in the ...

Scientists at the University of Sussex have successfully trialed new biodegradable health sensors that could change the way we experience personal healthcare and fitness monitoring technology.   The team at Sussex have developed the new health sensors – such as those worn by runners or patients to monitor heart rate and temperature – using natural elements like rock salt, water and seaweed, combined with graphene. Because they are solely made with ingredients found in nature, the sensors are fully biodegradable, making them more environmentally friendly than commonly used rubber and plastic-based alternatives. Their natural ...

Des Plaines, IL — When compared to cocaine exposure alone, cocaine and ethanol exposure in emergency department (ED) patients with acute drug overdose was significantly associated with higher occurrence of cardiac arrest, higher mean lactate concentrations, and lower occurrence of myocardial injury. This is the conclusion of a study titled, Cocaethylene cardiotoxicity in emergency department patients with acute drug overdose published in the February issue of Academic Emergency Medicine (AEM), the peer-reviewed journal of the Society for Academic Emergency ...

According to the US Centers for Disease Control and Prevention, prostate cancer is the second leading cause of cancer death among men. One of the standard approaches for the diagnosis and treatment of prostate cancer involves transperineal (TP) biopsy. This involves inserting a needle through the perineum wall to collect tissue samples. Current methods for TP biopsy generally include a pre-operation MRI scan and a transrectal ultrasound. These images are then fused together and shown on a monitor to the urologist, who then inserts the needle. The needle insertion can be ...

A team of global experts has discovered new signals of natural selection in humans.  Led by UC Santa Barbara Tsimane Health and Life History Project co-director Michael Gurven, the team studied two populations living in the Bolivian Amazon rainforest — the Tsimane and the Moseten. Previous studies show that these tropical populations are exposed to many parasites and a variety of pathogens; at the same time, the Tsimane rarely suffer from cardiovascular diseases and dementia. This new research suggests that the Tsimane genome has undergone selection ...

A large Bronze Age debris deposit in Mycenae, Greece provides important data for understanding the history of animal resources at the site, according to a study published March 1, 2023 in the open-access journal PLOS ONE by Jacqueline Meier of the University of North Florida and colleagues. Animals were an important source of subsistence and symbolism at the Late Bronze Age site of Mycenae in Greece, as evidenced by their depictions in art and architecture, but more research is needed on the animals ...

A survey study of U.S. college students provides new insights into factors associated with the tendency to engage in celebrity stalking behaviors. Maria Wong (Idaho State University, U.S.), Lynn McCutcheon (North American Journal of Psychology, U.S.), Joshua Rodefer (Mercer University, U.S.) and Kenneth Carter (Emory University, U.S.) present these findings in the open-access journal PLOS ONE on March 1, 2023. Celebrities around the world deal with the threat of unwanted and threatening or intimidating attention or harassment—commonly known as stalking. A growing body of research is exploring and identifying factors that are associated ...

Most people find sharks threatening. Who doesn’t have an image in their mind of a menacing shark fin racing through the ocean in search of its next meal?  But it is the shark that is threatened.  According to Defenders of Wildlife, a national nonprofit dedicated to protecting imperiled species, 75% of shark species are threatened with extinction and up to 73 million sharks are being killed each year for their fins.  Habitats that were once secure places for sharks to give birth have also been affected. And the fact that sharks have long gestation periods, giving birth ...

**Strictly embargoed until 19:00 (GMT) Wednesday 1 March 2023**    Scientists discover how to prevent death of nerve cells in most common forms of MND and dementia   Researchers from the University of Sheffield’s Institute of Translational Neuroscience have discovered how to prevent the death of nerve cells and protect nerves from neurodegeneration in the most common forms of MND and frontotemporal dementia The researchers used a peptide, a small assembly of amino acids or protein bricks, with a cell-penetrating ...

Black women at high risk of breast cancer face a variety of obstacles that may keep them from care that could prevent cancer and increase the chances they’ll survive if they develop the disease, new research has found. A study from researchers at The Ohio State University provides insights into the factors that contribute to racial disparities in use of preventive measures, including genetic testing, prophylactic mastectomies and medication to thwart breast cancer. In the new study, which appears today (March 1, 2023) in the journal PLOS ONE, the ...

A world-first model of paleoclimate and hydrology in Iran has highlighted favourable routes for Neanderthals and modern human expansions eastwards into Asia.  Published in PLOS ONE, the findings reveal for the first time that multiple humid periods in ancient Iran led to the expansions of human populations, opening dispersal route across the region, and the possible interactions of species such as Neanderthals and our own Homo sapiens.   Professor Michael Petraglia, a key researcher in the study, said historic humid ...