Women at high risk of breast cancer face cost-associated barriers to care even when they have health insurance, a new study has found. The findings suggest the need for more transparency in pricing of health care and policies to eliminate financial obstacles to catching cancer early. The study led by researchers at The Ohio State University included in-depth interviews with 50 women - 30 white, 20 Black - deemed at high risk of breast cancer based on family history and other factors. It appears in the Journal of Genetic Counseling. The researchers considered it a given that women without any insurance would face serious barriers to preventive care including genetic counseling and testing, prophylactic mastectomy and ...

OAK BROOK, Ill. - An artificial intelligence-driven system that automatically combs through brain MRIs for abnormalities could speed care to those who need it most, according to a study published in Radiology: Artificial Intelligence. MRI produces detailed images of the brain that help radiologists diagnose various diseases and damage from events like a stroke or head injury. Its increasing use has led to an image overload that presents an urgent need for improved radiologic workflow. Automatic identification of abnormal findings in medical images offers a potential solution, enabling improved patient care and accelerated patient discharge. "There are an increasing number of MRIs that are performed, ...

Certain signalling proteins, which are responsible for the development of innate immune function in almost all animals are also required for the formation of the dorsal-ventral (back-belly) axis in insect embryos. A new study by researchers from the University of Cologne's Institute of Zoology suggests that the relevance of these signalling proteins for insect axis formation has increased independently several times during evolution. For example, the research team found similar evolutionary patterns in the Mediterranean field cricket as in the fruit fly Drosophila, although the two insects are only very distantly related and previous observations suggested different evolutionary ...

Metaplasia is defined as the replacement of a fully differentiated cell type by another. There are several classical examples of metaplasia, one of the most frequent is called Barrett's oesophagus. Barrett's oesophagus is characterized by the replacement of the keratinocytes by columnar cells in the lower oesophagus upon chronic acid reflux. This metaplasia is considered a precancerous lesion that increases by around 50 times the risk of this oesophageal adenocarcinoma. Nonetheless, the mechanisms involved in the development of metaplasia in the oesophagus are still partially unknown. In a new study published in Cell Stem Cell, researchers led by Mr. Benjamin Beck, ...

Drawing on epidemiological field studies and the FrenchCOVID hospital cohort coordinated by Inserm, teams from the Institut Pasteur, the CNRS and the Vaccine Research Institute (VRI, Inserm/University Paris-Est Créteil) studied the antibodies induced in individuals with asymptomatic or symptomatic SARS-CoV-2 infection. The scientists demonstrated that infection induces polyfunctional antibodies. Beyond neutralization, these antibodies can activate NK (natural killer) cells or the complement system, leading to the destruction of infected cells. Antibody levels are slightly lower in asymptomatic ...

Creativity--the "secret weapon" of Homo sapiens--constituted a major advantage over Neanderthals and played an important role in the survival of the human species. This is the finding of an international team of scientists, led by the University of Granada (UGR), which has identified for the first time a series of 267 genes linked to creativity that differentiate Homo sapiens from Neanderthals. This important scientific finding, published today in the prestigious journal Molecular Psychiatry (Nature), suggests that it was these genetic differences linked to creativity that enabled Homo sapiens to eventually replace Neanderthals. It was creativity that gave Homo sapiens the ...

Children with weakened immune systems have not shown a higher risk of developing severe COVID-19 infection despite commonly displaying symptoms, a new study suggests. During a 16-week period which covered the first wave of the pandemic, researchers from Southampton carried out an observational study of nearly 1500 immunocompromised children - defined as requiring annual influenza vaccinations due to underlying conditions or medication. The children, their parents or guardians completed weekly questionnaires to provide information about any symptoms they had experienced, COVID-19 test results and the impact of the pandemic on their daily life. The results, published in BMJ Open, showed that symptoms of COVID-19 infection were common in many of the children - with ...

The effects of the steadily increasing amount of plastic in the ocean are complex and not yet fully understood. Scientists at GEOMAR Helmholtz Centre for Ocean Research Kiel have now shown for the first time that the uptake of microplastics by zooplankton can have significant effects on the marine ecosystem even at low concentrations. The study, published in the international journal Nature Communications, further indicates that the resulting changes may be responsible for a loss of oxygen in the ocean beyond that caused by global warming. Plastic debris in the ocean is a widely known problem for large marine mammals, fish and seabirds. These ...

The results, exceptional first time evidence of how early flocks of domesticated sheep fed and reproduced within the Iberian Peninsula, are currently the first example of the modification of sheep's seasonal reproductive rhythms with the aim of adapting them to human needs. The project includes technical approaches based on stable isotope analysis and dental microwear of animal remains from more than 7,500 years ago found in the Neolithic Chaves cave site in Huesca, in the central Pyrennean region of Spain. The research was coordinated from the Arqueozoology Laboratory of the UAB Department of Antiquity, with the participation of researchers from the University of Zaragoza, the Museum of Natural History of Paris, and the Catalan Institute of Human Palaeocology and Social Evolution (IPHES) ...

Most battery materials, novel catalysts, and storage materials for hydrogen have one thing in common: they have a structure comprised of tiny pores in the nanometer range. These pores provide space which can be occupied by guest atoms, ions, and molecules. As a consequence, the properties of the guest and the host can change dramatically. Understanding the processes inside the pores is crucial to develop innovative energy technologies. Observing the filling process So far, it has only been possible to characterise the pore structure of the substrate materials precisely. The exact structure of the adsorbate inside the pores has remained hidden. To probe this, a team from the HZB together with colleagues ...

The natural menopause occurs when the menstrual periods cease due to the naturally decreased ovary function. There is a significant interindividual variation in the age at natural menopause but, on average, women undergo it around the age of 51 in Western countries. Furthermore, the length of the preceding menopausal transition, characterized by irregular menstrual cycles and menopausal symptoms, is also known to vary between individuals. The study revealed that higher estradiol and follicle-stimulating hormone levels, irregular menstrual cycles, and menopausal symptoms are strong indicators of approaching menopause in middle-aged women. Additionally, information related ...

DALLAS - April 21, 2021 - Food banks should be used more consistently rather than only during emergencies to better address food insecurity and related health issues, a joint study by researchers at UT Southwestern Medical Center and economists at the University of Dallas shows. "The main discovery in our research is that encouraging clients and making it easier for clients to receive food frequently improves their food security, health, and well-being," says Sandi Pruitt, Ph.D., associate professor of population and data sciences at UT Southwestern, and senior author of the ...

Perhaps no other ocean creature lives in the human imagination like the great white shark. But while great white sharks might be plentiful in the minds of beachgoers across the country, there are only a handful of places in the world where white sharks can be consistently found. In those areas -- such as Central California, Guadalupe Island Mexico, South Australia and South Africa -- they tend to be found aggregated in small hotspots, often located around seal colonies. Researchers have estimated that white shark populations are incredibly small, with only hundreds of large adults and a few thousand white sharks total in any of their global ...

UNIVERSITY PARK, Pa. -- A new approach to gene editing using the CRISPR/Cas9 system bypasses disease-causing mutations in a gene, enabling treatment of genetic diseases linked to a single gene, such as cystic fibrosis, certain types of sickle cell anemia, and other rare diseases. The method, developed and tested in mice and human tissue cultures by researchers at Penn State, involves inserting a new, fully functional copy of the gene that displaces the mutated gene. A proof-of-concept for the approach is described in a paper appearing online April 20 in the journal Molecular Therapy. The CRISPR/Cas9 system has allowed promising new gene therapies ...

The number of solar panels within shortest distance from a house is the most important factor in determining the likelihood of that house having a solar panel, when compared with a host of socio-economic and demographic variables. This is shown in a new study by scientists using satellite and census data of the city of Fresno in the US, and employing machine learning. Although it is known that peer effects are relevant for sustainable energy choices, very high-resolution data combined with artificial intelligence techniques were necessary to single out the paramount importance of proximity. The finding is relevant for policies that aim at a broad deployment of solar panels in order to replace unsustainable ...

The lifestyle and eating habits of human groups that have lived for thousands of years can be examined by tooth. An international research group analyzed the prehistoric findings of the Neolithic Age. In addition to providing knowledge about the lifestyles of people who lived in prehistoric times, a novel study of tooth remains paved the way for other methods previously not used. This study applies the complementary approaches of stable isotope and dental microwear analyses to study the diets of past people living in today's Hungary. Their joint results were published in the scientific journal Scientific Reports. The Great Hungarian Plain is considered one of the most interesting areas for archeology because ...

Coronavirus researchers led by Professor Rolf Hilgenfeld of the University of Luebeck and PD Dr. Albrecht von Brunn of the Ludwig-Maximilian Universitaet (LMU) in Munich have discovered how SARS viruses enhance the production of viral proteins in infected cells, so that many new copies of the virus can be generated. Notably, coronaviruses other than SARS-CoV and SARS-CoV-2 do not use this mechanism, which may therefore provide a possible explanation for the much higher pathogenicity of the SARS viruses. The findings appear in the EMBO Journal. Coronaviruses that cause harmless colds in humans were discovered more than 50 years ago. When it emerged in 2002/2003, the SARS coronavirus was the first coronavirus found to cause severe pneumonia ...

For more sustainability on a global level, EU legislation should be changed to allow the use of gene editing in organic farming. This is what an international research team involving the Universities of Bayreuth and Göttingen demands in a paper published in the journal "Trends in Plant Science". In May 2020, the EU Commission presented its "Farm-to-Fork" strategy, which is part of the "European Green Deal". The aim is to make European agriculture and its food system more sustainable. In particular, the proportion of organic farming in the EU's total agricultural land is to be increased to 25 percent by 2030. However, if current EU legislation remains in place, this increase will by no means guarantee more sustainability, as the current study by scientists from Bayreuth, Göttingen, ...

Meaningful legislation addressing health care inequities in the U.S. will require studies examining potential health disparities due to geographic location or economic status. An interdisciplinary team at the Medical University of South Carolina (MUSC) and the University of South Carolina (UofSC) report in the Journal of Public Health Dentistry that rural children are less likely to receive preventive dental care than urban children. Using samples from 20,842 respondents from a 2017 National Survey of Children's Health, the team determined the existence of an urban-rural disparity in U.S. children's oral health. ...

After pouring beer into a glass, streams of little bubbles appear and start to rise, forming a foamy head. As the bubbles burst, the released carbon dioxide gas imparts the beverage's desirable tang. But just how many bubbles are in that drink? By examining various factors, researchers reporting in ACS Omega estimate between 200,000 and nearly 2 million of these tiny spheres can form in a gently poured lager. Worldwide, beer is one of the most popular alcoholic beverages. Lightly flavored lagers, which are especially well-liked, are produced through a cool fermentation process, converting the sugars in malted grains to alcohol and carbon dioxide. During commercial packaging, more carbonation can be added to get a desired level of fizziness. That's ...

(Boston)--A major obstacle in understanding and treating posttraumatic stress disorder (PTSD) is its clinical and neurobiological heterogeneity. In order to better treat the condition and address this barrier, the field has become increasingly interested in identifying subtypes of PTSD based on dysfunction in neural networks alongside cognitive impairments that may underlie the development and maintenance of symptoms. VA and BU researchers have now found a marker of PTSD in brain regions associated with emotional regulation. "This marker was strongest in those with clinically impaired executive function or the ability to engage in complex ...

Careful criminals usually clean a scene, wiping away visible blood and fingerprints. However, prints made with trace amounts of blood, invisible to the naked eye, could remain. Dyes can detect these hidden prints, but the dyes don't work well on certain surfaces. Now, researchers reporting in ACS Applied Materials & Interfaces have developed a fluorescent polymer that binds to blood in a fingerprint -- without damaging any DNA also on the surface -- to create high-contrast images. Fingerprints are critical pieces of forensic evidence because their whorls, loops and arches are unique to each person, and these patterns don't change as people age. When violent crimes are committed, a culprit's fingerprints inked in ...

Water touches virtually every aspect of human society, and all life on earth requires it. Yet, fresh, clean water is becoming increasingly scarce -- one in eight people on the planet lack access to clean water. Drivers of freshwater salt pollution such as de-icers on roads and parking lots, water softeners, and wastewater and industrial discharges further threaten freshwater ecosystem health and human water security. "Inland freshwater salt pollution is rising nationwide and worldwide, and we investigated the potential conflict between managing freshwater salt ...

Screening for a sometimes fatal condition among patients with a rare autoimmune disease could soon - thanks to a computer algorithm - become even more accurate. Researchers at Michigan Medicine found that an internet application improved their ability to spot pulmonary arterial hypertension in patients with systemic sclerosis, or scleroderma. The unpredictable condition is marked by tightening of the skin that can damage internal organs. The algorithm, aptly named DETECT, outperformed standard methods used to identify the form of high blood pressure in the lungs that causes the heart to weaken and fail. "We've been advocating for a long time that every scleroderma patient should be screened on an annual basis using DETECT, and ...

BETHESDA, Md. -- The COVID-19 pandemic heavily influenced spending on prescription drugs in the U.S. in 2020, according to the ASHP's (American Society of Health-System Pharmacists) National Trends in Prescription Drug Expenditures and Projections for 2021. Shifts in care related to the pandemic will continue to be a significant driver of drug expenditures in 2021, along with uptake in the use of biosimilars, a large pipeline of new cancer drugs, and increased approvals of specialty medications. Prescription drug spending in 2020 grew at a moderate rate of 4.9% to $535.3 billion. Increased utilization drove the ...