A new study from University of Alberta researchers has shown that traumatic or stressful events in childhood may lead to tiny changes in key brain structures that can now be identified decades later. The study is the first to show that trauma or maltreatment during a child's early years--a well-known risk factor for developing mental health conditions such as major depressive disorder in adulthood--triggers changes in specific subregions of the amygdala and the hippocampus. Once these changes occur, researchers believe the affected regions of the brain may not function as well, potentially increasing the risk of developing mental health disorders as adults during times of stress. "Now ...

CORVALLIS, Ore. - Marching band members in leadership roles are more likely to feel discomfort in the neck and upper back than their less experienced bandmates, who in turn are more susceptible to left-hand pain and cognitive strain, a new study by Oregon State University suggests. The findings also showed that gender had no bearing on how much discomfort a musician felt or the band member's perception of workload. "The study really seems to indicate that a player's level of experience and role within the band are what drive how much discomfort they feel," said industrial ...

Neurons are the primary cells of the nervous system, and the signals that are transmitted between them are responsible for all our actions and our cognitive ability. In particular, learning and memory are believed to be associated with a process called "long-term potentiation," which is the strengthening of connections between specific neurons via continued signal transmission through "synapses" (small gaps between neurons). Long-term potentiation can change the connection between neurons via synapses--by changing their size and composition. Understanding ...

Researchers report that large-scale commercial farms on deforested land in the southern Amazon result in higher temperature increases and less rainfall than small-scale farms. Deforestation has converted swaths of land in the southern Amazon region from rainforest to farmland. The uses of the deforested land are diverse, and activities can range from small-scale farming in rural settlements to large-scale commodity agriculture. Commercial farms in the Southern Amazon can reach hundreds of thousands of hectares in area, exporting millions of tons in grains and beef every year. Eduardo Maeda from the University of Helsinki and colleagues used satellite data to compare areas dominated by different land uses and farm sizes to evaluate their impacts on ...

Li-ion batteries (LIBs) are widely used in various mobile electronics. Concerns of global warming and climate change have recently boosted the demand for LIBs in electric vehicles and solar photovoltaic output smoothing. Si has been studied as an active material with a high theoretical capacity of 3578 mAh/g, which is around ten times higher than that of graphite (372 mAh/g). Now, a team of researchers at Osaka University has used flake-shaped Si nanopowder wrapped by ultrathin graphite sheets (GSs) to fabricate LIB electrodes with high areal capacity and current density. Generally ...

Rivers and lakes at high latitudes are considered to be major sources for greenhouse gas emissions to the atmosphere, but these losses are poorly constrained. In a study published in Nature Communications, Umeå University researchers and collaborators quantify carbon emissions from rivers and lakes across Western Siberia, finding that emission are high and exceed carbon export to the Arctic Ocean. High latitude regions play a key role in the global carbon cycle and climate system. An important question is the degree of mobilization and atmospheric release of vast soil carbon stocks, partly stored in permafrost, with amplified warming of these regions. A fraction of this carbon is exported to inland waters and emitted to the atmosphere, yet these ...

Cryopreservation involves preserving biological materials, such as cells, tissues, and organs, at ultra-low temperatures so that they can be revived and used at a later date. To achieve cryopreservation such that the preserved materials are not damaged, scientists use various chemicals called cryoprotectants, which facilitate the freezing process. Unfortunately, many of the existing cryoprotective agents have major limitations. For example, dimethyl sulfoxide is useful for cryopreserving red blood cells, but it is also toxic to the cells. To overcome these limitations, researchers at the Japan Advanced Institute of Science and Technology (JAIST) and Japan's RIKEN have experimented with a class of chemicals known as polyampholytes, identifying one ...

In research on solar energy and climatology, "clear sky" or "cloudless" conditions are very important. For instance, the number of clear-sky days (number of days having an average cloud cover less than 10%) is a key parameter of solar resource assessments. The instantaneous surface irradiance is highly affected by cloud variations, based on which clear-sky detection (CSD) methods can be developed. However, a general tendency in common among all CSD methods is the detection accuracy deteriorates when aerosol loading increases. "The lack of accurate clear-sky detection data makes it difficult to assess existing clear-sky detection methods in polluted areas," explains Liu Mengqi, a PhD student from the group of Prof. Xiang'ao Xia at the Institute of Atmospheric Physics, Chinese ...

Researchers at the Garvan Institute of Medical Research have developed a computational model to calculate 'skeletal age', a personalised estimate of an individual's risk of bone fracture and premature death. The skeletal age calculator, which will be accessible to doctors and health professionals, aims to better identify those at risk of a first bone fracture and subsequent fractures, and also estimates how fractures impact life expectancy. Osteoporosis, a disease which reduces bone strength and increases bone fracture risk, is a major national health issue and estimated to affect over 900,000 Australians. ...

Research groups at University of Helsinki and Institut Jacques Monod, Paris, discovered a new molecular mechanism that promotes cell migration. The discovery sheds light on the mechanisms that drive uncontrolled movement of cancer cells, and also revises the 'text book view' of cell migration. The ability of cells to move within our bodies is critical in wound healing, as well as for immune cells to patrol in our tissues to hunt bacterial and viral pathogens. On the flip-side, uncontrolled movement of cells is a hallmark of cancer invasion and metastasis. The machinery that drives cell migration is a complex network of dynamic filaments composed of a protein actin. Actin exists in monomeric form, but ...

Glaciers are not only melting, but also collapsing in the Third Pole region. In 2016, two glaciers in the western Third Pole's Aru Mountains collapsed, one after another. The first collapse caused nine human casualties and the loss of hundreds of livestock. However, that may not be the end of the catastrophe. According to a study recently published in The Cryosphere, meltwater from ice avalanches has been filling downstream lakes in a way that may cause previously separated lakes to merge within the next decade, thus disrupting the function of ecosystems in the region. "The collapse of Aru glaciers has both short-term and long-term impacts on downstream lakes," said Dr. LEI Yanbin, lead author of the study and a researcher at the Institute of Tibetan Plateau Research ...

Science always strives to replace complex natural objects and phenomena with simpler models. Scientists of Samara Center for Theoretical Materials Science (SCTMS) of Samara Polytech have developed methods to simplify the crystal structure of a substance to obtain chemically important knowledge. The main approaches are described in the article published in the Structural Chemistry journal IF 2.081 (doi:10.1007/s11224-020-01724-4). "The main goal of simplifying any crystal structure is to understand the features of its structure and properties, and the simplification ...

The BioRescue research project, a programme aiming at saving the northern white rhinoceros from extinction, exemplifies the challenges to overcome when conducting research and conservation in an international consortium in times of a global pandemic. COVID-19 hampered communication and travels, prevented or delayed crucial procedures, caused losses in revenues and by that may have lowered the chances of a survival of the northern white rhino. The consortium adjusted strategies, gained valuable knowledge during these challenging times and continued with its mission. The effects of the pandemic on the BioRescue project are described in detail in a scientific paper published in the Journal ...

Adult progenitor cells are present in the Drosophila fly as early as its larvae stage. These cells are the only ones that are maintained throughout development and they are responsible for giving rise to adult tissues and organs. Headed by Jordi Casanova (also an IBMB-CSIC researcher), the Development and Morphogenesis in Drosophila lab at IRB Barcelona has identified the headcase (hdc) gene as responsible for the unique characteristics of these adult progenitor cells. "In our study, mainly using the powerful genetic tools available in Drosophila, we were able to show that this gene regulates the development ...

Scientists studying forest dwelling butterflies in Central and South America have discovered that changes in the way animals perceive and process information from their environment can support the emergence of new species. The study led by the University of Bristol, and published today [9 February] in the Proceedings of the National Academy of Sciences (PNAS), has implications for how new species might evolve and the underappreciated role of changes in the brain. The international team, led by Dr Stephen Montgomery from the School of Biological Sciences at the University of Bristol, compared ...

BOSTON -- Hospitals across the United States have gone to great lengths to implement infection control measures to prevent transmission of SARS-CoV-2. And yet, as the pandemic has unfolded, many health care settings have experienced clusters of cases, with the virus spreading among patients, staff or both. Some clusters have been easily traced back to break rooms and shared meals. But other clusters have been challenging to trace and contain. In September 2020, Brigham and Women's Hospital detected a cluster of infections that would ultimately include 14 patients and 38 staff members. The hospital rapidly activated its incident command structure in order to coordinate a controlled response to contain the cluster. Steps taken included widespread ...

DES PLAINES, IL -- The combination of a high?dose NSAID with paracetamol does not increase the analgesic effect compared to paracetamol alone. Researchers also found that paracetamol alone is superior to high?dose NSAID alone for posttraumatic extremity pain. These are the findings of a study titled Acetaminophen, or nonsteroidal anti-inflammatory drugs, or combination of both analgesics in acute post-trauma pain: a randomized controlled trial, to be published in the February 2021 issue of Academic Emergency Medicine (AEM), a journal of the Society for Academic Emergency Medicine (SAEM). According to the study, taking into account its superior efficacy ...

Today, the average American is unlikely to spend time worrying about malaria. Although the disease is commonly perceived to be restricted to other parts of the world, it played a significant role in shaping American history. It even helped turn the tide of the American Revolutionary War by infecting so many British soldiers that General Cornwallis was forced to surrender at Yorktown. First-year students in a 2019 introductory seminar class led by Erin Mordecai, an assistant professor of biology in the School of Humanities and Sciences (H&S), delved ...

Samara Polytech chemists investigated the potential anticarcinogenic effects of extracts obtained from plant materials of lingonberry, raspberry, black chokeberry, grapes, Krasnodar green tea, ginseng, fireweed and coffee, and also evaluated their effect on the growth and viability of colon cancer cells. The research was carried out within the framework of the state assignment for fundamental research No. 0778-2020-0005, its results were published Dec. 29, 2020 in the journal Proceedings of Universities. Applied Chemistry and Biotechnology (DOI: https://doi.org/10.21285/2227-2925-2020-10-4-613-626). Prevention is the most cost-effective and long-term strategy for controlling this disease. It is now well known ...

A lot of our medicines and other bioactive drugs are based on chemical structures called "enantiomers"-- molecules that are mirror images of each other and are non-superimposable. Notable among them are chiral N,N-acetals contained in diuretic drugs like bendroflumethiazide and thiabutazide, used to treat high blood pressure and edema. Because an enantiomer and its mirror image version often have different biological activities, with only one of them having pharmacological utility, an "enantioselective" or asymmetric synthesis yielding the desired enantiomer in greater amounts is highly desirable. In the case of N,N-acetals, several studies have demonstrated their enantioselective preparation from aldehydes, aldimines, or enamines. However, in all these cases, ...

CLEVELAND (Feb. 9)--A study led by Case Western Reserve University researchers found that patients with dementia were at a significantly increased risk for COVID-19--and the risk was higher still for African Americans with dementia. Reviewing electronic health records of 61.9 million adults in the United States, researchers found the risk of contracting COVID-19 was twice as high for patients with dementia than for those without it--while among those with dementia, African Americans had close to three times the risk of being infected with COVID-19 as Caucasians did. In addition, patients with dementia who ...

KEY STUDY FINDINGS INCLUDE: 2.9% of U.S. adults report a current peanut allergy. About one in six adults with a peanut allergy developed it after age 18. Approximately one in five adults with peanut allergy report visiting the emergency department for food allergy treatment each year. Patients who developed their peanut allergy during adulthood are less likely to report having an epinephrine auto-injector prescription than those who developed their peanut allergy during childhood, despite similar frequencies of severe reactions among both groups. CHICAGO --- Peanut allergy affects at least 4.5 million adults in the U.S., many of whom report developing their ...

Researchers at Baylor College of Medicine and other institutions have identified a novel strategy that can eliminate bacteria in a specific location before they cause an infection. The strategy uses a phage, a virus that infects and destroys bacteria, that can specifically locate in the same place the bacteria live in the gastrointestinal tract. The proximity between phage and bacteria facilitates the phage's attack and subsequent elimination of the bacteria. This strategy has the potential of becoming a game changer in the fight against antibiotic-resistant bacteria ...

DALLAS, Feb. 9, 2021 -- Participants in a two-year, lifestyle intervention/weight-loss program provided through health coaches at their primary care center were able to lower their blood sugar and improve their cholesterol levels, according to new research published today in the American Heart Association's flagship journal Circulation Journal. Researchers with the PROmoting Successful Weight Loss in Primary CarE in Louisiana (PROPEL) Trial reported previously that participants also reduced body weight by an average of 5% and note that patients who lost more weight experienced greater improvements in their heart disease risk factors. "Our results demonstrate lifestyle intervention and weight-loss programs can be successful for people in underserved, low-income ...

DALLAS, Feb. 9, 2021 -- Dietary information from three large, well-known heart disease studies suggests drinking one or more cups of caffeinated coffee may reduce heart failure risk, according to research published today in Circulation: Heart Failure, an American Heart Association journal. Coronary artery disease, heart failure and stroke are among the top causes of death from heart disease in the U.S. "While smoking, age and high blood pressure are among the most well-known heart disease risk factors, unidentified risk factors for heart disease remain," according to David P. Kao, M.D., senior author of the study, assistant professor of cardiology and medical director at the Colorado Center for Personalized Medicine at the University of Colorado School of Medicine ...