A University of Arizona Health Sciences study has estimated total lifetime costs at $736 million for the 10,359 valley fever patients diagnosed in Arizona in 2019, underscoring the economic burden the disease places on the state and its residents. The prevalence of valley fever, formally known as coccidioidomycosis or cocci, has increased in recent years, from 5,624 cases diagnosed in Arizona in 2014 to 10,359 cases in 2019. There currently are no certain means of prevention or vaccination for the fungal disease, which is caused by spores of Coccidioides, a family of fungi found in soils of the Southwest. The findings highlight the need ...

Feb. 10, 2021 - A new paper published online in the Annals of the American Thoracic Society describes a "virtual" recovery program for sepsis patients that may also help post-COVID-19 patients and survivors of other serious illnesses. In " END ...

Scientists from Nanjing University and the University of Macau have devised a new approach to extend the survival of transplanted probiotics in vivo, enhancing the efficacy of cancer chemo-/immunotherapies in mice. The paper entitled "Smectite promotes probiotic biofilm formation in the gut for cancer immunotherapy" appears online today in Cell Reports. The gut contains trillions of symbiotic bacteria. Disturbing the balance of intestinal flora may increase the occurrence of major diseases, including cancers. The gut microbiome plays an essential role in regulating the host immunity, which has inspired strategies to modulate intestinal microorganisms ...

Nagoya University scientists have developed a chemical reaction that produces high yields of a compound used in a wide variety of industries, without needing high temperatures or toxic catalysts. The approach was described in the journal ACS Catalysis and offers a practical and sustainable solution for industrial (meth)acrylate (= acrylate or methacrylate) ester synthesis. (Meth)acrylate esters are used in industrial coatings and masonry, and to make plastics, dyes and adhesives. But the chemical process for making them from methyl (meth)acrylates ...

As families settle back into a new school year, sleep experts at the University of South Australia are reminding parents about the importance of teenagers getting enough sleep, cautioning them that insufficient sleep can negatively affect their mental health. In a new research paper, UniSA sleep experts Dr Alex Agostini and Dr Stephanie Centofanti confirm that sleep is intrinsically linked to mental health, but is commonly overlooked by health practitioners as a contributing factor. Dr Agostini says it's imperative that parents and medical practitioners ...

For all their importance as a breakthrough treatment, the cancer immunotherapies known as checkpoint inhibitors still only benefit a small minority of patients, perhaps 15 percent across different types of cancer. Moreover, doctors cannot accurately predict which of their patients will respond. A new study finds that inherited genetic variation plays a role in who is likely to benefit from checkpoint inhibitors, which release the immune system's brakes so it can attack cancer. The study also points to potential new targets that could help even more patients unleash their immune system's natural power to fight ...

DALLAS, Feb. 10, 2021 — Reducing the prevalence of obesity may prevent up to half of new Type 2 diabetes cases in the United States, according to new research published today in the Journal of the American Heart Association, an open access journal of the American Heart Association. Obesity is a major contributor to diabetes, and the new study suggests more tailored efforts are needed to reduce the incidence of obesity-related diabetes. Type 2 diabetes is the most common form of diabetes, affecting more than 31 million Americans, according to the U.S. Centers ...

Researchers at Uppsala University and the Swedish University of Agricultural Sciences have used new methods for DNA sequencing and annotation to build a new, and more complete, dog reference genome. This tool will serve as the foundation for a new era of research, helping scientists to better understand the link between DNA and disease, in dogs and in their human friends. The research is presented in the journal Communications Biology. The dog has been aiding our understanding of the human genome since both genomes were released in the early 2000s. At that time, a comparison of both genomes, and two others, revealed that the human genome contained circa 20,000 genes, down ...

Increased level of plasma cells linked to improved cancer survival 1,300 prostate tumor samples studied Immunotherapy-based precision medicine clinical trials being developed CHICAGO--- Black men die more often of prostate cancer yet, paradoxically, have greater survival benefits from immunotherapy treatment. A new Northwestern Medicine study discovered the reason appears to be an increase of a surprising type of immune cell in the tumor. The findings could lead to immune-based precision medicine treatment for men of all races with localized aggressive and advanced prostate cancer. In the new study, Northwestern scientists showed tumors from Black men and men ...

CHAMPAIGN, Ill. -- When modified using a process known as epoxidation, two naturally occurring lipids are converted into potent agents that target multiple cannabinoid receptors in neurons, interrupting pathways that promote pain and inflammation, researchers report. These modified compounds, called epo-NA5HT and epo-NADA, have much more powerful effects than the molecules from which they are derived, which also regulate pain and inflammation. Reported in the journal Nature Communications, the study opens a new avenue of research in the effort to find alternatives to potentially addictive opioid pain killers, researchers say. The ...

Tokyo, Japan - Researchers from Institute of Industrial Science at The University of Tokyo investigated the mechanism of phase separation into the two phases with very different particle mobilities using computer simulations. They found that slow dynamics of complex connected networks control the rate of demixing, which can assist in the design of new functional porous materials, like lithium-ion batteries. According to the old adage, oil and water don't mix. If you try to do it anyway, you will see the fascinating process of phase separation, in which the two immiscible liquids spontaneously "demix." In this case, the minority phase always forms droplets. Contrary to this, the researchers ...

Osaka, Japan - Investigators from the Institute of Scientific and Industrial Research at Osaka University, together with Hiroshima Institute of Technology, have announced the discovery of a new protein that allows an organism to conduct an initial and essential step in converting amino acid residues on a crosslinked polypeptide into an enzyme cofactor. This research may lead to a better understanding of the biochemistry underlying catalysis in cells. Every living cell is constantly pulsing with an array of biochemical reactions. The rates of these reactions are controlled by special proteins called enzymes, which catalyze specific processes that would otherwise take much longer. A number of enzymes require specialized molecules called "cofactors," which can help shuttle electrons ...

As indicated by other studies, different parts of the brain are responsible for different types of decisions. A research team led by Luca Franziska Kaiser and Prof. Dr. Gerhard Jocham from the HHU working group 'Biological Psychology of Decision Making', and Dr. Theo Gruendler together with colleagues in Magdeburg analysed the balance of the messenger substances GABA and glutamate in two forms of decision-making. The background to the research was to find out how different concentrations of these substances influence the person making the decision. On the one hand, the researchers looked at 'reward-based decisions', which involve maximising reward by selecting the better of two ...

It is now possible to capture images of planets that could potentially sustain life around nearby stars, thanks to advances reported by an international team of astronomers in the journal Nature Communications. Using a newly developed system for mid-infrared exoplanet imaging, in combination with a very long observation time, the study's authors say they can now use ground-based telescopes to directly capture images of planets about three times the size of Earth within the habitable zones of nearby stars. Efforts to directly image exoplanets - planets outside our solar system - have been hamstrung by technological limitations, resulting in a bias toward the detection of easier-to-see planets that are much larger than Jupiter and are located around very young stars and far outside the ...

A study published in Nature Communications today (Wednesday 10 February) presents a compelling new evidence about what a key protein called alpha-synuclein actually does in neurons in the brain. Dr Giuliana Fusco, Research Fellow at St John's College, University of Cambridge, and lead author of the paper, said: "This study could unlock more information about this debilitating neurodegenerative disorder that can leave people unable to walk and talk. If we want to cure Parkinson's, first we need to understand the function of alpha-synuclein, a protein present in everyone's brains. ...

While deforestation levels have decreased significantly since the turn of the 21st century, the United Nations (UN) estimates that 10 million hectares of trees have been felled in each of the last five years. Aside from their vital role in absorbing CO2 from the air, forests play an integral part in maintaining the delicate ecosystems that cover our planet. Efforts are now underway across the world to rectify the mistakes of the past, with the UN Strategic Plan for Forests setting out the objective for an increase in global forest coverage by 3% by 2030. With time being of the essence, one of the most popular methods of reforestation in humid, tropical regions ...

Commuters now have yet another reason to avoid packing themselves into subway stations. New York City's transit system exposes riders to more inhaled pollutants than any other metropolitan subway system in the Northeastern United States, a new study finds. Yet even its "cleaner" neighbors struggle with enough toxins to give health-conscious travelers pause. Led by NYU Grossman School of Medicine researchers, the study measured air quality samples in 71 stations at morning and evening rush hours in Boston, New York City, Philadelphia, and Washington, D.C. ...

A treatment, known as KEDRAB (Rabies Immune Globulin [Human]), currently used in the prevention of rabies has been demonstrated to be safe and effective for patients age 17 and under. Results published today in Human Vaccines & Immunotherapeutics report the first and only pediatric trial of any human rabies immunoglobulin (HRIG) currently available in the US. Findings have been submitted to the US Food and Drug Administration for review. In the United States, someone is treated for possible exposure to rabies every 10 minutes. Globally, the World ...

A new paper in Oxford Open Immunology, published by Oxford University Press, examines prior findings in the field of neuroimmunology that suggest potential treatment strategies for patients suffering long-term symptoms from COVID-19. Though COVID-19 was initially believed to be a short-term illness, lasting between one and three weeks, it's clear that a substantial number of patients will experience symptoms beyond that, with some patients suffering from health problems for more 12 weeks. In fact, for patients who were initially hospitalized, more than 80% reported at least one symptom that persisted beyond the first month. The symptoms of long-COVID can vary widely, ...

Yams are a staple food in West Africa, which produces over 90% of the world's yams each year. Yams play a key role in the food security, economic income, and traditional culture for the region. While they are commonly assumed to be the same as sweet potatoes in the U.S., yams are a completely different plant. The yam tubers are much starchier and drier compared to sweet potatoes. Yams are native to Africa and Asia, and most Americans have never had a true yam. Even though yam is a staple crop for West Africa, there has been limited research to improve the genetic diversity or productivity. Researcher Shinsuke Yamanaka focuses on improving crop breeding resources for ...

Tungsten hexanitride with armchairlike hexazine N6 ring has been synthesized by a group of scientists led by Dr. Jin Liu and his former postdoc Nilesh Salke at HPSTAR (Center for High Pressure Science & Technology Advanced Research). WN6 is a promising high-energy-density and superhard material. Their findings are published in the recent issue of Physical Review Letters. Diatomic nitrogen is the most abundant molecule in Earth's atmosphere accounting for almost 78% volume. The strong triple bond in nitrogen makes it very stable and unreactive at near ambient conditions. However, in the intense-pressure and high-temperature conditions, nitrogen will behave entirely differently, it can form double- or even single-bonded structure or react with other elements ...

As abundant and widespread bees, it is common to see both bumble bees and honey bees foraging on the same flower species during the summer, whether in Britain or many other countries. Yet researchers at the Laboratory of Apiculture and Social Insects (LASI) at the University of Sussex, have found that different bees dominate particular flower species and revealed why. By studying 22 flower species in southern England and analysing the behaviour of more than 1000 bees, they found that 'energy efficiency' is a key factor when it comes to mediating competition. Bee bodyweight and the rate at which a bee visits flowers determine how energy efficient they are. Bodyweight determines the energy used while flying and walking between flowers, with a bee ...

Space cooling already accounts for 14% of residential electricity demand in Brazil, and it is expected to increase further because of climate change. Very few studies investigate the relationship between climate change, cooling needs, and electricity demand. In a new study in Energy and Buildings, a team of researchers from Universidade Federal do Rio de Janeiro and CMCC@Ca'Foscari - a joint program of Ca'Foscari University of Venice and CMCC Foundation - investigate how climate and income during the period 1970-2010 shaped cooling services in Brazil. This historical relationship allows projecting the resulting energy demand for cooling services across three warming scenarios: +1.5°C, +2°C, +4°C. The study shows ...

WEST LAFAYETTE, Ind. - Emerging robotics technology may soon help construction companies and contractors create buildings in less time at higher quality and at lower costs. Purdue University innovators developed and are testing a novel construction robotic system that uses an innovative mechanical design with advances in computer vision sensing technology to work in a construction setting. The technology was developed with support from the National Science Foundation. "Our work helps to address workforce shortages in the construction industry by automating key construction operations," said Jiansong Zhang, an assistant professor of construction ...

The findings add to current knowledge of how insects fly and keep stable in the air. They could also help to inspire new designs in small aerial vehicles like drones, which can be useful for search-and-rescue attempts and building inspection. Our colourful sunny-day companions can glide, fly backwards, and travel up to 54 km/h when hunting prey or escaping predators - but like any flying creature, they can be thrown off balance and even find themselves upside down. Many land-based animals like cats, and aerial animals like hoverflies, rotate themselves around a head-to-tail ...