KANSAS CITY, MO--What if the degenerative eye conditions that lead to glaucoma, corneal dystrophy, and cataracts could be detected and treated before vision is impaired? Recent findings from the lab of Investigator Ting Xie, PhD, at the Stowers Institute for Medical Research point to the ciliary body as a key to unlocking this possibility. Previous work from the lab showed that when mouse stem cells were differentiated into light-sensing photoreceptor cells in vitro, and then transplanted back into mice with a degenerative condition of the retina, they could partially restore vision. However, the transplanted photoreceptors only lasted three to four months. "You cannot cure the condition in a diseased eye if you don't know what ...

Scientists in China and Sweden have determined that a pinch of capsaicin, the chemical compound that gives chili peppers their spicy sting, may be a secret ingredient for more stable and efficient perovskite solar cells. The research, published January 13 in the journal Joule, determined that sprinkling capsaicin into the precursor of methylammonium lead triiodide (MAPbI3) perovskite during the manufacturing process led to a greater abundance of electrons (instead of empty placeholders) to conduct current at the semiconductor's surface. The addition resulted in polycrystalline MAPbI3 solar cells with the most efficient charge transport to date. "In the future, green and sustainable forest-based biomaterial ...

NEW YORK, January 13, 2021 -- Many animal and insect species use Batesian mimicry -- mimicking a poisonous species -- as a defense against predators. The common palmfly Elymnias hypermnestra -- a species of satyrine butterfly that is found throughout wide areas of tropical and subtropical Asia -- adds a twist to this evolutionary strategy. The females evolved two distinct forms, either orange or dark brown, imitating two separate poisonous model species, Danaus or Euploea. The males are uniformly brown. A population group is either entirely brown (both males and females) or mixed (brown males and orange females). David Lohman, ...

The iconic, prehistoric dire wolf, which prowled through Los Angeles and elsewhere in the Americas over 11 millennia ago, was a distinct species from the slightly smaller gray wolf, an international team of scientists reports today in the journal Nature. The study, which puts to bed a mystery that biologists have pondered for more than 100 years, was led by researchers from UCLA, along with colleagues from Durham University in the U.K., Australia's Adelaide University and Germany's Ludwig Maximilian University. "The terrifying dire wolf, a legendary symbol of Los Angeles and the La Brea Tar Pits, has earned its place among the many large, unique species that went extinct at the end of the Pleistocene ...

Mutations that occur in certain DNA regions, called tandem repeats, may play a significant role in autism spectrum disorders, according to research led by Melissa Gymrek, assistant professor in the UC San Diego Department of Computer Science and Engineering and School of Medicine. The study, which was published in Nature on Jan. 14, was co-authored by UCLA professor of human genetics Kirk Lohmueller and highlights the contributions these understudied mutations can make to disease. "Few researchers really study these repetitive regions because they're generally non-coding--they do not make proteins; their function is ...

Extinct dire wolves split off from other wolves nearly six million years ago and were only a distant relative of today's wolves, according to new research published in Nature today (13 January). Dire wolves, made famous in the TV show Game of Thrones, were common across North America until around 13,000 years ago, after which they went extinct. The study shows that dire wolves were so different from other canine species like coyotes and grey wolves that they were not able to breed with each other. Previous analyses, based on morphology alone, had led scientists to believe that dire wolves were closely related to grey wolves. The research was led by Durham University in the UK alongside scientists at the University of Oxford, Ludwig Maximilian University in ...

New York, NY--January 13, 2021--Researchers at Columbia Engineering report today that they have developed the first nanomaterial that demonstrates "photon avalanching," a process that is unrivaled in its combination of extreme nonlinear optical behavior and efficiency. The realization of photon avalanching in nanoparticle form opens up a host of sought-after applications, from real-time super-resolution optical microscopy, precise temperature and environmental sensing, and infrared light detection, to optical analog-to-digital conversion and quantum sensing. "Nobody has seen avalanching behavior like this in nanomaterials before," said James Schuck, associate professor of mechanical engineering, who led the study published today by Nature. "We ...

Even computers can miscalculate. Already small disturbances change stored information and corrupt results. That is why computers use methods to continuously correct such errors. In quantum computers, the vulnerability to errors can be reduced by storing quantum information in more than a single quantum particle. These logical quantum bits are less sensitive to errors. In recent years, theorists have developed many different error correction codes and optimized them for different tasks. "The most promising codes in quantum error correction are those defined on a two-dimensional lattice," ...

A new study by researchers at the University of Chicago and the City College of New York (CCNY) has identified a unique, genetic "mimicry switch" that determines whether or not male and female Elymnias hypermnestra palmflies mimic the same or different species of butterflies. The results indicate that sexual dimorphism has repeatedly emerged in different palmfly populations, and linked the trait to a gene associated with melanin localization and regulation. Published on Jan. 13 in the journal END ...

Red and green algae that grow on snow in the Antarctic Peninsula (AP) cause significant extra snowmelt on par with melt from dust on snow in the Rocky Mountains, according to a first-of-its-kind scientific research study led by Alia Khan, affiliate research scientist at the National Snow and Ice Data Center (NSIDC) and assistant professor at Western Washington University. Algal blooms are likely to increase in Antarctica as the planet continues to warm, which will further exacerbate seasonal snowmelt and contribute to the expansion of ice-free areas in the AP region. This could have serious impacts on regional climate, snow and ice melt, freshwater availability and ecosystems, yet is not accounted for in current global climate models. Results of the research were published on ...

Scientists claim to have found the 'missing link' in the process that leads to an ice age on Earth. Melting icebergs in the Antarctic are the key, say the team from Cardiff University, triggering a series of chain reactions that plunges Earth into a prolonged period of cold temperatures. The findings have been published today in Nature from an international consortium of scientists from universities around the world. It has long been known that ice age cycles are paced by periodic changes to Earth's orbit of the sun, which subsequently changes the amount of solar radiation that reaches the Earth's surface. However, ...

KU Leuven researchers have identified the biological mechanism that explains why some people experience abdominal pain when they eat certain foods. The finding paves the way for more efficient treatment of irritable bowel syndrome and other food intolerances. The study, carried out in mice and humans, was published in Nature. Up to 20% of the world's population suffers from the irritable bowel syndrome (IBS), which causes stomach pain or severe discomfort after eating. This affects their quality of life. Gluten-free and other diets can provide some relief, but why this works is a mystery, since the patients are not allergic to the foods in question, nor do they ...

Researchers have shown that the link between physical and mental illness is closer than previously thought. Certain changes in physical health, which are detectable in childhood, are linked with the development of mental illness in adulthood. The researchers, led by the University of Cambridge, used a sample of over 10,000 people to study how insulin levels and body mass index (BMI) in childhood may be linked with depression and psychosis in young adulthood. They found that persistently high insulin levels from mid-childhood were linked with a higher chance of developing psychosis in adulthood. In addition, they found that an increase in BMI around the onset of puberty, was linked with a higher chance of developing depression in adulthood, ...

Since the earliest microscopes, scientists have been on a quest to build instruments with finer and finer resolution to image a cell's proteins - the tiny machines that keep cells, and us, running. But to succeed, they need to overcome the diffraction limit, a fundamental property of light that long prevented optical microscopes from bringing into focus anything smaller than half the wavelength of visible light (around 200 nanometers or billionths of a meter) - far too big to explore many of the inner-workings of a cell. For over a century, scientists have experimented with different approaches - from intensive calculations to special lasers and microscopes - to resolve cellular features at ever smaller scales. And ...

TORONTO, Jan. 13, 2021 - Close to 5,700 lakes in the Northern Hemisphere may permanently lose ice cover this century, 179 of them in the next decade, at current greenhouse gas emissions, despite a possible polar vortex this year, researchers at York University have found. Those lakes include large bays in some of the deepest of the Great Lakes, such as Lake Superior and Lake Michigan, which could permanently become ice free by 2055 if nothing is done to curb greenhouse gas emissions or by 2085 with moderate changes. Many of these lakes that are ...

SILVER SPRING, Md.--A new study confirms that treatment with Bimagrumab, an antibody that blocks activin type II receptors and stimulates skeletal muscle growth, is safe and effective for treating excess adiposity and metabolic disturbances of adult patients with obesity and type 2 diabetes. "These exciting results suggest that there may be a novel mechanism for achieving weight loss with a profound loss of body fat and an increase in lean mass, along with other metabolic benefits," said Steve Heymsfield, MD, FTOS, past president of The Obesity Society and corresponding author of the study. Heymsfield is professor and director of the Metabolism and Body Composition Laboratory at the Pennington Biomedical Research Center in Baton Rouge, La. A ...

LAWRENCE -- Parents around the world have long told us that breakfast is the most important meal of the day. Soon, basketball coaches may join them. Researchers at the University of Kansas have published a study showing that eating breakfast can improve a basketball player's shooting performance, sometimes by significant margins. The study, along with one showing that lower body strength and power can predict professional basketball potential, is part of a larger body of work to better understand the science of what makes an elite athlete. Breakfast and better basketball shooting Dimitrije Cabarkapa left his native Novi Sad, Serbia, to play basketball at James Madison University. Never a fan of 6 a.m. workouts, he was discussing ...

A team of researchers led by the University of California, Berkeley and the University of Michigan has discovered an antibody that blocks the spread within the body of the dengue virus, a mosquito-borne pathogen that infects between 50 and 100 million people a year. The virus causes what is known as dengue fever, symptoms of which include fever, vomiting and muscle aches, and can lead to more serious illnesses, and even death. "Protein structures determined at the APS have played a critical role in the development of drugs and vaccines for several diseases, and these new results are key to the development of a potentially effective treatment against flaviviruses." -- Bob Fischetti, group leader with Argonne's X-ray Sciences Division and life sciences ...

The fascinating compound eyes of insects consist of hundreds of individual eyes known as "facets". In the course of evolution, an enormous variety of eye sizes and shapes has emerged, often representing adaptations to different environmental conditions. Scientists, led by an Emmy Noether research group at the University of Göttingen, together with scientists from the Andalusian Centre for Developmental Biology (CABD) in Seville, have now shown that these differences can be caused by very different changes in the genome of fruit flies. The study was published ...

HOUSTON - (Jan. 13, 2021) - Pyrolyzed plastic ash is worthless, but perhaps not for long. Rice University scientists have turned their attention to Joule heating of the material, a byproduct of plastic recycling processes. A strong jolt of energy flashes it into graphene. The technique by the lab of Rice chemist James Tour produces turbostratic graphene flakes that can be directly added to other substances like films of polyvinyl alcohol (PVA) that better resist water in packaging and cement paste and concrete, dramatically increasing their compressive strength. ...

CHAMPAIGN, Ill. -- A dramatic decline in bees and other pollinating insects presents a threat to the global food supply, yet it's getting little attention in mainstream news. That's the conclusion of a study from researchers at the University of Illinois Urbana-Champaign, published this week in a special issue of the Proceedings of the National Academy of Sciences. The study was based on a search of nearly 25 million news items from six prominent U.S. and global news sources, among them The New York Times, The Washington Post and The Associated Press. The study found "vanishingly low levels of attention to pollinator population topics" over several decades, even compared with ...

Wetlands are the dominant natural source of atmospheric methane, a potent greenhouse gas which is second only to carbon dioxide in its importance to climate change. Anthropogenic climate change is expected to enhance methane emissions from wetlands, resulting in further warming. However, wetland methane feedbacks were not fully assessed in the Intergovernmental Panel on Climate Change (IPCC) Fifth Assessment Report, posing a challenge to meeting the global greenhouse gas mitigation goals set under the Paris Agreement. To understand how wetland methane cycling may evolve and drive climate feedbacks in the future, scientists are increasingly looking to Earth's past. "Ice core records indicate ...

People worldwide want their coffee to be both satisfying and reasonably priced. To meet these standards, roasters typically use a blend of two types of beans, arabica and robusta. But, some use more of the cheaper robusta than they acknowledge, as the bean composition is difficult to determine after roasting. Now, researchers reporting in ACS' Journal of Agricultural and Food Chemistry have developed a new way to assess exactly what's in that cup of joe. Coffee blends can have good quality and flavor. However, arabica beans are more desirable than other types, resulting in a higher market value for blends containing a higher proportion of this variety. In some cases, producers dilute their blends with the less expensive robusta beans, yet that is hard for consumers ...

DURHAM, N.C. -- Biomedical engineers at Duke University have devised an algorithm to remove contaminated microbial genetic information from The Cancer Genome Atlas (TCGA). With a clearer picture of the microbiota living in various organs in both healthy and cancerous states, researchers will now be able to find new biomarkers of disease and better understand how numerous cancers affect the human body. In the first study using the newly decontaminated dataset, the researchers have already discovered that normal and cancerous organ tissues have a slightly different microbiota composition, that bacteria from these diseased sites can enter the bloodstream, and that this bacterial information could help diagnose ...

Liver transplant priority in the U.S. goes to the sickest patients, which fails to consider other important factors, including how long patients are likely to survive post-transplant. Researchers with Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine are collaborating with faculty at the University of Pennsylvania to develop a risk score that more comprehensively prioritizes liver cancer patients for transplantation. Their paper documenting the development and validation of the LiTES-HCC score to predict post-transplant survival for hepatocellular carcinoma, or liver cancer, patients was published in the highly respected peer-reviewed Journal of Hepatology. The ...