Oak Brook, IL - The July edition of SLAS Discovery is a Special Edition featuring the cover article, "Development of a High-Throughput Screening Assay to Identify Inhibitors of the SARS-CoV-2 Guanine-N7-Methyltransferase Using RapidFire Mass Spectrometry" by Lesley-Anne Pearson, Charlotte J. Green, Ph.D., De Lin, Ph.D., Alain-Pierre Petit, Ph.D., David W. Gray, Ph.D., Victoria H. Cowling, Ph.D., and Euan A. F. Fordyce, Ph.D., (Drug Discovery Unit, School of Life Sciences, University of Dundee, Dundee, UK). In January 2021, a survey of immunologists, infectious-disease researchers and virologists found that 90% of respondents believe SARS-CoV-2 will become endemic, continuing to circulate in pockets of the global population for years to come. Even as vaccines are ...

Boulder, Colo., USA: GSA's dynamic online journal, Geosphere, posts articles online regularly. Locations and topics studied this month include the central Appalachian Mountains; fossil pollen in Colombia; the precision and accuracy of model analyses; the Bone Spring Formation, Permian Basin, west Texas; and the geochronology of modern river sediment in south-central Alaska. You can find these articles at https://geosphere.geoscienceworld.org/content/early/recent . Spatially variable syn- and post-Alleghanian exhumation of the central Appalachian Mountains from zircon (U-Th)/He thermochronology Luke C. Basler; Jaclyn S. Baughman; Michelle L. Fame; Peter J. Haproff Abstract: To assess spatial and temporal patterns of Phanerozoic orogenic burial and subsequent ...

Key Takeaways: Research reveals consumer demand declines when product packaging and marketing materials removed the claim, "Made in USA" and increase when the claim was featured. The impact on sales is insufficient to convince some companies to manufacture more products in the United States but enough to incentivize companies to make deceptive "Made in USA" claims. CATONSVILLE, MD, June 30, 2021 - Pick up any product in just about any store and you're likely to find information that indicates the country of origin of the product. The U.S. Federal Trade Commission (FTC) requires this for any imported product, but not for products made in the United States. When you see the words "Made in USA" on a product, it's purely for marketing purposes. So, does it work? According to a ...

LA JOLLA--(June 30, 2021) Scientists--and gardeners--have long known that plants grow taller and flower sooner when they are shaded by close-growing neighbors. Now, for the first time, researchers at the Salk Institute have shown the detailed inner workings of this process. The study, published June 17, 2021, in Nature Genetics, offers a new understanding of how gene activity directs plant growth, and how quickly plants respond to their environment--with shifting light conditions triggering molecular changes in as little as five minutes. The findings provide insights ...

When it comes to defense, the body relies on attack thanks to the lymphatic and immune systems. The immune system is like the body's own personal police force as it hunts down and eliminates pathogenic villains. "The body's immune system is very good at identifying cells that are acting strangely. These include cells that could develop into tumors or cancer in the future," says Federica Eduati from the department of Biomedical Engineering at TU/e. "Once detected, the immune system strikes and kills the cells." Stopping the attack But it's not always so straightforward as tumor cells can develop ways to hide themselves from the immune system. "Unfortunately, tumor cells can block the ...

Growing resistance to our go-to antibiotics is one of the biggest threats the world faces. As common bacteria like strep and salmonella become resistant to medications, what used to be easily treatable infections can now pose difficult medical challenges. New research from the University of Georgia shows that there may be more antimicrobial-resistant salmonella in our food animals than scientists previously thought. Using technology she developed, UGA researcher Nikki Shariat and Amy Siceloff, a first-year doctoral student in UGA's Department of Microbiology, found that traditional culturing methods used to test livestock for problematic bacteria often miss drug-resistant ...

Since the onset of the COVID-19 pandemic last year, medical experts have stressed the importance of having a plan in the event of a positive test result. Where should you self-isolate? Do you have personal protective equipment for family members? Who should you notify about your diagnosis? An overwhelming 96% of healthy, educated adults surveyed by University of Houston researchers in the early stages of the pandemic did not have a comprehensive plan in mind, while 62% didn't have a plan at all. "What that suggests is that it was difficult even for very high functioning people to digest and use all the complex information that was quickly emerging about ...

Following the first wave of SARS-CoV-2 infections in spring 2020, Europe experienced a resurgence of the virus starting late summer. Although it appears clear that travel had a significant impact on the circulation of the virus, it remains challenging to assess how it may have restructured and reignited the epidemic in the different European countries. In a new study published in the journal Nature this June 30th, 2021, Philippe Lemey - Rega Institute, KU Leuven, Simon Dellicour - SpELL, Spatial Epidemiology Lab, Université Libre de Bruxelles, and their collaborators, built a phylogeographic model to assess how newly introduced viral lineages, as opposed to ...

Levelling up access to finance so that poorer countries can afford the funds needed to switch to renewable energy could see regions like Africa reaching net zero emissions a decade earlier, according to a study led by UCL researchers. Access to finance (credit) is vital for the green energy transition needed to reduce global greenhouse gas emissions, as laid out in the Paris Agreement. But access to low-cost finance is uneven, with the cost of securing capital to help reach net zero differing substantially between regions. Modelling created for the study, Higher cost of finance exacerbates a climate investment trap in developing economies, published in Nature Communications, ...

HOUSTON - The University of Texas MD Anderson Cancer Center's Research Highlights provides a glimpse into recently published studies in basic, translational and clinical cancer research from MD Anderson experts. Current advances include expanded use of a targeted therapy for a new group of patients with leukemia, molecular studies yielding novel cancer therapeutic targets, insights into radiation therapy resistance and a community intervention to reduce cervical cancer rates. Using acalabrutinib as initial treatment for chronic lymphocytic leukemia Chronic lymphocytic leukemia (CLL) is a cancer that occurs in the blood, bone marrow, lymph nodes, liver and spleen. It is the most common leukemia in adults, and while there are treatments ...

Heart attack, medically known as myocardial infarction (MI), is a common heart condition. MI is caused by problems in blood supply to parts of the heart. In severe cases, MI could be accompanied by ruptures in the wall separating different parts of the heart, such as in the ventricular septum (a wall that separates the right ventricle that pumps deoxygenated blood to the lungs for oxygenation, from the left ventricle that pumps oxygenated blood to rest of the body). Not surprisingly, without appropriate surgical intervention, a VSR due to MI increases the chances of death. Current surgical techniques ...

Bioplastics -- biodegradable plastics made from biological substances rather than petroleum -- can be created in a more economical and environmentally friendly way from the byproducts of corn stubble, grasses and mesquite agricultural production, according to a new study by a Texas A&M AgriLife Research scientist. green tractor pulling a red cart through a field of bioenergy sorghum that is taller than the tractor A bioenergy sorghum crop is harvested near College Station. (Texas A&M AgriLife photo) This new approach involves a "plug-in" preconditioning process, a simple adjustment for biofuel refineries, said Joshua Yuan, Ph.D., AgriLife Research scientist, ...

Dinosaurs roamed the Earth more than 65 million years ago, and paleontologists and amateur fossil hunters are still unearthing traces of them today. The minerals in fossilized eggs and shell fragments provide snapshots into these creatures' early lives, as well as their fossilization processes. Now, researchers reporting in ACS Earth and Space Chemistry have analyzed the molecular makeup of fossilized dinosaur eggshells from Mexico, finding nine amino acids and evidence of ancient protein structures. Current research indicates that all dinosaurs laid eggs, though most haven't survived the test of time. And because whole eggs and shell fragments are very rare fossils, their mineral composition ...

Newly published research shows that a screening program in the University of Cincinnati Medical Center Emergency Department helped detect an outbreak of HIV among persons who inject drugs in Hamilton County, Ohio, from 2014-18. The study was published in PLOS ONE. The results of the study highlight UC contributions to public health surveillance as yet another reason why emergency departments should be screening for undiagnosed HIV infections, according to Michael Lyons, MD, associate professor in the Department of Emergency Medicine at the UC College of ...

Some people casually smoke cigarettes for a while and then stop without a problem, while others develop long-term, several packs-per-day habits. A complex mix of environmental, behavioral and genetic factors appear to raise this risk for nicotine dependence. Studies of groups of twins suggest that 40 to 70 percent of the risk factors are heritable. Until recently, however, studies have only explained about 1 percent of the observed variation in liability to nicotine dependence, using a genetic score based on how many cigarettes a person smokes per day. A new study led by psychologists ...

Using an experimental model to simulate the blood-brain barrier, scientists in Sweden reported in unprecedented detail how antioxidants protect the brain from inflammation caused by neurodegenerative diseases such as Alzheimer's and Parkinson's. The study, conducted as a proof of concept by brain model developers at KTH Royal Institute of Technology in Stockholm, showed in minute-by-minute detail how the blood-brain barrier reacts to high levels of inflammation after the administration of a next-generation derivative of the widely-used anti-inflammatory drug, NAC (N-acetylcysteine). The testing of NACA (N-Acetylcysteine Amide) for the first time with ...

A new way to target a mutant protein which can cause the deadliest of cancers in humans has been uncovered by scientists at the University of Leeds. The mutated form of the RAS protein has been referred to as the "Death Star" because of its ability to resist treatments and is found in 96% of pancreatic cancers and 54% of colorectal cancers. RAS is a protein important for health but in its mutated form it can be switched on for longer, leading to the growth of tumours. One drug has already been approved for treatment but it can only tackle a small subset of ...

In a study involving 34 women aged 50-70, researchers at the University of São Paulo (USP) in Brazil performed objective measurements of the impact on the subjects' health of the decrease in physical activity observed during the period of social distancing and isolation imposed by COVID-19. Tests conducted after the first 16 weeks of confinement pointed to a deterioration in their overall health, including loss of muscle strength and diminished aerobic capacity, as well as elevated levels of cholesterol and glycated hemoglobin, both of which are risk factors for metabolic disorders. The study was supported by São Paulo Research Foundation ...

When it comes to understanding and predicting trends in energy use, the internet is a tough nut to crack. So say energy researchers Eric Masanet, of UC Santa Barbara, and Jonathan Koomey, of Koomey Analytics. The two just published a peer-reviewed commentary in the journal Joule discussing the pitfalls that plague estimates of the internet's energy and carbon impacts. The paper describes how these errors can lead well-intentioned studies to predict massive energy growth in the information technology (IT) sector, which often doesn't materialize. "We're not saying the energy use of the internet isn't a ...

CHAMPAIGN, Ill. -- The chance of detecting the virus that causes COVID-19 increases with more frequent testing, no matter the type of test, a new study found. Both polymerase chain reaction and antigen tests, paired with rapid results reporting, can achieve 98% sensitivity if deployed at least every three days. "This study shows that frequent testing can be really effective at catching COVID-19 infections and potentially blocking transmission," said study leader Christopher Brooke, a virologist and professor of microbiology at the University of Illinois Urbana-Champaign. "There are many places where vaccination is not yet widespread. With the rise of variants, testing remains an important tool ...

QUT researchers have developed a new machine learning mathematical system that helps to identify and detect changes in biodiversity, including land clearing, when satellite imagery is obstructed by clouds. Using statistical methods to quantify uncertainty, the research, published in Remote Sensing in Ecology and Conservation, analysed available satellite images of an 180km square area in central south-east Queensland. The region is home to many native species including the critically endangered northern hairy-nosed wombat and the vulnerable greater glider, and the ...

Fossilized feces are common finds at paleontological dig sites and might actually contain hidden treasures. By scanning fossilized dung assigned to a close dinosaur relative from the Triassic period, scientists discovered a 230-million-year-old beetle species, representing a new family of beetles, previously unknown to science. The beetles were preserved in a 3D state with their legs and antennae fully intact. The finding appears June 30 in the journal Current Biology. The discovery that fossilized droppings, also known as coprolites, can preserve ancient insect species offers a new alternative to amber fossils--fossilized tree resin, which normally yield the best-preserved insect fossils. The oldest ...

Don't let the great snipe's pudginess fool you. A stocky marsh bird with a 20-inch wingspan, great snipes are also speedy marathoners that can migrate from Sweden to Central Africa in just three days, without even stopping to eat, drink, or sleep. Now, researchers find that the snipes also rise nearly 2,500 meters in elevation at dawn and descend again at dusk each day, perhaps to avoid overheating from daytime solar radiation by climbing to higher, cooler altitudes. The findings appear June 30 in the journal Current Biology. The birds also spent much more time in higher elevations ...

Election outcomes are notoriously difficult to predict. In 2016, for example, most polls suggested that Hillary Clinton would win the presidency, but Donald Trump defeated her. Researchers cite multiple explanations for the unreliability in election forecasts -- some voters are difficult to reach, and some may wish to remain hidden. Among those who do respond to surveys, some may change their minds after being polled, while others may be embarrassed or afraid to report their true intentions. In a new perspective piece for END ...

30 June 2021: A large cohort study drawn from the national IVF registry of France, which included almost 70,000 pregnancies delivered after 22 weeks gestation between 2013 and 2018, has found a higher risk of pre-eclampsia and hypertension in pregnancies derived from frozen-thawed embryos. This risk was found significantly greater in those treatments in which the uterus was prepared for implantation with hormone replacement therapies. The results confirm with real-life data what has been observed in sub-groups of patients in other studies. The results are presented today by Dr Sylvie Epelboin from the Hôpital Bichat-Claude Bernard, Paris, at the online annual meeting of ESHRE. The study was performed on behalf ...