Oncotarget recently published "Evaluation of cancer-derived myocardial impairments using a mouse model" which reported that Myocardial damage in cancer patients is emphasized as a cause of death; however, there are not many murine cachexia models to evaluate cancer-derived heart disorder. Using the mouse cachexia model that they established previously, the authors investigated myocardial damage in tumor-bearing mice. When rat cardiomyoblasts were treated with mouse cachexia model ascites and subjected to flux analysis, both oxidative phosphorylation and glycolysis were suppressed, and the cells were in a quiescent state. These results are in good agreement with those previously reported on cancerous myocardial damage. The established mouse cachexia ...

Amsterdam, NL, February 10, 2021 - Neuroplasticity, the remarkable ability of the brain to modify and reorganize itself, is affected by or in response to excessive alcohol, whether through individual consumption or exposure in the womb. It is now well accepted that the birth and integration of new neurons continue beyond development and into adulthood. New discoveries and insights on how alcohol impacts this and other plastic processes are discussed in " END ...

10th of February, Wednesday, Hong Kong - Deep Longevity, a fully-owned subsidiary of Regent Pacific (SEHK:0575.HK), specializing in the development and the application of next-generation artificial intelligence (AI) for aging and longevity research, today announced the publication of an article in Lancet Healthy Longevity titled "The potential of rapalogs to enhance resilience against SARS-CoV-2 infection and reduce the severity of COVID-19". While the pandemic continues to unfold, targeted therapeutic solutions for COVID-19 are still not established. The extremely rapid development of various vaccines as a preventative approach provides ...

New Rochelle, NY, February 9, 2021--The rapid upscaling of a telemonitoring program in which health care providers performed daily telemedicine check-ins on COVID-19 patients faced a unique set of challenges. How these were resolved, and early outcomes are reported in the peer-reviewed journal Telemedicine and e-Health, Click here to read the article now. "Kaiser Permanente's Virtual Home Care Program (VHCP) was able to rapidly establish a telemedicine-based program for the management of COVID-19 positive patients in the DC and Baltimore Metro regions. Preliminary data suggest that such a program may be effective ...

Mini-Neptunes and super-Earths up to four times the size of our own are the most common exoplanets orbiting stars beyond our solar system. Until now, super-Earths were thought to be the rocky cores of mini-Neptunes whose gassy atmospheres were blown away. In a new study published in The Astrophysical Journal, astronomers from McGill University show that some of these exoplanets never had gaseous atmospheres to begin with, shedding new light on their mysterious origins. From observations, we know about 30 to 50 percent of host stars have one or the other, and the two populations appear in about equal proportion. But where did they come from? One theory is that most exoplanets ...

Lung ultrasound, considered a simple method for diagnosing lung disease, can also help predict the clinical progression of severe COVID-19 patients, according to a study conducted at the University of São Paulo's Medical School (FM-USP) in São Paulo City, Brazil. The principal investigator for the study was Heraldo Possolo de Souza, a professor at FM-USP and an attending physician at its teaching and general hospital, Hospital das Clínicas (HC). The researchers applied an ultrasound examination protocol covering 12 lung regions in 180 COVID-19 patients undergoing treatment at HC. The results showed that the higher the lung ultrasound score, the greater the risk of admission to an intensive care unit (ICU), intubation, and death. The study was supported ...

Gulls are one of the main wild birds that act as reservoirs of Campylobacter and Salmonella, two most relevant intestinal antibiotic-resistant bacteria causing gastroenteritis in humans. Therefore, according to an article published in the journal Science of the Total Environment seagulls could act as sentinels of the antibiotic pressure in the environment. The study was carried out by experts of the Faculty of Biology and the Biodiversity Research Institute (IRBio) of the University of Barcelona, and the Institute of Agrifood Research and Technology (IRTA). Resistant bacteria to antibiotics represent a serious problem for human health and other species since they can harden the treatment ...

BOSTON - How often a person takes daytime naps, if at all, is partly regulated by their genes, according to new research led by investigators at Massachusetts General Hospital (MGH) and published in Nature Communications. In this study, the largest of its kind ever conducted, the MGH team collaborated with colleagues at the University of Murcia in Spain and several other institutions to identify dozens of gene regions that govern the tendency to take naps during the day. They also uncovered preliminary evidence linking napping habits to cardiometabolic health. "Napping is somewhat controversial," says Hassan Saeed Dashti, PhD, RD, of the MGH Center for Genomic Medicine, co-lead author of the report with Iyas Daghlas, a medical student at ...

Alongside the effects of lifestyle, including physical exercise and diet, on ageing, research has increasingly turned its attention to the potential cognitive benefits of musical hobbies. However, such research has mainly concentrated on hobbies involving musical instruments. The cognitive benefits of playing an instrument are already fairly well known: such activity can improve cognitive flexibility, or the ability to regulate and switch focus between different thought processes. However, the cognitive benefits of choir singing have so far been investigated very little. Now, a study recently ...

BOSTON - When patients arrive in emergency departments and hospitals with symptoms consistent with COVID-19, it's critical to isolate them to avoid the potential spread of infection, but keeping patients isolated longer than needed could delay patient care, take up hospital beds needed for other patients, and unnecessarily use up personal protective equipment. A team led by investigators at Massachusetts General Hospital (MGH) has now created a tool to guide frontline clinicians through diagnostic evaluations of such patients so that they'll know when it's safe to discontinue precautions. The tool was developed and validated in a study published in Clinical Infectious Diseases. In the spring of 2020, due to the risk of false-negative ...

UPTON, NY--Scientists at the U.S. Department of Energy's Brookhaven National Laboratory, Stony Brook University (SBU), and other collaborating institutions have uncovered dynamic, atomic-level details of how an important platinum-based catalyst works in the water gas shift reaction. This reaction transforms carbon monoxide (CO) and water (H2O) into carbon dioxide (CO2) and hydrogen gas (H2)--an important step in producing and purifying hydrogen for multiple applications, including use as a clean fuel in fuel-cell vehicles, and in the production of hydrocarbons. But because ...

A team of Russian scientists from NUST MISIS, Tomsk Polytechnic University (TPU) and Boreskov Institute of Catalysis has suggested a new approach to modifying the combustion behavior of coal. The addition of copper salts reduces the content of unburnt carbon in ash residue by 3.1 times and CO content in the gaseous combustion products by 40%, the scientists found. The research was published in Fuel Processing Technology. According to the International Energy Agency (IEA), coal is the predominant energy resource used as the primary fuel for power generation. According to reports, coal supplied over one-third of global electricity generation in ...

Oncotarget published "Combination of copanlisib with cetuximab improves tumor response in cetuximab-resistant patient-derived xenografts of head and neck cancer" which reported that HNSCC is frequently associated with either amplification or mutational changes in the PI3K pathway, making PI3K an attractive target, particularly in cetuximab-resistant tumors. Here, the authors explored the antitumor activity of the selective, pan-class I PI3K inhibitor copanlisib with predominant activity towards PI3Kα and δ in monotherapy and in combination with cetuximab using a mouse clinical trial set-up with 33 patient-derived xenograft models with known HPV and PI3K mutational status and available data ...

Scientists and public health experts have long known that certain individuals, termed "super-spreaders," can transmit COVID-19 with incredible efficiency and devastating consequences. Now, researchers at Tulane University, Harvard University, MIT and Massachusetts General Hospital have learned that obesity, age and COVID-19 infection correlate with a propensity to breathe out more respiratory droplets -- key spreaders of SARS-CoV-2, the virus that causes COVID-19. Their findings were published in Proceedings of the National Academy of Sciences. Using data from an observational study of 194 healthy people and an experimental study of nonhuman primates with COVID-19, researchers found that exhaled aerosol particles vary greatly ...

(New York, NY) February 10, 2021 - A research team led by the Icahn School of Medicine at Mount Sinai (Icahn Mount Sinai) has built the first cellular model to depict the evolution of acute myeloid leukemia (AML), from its early to late stages. By using gene editing technologies to alter genes that make cells malignant, the team was able to identify potential therapeutic targets for early disease stages. The study was reported in the journal Cell Stem Cell in February. The therapeutic targets could be applicable not just to AML but also to the blood cancer myelodysplastic syndrome and clonal hematopoiesis, which is often a preleukemic condition. "We essentially built from scratch a model of leukemia that characterizes the ...

Global emissions of a potent substance notorious for depleting the Earth's ozone layer - the protective barrier which absorbs the Sun's harmful UV rays - have fallen rapidly and are now back on the decline, according to new research. Two international studies published today in Nature, show emissions of CFC-11, one of the many chlorofluorocarbon (CFC) chemicals once widely used in refrigerators and insulating foams, are back on the decline less than two years after the exposure of their shock resurgence in the wake of suspected rogue production. Dr Luke Western, from the University of Bristol, a co-lead author of one ...

When we tear a muscle " stem cells within it repair the problem. We can see this occurring not only in severe muscle wasting diseases such as muscular dystrophy and in war veterans who survive catastrophic limb injuries, but also in our day to day lives when we pull a muscle. Also when we age and become frail we lose much of our muscle and our stem cells don't seem to be able to work as well as we age. These muscle stem cells are invisible engines that drive the tissue's growth and repair after such injuries. But growing these cells in the lab and then using them to therapeutically replace damaged muscle has been frustratingly difficult. Researchers at the Australian Regenerative Medicine Institute at Monash University in Melbourne, ...

Researchers at the Centre for Genomic Regulation (CRG) reveal that newly formed embryos clear dying cells to maximise their chances of survival. It is the earliest display of an innate immune response found in vertebrate animals to date. The findings, which are published today in the journal Nature, may aid future efforts to understand why some embryos fail to form in the earliest stages of development, and lead to new clinical efforts in treating infertility or early miscarriages. An embryo is fragile in the first hours after its formation. Rapid cell division and environmental stress make them prone to cellular errors, which in turn cause the sporadic death of embryonic stem cells. This is ...

For nearly a century, scientists have worked to unravel the mystery of dark matter--an elusive substance that spreads through the universe and likely makes up much of its mass, but has so far proven impossible to detect in experiments. Now, a team of researchers have used an innovative technique called "quantum squeezing" to dramatically speed up the search for one candidate for dark matter in the lab. The findings, published today in the journal Nature, center on an incredibly lightweight and as-of-yet undiscovered particle called the axion. According to theory, axions are likely billions to trillions of times smaller than electrons and may have been created during the Big Bang in humungous numbers--enough ...

What The Study Did: This observational study describes differences in the number of COVID-19 deaths by nursing home racial composition and examines the factors associated with these differences. Authors: Rebecca J. Gorges, Ph.D., of the University of Chicago, is the corresponding author. To access the embargoed study:  Visit our For The Media website at this link https://media.jamanetwork.com/  (doi:10.1001/jamanetworkopen.2020.37431) Editor's Note: The article includes funding/support disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest ...

What The Study Did: This article revisits the role of dermatologists in the early HIV/AIDS epidemic for the 40th anniversary of the epidemic. Authors: Heather Milbar, M.D., M.P.H., of the University of Pennsylvania in Philadelphia, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamadermatol.2020.5545) Editor's Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support. INFORMATION: Media ...

What The Study Did: Researchers examined changes in how organ donation from deceased donors differed by race and ethnicity in the United States over time. Authors: Dorry L. Segev, M.D., Ph.D., of the Johns Hopkins University School of Medicine in Baltimore, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamasurg.2020.7083) Editor's Note: The article includes conflicts of interest and funding/support disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support. INFORMATION: Media advisory: The full study is linked to this news ...

Researchers in Southampton and San Francisco have developed the first compact 3D LiDAR imaging system that can match and exceed the performance and accuracy of most advanced, mechanical systems currently used. 3D LiDAR can provide accurate imaging and mapping for many applications; it is the "eyes" for autonomous cars and is used in facial recognition software and by autonomous robots and drones. Accurate imaging is essential for machines to map and interact with the physical world but the size and costs of the technology currently needed has limited LIDAR's use in ...

CINCINNATI--Imagine a day when clinicians treating people with blood diseases such as leukemia or multiple myeloma can send in requests for laboratories to custom-produce specific types of blood cells to replace those affected by the disease. That day became one step closer to reality with a new study led by experts at Cincinnati Children's that provides powerful new insights into how bone marrow tissue works. The study, published Feb. 10, 2021 in Nature, was led by senior author Daniel Lucas, PhD, and first authors Jizhou Zhang, MD, and Qingqing Wu, PhD, from the Division of Experimental Hematology and Cancer Biology. Co-authors include a team of scientists from Cincinnati Children's and the University of Cincinnati, plus collaborators in Colorado, Texas and Michigan. The ...

Imaging planets orbiting around nearby stars, which could potentially harbour life, has become a possibility thanks to the progress made in observational methods by an international team of astronomers. First candidate: Alpha Centauri, a system similar to ours, "only" 4.3 light years away. This study is the subject of a publication in the journal Nature Communications. Efforts to obtain direct images of exoplanets - planets outside our solar system - have so far been hampered by technological limitations, which have led to a bias towards detecting planets much larger than Jupiter, around very young stars and far from the habitable zone, the area in which a planet may have liquid water on its surface, and thus ...