Although the Antibody Mediated Prevention (AMP) study that launched in 2016 failed to show significant efficacy in a pair of clinical trials, Denis Burton argues in a Perspective that the AMP study's results represent a landmark in AIDS research; they show - for the first time - that a broadly neutralizing antibody (bnAb) can protect humans against exposure to some strains of HIV. According to Burton, the AMP study's data - despite not showing a significant difference between the numbers of infected individuals in the treated groups versus those in the placebo groups - still have tremendous implications for future HIV vaccine design and passive bnAb use strategies. The AMP study evaluated the immunotherapeutic ...

BINGHAMTON, N.Y. -- Analysis of recently discovered fossils found in Israel suggest that interactions between different human species were more complex than previously believed, according to a team of researchers including Binghamton University anthropology professor Rolf Quam. The research team, led by Israel Hershkovitz from Tel Aviv University, published their findings in Science, describing recently discovered fossils from the site of Nesher Ramla in Israel. The Nesher Ramla site dates to about 120,000-140,000 years ago, towards the very end of the Middle Pleistocene time period. The human fossils were found by Dr. Zaidner of ...

Researchers at Tufts University, University College London (UCL), Cambridge University and University of California at Santa Barbara have demonstrated that a catalyst can indeed be an agent of change. In a study published today in Science, they used quantum chemical simulations run on supercomputers to predict a new catalyst architecture as well as its interactions with certain chemicals, and demonstrated in practice its ability to produce propylene - currently in short supply - which is critically needed in the manufacture of plastics, fabrics and other chemicals. The improvements have potential for highly efficient, "greener" chemistry with a lower carbon footprint. The demand for propylene is ...

The discovery of a new Homo group in this region, which resembles Pre-Neanderthal populations in Europe, challenges the prevailing hypothesis that Neanderthals originated from Europe, suggesting that at least some of the Neanderthals' ancestors actually came from the Levant. The new finding suggests that two types of Homo groups lived side by side in the Levant for more than 100,000 years (200-100,000 years ago), sharing knowledge and tool technologies: the Nesher Ramla people who lived in the region from around 400,000 years ago, and the Homo sapiens who arrived later, some 200,000 years ago. The new discovery also gives clues about a mystery in human evolution: How did genes of Homo sapiens penetrate the Neanderthal population that had presumably lived in Europe long before ...

Mythological nymphs reincarnate as a group of corn smut proteins to launch a battle on maize immunity. One of these proteins appears to stand out among its sister Pleiades, much like its namesake character in Greek mythology. The research carried out at GMI - Gregor Mendel Institute of Molecular Plant Biology of the Austrian Academy of Sciences - is published in the journal PLOS Pathogens. Pathogenic organisms exist under various forms and use diverse strategies to survive and multiply at the expense of their hosts. Some of these pathogens are termed "biotrophic", as they are parasites that maintain their hosts alive. These biotrophic pathogens deregulate physiological processes in their hosts by suppressing their immune defenses and favoring disease development. ...

INDIANAPOLIS -- A first-of-its-kind large-scale study of vegetation growth in the Northern Hemisphere over the past 30 years has found that vegetation is becoming increasingly water-limited as global temperatures increase. The results are significant since vegetation is one of the biggest factors when it comes to controlling water and carbon cycling across Earth, which influences global temperatures. The work by IUPUI and Indiana University Bloomington researchers Wenzhe Jiao, END ...

(Denver)-Patients with primary lung cancer detected using low-dose computed tomography screening are at reduced risk of developing brain metastases after diagnosis, according to a study published in the Journal of Thoracic Oncology. JTO is an official journal of the International Association for the Study of Lung Cancer. The full study is available here: Impact of Low-Dose Computed Tomography Screening for Primary Lung Cancer on Subsequent Risk of Brain Metastasis - Journal of Thoracic Oncology (jto.org) The researchers, led by Summer Han, PhD, from Stanford University School of Medicine in Palo ...

A new research paper published in the American Journal of Clinical Nutrition last week showed that a low Omega-3 Index is just as powerful in predicting early death as smoking. This landmark finding is rooted in data pulled and analyzed from the Framingham study, one of the longest running studies in the world. The Framingham Heart Study provided unique insights into cardiovascular disease (CVD) risk factors and led to the development of the Framingham Risk Score based on eight baseline standard risk factors--age, sex, smoking, hypertension treatment, diabetes status, systolic blood pressure, total cholesterol (TC), and HDL cholesterol. CVD is still the leading cause of death globally, and risk can be reduced by changing behavioral factors such as unhealthy diet, ...

A new technique to look at tumors under the microscope has revealed the cellular make-up of Wilm's tumors, a childhood kidney cancer, in unprecedented detail. This new approach could help understand how tumors develop and grow, and fuel research into new treatments for children's cancers. Scientists at the Princess Máxima Center for pediatric oncology developed a new imaging technique and computational pipeline to study millions of cells in 3D tissue, revealing hundreds of features from each individual cell. Their research was published this month in Nature Biotechnology. By offering a look at individual cells within an intact organ, the new technique helps scientists analyze the molecular profile of the cells, as well as their ...

DURHAM, N.C. - The brain's neurons tend to get most of the scientific attention, but a set of cells around them called astrocytes - literally, star-shaped cells - are increasingly being viewed as crucial players in guiding a brain to become properly organized. Specifically, astrocytes, which form about half the mass of a human brain, seem to guide the formation of synapses, the connections between neurons that are formed and remodeled as we learn and remember. A new study from Duke and UNC scientists has discovered a crucial protein involved in the communication and coordination between astrocytes as they build synapses. Lacking this molecule, called hepaCAM, astrocytes aren't as sticky as they ...

GRAND RAPIDS, Mich. (June 24, 2021) -- The same taste-sensing molecule that helps you enjoy a meal from your favorite restaurant may one day lead to improved ways to treat diabetes and other metabolic and immune diseases. TRPM5 is a specialized protein that is concentrated in the taste buds, where it helps relay messages to and from cells. It has long been of interest to researchers due to its roles in taste perception and blood sugar regulation. Now, a team led by scientists at Van Andel Institute has published the first-ever high-resolution images of TRPM5, which reveal two areas that may serve as targets for new medications. The structures also may aid in the development of low-calorie alternative sweeteners that mimic sugar. The findings were published today in Nature ...

BELLINGHAM, Washington, USA - The open access Journal of Astronomical Telescopes, Instruments, and Systems (JATIS) has published END ...

The study was conducted by an international collaboration involving the research team led by Luca Tiberi of the Armenise-Harvard Laboratory of Brain Cancer at the Department of Cellular, computational and integrative biology - Cibio of UniTrento, the Paris Brain Institute-Institut du Cerveau at Sorbonne Université in Paris, the Hopp Children´s Cancer Center (KiTZ) in Heidelberg, Germany, and Sapienza University in Rome. It was supported by Fondazione Armenise-Harvard, Fondazione Airc (Italian Association for Cancer Research) and Fondazione Caritro from Trento. The findings of the study, published in Science Advances, could lead to better and more effective treatments. The team of researchers is proud of the results achieved. Luca Tiberi, coordinator of the study and corresponding ...

Dmitry Blinov is a co-author of the article and Senior Research Associate in the Department of Astrophysics, St Petersburg University. He notes that researchers have been studying the optical polarisation from active galactic nuclei for more than 50 years. Some of the first academic papers on this topic were published back in the 1960s by Vladimir Hagen-Thorn, Professor in the Department of Astrophysics, St Petersburg University, and Viktor Dombrovskiy, Associate Professor in the Department of Astrophysics, Leningrad State University. In the Universe, the main material is concentrated in galaxies with hundreds of billions of stars: there are about 200-400 of them in the Milky Way. At the centre of galaxies there are supermassive ...

An international team of researchers co-led by the University of Adelaide and the University of Arizona has analysed the genomes of more than 2,500 modern humans from 26 worldwide populations, to better understand how humans have adapted to historical coronavirus outbreaks. In a paper published in Current Biology, the researchers used cutting-edge computational methods to uncover genetic traces of adaptation to coronaviruses, the family of viruses responsible for three major outbreaks in the last 20 years, including the ongoing pandemic. "Modern human genomes contain evolutionary ...

Rheumatologists are familiar with the everyday use of immunomodulatory drugs. These are designed to treat the inflammation caused by autoimmune diseases such as rheumatoid arthritis. A EULAR taskforce was set up to develop a set of new points to consider to give guidance and advice on the best way to use these medicines to treat COVID-19. The taskforce included rheumatologists, immunologists, haematologists, paediatricians, patients and other health professionals. They looked at the published evidence on the use of immunomodulatory therapies to treat severe COVID-19. In total, there are two overarching principles and 14 points to consider. The principles stress that the picture of SARS-CoV-2 infection can be very different in different people. Infections range from asymptomatic ...

Measuring ethane in the atmosphere shows that the amounts of methane going into the atmosphere from oil and gas wells and contributing to greenhouse warming is higher than suggested by the U.S. Environmental Protection Agency, according to an international team of scientists who spent three years flying over three areas of the U.S. during all four seasons. "Ethane is a gas that is related only to certain sources of methane," said Zachary R. Barkley, researcher in meteorology and atmospheric science, Penn State. "Methane, however, is produced by oil, ...

Understanding work participation is important, but the way in which this is defined and measured in clinical trials is not always the same, which has made it hard to compare data. EULAR set up a taskforce to draft points to consider when designing studies that use work participation as a measure. The taskforce included doctors, experts and patients from 11 countries. They used the published evidence to draw up a set of points to consider. Two overarching principles and nine points to consider were developed. The principles say that work participation is important for people with inflammatory arthritis, their ...

Paper Title: Analysis of Common Shoulder Injuries in Collegiate Baseball Players Journal: The Physician and Sportsmedicine (June 23, 2021, online edition) Authors: Alexis Chiang Colvin, MD, Professor, Department of Orthopedic Surgery at the Icahn School of Medicine at Mount Sinai; Daniel A. Charen, MD, Resident, Department of Orthopedic Surgery at the Icahn School of Medicine at Mount Sinai; and other coauthors. Bottom Line: Baseball players are highly susceptible to shoulder injuries due to significant microtrauma including repetitive overhead throwing. Mount Sinai researchers investigated men's National Collegiate ...

Fibromyalgia is one of many chronic pain conditions that remains stubbornly difficult to treat. As the ravages of the opioid epidemic lead many to avoid these powerful painkillers, a significant number of people with fibromyalgia are finding an effective replacement in CBD-containing products, finds a new Michigan Medicine study. CBD, short for cannabidiol, is the second most common cannabinoid in the cannabis plant, and has been marketed for everything from mood stabilization to pain relief, without the intoxicating effects produced by the most common cannabinoid, THC. THC, which stands for ...

The cells of simple organisms, such as bacteria, as well as human cells are surrounded by a membrane, which fulfills various tasks including protecting the cell from stress. In a joint project, teams from Johannes Gutenberg University Mainz (JGU) and Forschungszentrum Jülich, with participation of Heinrich Heine University Düsseldorf (HHU), have now discovered that a membrane protein found in bacteria has a similar structure and function as a group of proteins that are responsible for remodeling and rebuilding the cell membrane in humans. No connection between the two protein groups was known before. The team's research work has been published recently in the renowned journal Cell. PspA plays a key role in bacterial stress response The phage shock protein ...

Boston - In recent years, cancer immunotherapy has been effective in treating patients with immunogenic, or so-called "hot" tumors with increased levels of inflammation and the presence of immune cells in and around the tumors. Prostate cancer, however, is considered a "cold" tumor, with few immune cells recognizing and infiltrating prostate malignancies. Accordingly, prostate cancer has been found to respond poorly to the class of immunotherapies known as immune checkpoint inhibitors. In previous work, a team led by medical oncologists at Beth Israel Deaconess Medical Center (BIDMC) identified a subset of prostate cancers that exhibited ...

Cosmic dawn, when stars formed for the first time, occurred 250 million to 350 million years after the beginning of the universe, according to a new study led by researchers at University College London (UCL) and the University of Cambridge. The study, published in the Monthly Notices of the Royal Astronomical Society, suggests that the NASA James Webb Space Telescope (JWST), scheduled to launch in November, will be sensitive enough to observe the birth of galaxies directly. The UK-led research team examined six of the most distant galaxies currently known, whose light has taken most of the universe's ...

Researchers at the Niels Bohr Institute, University of Copenhagen, together with epidemiologist Lone Simonsen from Roskilde University form part of the panel advising the Danish government on how to tackle the different infection-spreading situations we have all seen unfold over the past year. Researchers have modelled the spread of infections under a variety of scenarios, and the Coronavirus has proven to not follow the older models of disease spreading. An increasingly varied picture of its behaviour and thus its impact on society has emerged. In several scientific articles, researchers ...

During the continued progression of the Corona pandemic, rapid, inexpensive, and reliable tests will become increasingly important to determine whether people have the associated antibodies - either through infection or vaccination. Researchers at the Technical University of Munich (TUM) have now developed such a rapid antibody test. It provides the result in only eight minutes; the aim is to further reduce the process time to four minutes. There are currently more than 20 different test procedures available for determining whether a person has antibodies against the new Corona virus. The waiting times for the results range between ten minutes and two and a half hours. Matrix effects reduce the sensitivity of many of the methods. The more sensitive assays require numerous steps, ...