Skoltech researchers and their colleagues from Russia and the UK investigated the safety and efficacy of new chemistry in antisense oligonucleotides used to treat spinal muscular atrophy (SMA), a debilitating genetic disease. Their results may lead to the development of drugs with less toxicity and fewer injections needed thanks to prolonged action. The paper was published in the journal Nucleic Acid Therapeutics. Antisense oligonucleotides are single stranded chemically modified fragments of DNA that target pre-messenger RNA, short bits of genetic information a ribosome reads to make a protein. Depending on how a particular antisense oligonucleotide works, the target mRNA can either be destroyed or undergo subtle changes in how it's spliced, i.e. how exons, the ...

Russian scientists have experimentally proved the existence of a new type of quasiparticle - previously unknown excitations of coupled pairs of photons in qubit chains. This discovery could be a step towards disorder-robust quantum metamaterials. The study was published in Physical Review B. Superconducting qubits are a leading qubit modality today that is currently being pursued by industry and academia for quantum computing applications. However, the performance of quantum computers is largely affected by decoherence that contributes to a qubits extremely short lifespan and causes computational errors. Another ...

Pioneering research has revealed the erosion of ancient sediments found deep beneath Antarctic ice could be a vital and previously unknown source of nutrients and energy for abundant microbial life. The study, led by the University of Bristol and published today in Nature's Communications Earth & Environment journal, sheds new light on the many compounds supporting various microbes which form part of a huge subglacial ecosystem. Lead author Dr Beatriz Gill Olivas, a Post-Doctoral Research Associate at the University of Bristol, said: "Although the study focused on samples obtained from a single ...

During summer 2020, the Yangtze River basin experienced persistent, record-breaking meiyu rainfall. Likewise, the region suffered from severe flooding and water damage as accumulated rainfall broke records dating back to 1954. Regions outside the meiyu rain belt received significant summer rainfall as well, including Beijing, located in northeastern China. Typically, an above average meiyu rainfall season follows a strong El Niño during the previous winter. However, summer 2020 followed a neutral El Niño-Southern Oscillation (ENSO) event. Therefore, scientists are working ...

A stimulating environment keeps the "hippocampus" - which is the brain's memory control center - young, so to speak. Causes of this are molecular mechanisms that affect gene regulation. These current findings from studies in mice provide clues as to why an active, varied life can help preserve mental fitness in old age. Researchers from the DZNE and the Center for Regenerative Therapies Dresden (CRTD) at the Technische Universität Dresden report on this in the journal Nature Communications. Human DNA - and this also applies to mice - contains thousands of genes. However, it is not only the genetic blueprint that is decisive for the function of a cell and whether it is healthy or not, but above all which genes can be switched on or off. ...

FECYT - Spanish Foundation for Science and Technology - presented today at the headquarters of the National Museum of Science and Technology, MUNCYT, IN Alcobendas, the results of the third Social Perception Survey of scientific aspects of the COVID-19 in a debate moderated by Pampa García Molina, Editor-in-Chief of the SINC Agency, in which Raquel Yotti, Director of the Carlos III Health Institute of Madrid, Josep Lobera, Professor of Sociology at the Universidad Autónoma de Madrid (UAM) and scientific director of the Social Perception Survey on the scientific aspects of COVID-19 and ...

Polymers are long, chain-like molecules which are everywhere in biology. DNA and RNA are polymers formed by many consecutive copies of nucleotides coupled together. When being transported within or between cells, these biological polymers must pass through nanometre-sized holes called "nanopores". This process also underlies a rapidly developing method for analysing and sequencing DNA called nanopore sensing. The study, published in the journal END ...

Researchers at the University of Leicester have developed a new method to recycle electric vehicle batteries using a ground-breaking new approach that many will have experienced in the dentist's chair. The Faraday Institution project on the recycling of lithium-ion batteries (ReLiB) led by Professor Andy Abbott at the University of Leicester used a new method, involving ultrasonic waves, to solve a critical challenge: how to separate out valuable materials from electrodes so that the materials can be fully recovered from batteries at the end of their life. Current recycling ...

A new corona test developed at the University Hospital Bonn can analyze a large number of swabs simultaneously using sequencing technology and has a similarly high sensitivity as the common qPCR test. The innovative method offers great potential, especially for systematic testing in daycare centers, schools or companies. Today, the results of the study on the new Corona test have been published in the renowned journal "Nature Biotechnology". Bonn, 6/29/2021 - In addition to vaccination, systematic testing of the population remains of central importance in order to effectively monitor and contain the spread of infections during the Coronavirus pandemic. Only in this way can the spread of the virus be effectively monitored and ...

Crystallization is one of the most fundamental processes found in nature - and it's what gives minerals, gems, metals, and even proteins their structure. In the past couple of decades, scientists have tried to uncover how natural crystals self-assemble and grow - and their pioneering work has led to some exciting new technologies - from the quantum dots behind colorful QLED TV displays, to peptoids, a protein-mimic that has inspired dozens of biotech breakthroughs. Now, a research team led by scientists at the Department of Energy's Lawrence Berkeley National Laboratory (Berkeley Lab) and UC Berkeley has developed a nanoparticle composite that grows ...

The electronic properties of graphene can be specifically modified by stretching the material evenly, say researchers at the University of Basel. These results open the door to the development of new types of electronic components. Graphene consists of a single layer of carbon atoms arranged in a hexagonal lattice. The material is very flexible and has excellent electronic properties, making it attractive for numerous applications - electronic components in particular. Researchers led by Professor Christian Schönenberger at the Swiss Nanoscience Institute and the Department of Physics at the University of Basel have now studied how the material's ...

Mineral resources from Chile are of great importance to Germany. According to statistics from the World Bank, thousands of tons of valuable minerals are imported from the South American country every year, including raw materials for lithium-ion batteries. But their extraction causes ecological and social problems: "The use of the limited freshwater resources in northern Chile for mining regularly fuels conflicts with the local population," says Professor Thomas Kohl from KIT's Institute of Applied Geosciences (AGW). "Northern Chile is one of the driest regions on earth, but has extensive geothermal resources. With a novel type of plant, it is not only possible to generate electricity in a climate-friendly way, but also to extract ...

When positioned strategically, garment seams sewn with conductive yarn can be used to accurately track body motion, according to computer scientists at the University of Bath in the UK. Best of all, these charged seams are able to respond to subtle movements that aren't picked up by popular fitness trackers, such as watches and wristbands. In a new study, the Bath researchers found that clothing made with conductive seams can be analysed to identify the wearer's movements. PhD student Olivia Ruston, who presented the work at the ACM Designing Interactive Systems conference this month, said: "There are lots of potential applications for conductive yarn in any activity where you want to identify and improve ...

Mice are an important animal model of human vision due to the powerful genetic tools available in this species. However, mouse vision was thought to be different to that of humans because humans have a region of the retina specialized for fine details called the 'fovea' whereas mice do not. Researchers from the Netherlands Institute of Neuroscience (NIN) have shown that the visual cortex of mice does contain a region of enhanced visual sensitivity dubbed the 'focea', making the mouse a better model of human vision than previously expected. The findings were published ...

Lithia, Florida -- June 29, 2021 -- Surgical resident training has traditionally occurred in a master-apprentice-type relationship, with graduated responsibilities until trainees are expected to perform procedures on their own. Given recent changes in the health care system, including reduced operating room time, increased difficulty of procedures and working hour restrictions, there is less time for residents to learn using traditional methods. Researchers from the University of Manitoba and the Pan Am Clinic recently published a paper in the journal Arthroscopy, Sports Medicine, ...

Aerosol generated by playing woodwind and brass instruments is less than that produced when vocalising (speaking and singing) and is no different than a person breathing, new research has found. The findings, published online in the journal Aerosol Science and Technology, could be crucial to developing a roadmap for lifting COVID-19 restrictions in the performing arts, which have been significantly restricted since the start of the pandemic. The research project, known as PERFORM (ParticulatE Respiratory Matter to InForm Guidance for the Safe Distancing of PerfOrmeRs in a COVID-19 PandeMic), was supported by Public Health England, the Department for Digital, Culture, Media and Sport (DCMS), and UKRI and was carried out by a collaborative team from ...

The death of neurons specialised in the synthesis of dopamine, one of the brain's main neurotransmissors, deteriorates the motor and cognitive capacities of those with Parkinson's disease. The loss of these neurons is related to alpha-synuclein aggregation. Recent studies show that oligomers, the initial aggregates of this protein, are the most pathogenic forms of α-synuclein and are responsible for the spreading of the disease in the brain. Therefore, one of the more promising approaches in fighting this disorder consists in neutralising these oligomers and, thus, slow down the pathological progression. ...

During the last twenty years, the trading in stock markets has undergone significant changes. Researchers from the University of Turku and the University of Palermo have investigated the role of high-frequency traders in the markets. Technological evolution and innovations both in the technology used by stock exchanges and the resources of the traders using their services have made faster trading possible. As a result, high-frequency trading in sub millisecond scale has increased. However, not everyone has the opportunity to use high-frequency trading, and generally, the scales can be anything from microseconds to tens of thousands of seconds. The role of high-frequency traders has given rise to broad debate over ...

HERSHEY, Pa. -- A new study by researchers at Penn State College of Medicine indicates that people living with human immunodeficiency virus (HIV) and acquired immune deficiency syndrome (AIDS) -- approximately 38 million worldwide -- are more likely to have suicidal thoughts and die from suicide than members of the general population. The researchers said that despite significant medical advancements related to HIV treatment and patients' quality of life, risk of suicide in these patients is high and health care providers should prioritize mental health screenings in this population. According to the World Health Organization, roughly 800,000 people worldwide die from suicide annually. Among ...

Tuesday, 29 June 2021 - New research has shown that early testing for blood clots in patients who had received the AstraZeneca/Oxford vaccine led to them being treated successfully, highlighting the need for heightened awareness of the risk among doctors. The work, led by researchers from RCSI University of Medicine and Health Sciences and the National Coagulation Centre at St James's Hospital, is published in the British Journal of Haematology. Unusual blood clots with low blood platelets have been recognised as a very rare complication of the AstraZeneca vaccine. However, with increased awareness, ...

RUDN University chemists derived molecules that can assemble into complex structures using chlorine and bromine halogen atoms. They bind to each other as "velcro" - chlorine "sticks" to bromine, and vice versa. As a result supramolecules are assembled from individual molecules. The obtained substances will help to create supramolecules with catalytic, luminescent, conducting properties. The study is published in Mendeleev Communications. Supramolecules are the structures made of several molecules. Individual molecules are combined, for example, by self-assembly or without external control. The resulting structure has properties that the molecules did not have individually. That is the way to create new materials, catalysts, molecular machines for ...

For the first time, scientists detected gravitational waves caused by mergers between black holes and neutron stars. Researchers from LIGO, Virgo, and KAGRA detected the two gravitational wave events--from distances of more than 900 million light-years away--within a span of 10 days in January 2020 during the second half of LIGO and Virgo's third observing run. Astrophysical Journal Letters published the results and their implications today: https://iopscience.iop.org/article/10.3847/2041-8213/ac082e. Researchers from Rochester Institute of Technology's Center ...

The LSL60101 compound, a specific ligand of the I2-IR receptors in the brain, could shed light on the development of future strategies against Alzheimer's disease. This is stated in the recent studies by the Research Group on Medicinal Chemistry and Pharmacology of Neurodegenerative Diseases of the University of Barcelona, published in the journals European Journal of Medicinal Chemistry and British Journal Pharmacology. In studies carried out with mice, LSL60101 has improved the cognitive deficit and the biomarkers related to the disease in these animal models. These studies result from the collaboration of the research teams led by professors Carmen Escolano, from the Faculty of Pharmacy and Food Sciences and the Institute of Biomedicine of the UB ...

Preschool children are sensitive to the gap between how much they know and how much there is to learn, according to a Rutgers University-New Brunswick study. The research, published in the journal END ...

Under a concrete drainage culvert at the edge of a town in Botswana, a troop of banded mongoose is getting ready to leave its den. Moving from shade into light, the cat-sized animals scan the area for signs of danger and for opportunities to find something to eat in an increasingly crowded neighborhood. Unbeknownst to them, the genetics of this troop's members -- and others like them -- are providing researchers in the College of Natural Resources and Environment with new understandings of how and why animal behavior changes in proximity to human development and how that change can impact infectious disease spread. The researchers used genetic tools to identify changes in movement behavior among mongooses ...