Rituximab, an anti-cancer drug targeting the membrane protein CD20, was the first approved therapeutic antibody against B tumor cells. Immunologists at the University of Freiburg have now solved a mystery about how it works. A team headed by Professor Dr. Michael Reth used cell cultures, healthy cells, and cells from cancer patients to investigate how CD20 organizes the nanostructures on the B cell membrane. If the protein is missing or Rituximab binds to it, the organization of the B cell surface changes. The resting B cell is activated in the process. The team has published the research in the journal PNAS as part of contributions by new members of the National Academy of Science. B cells are white blood cells and part of the immune system. When they recognize ...

Oncotarget recently published "Melatonin increases overall survival of prostate cancer patients with poor prognosis after combined hormone radiation treatment" which reported that a retrospective study included 955 patients of various stages of prostate cancer who received combined hormone radiation treatment from 2000 to 2019. Comprehensive statistical methods were used to analyze the overall survival rate of PCa patients treated with melatonin in various prognosis groups. The overall survival rate of PCa patients with favorable and intermediate prognoses treated or not treated ...

JACKSONVILLE, Fla. (February 10, 2021) - Brain volume, verbal IQ, and overall IQ are lower in children with Type 1 diabetes (T1D) than in children without diabetes, according to a new longitudinal study published in Diabetes Care, a journal of the American Diabetes Association. The nearly eight-year study, led by Nelly Mauras, MD, a clinical research scientist at Nemours Children's Health System in Jacksonville, Florida, and Allan Reiss MD, a Professor at the Stanford University School of Medicine in California, compared brain scans of young children who have T1D with those of non-diabetic children to assess the extent to which glycemic exposure may adversely affect the ...

It was reported that volume of the brain areas such as superior temporal gyrus and anterior cingulate cortex reduces in schizophrenia but precise change of three-dimensional structure of neuron has remains unclear. Dr. Itokawa and colleague performed Nanotomography experiments using Fresnel zone plate optics at the BL37XU beamline of the SPring-8 synchrotron radiation facility and at the 32-ID beamline of the Advanced Photon Source (APS) of Argonne National Laboratory. A total of 34 three-dimensional image datasets of layer V of the BA22 cortex were blinded ...

The recent review, published in Environment International and led by the University of Tartu, summarises the effect of aquatic pollution on cancer prevalence in wild animals with the help of more than 300 reviewed studies. Authors shed light on understudied yet important fields in cancer research in wild animals - summarising the key effects and pointing to future research avenues to crack the puzzle of why cancer develops in polluted environments. „What was immediately evident was the bias towards fish in current research into aquatic wildlife cancer. However, given this bias it is especially interesting ...

Sophia Antipolis, 10 February 2021: A nationwide US study has found increasing death rates from heart disease in women under 65. The research is published in European Heart Journal - Quality of Care and Clinical Outcomes, a journal of the European Society of Cardiology (ESC).1 The study found that while death rates from cancer declined every year between 1999 and 2018, after an initial drop, heart disease death rates have been rising since 2010. "Young women in the US are becoming less healthy, which is now reversing prior improvements in heart disease deaths," said senior author Dr. Erin Michos of Johns Hopkins University School of Medicine, Baltimore, US. "With ...

Satellite images reveal that the timing of algal blooms in the Red Sea may affect the next haul of sardines and squid by commercial fisheries. Rising temperatures in the Red Sea have changed the timing of phytoplankton blooms. These microscopic algae form the base of many marine food webs and so are critical to ocean biodiversity and the industries that they support on land, such as fisheries and tourism. A team led by KAUST climate modeler Ibrahim Hoteit has used satellite images to study the phenology of algal blooms in the northern Red Sea and ...

A new method has enabled the natural structure of particularly large and complex enzymes to be revealed. Scientists at Martin Luther University Halle-Wittenberg (MLU) and TU Berlin have published their findings in the journal Cell Reports. They investigated a multi-enzyme complex that plays an essential role in metabolism and have discovered that it functions differently than previously thought. This will help scientists better understand certain diseases. Enzymes are a cell's biocatalysts. They accelerate chemical reactions in the body or ensure that these reactions even take place at all. As a result, they play an extremely important role in metabolism. Individual enzymes frequently form a complex with many subunits, as in the case of the ...

In a study conducted at the University of Helsinki, Finland, 136 adults adhered to one of three study diets for 12 weeks. One of them corresponded to the average Finnish diet, containing roughly 70% animal-derived protein of total protein, while most of the plant-based protein originated from cereal products. In the second study diet, half of the protein was derived from plant products and the other half from animal products, while the third one contained 30% animal protein and 70% plant-based protein of total protein. Sources of animal protein, both red and white meat as well as dairy products, were partially replaced with plant-based proteins by adding a diverse range of legumes, nuts, ...

Your breath holds the key to monitoring fat burning, and now a research group from Tohoku University has created a compact and low-cost device that can measure how our body metabolizes fat. The device uses an ultraviolet lamp to gauge exhaled acetone gas, which is produced in the blood through the metabolic reaction of fat. "Precise measurements of acetone gas concentration allows us to determine the body's ability to metabolize fat and develop exercise methods for efficient fat burning," says Professor Yuji Matsuura from Tohoku University's Graduate School of Biomedical ...

Many natural and human-made networks, such as computer, biological or social networks have a connectivity structure that critically shapes their behavior. The academic field of network science is concerned with analyzing such real-world complex networks and understanding how their structure influences their function or behavior. Examples are the vascular network of our bodies, the network of neurons in our brain, or the network of how an epidemic is spreading through a society. The need for reliable null models The analysis of such networks often focuses on finding interesting properties and features. For example, does the structure of a particular contact network help diseases spread ...

The research team led by Masakazu Ohara, graduate student of the Department of Computer Science and Engineering at Toyohashi University of Technology (student in the Leading Program doctoral program); Associate Professor Kowa Koida of the Electronics-Inspired Interdisciplinary Research Institute; and Associate Professor Juno Kim of the University of New South Wales (Australia) discovered that when people judge the thickness of an object, objects with glass-like transparent optical properties are perceived to be flatter than they actually are. It was previously known that objects made of metallic or glossy materials are perceived to be thicker than what they are, but now the current research has identified that transparent ...

A description of gravity compatible with the principles of quantum mechanics has long been a widely pursued goal in physics. Existing theories of this 'quantum gravity' often involve mathematical corrections to Heisenberg's Uncertainty Principle (HUP), which quantifies the inherent limits in the accuracy of any quantum measurement. These corrections arise when gravitational interactions are considered, leading to a 'Generalized Uncertainty Principle' (GUP). Two specific GUP models are often used: the first modifies the HUP with a linear correction, while the second introduces a quadratic one. Through new research published in EPJ C, Serena Giardino and Vincenzo ...

A unique 'heart-shape', with wisps of gas filaments showing an intricate honeycomb-like arrangement, has been discovered at the centre of the iconic supernova remnant, the Crab Nebula. Astronomers have mapped the void in unprecedented detail, creating a realistic three-dimensional reconstruction. The new work is published in Monthly Notices of the Royal Astronomical Society. The Crab, formally known as Messier 1, exploded as a dramatic supernova in 1054 CE, and was observed over the subsequent months and years by ancient astronomers across the ...

Dimerization (Note: combination of two identical or different molecules) of the human neuropeptides oxytocin and vasopressin can produce new types of bioactive molecules. In a recent study, an international research team led by MedUni Vienna and the University of Vienna demonstrated that dimerized and therefore significantly larger versions of oxytocin and vasopressin are still able to activate their receptors. Such new constructs provide several opportunities to optimize the efficacy of these neuropeptides for therapeutic application. The researchers were inspired for this approach from naturally occurring dimers. The results have been published in the journal "Chemical Science". Oxytocin/vasopressin receptors are typical examples of so-called G protein-coupled receptors - the most ...

In order for a drug to be effective at the right places in the body, it helps if scientists can predict as accurately as possible how the molecules of that drug will interact with human cells. In a joint research project, scientists from Collaborative Research Centre 1423 at Leipzig University and the Chinese Academy of Sciences in Shanghai have succeeded in elucidating such a structure, namely that of the neuropeptide Y receptor Y2 with one of its ligands. This is the first time that a molecular blueprint for this receptor is available, which will enable the development of tailor-made new drugs, for example to treat epilepsy or cardiovascular diseases. The researchers' findings have now been published in Nature Communications. The Y2 receptor plays ...

"Insulin is a prime example for a successful peptide drug that has been essential for the health of millions of diabetic patients in the past 100 years," says Markus Muttenthaler, who leads research groups at the Institute of Biological Chemistry of the Faculty of Chemistry at University in Vienna as well as at the Institute for Molecular Bioscience, at the University of Queensland in Brisbane. Worldwide, peptide therapeutics account for 5% of the global pharmaceutical market, with global sales exceeding US$ 50 billion. More than 150 peptides are in clinical development and another 400-600 peptides undergoing preclinical ...

Children with epilepsy sleep poorly compared to healthy children, and are more likely to experience disruptions such as night terrors, sleep walking or sleep disordered breathing, according to a new study. A team at the University of Birmingham's Centre for Human Brain Health analysed 19 published studies on sleep and epilepsy in children and adolescents to try to better understand and articulate the links between them. Their findings, published in Sleep Medicine Reviews, highlight the significantly poorer sleep experienced by children and adolescents with epilepsy, and present a strong argument for screening children for sleep problems as an integral part of diagnosis and management of the condition. Lead author Alice Winsor explains: "We know that sleep and epilepsy ...

Among the most active fields of research in modern physics, both at an academic level and beyond, are quantum computation and communication, which apply quantum phenomena such as superposition and entanglement to perform calculations, or to exchange information. A number of research groups around the world have built quantum devices that are able to perform calculations faster than any classical computer. Yet, there is still a long way to go before these devices can be converted into marketable quantum computers. One reason for this is that both quantum computation and ...

A new study shows that proteins called IAPs, which can trigger programmed cell death, are inhibited by a specific chemical modification, and reveals that they play a wider role in protein quality control than previously assumed. N-terminal acetylation - the attachment of an acetyl group (CH3-COO-) directly to the N-terminus of a protein - is one of the most common modifications found in the protein complements of higher organisms. The chemical tag has been linked to a wide variety of cellular signaling pathways. Now researchers led by Tanja Bange (Institute of Medical Psychology, Ludwig-Maximilians-Universitaet (LMU) in Munich) have shown that N-terminal acetylation shields certain proteins from degradation, and inhibits programmed cell death ('apoptosis'). ...

People who eat a Mediterranean-style diet--particularly one rich in green leafy vegetables and low in meat--are more likely to stay mentally sharp in later life, a study shows. Closely adhering to a Mediterranean diet was associated with higher scores on a range of memory and thinking tests among adults in their late 70s, the research found. The study found no link, however, between the Mediterranean-style diet and better brain health. Markers of healthy brain ageing - such as greater grey or white matter volume, or fewer white matter lesions--did not differ between those regularly eating a Mediterranean diet and those who did not. These ...

Washington, DC - February 9, 2021 - A team of investigators from the Republic of China has discovered that 6 drugs previously approved by the US Food and Drug Administration (FDA) for other indications could be repurposed to treat or prevent COVID-19. The research is published in Antimicrobial Agents and Chemotherapy, a journal of the American Society for Microbiology. Using FDA-approved drugs saves time -- the drugs don't need to go through the FDA approval process again -- making them available quickly to treat patients who need them. The research shows that the investigators screened 2 large drug libraries cumulatively containing 3,769 FDA-approved drugs and found drugs that can inhibit 2 protein-cutting ...

MOSCOW, Idaho -- Feb. 9, 2021 -- Breastfeeding women with COVID-19 do not pass along the SARS-CoV-2 virus in their milk but do transfer milk-borne antibodies that are able to neutralize the virus, a multi-institutional team of researchers led by the University of Idaho reported. The team analyzed 37 milk samples submitted by 18 women diagnosed with COVID-19. None of the milk samples were found to contain the virus, but nearly two-thirds of the samples did contain two antibodies specific to the virus. "Taken together, our data do not support maternal-to-infant transmission of SARS-CoV-2 via milk," the researchers reported ...

ALBUQUERQUE, N.M. -- Something lurks beneath the Arctic Ocean. While it's not a monster, it has largely remained a mystery. According to 25 international researchers who collaborated on a first-of-its-kind study, frozen land beneath rising sea levels currently traps 60 billion tons of methane and 560 billion tons of organic carbon. Little is known about the frozen sediment and soil -- called submarine permafrost -- even as it slowly thaws and releases methane and carbon that could have significant impacts on climate. To put into perspective the amount of greenhouse gases in submarine permafrost, humans have released about 500 billion tons of carbon into the atmosphere since the Industrial Revolution, said Sandia National Laboratories geosciences engineer ...

The Texas Heart Institute (THI) has announced that a research team led by Dr. Mehdi Razavi, Director of Electrophysiology Clinical Research & Innovations, has developed a breakthrough new ex vivo benchtop system for evaluating the effects of ablation systems on excised tissues and assessing potential damage to collateral heart tissues. The unique system allows for fast and easy benchtop assessments rather than using costly in vivo tests. Critical findings associated with this innovation are outlined in a study published in the Journal of Cardiovascular Physiology. The new ablation method evaluated by Dr. Razavi and team is being ...