A new cancer vaccine could boost the positive effects of existing immunotherapy drugs, improving the success rate of treatments from 20% to 75% of cases, according to a new study by immunologists from the University of Konstanz. The vaccine, which incorporates a new immunostimulant that is safe for use in humans, was shown to partially eliminate tumours in mice. However, the study further demonstrated that combining the vaccine with an immune checkpoint inhibitor -- an established immunotherapy drug with a 20% success rate overall for patients -- can vastly ...

Climate change induced yield reductions can be compensated by cultivar adaptation and global production can even be increased. Global agriculture both is one of the major drivers of climate change and strongly affected by it. Rising temperatures are among the main reasons for yield reductions. Therefore, the agricultural sector is faced with the major challenge of adapting to climate change in order to ensure food security in the future. According to a new study carried out by international researchers, the use of locally adapted cultivars can significantly contribute to achieve this goal. The study ...

(Boston)--Researchers from Boston University School of Medicine (BUSM) report the formation of human cells containing a green fluorescent protein or GFP (one of the most important proteins in biology and fluorescence imaging) genetically fused with two interferon stimulated genes (ISGs), namely Viperin and ISG15. This new creation makes these cells highly valuable reagents for reporting innate immune responses to viral infections, including those caused by coronaviruses. These engineered cells, which turn green when treated with interferon, are highly novel because this is the first time a reporter gene (a gene ...

A filter made from polymer nanothreads blew three kinds of commercial masks out of the water by capturing 99.9% of coronavirus aerosols in an experiment. "Our work is the first study to use coronavirus aerosols for evaluating filtration efficiency of face masks and air filters," said corresponding author Yun Shen, a UC Riverside assistant professor of chemical and environmental engineering. "Previous studies have used surrogates of saline solution, polystyrene beads, and bacteriophages -- a group of viruses that infect bacteria." The study, led by engineers at UC Riverside and The George Washington University, compared ...

The wild relatives of modern peanut plants have the ability to withstand disease in ways that peanut plants can't. The genetic diversity of these wild relatives means that they can shrug off the diseases that kill farmers' peanut crops, but they also produce tiny nuts that are difficult to harvest because they burrow deep in the soil. Consider it a genetic trade-off: During its evolution, the modern peanut lost its genetic diversity and much of the ability to fight off fungus and viruses, but gained qualities that make peanut so affordable, sustainable and tasty that people all over the world grow and eat them. Modern peanut plants were created 5,000 to ...

OAK BROOK, Ill. - An artificial intelligence (AI) program accurately predicts the risk that lung nodules detected on screening CT will become cancerous, according to a study published in the journal Radiology. Lung cancer is the leading cause of cancer death worldwide, with an estimated 1.8 million deaths in 2020, according to the World Health Organization. Low-dose chest CT is used to screen people at a high risk of lung cancer, such as longtime smokers. It has been shown to significantly reduce lung cancer mortality, primarily by helping to detect cancers at an early stage when they are easier to treat successfully. While lung cancer typically shows up as pulmonary nodules on CT images, most nodules are benign ...

Researchers have identified specific influenza targets that could be used to better protect Indigenous people from experiencing severe influenza disease through a universal, T cell-based vaccine. In a collaboration with Monash Biomedicine Discovery Institute, Menzies School of Health Research and CQUniversity, Peter Doherty Institute for Infection and Immunity (Doherty Institute) researchers took a deep-dive look into how the immune system can protect Aboriginal and Torres Strait Islander people from severe influenza disease. "We know that some populations are at high risk from severe influenza, and these include Indigenous people ...

Fields of opium poppies once bloomed where the Zurich Opera House underground garage now stands. Through a new analysis of archaeological seeds, researchers at the University of Basel have been able to bolster the hypothesis that prehistoric farmers throughout the Alps participated in domesticating the opium poppy. Although known today primarily as the source of opium and opiates, the poppy is also a valuable food and medicinal plant. Its seeds can be used to make porridge and cooking oil. Unlike all other previously domesticated crops, which are assumed to ...

The research team, led by Academician GUO Guangcan from University of Science and Technology of China (USTC) of the Chinese Academy of Sciences, collaborating with LI Bo from Shangrao Normal University and CHEN Jingling from Nankai University, achieved the masking of optical quantum information. The researchers concealed quantum information into non-local quantum entangled states. The study was published in the journal Physical Review Letters. Quantum information masking as one of the new information processing protocol transfers quantum information from a single quantum carrier to the quantum entangled state between multiple carriers avoiding the information ...

Fossils of land animals from South America have been found in the Antilles, but how did these animals get there? According to scientists from the CNRS, l'Université des Antilles, l'Université de Montpellier and d'Université Côte d'Azur, land emerged in this region and then disappeared beneath the waves for millions of years, explaining how some species were able to migrate to the Antilles. This study will be published in June 2021 issue in Earth-Science Reviews. Fossils of land animals from the Antilles, including mammals and amphibians, have their closest relatives in South America. The crossing of the Caribbean Sea from South America was therefore possible, but how? As swimming across the continent ...

Urban megaprojects tend to be the antithesis of good urban planning. They have a negative impact on local water systems, deprive local communities of water-related human rights, and their funders and sponsors have little accountability for their impact. These are the findings of the University of Adelaide's Dr Scott Hawken from the School of Architecture and Built Environment who led a review of the impact of urban megaprojects on water justice in South East Asia. "Urban megaprojects have severe implications for environmental processes," said Dr Hawken. "They have a major impact on hydrological systems and during all phases of development affect water security and human ...

China's Large High Altitude Air Shower Observatory (LHAASO)--one of the country's key national science and technology infrastructure facilities--has found a dozen ultra-high-energy (UHE) cosmic accelerators within the Milky Way. It has also detected photons with energies exceeding 1 peta-electron-volt (quadrillion electron-volts or PeV), including one at 1.4 PeV. The latter is the highest energy photon ever observed. These findings overturn the traditional understanding of the Milky Way and open up an era of UHE gamma astronomy. These observations will prompt people to rethink the mechanism by which high-energy particles are generated and propagated in the Milky Way, and will encourage people to explore more deeply violent celestial phenomena and their physical processes ...

Graphene nanoribbons (GNRs), narrow strips of single-layer graphene, have interesting physical, electrical, thermal, and optical properties because of the interplay between their crystal and electronic structures. These novel characteristics have pushed them to the forefront in the search for ways to advance next-generation nanotechnologies. While bottom-up fabrication techniques now allow the synthesis of a broad range of graphene nanoribbons that feature well-defined edge geometries, widths, and heteroatom incorporations, the question of whether or not structural disorder is present in these atomically precise GNRs, and to what extent, is still subject to debate. The answer to ...

Manufactured in a new process based on crystalline materials, these low-loss mirrors promise to open up completely new application areas, for example in optical respiratory gas analysis for early cancer detection or the detection of greenhouse gases. This work will be published in the current issue of the journal Optica. In 2016 researchers at the LIGO laser interferometer succeeded in the first direct observation of gravitational waves, which had originally been predicted by Albert Einstein in 1916. A significant contribution to the observation of this wave-like propagation of disturbances in space-time, which was rewarded with the Nobel Prize a year later, was provided by the laser mirrors of the kilometer-long interferometer assembly. ...

Spintronics is an emerging technology for manufacturing electronic devices that take advantage of electron spin and its associated magnetic properties, instead of using the electrical charge of an electron, to carry information. Antiferromagnetic materials are attracting attention in spintronics, with the expectation of spin operations with higher stability. Unlike ferromagnetic materials, in which atoms align along the same direction like in the typical refrigerator magnets, magnetic atoms inside antiferromagnets have antiparallel spin alignments that cancel out the net magnetization. Scientists have worked on controlling the alignment of magnetic atoms within antiferromagnetic ...

In today's plants, photorespiration dissipates some of the energy produced by photosynthesis and releases CO2. It begins when the enzyme RuBisCO acts on oxygen instead of carbon dioxide and creates toxic side-products requiring costly recycling reactions. The detoxification process uses up fixed carbon and wastes energy, thus strongly limiting agricultural productivity. Scientists generally pursue two approaches to minimizes the deleterious effects of photorespiration: mimic the carbon concentrating mechanism of C4 plants or introduce new metabolic pathways to bypass the photorespiration. Researchers led by Andreas Weber from Heinrich ...

In a recent research, researchers led by Prof. ZHANG Haimin from the Institute of Solid State Physics of the Hefei Institutes of Physical Science (HFIPS) realized the synthesis of Mo single atoms anchored on activated carbon (Mo-SAs/AC) by the formed Mo-Ox bonds. The result was published on Chemical Communications. According to the researchers, this new oxygen-coordinated molybdenum single atom catalyst was proved efficient to electrosynthesis of ammonia. The O-coordinated environment in this study, different from N-coordinated environment reported before, provided the sites to anchor Mo single atoms and form Mo-Ox sites, which could be used as the active centers for the adsorption and activation of N2, resulting in high ...

A new software tool developed by Earlham Institute researchers will help bioinformaticians improve the quality and accuracy of their biological data, and avoid mis-assemblies. The fast, lightweight, user-friendly tool visualises genome assemblies and gene alignments from the latest next generation sequencing technologies. Called Alvis, the new visualisation tool examines mappings between DNA sequence data and reference genome databases. This allows bioinformaticians to more easily analyse their data generated from common genomics tasks and formats by producing efficient, ready-made vector images. First author and post-doctoral scientist at the Earlham Institute Dr Samuel Martin in the Leggett Group, said: "Typically, alignment tools output plain ...

One day in the near future dyes in electric motors might indicate when cable insulation is becoming brittle and the motor needs replacing. Scientists at Martin Luther University Halle-Wittenberg (MLU), together with ELANTAS, a division of the specialty chemicals group ALTANA, have developed a new process that enables the dyes to be directly integrated into the insulation. By changing colour, they reveal how much the insulating resin layer around the copper wires in the motor has degraded. The results were published in the journal "Advanced Materials". Modern combustion engines have long had detectors that recognise, for example, when an oil change is needed, saving unnecessary inspections. Electric motors also show signs of wear. Inside, ...

Combining natural salt marsh habitats with conventional dikes may provide a more sustainable and cost-effective alternative for fully engineered flood protection. Researchers of the University of Groningen (UG) and the Royal Netherlands Institute for Sea Research (NIOZ) studied how salt marsh nature management can be optimized for coastal defence purposes. They found that grazing by both cattle and small herbivores such as geese and hare and artificial mowing can reduce salt marsh erosion, therefore contributing to nature-based coastal defence. People around the world live in coastal areas that are ...

Recently, Prof. WANG Junfeng from the High Magnetic Field Laboratory of the Hefei Institutes of Physical Science (HFIPS), together with international scholars, developed a novel circular permutated light-oxygen-voltage 2 (LOV2) to expand the repertoire of genetically encoded photoswitches, which will accelerate the design of novel optogenetic devices. The result was published in Nature Chemical Biology. LOV2 domain is a blue light-sensitive photoswitch. In a typical LOV2-based optogenetic device, an effector domain is fused after the C-terminal Jα helix of LOV2, intending to cage the effector via steric hindrance in the dark. On photostimulation, light-triggered unfolding of the Jα helix exposes the effector domain to restore its function. Crafting a LOV2-based ...

With the rise of the digital age, the amount of WiFi sources to transmit information wirelessly between devices has grown exponentially. This results in the widespread use of the 2.4GHz radio frequency that WiFi uses, with excess signals available to be tapped for alternative uses. To harness this under-utilised source of energy, a research team from the National University of Singapore (NUS) and Japan's Tohoku University (TU) has developed a technology that uses tiny smart devices known as spin-torque oscillators (STOs) to harvest and convert wireless radio frequencies into energy ...

A new study may have uncovered why wall lizards have become the most successful reptile in the Mediterranean region. The results reveal how drastic changes in sea levels and climate 6 million years ago affected species formation in the area. The researchers believe they can now explain why the lizards became so diverse and widespread, something that has puzzled biologists since the 19th century. The study is published in Nature Communications. The evolution of wall lizards offers clues on how major events in the Mediterranean climate and geology millions of years ago affected how species formed or became extinct, and also paved the way for biodiversity. Wall lizards date back around 20 million years. However, ...

A University of Surrey project has revealed innovative methods that could dramatically improve the performance of future electrical vehicles (e-vehicles). As part of the European Union's STEVE* project, Surrey has developed several pioneering approaches to torque vectoring in electric vehicles. In e-vehicles with multiple motors, it is possible to deliver different amounts of drive power to each wheel. This benefits the vehicles' power consumption, safety and driveability. The process of calculating and optimising the precise amount of power needed while the vehicle ...

To support growing human and animal life, freshwater sources must continuously supply water. Freshwater from lakes, rivers, and underground is mainly recharged by rainfall. Ground reservoirs can store rainwater over time, depending on that location's storage capability. However, estimating freshwater storage capability (FSC) is still a challenge due to few observation opportunities and methods to measure and quantify FSC. Prof. Xing Yuan and his Ph.D. student Enda Zhu, from the Institute of Atmospheric Physics at the Chinese Academy of Sciences, developed and applied a new metric that characterizes the "inertia" of water after rainfall. This method allows better ...