Eating a healthy diet, such as the Mediterranean diet, has a positive impact on health, but little is known about the effects of including unhealthy foods in an otherwise healthy diet. Now researchers at Rush University Medical Center have reported diminished benefits of a Mediterranean diet among those with high frequency of eating unhealthy foods. The results of their study were published in Alzheimer's & Dementia: The Journal of the Alzheimer's Association on Jan. 7. "Eating a diet that emphasizes vegetables, fruit, fish and whole grains may positively affects a person's health," said Puja Agarwal, PhD, a nutritional epidemiologist and assistant professor in the Department of Internal Medicine at Rush Medical College. "But when it is combined with fried food, ...

In a technique known as DNA origami, researchers fold long strands of DNA over and over again to construct a variety of tiny 3D structures, including miniature biosensors and drug-delivery containers. Pioneered at the California Institute of Technology in 2006, DNA origami has attracted hundreds of new researchers over the past decade, eager to build receptacles and sensors that could detect and treat disease in the human body, assess the environmental impact of pollutants, and assist in a host of other biological applications. Although the principles of DNA origami are straightforward, the technique's tools and methods for designing new structures are not always easy to grasp and have not been well documented. In addition, scientists new to the method have had no single reference they ...

Canada is at the forefront of global efforts to end child marriage abroad. Yet this practice remains legal and persists across the country. In Canada, more than 3,600 marriage certificates were issued to children, usually girls, under the age of 18 between 2000 and 2018, according to a new study from researchers at McGill University. In recent years, an increasing number of child marriages have been common-law unions. Child marriage, defined as formal or informal (common-law) marriage before the age of 18, is a globally-recognized indicator of gender inequality because the negative consequences for ...

BOSTON - Patients with tuberous sclerosis complex, a genetic disorder characterized by the growth of noncancerous tumors in multiple organs of the body, have limited treatment options. A team led by investigators at Massachusetts General Hospital (MGH) has now shown that gene therapy can effectively treat mice that express one of the mutated genes that cause the disease. The research is published in Science Advances. The gene, called TSC2, codes for tuberin, a protein that acts to inhibit cell growth and proliferation. When mutations occur in TSC2, resulting in a lack of tuberin in cells, the cells enlarge ...

ORLANDO, Jan. 8, 2021 - Florida's threatened coral reefs have a more than $4 billion annual economic impact on the state's economy, and University of Central Florida researchers are zeroing in on one factor that could be limiting their survival - coral skeleton strength. In a new study published in the journal Coral Reefs, UCF engineering researchers tested how well staghorn coral skeletons withstand the forces of nature and humans, such as impacts from hurricanes and divers. The researchers subjected coral skeletons to higher stresses than those caused by ocean waves, says Mahmoud Omer, a doctoral student in UCF's Department ...

A research team at the University of Basel has discovered immune cells resident in the lungs that persist long after a bout of flu. Experiments with mice have shown that these helper cells improve the immune response to reinfection by a different strain of the flu virus. The discovery could yield approaches to developing longer-lasting vaccinations against quickly-mutating viruses. At the start of the coronavirus pandemic, some already began to raise the question of how long immunity lasts after weathering SARS-CoV-2. The same question has now arisen regarding the COVID-19 vaccination. A key role is played by immunological memory - a complex interplay of immune cells, antibodies and signaling ...

Humans have them, so do other animals and plants. Now research reveals that bacteria too have internal clocks that align with the 24-hour cycle of life on Earth. The research answers a long-standing biological question and could have implications for the timing of drug delivery, biotechnology, and how we develop timely solutions for crop protection. Biological clocks or circadian rhythms are exquisite internal timing mechanisms that are widespread across nature enabling living organisms to cope with the major changes that occur from day to night, even across seasons. Existing inside cells, these molecular rhythms use external cues such as daylight and temperature to synchronise ...

CORVALLIS, Ore. - Efficiently mass-producing hydrogen from water is closer to becoming a reality thanks to Oregon State University College of Engineering researchers and collaborators at Cornell University and the Argonne National Laboratory. The scientists used advanced experimental tools to forge a clearer understanding of an electrochemical catalytic process that's cleaner and more sustainable than deriving hydrogen from natural gas. Findings were published today in Science Advances. Hydrogen is found in a wide range of compounds on Earth, most commonly combining with oxygen to make water, and it has many scientific, industrial and energy-related roles. It also occurs in the form of hydrocarbons, compounds consisting of hydrogen and carbon such ...

Researchers have for the first time identified the way viruses like the poliovirus and the common cold virus 'package up' their genetic code, allowing them to infect cells. The findings, published today (Friday, 8 January) in the journal PLOS Pathogens by a team from the Universities of Leeds and York, open up the possibility that drugs or anti-viral agents can be developed that would stop such infections. Once a cell is infected, a virus needs to spread its genetic material to other cells. This is a complex process involving the creation of what are known as virions - newly-formed infectious copies of the virus. Each virion is a protein shell containing a complete copy of the virus's genetic code. ...

Corals have evolved over millennia to live, and even thrive, in waters with few nutrients. In healthy reefs, the water is often exceptionally clear, mainly because corals have found ways to make optimal use of the few resources around them. Any change to these conditions can throw a coral's health off balance. Now, researchers at MIT and the Woods Hole Oceanographic Institution (WHOI), in collaboration with oceanographers and marine biologists in Cuba, have identified microbes living within the slimy biofilms of some coral species that may help protect the coral against certain nutrient imbalances. The team found these microbes can take up and ...

More than half of Latina mothers surveyed in Yolo and Sacramento counties reported making economic cutbacks in response to the pandemic shutdown last spring -- saying they bought less food and missed rent payments. Even for mothers who reported receiving the federal stimulus payment during this time, these hardships were not reduced, University of California, Davis, researchers found in a recent study. "Latino families are fighting the pandemic on multiple fronts, as systemic oppression has increased their likelihood of contracting the virus, having complications from the virus and having significant economic hardship due to the virus," said Leah C. Hibel, associate professor of human development and family studies at UC Davis and ...

Like Peter Pan, some cells never grow up. In cancer, undifferentiated stem cells may help tumors such as glioblastoma become more aggressive than other forms of the disease. Certain groups of genes are supposed to help cells along the path to maturity, leaving their youthful "stemness" behind. This requires sweeping changes in the microRNAome -- the world of small non-coding material, known as microRNAs, that control where and when genes are turned on and off. Many microRNAs are tumor-suppressive; in cancer, the microRNAome is distorted and disrupted. Recent work by researchers at Brigham and Women's Hospital pinpoints critical changes in an enzyme known as DICER, which create a cascade of effects on this microRNAome. ...

The BioScience Talks podcast features discussions of topical issues related to the biological sciences. In a career-spanning installment of the journal BioScience's In Their Own Words oral history series, Missouri Botanical Garden President Emeritus Peter Raven illuminates numerous topics, sharing insights related to the sustainability of human civilization, the COVID-19 pandemic, and the importance of science in addressing the world's greatest challenges. Raven, a recent coauthor of "A Call to Action: Marshaling Science for Society," highlights the importance of public outreach in overcoming deeply rooted societal problems. Among them, he argues that our present economic system "sees natural productivity like every other ...

Before the pandemic, the lab of Stanford University biochemist Peter S. Kim focused on developing vaccines for HIV, Ebola and pandemic influenza. But, within days of closing their campus lab space as part of COVID-19 precautions, they turned their attention to a vaccine for SARS-CoV-2, the virus that causes COVID-19. Although the coronavirus was outside the lab's specific area of expertise, they and their collaborators have managed to construct and test a promising vaccine candidate. "Our goal is to make a single-shot vaccine that does not require a cold-chain for storage or transport. If we're successful at doing it ...

While rare, botulism can cause paralysis and is potentially fatal. It is caused by nerve-damaging toxins produced by Clostridium botulinum -- the most potent toxins known. These toxins are often found in contaminated food (home canning being a major culprit). Infants can also develop botulism from ingesting C. botulinum spores in honey, soil, or dust; the bacterium then colonizes their intestines and produces the toxin. Once paralysis develops, there is no way to reverse it, other than waiting for the toxins to wear off. People with serious cases of botulism may need to be maintained on ventilators for weeks or months. But a new treatment approach and delivery vehicle, ...

More than half of people who use medical marijuana products to ease pain also experience clusters of multiple withdrawal symptoms when they're between uses, a new study finds. And about 10% of the patients taking part in the study experienced worsening changes to their sleep, mood, mental state, energy and appetite over the next two years as they continued to use cannabis. Many of them may not recognize that these symptoms come not from their underlying condition, but from their brain and body's reaction to the absence of substances in the cannabis products they're smoking, vaping, eating or applying to their skin, says the University of Michigan Addiction Center psychologist who led the study. When someone ...

Gastric bypass surgery is sometimes the last resort for those who struggle with obesity or have serious health-related issues due to their weight. Since this procedure involves making a small stomach pouch and rerouting the digestive tract, it is very invasive and prolongs the recovery period for patients. In a new study, researchers at Texas A&M University have described a medical device that might help with weight loss and requires a simpler operative procedure for implantation. Researchers said their centimeter-sized device provides the feeling of fullness by stimulating the endings of the vagus nerve with light. Unlike other devices that require a power cord, their device is wireless and can be controlled ...

TAMPA, Fla. (Jan. 8, 2021)- New research led by the University of South Florida has uncovered one of the reasons jellyfish have come to be known as the "world's most efficient swimmer." Brad Gemmell, associate professor of integrative biology, found jellyfish produce two vortex rings, which are donut-shaped bodies of fluid underneath their translucent bodies, that spin in opposite directions. They appear as jellyfish squeeze and reopen throughout each swim cycle, providing a "ground effect" force as if they were to be pushing off the seafloor. The "ground effect" is most widely understood ...

Scientists from Russia, Austria, and the USA have discovered virus-like particles in the bacterial symbionts of Bryozoa - a phylum of colonial aquatic invertebrates - filter-feeders dominating in many bottom ecosystems. The research project was planned and supervised by scientists from St Petersburg University. Some of the virus-like particles resemble red blood cells, while others have a sea-urchin-like appearance. Although viruses have never been reported inside symbiotic bacteria in bryozoans, scientists suggest that this "matryoshka doll" may have a prominent effect on the bacterial ...

What The Study Did: This study adapted a well-established tool for measuring inequity from economics--the Lorenz curve--to measure racial inequities in COVID-19 testing. Author: Aaloke Mody, M.D., of the Washington University School of Medicine in St Louis, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2020.32696) Editor's Note: The article includes funding/support disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support. INFORMATION: Media ...

CHAMPAIGN, Ill. -- Religious people facing life crises rely on emotion-regulation strategies that psychologists also use, a new study finds. They look for positive ways of thinking about hardship, a practice known to psychologists as "cognitive reappraisal." They also tend to have confidence in their ability to cope with difficulty, a trait called "coping self-efficacy." Both have been shown to reduce symptoms of anxiety and depression. The new findings are reported in the Journal of Religion and Health. "It appears that religious people are making use of some of the same tools that psychologists have systematically identified as effective in ...

Announcing a new publication for BIO Integration journal. In this opinion article the authors Daiyun Xu, Yonghui Lü, Yongxiao Li, Shengbin Li, Zhe Wang and Junqing Wang from Sun Yat-Sen University, Guangzhou, China discuss ferroptosis resistance in cancer. Ferroptosis is a lethal consequence of accumulated lipid peroxidation catalyzed by ferrous iron and oxygen. This unique cell death process appears to involve many diseases, such as neurodegeneration, ischemia/ reperfusion injury, kidney disease, and a druggable target in therapy-resistant cancers. Ferroptosis may provide hope for ...

Humans depend on their senses to perceive the world, themselves and each other. Despite senses being the only window to the outside world, people do rarely question how faithfully they represent the external physical reality. During the last 20 years, neuroscience research has revealed that the cerebral cortex constantly generates predictions on what will happen next, and that neurons in charge of sensory processing only encode the difference between our predictions and the actual reality. A team of neuroscientists of TU Dresden headed by Prof Dr Katharina von Kriegstein presents new findings that show that not only the cerebral cortex, but ...

In a study published in Physical Review Letters, the team led by academician GUO Guangcan from University of Science and Technology of China (USTC) of the Chinese Academy of Sciences (CAS) made progress in high dimensional quantum teleportation. The researchers demonstrated the teleportation of high-dimensional states in a three-dimensional six-photon system. To transmit unknown quantum states from one location to another, quantum teleportation is one of the key technologies to realize the long-distance transmission. Compared with two-dimensional ...

In a study published in Advanced Materials, the researchers from Hefei National Laboratory for Physical Sciences at the Microscale, the University of Science and Technology of China of the Chinese Academy of Sciences, using an electron-proton co-doping strategy, invented a new metal-like semiconductor material with excellent plasmonic resonance performance. This material achieves a metal-like ultrahigh free-carrier concentration that leads to strong and tunable plasmonic field. Plasmonic materials are widely used in the fields including microscopy, sensing, optical computing and photovoltaics. Most common plasmonic materials are gold and silver. Some other materials ...