A program designed to improve hospital care for patients with heart failure, the leading cause of hospitalization among adults over age 65, did not bring additional benefits beyond existing hospital quality improvement programs in a randomized controlled trial presented at the American College of Cardiology's 70th Annual Scientific Session. Heart failure is a condition in which the heart becomes too weak or too stiff to pump blood effectively to the rest of the body. It causes symptoms such as swelling and fluid retention, shortness of breath and coughing. In the CONNECT-HF study, one group of hospitals received additional auditing and ...

For the first time, Penn State researchers have identified a gene that controls flowering in cacao, a discovery that may help accelerate breeding efforts aimed at improving the disease-ridden plant, they suggested. Characterizing the Flowering Locus T gene in cacao, responsible for the production of florigen -- a protein that triggers flowering in most plants -- is important, according to study co-author Mark Guiltinan, J. Franklin Styer Professor of Horticultural Botany and professor of plant molecular biology. He expects this advancement to enable scientists to develop disease-resistant trees faster, which is critical because 20% to 30% ...

Some words sound like what they mean. For example, "slurp" sounds like the noise we make when we drink from a cup, and "teeny" sounds like something that is very small. This resemblance between how a word sounds and what it means is known as iconicity. In her lab at the University of Miami, Lynn Perry, an associate professor in the College of Arts and Sciences Department of Psychology, previously found that children tend to learn words higher in iconicity earlier in development then they do words lower in iconicity. She also found that adults tend to use more iconic words when they speak to children than when they speak to other adults. "That got us curious about why," said Stephanie Custode, a doctoral student in psychology, who ...

University researchers have carried out the largest systematic review and meta-analysis to date of how people's perceptions of their screen time compare with what they do in practice, finding estimates of usage were only accurate in about five per cent of studies. The international team say this casts doubt on the validity of research on the impact of screen time on mental health, and its influences on government policy, as the vast majority rely on participants to estimate (self-report) how long they spend on digital devices, rather than logs of actual usage, or tracked time. "For decades, researchers have relied on estimates of how we use various technologies to study how people use digital ...

A new study led by researchers from the Oxford University Museum of Natural History, University of Oxford and the University of Birmingham for Current Biology has used new methods to analyse the variability of mammal fossils, revealing extraordinary results: it was not dinosaurs, but possibly other mammals, that were the main competitors of modern mammals before and after the mass extinction of dinosaurs. The study challenges old assumptions about why mammals only seemed to diversify, becoming larger and exploring new diets, locomotion and ways of life, after the extinction of the non-bird dinosaurs. It points to a more complex story of competition between distinct mammal groups. ...

Before undergoing surgery, patients often go through a number of tests: blood work, sometimes a chest X-ray, perhaps tests to measure heart and lung function. In fact, about half of patients who had one of three common surgical procedures done in Michigan between 2015 and the midway point of 2019 received at least one routine test beforehand. That's according to new research in JAMA Internal Medicine from a collaboration between the University of Michigan-based Michigan Program on Value Enhancement (MPrOVE) and the Michigan Value Collaborative, a statewide initiative that focuses on improving medical and surgical quality. Yet plenty of evidence suggests that preoperative testing is often unnecessary ...

The experimental heart failure drug omecamtiv mecarbil reduced heart failure hospitalizations by a greater margin among patients with more severely reduced ejection fraction, a measure indicating severe impairment in the heart's pumping ability, compared with those who had moderately reduced ejection fraction, according to research presented at the American College of Cardiology's 70th Annual Scientific Session. Omecamtiv mecarbil works by improving the ability for heart muscle cells to contract and operates through a different biological pathway than any of the current heart failure medications. The research ...

One of the enduring mysteries of the COVID-19 pandemic is why most children tend to experience fewer symptoms than adults after infection with the coronavirus. The immune system response that occurs in the rare cases in which children experience life-threatening reactions after infection may offer an important insight, a Yale-led study published in the journal Immunity suggests. While many children infected with the virus are asymptomatic or go undiagnosed, about one in 1,000 children experience multi-system inflammatory response (MIS-C) four to six weeks after confirmed infection with SARS-CoV-2, the virus that causes COVID-19. The condition ...

Inserm teams led by Laurent Reber (Infinity, Toulouse) and Pierre Bruhns (Humoral Immunity, Institut Pasteur, Paris) and French company NEOVACS have developed a vaccine that could induce long-term protection against allergic asthma, reducing the severity of its symptoms and thus significantly improving patient quality of life. Their research in animals has been published in the journal Nature Communications. Asthma is a chronic disease affecting around 4 million people in France and 340 million worldwide. Allergic asthma is characterized by inflammation of the bronchial tubes and respiratory discomfort caused by the inhalation of allergens, most often dust mites. This exposure to dust mites and other allergens leads to ...

A randomized double-blind controlled trial of convalescent plasma for adults hospitalized with severe COVID-19 found that mortality at 28 days in the treatment arm was half the rate seen in the control arm (12.6% vs. 24.6%), although treatment was not associated with other improvements in clinical status. The study was led by investigators from the Center for Infection and Immunity at Columbia University Mailman School of Public Health; Columbia University Irving Medical Center; ICAP at Columbia University; Instituto Nacional de Infectologia and Hospital Federal dos Servidores do Estado in Rio de Janeiro, Brazil; University of Washington; and New York Blood Center. The results are published in the Journal of Clinical Investigation. According ...

Patients with heart failure with preserved ejection fraction who took the antifibrotic drug pirfenidone saw a significant reduction in a marker of heart muscle scarring compared with patients who received a placebo, based on findings from an early-phase trial presented at the American College of Cardiology's 70th Annual Scientific Session. "Observational data suggests that heart muscle scarring, or fibrosis, is an important disease process for heart failure prognosis," said Chris Miller, MD, a cardiologist and National Institute for Health Research Clinician Scientist at the University ...

Patients with heart failure with reduced ejection fraction (HFrEF) did not have better health outcomes if they took sacubitril/valsartan combination therapy compared with valsartan alone, according to new data presented at the American College of Cardiology's 70th Annual Scientific Session. Heart failure, a leading cause of hospitalization among adults over age 65, is a condition in which the heart becomes too weak to pump blood effectively to the rest of the body, causing fatigue and shortness of breath. For patients with severe heart failure, treatment options are limited to a mechanical heart pump or heart transplant. Doctors have sought ways to slow the progression of severe heart failure ...

The likelihood of people surviving COVID-19 in UK hospitals has been improving over time, a new study has found. Research published in The Lancet Respiratory Medicine by the ISARIC Coronavirus Clinical Characterisation Consortium found that in-hospital mortality declined from 32% at the start of the first wave (Mar-Apr 2020) to 16% at the end of the first wave (Jun-Jul 2020). In their study of 63,972 adults admitted to 247 UK hospitals the researchers found reductions in mortality were observed in all age groups, in all ethnic groups, for both sexes, and in patients with and without comorbidities. This improvement was ...

A group of Brazilian and Portuguese researchers observed a correlation between the presence of lead in the organism and a microRNA (miRNA) that could be associated with the mechanisms that regulate DNA methylation, a physiological process required to control gene expression and ensure that genes function properly. The alterations were detected in blood cells from workers in automotive battery plants, which use lead as a raw material. Curiously, lead levels in blood samples from 85 volunteers – averaging 20 micrograms per deciliter of blood (20 μg/dl) – were lower than the acceptable ceiling defined in Brazilian law (60 μg/dl). The study was supported by FAPESP and ...

A long noncoding RNA whose function was previously unknown turns out to play an important role in promoting the body's immune response against cancer and holds promise for enhancing the efficacy of anti-cancer immunotherapy. That's according to new findings reported in Nature Cell Biology by researchers at the University of Michigan Rogel Cancer Center. The group dubbed the RNA they identified LIMIT -- for long noncoding RNA inducing major histocompatibility complex class I and immunogenicity of tumor. "LIMIT is easy to remember, but really it does the opposite. It stimulates immune functions against cancer," says senior study author Weiping Zou, M.D., Ph.D., the Charles B. de Nancrede Professor of Pathology, Immunology, Biology, and Surgery at U-M. Only a small part of the human ...

Researchers at the University of California, Davis, have found a link between traffic-related air pollution and an increased risk for age-related dementia, including Alzheimer's disease. Their study, based on rodent models, corroborates previous epidemiological evidence showing this association. Alzheimer's disease is the most common cause of age-related dementia and the sixth leading cause of death in the United States. More than 5 million Americans currently live with Alzheimer's disease -- a number that is expected to triple by 2050 as the population ages. ...

In patients receiving therapeutic hypothermia after suffering out-of-hospital cardiac arrest, those who were cooled below 31 degrees Celsius (about 88 degrees Fahrenheit) for 24 hours showed no difference in terms of death or poor neurological outcomes at six months compared with patients receiving guideline-recommended cooling of 34 C (about 93 F). These findings are part of a study presented at the American College of Cardiology's 70th Annual Scientific Session. Therapeutic hypothermia is a procedure in which a person's body is cooled far below normal body temperature. It has been shown to improve survival and reduce brain damage in people who have been resuscitated but remain comatose after suffering cardiac arrest (when the heart stops ...

Sperm are generally viewed as having just one action in reproduction - to fertilise the female's egg - but studies at the University of Adelaide are overturning that view. Published in Nature Research journal Communications Biology, new research shows that sperm also deliver signals directly to the female reproductive tissues to increase the chances of conception. Robinson Research Institute's Professor Sarah Robertson, who led the project, said: "This research is the first to show that the female immune response is persuaded by signals in sperm to allow the male partner ...

Marilyn Monroe famously sang that diamonds are a girl's best friend, but they are also very popular with quantum scientists - with two new research breakthroughs poised to accelerate the development of synthetic diamond-based quantum technology, improve scalability, and dramatically reduce manufacturing costs. While silicon is traditionally used for computer and mobile phone hardware, diamond has unique properties that make it particularly useful as a base for emerging quantum technologies such as quantum supercomputers, secure communications and sensors. However there are two key problems; cost, and difficulty in fabricating the single crystal diamond layer, which is smaller ...

The nanophotonics-based LiDAR technology developed by a POSTECH research team was presented as an invited paper in Nature Nanotechnology, the leading academic journal in the field of nanoscience and nanoengineering. In this paper, a POSTECH research team (led by Professor Junsuk Rho of the departments of mechanical engineering and chemical engineering, postdoctoral researcher Dr. Inki Kim of the Department of Mechanical Engineering, and Ph.D. candidate Jaehyuck Jang of the Department of Chemical Engineering) in cooperation with the French National Science Institute (CNRS-CRHEA) focused on the LiDAR device developed through studying the metamaterials based ultralight nanophotonics. In addition, the paper ...

Image fusion is a process that can enhance the clinical value of medical images, improving the accuracy of medical diagnoses and the quality of patient care. Researchers at the College of Data Science Software Engineering at China's Qingdao University, have developed a new 'multi-modal' image fusion method based on supervised deep learning that enhances image clarity, reduces redundant image features and supports batch processing. Their END ...

ATS 2021, New York, NY - The COVID-19 pandemic has, and will continue to have, a tremendous impact on ICU nurses' mental health and willingness to continue in the critical care work force, according to research presented at the ATS 2021 International Conference. Jill Guttormson, PhD, RN, associate dean for Academic Affairs and associate professor, College of Nursing, Marquette University, and colleagues sought to describe the impact of COVID-19 on ICU nurses through a survey using valid and reliable measures of burnout, moral distress, depression, anxiety, and posttraumatic stress symptoms. The researchers recruited a national sample of nurses who have worked in the ICU during the COVID-19 pandemic between October and ...

The cover for issue 7 of Oncotarget features Figure 14, "A hypothetical model of how a specific remodeling of cellular metabolism by CR slows down yeast chronological aging," published in "Caloric restriction creates a metabolic pattern of chronological aging delay that in budding yeast differs from the metabolic design established by two other geroprotectors" by Mohammad, et al. which reported that caloric restriction and the tor1Δ mutation are robust geroprotectors in yeast and other eukaryotes. The authors demonstrate that caloric restriction generates a unique metabolic pattern. Unlike the tor1Δ mutation or lithocholic acid, it slows down the metabolic pathway ...

A team of McMaster University researchers who studied heart patients found that stair-climbing routines, whether vigorous or moderate, provide significant cardiovascular and muscular benefits. The findings, published in closely related studies in the journals Medicine & Science in Sports & Exercise and Frontiers, address the most frequently cited barriers to exercise: time, equipment and access to gym facilities. "Brief, vigorous stair-climbing and traditional moderate intensity exercise both changed fitness, which is a key predictor of mortality after a cardiac event," says Maureen MacDonald, one of the lead researchers on both studies and a professor in McMaster's Department ...

Oncotarget published "The cancer testis antigens CABYR-a/b and CABYR-c are expressed in a subset of colorectal cancers and hold promise as targets for specific immunotherapy" which reported that Calcium-binding tyrosine phosphorylation-regulated protein is expressed in the human germ line but not in adult human tissues, thus, it is considered a cancer testis protein. The aim of this study is to evaluate the CABYR isoforms: a/b and c mRNA expression in colorectal cancer and to determine if these proteins hold promise as vaccine targets. CABYR mRNA expression in a set of normal human tissues, including the testis, were determined ...