Analysing the forces at work behind the obstructions that cause heart attacks is crucial for identifying patients at risk of these events, says a study published today in eLife. The findings suggest that bringing such biomechanical analyses into clinical practice could allow cardiologists to predict a future heart attack in patients by simulating the distribution of stress within diseased heart vessels. A myocardial infarction, commonly known as a heart attack, occurs when the supply of blood to the heart is blocked by a blood clot or similar obstruction. A build-up of fatty deposits (lipids) over time forms plaques in the heart's arteries. If the plaque ruptures, it can form a blood clot that blocks the arteries and causes a heart attack. Previous ...

A research group led by Prof. LUO Tianzhi from the University of Science and Technology of China (USTC) of the Chinese Academy of Sciences, collaborating with Prof. WANG Zhengzhi's team from Wuhan University, explored the natural defenses in the tail spike of mantis shrimps and left chela of hermit crabs. They revealed the chemical gradients from nanometer to centimeter and the correlation between micro-structure and mechanical properties. Also, they confirmed toughening mechanism and optimized structure principles through a 3D printing technique and finite-element analysis. The results were published in ACS Applied Materials ...

HERSHEY, Pa. -- According to the World Health Organization, cervical cancer is the fourth most common form of cancer affecting women worldwide, and those in developing countries face a higher risk of dying from it. If detected early, cervical cancer responds well to treatment, however not everyone receives cancer screenings. A team of researchers, including those from Penn State College of Medicine, took a closer look at cervical cancer in sub-Saharan Africa (SSA) to determine the prevalence and key factors that influence cancer screenings. The group found that despite high mortality rates, cancer screenings are substantially low, and there are multiple reasons why. In a new study, published in Cancer ...

Autism spectrum disorder is a neurodevelopmental condition involving impaired social abilities, and this makes it a fascinating subject for neuroscientists like Prof. Teiichi Furuichi of the Tokyo University of Science who study the neuroscience of social behavior. Prof. Furuichi and his colleagues have previously worked on developing mouse models of autism to unravel the condition's neurochemical mechanisms, and in a paper recently published in the prestigious Journal of Neuroscience, they provide evidence that a genetic mutation associated with autism can impair the release of a peptide called oxytocin that plays an important role in regulating social behavior. This finding promises to broaden our understanding of the neurobiology of social behavior. The gene that Prof. ...

In the field of international business research, lobbying is considered a legitimate and legal political action conducted in a developed economy. Bribery, on the other hand, is seen as an outright corrupt practice in an emerging economy. In a study published in the March issue of the journal Business & Society, a researcher from The University of Texas at Dallas examined the gray area between lobbying and bribery among multinational companies, especially in countries where lobbying is not regulated strongly or institutional development is insufficient. The analysis found that firms based in developed countries, as opposed to developing countries or transition economies, are more likely to influence the institutional ...

Counselling sessions improve long term mental health in primary-school aged children, according to a new study. The research has implications for reversing declining mental health in young people in a COVID-19 era. A team from the University of Exeter and the University of Cambridge worked in partnership with Place2Be to assess the longer-term impact of its school-based service. The study assessed the impact of Place2Be's programme, in which trained counsellors operated in 171 schools nationwide in the academic year 2015/16. Under the scheme, children could ...

The researchers found that the variants have a similar surface stability as the wild type virus under laboratory conditions, but can be effectively eliminated by disinfection and thorough hand washing, heat or alcohol treatment. They report their results in the Journal of Infectious Diseases from 16 May 2021. For this study, the team from the Department for Molecular and Medical Virology and the Chair of Materials Discovery and Interfaces at Ruhr-Universität Bochum (RUB) cooperated with the European Virus Bioinformatics Center Jena, the University Hospital Duisburg-Essen and Paracelsus Medical University Nuremberg. The ...

May 18, 2021 - Offering interventions to young people in the general community can prevent the emergence of certain mental health disorders, according to the first comprehensive systematic review to address this question. The results appear in the May/June issue of Harvard Review of Psychiatry, which is published in the Lippincott portfolio by Wolters Kluwer. "Preventive interventions for poor mental health outcomes in young people are feasible and appear to be effective," according to the review by Gonzalo Salazar de Pablo, MD, and Andrea De Micheli, MD, of King's College London, and colleagues. Evidence suggests that young people respond well to early interventions. Universal ...

Writing in the May 14, 2021 issue of The American Journal of Psychiatry, a multi-institution team of scientists led by researchers at University of California San Diego School of Medicine report that medications commonly prescribed to reduce the severity of physical and mental health symptoms associated with schizophrenia may have a cumulative effect of worsening cognitive function in patients. Psychotropic medications are often necessary and beneficial, but they possess other secondary properties that are not directly related to reducing symptoms, including anticholinergic properties. That ...

CORVALLIS, Ore. - Oregon State University researchers say "topographic templates" can help forest conservation managers develop strategies for protecting and restoring the most fire-resistant parts of vulnerable forests across a range of ecosystems. That's important because changing wildfire regimes are affecting forests around the globe, the scientists note, and areas that burn over and over in relatively quick succession may not be able to recover between fires. "Fire refugia" - areas that burn less frequently and/or less severely than the landscape around them - are crucial for supporting post-blaze ecosystem ...

The research teams at the University of Hong Kong led by Professor Xuechen LI from the Research Division for Chemistry and Department of Chemistry, and Professor Yu WANG from the Department of Pharmacology and Pharmacy, reported a synthetic biotherapeutics with promising anti-tumour, insulin sensitising and hepatoprotective activities in the Journal of the American Chemical Society. Obesity is a global pandemic associated with a significantly reduced life expectancy, it also increases the risk of type 2 diabetes, hypertension, coronary heart disease, stroke, chronic kidney disease and cancer. Adiponectin, as a protein hormone and adipokine, regulates glucose levels and improve lipid metabolism, and is a major player in the ...

A team including Northwestern University astrophysicists has developed the most realistic, highest-resolution 3D simulation of star formation to date. The result is a visually stunning, mathematically-driven marvel that allows viewers to float around a colorful gas cloud in 3D space while watching twinkling stars emerge. Called STARFORGE (Star Formation in Gaseous Environments), the computational framework is the first to simulate an entire gas cloud -- 100 times more massive than previously possible and full of vibrant colors -- where stars are born. It also is the first simulation to simultaneously model star formation, evolution and dynamics while accounting for stellar feedback, including jets, radiation, wind and nearby supernovae activity. ...

The challenges that many women face in today's labour market are well documented, from lower employment rates than men to lower rates of pay. Previous studies have considered how the burden of family care, which often falls largely on women's shoulders, has contributed to this imbalance. However, few of these studies have considered why women are the ones to bear that care burden. A new study, published in the KeAi journal China Economic Quarterly International, has used data from China to investigate the impact of the concept of gender roles on women's employment and earnings. Study author, Chuanchuan Zhang, of China's Zhejiang University, explains: "Traditionally, studies on women's labour supply ...

Tsukuba, Japan - Aggression is common in many neuropsychiatric diseases, such as dementia, autism spectrum disorder, and schizophrenia. It causes many problems for patients and their families, but can be difficult to treat because little is known about what causes it. In a study published last month in Molecular Psychiatry, researchers from the University of Tsukuba revealed that variation in levels of interleukin 1β (IL-1β), a protein that mediates the inflammatory response, is associated with individual differences in aggressive behaviors in male mice. In humans, levels ...

[Outline] A research group led by Specially appointed professor, Dr. Tatsuo Suzuki of Shinshu University School of Medicine developed a new purification protocol for Postsynaptic density (PSD) lattice, a core structure of the PSD of excitatory synapses in the central nervous system. The components of the PSD lattice were identified by comprehensive shotgun mass spectrometry and categorized as either minimum essential component (MEC) or non-MEC proteins. Tubulin was found to be a major component of the MEC, with non-microtubule tubulin widely distributed on the purified PSD lattice. The presence of tubulin in and around PSDs was verified by post-embedding immuno-gold labeling ...

Postpartum psychosis is a devastating, but rare, mental health problem that affects women in the first few weeks after giving birth. Symptoms vary widely, and can include high mood (mania), depression, confusion, hallucinations and delusions. Although the disorder affects only one in every 1,000 women who have a baby, it is much more common in mothers with a history of bipolar disorder or schizoaffective disorder (a condition which has symptoms of schizophrenia and bipolar disorder), or women who have suffered a previous episode of postpartum psychosis. There are currently no biological markers that help to identify women who ...

A study using a mouse model of eccentric contraction (*1) has revealed that icing injured muscles delays muscle regeneration. The discovery was made by a research group including Associate Professor ARAKAWA Takamitsu and then PhD. Student KAWASHIMA Masato from Kobe University's Graduate School of Health Sciences, and Chiba Institute of Technology's Associate Professor KAWANISHI Noriaki et al. In addition, the researchers illuminated that this phenomenon may be related to pro-inflammatory macrophages' (*2, 3, 4) ability to infiltrate damaged cells. This research raises questions as to whether or not severe muscle injuries (such as torn muscles) should be ...

Robust data and genetic research are providing important evidence on a colony of wild African vervet monkeys that landed in Dania Beach more than 70 years ago and settled in a thick mangrove forest near the Fort Lauderdale-Hollywood International Airport in South Florida. The non-native vervet monkey (Chlorocebus sabaeus) population living in this urban coastal region is well known and beloved among local residents and city officials; however, it is relatively unknown to primatologists. Despite wide public interest, there has been only one scientific study (early 1990s), suggesting that the monkeys escaped from a failed roadside zoo in the 1950s and 1970s. Until now, there was no confirmation about ...

Scientists from Hokkaido University have developed a rapid, efficient protocol for cross-coupling reactions, vastly expanding the pool of chemicals that can be used for the synthesis of useful organic compounds. Chemical reactions are a vital process in the synthesis of products for a diversity of purposes. For the most part, these reactions are carried out in the liquid phase, by dissolving the reactants in a solvent. However, there are a significant number of chemicals that are partially or completely insoluble, and thus have not been used for synthesis. The starting materials required for the synthesis of many cutting-edge organic materials--such as organic semiconductors and luminescent materials--are often poorly soluble, leading to problems in solution-based synthesis. Therefore, ...

Vaccines are turning the tide of the pandemic, but the risk of infection is still present in some situations. If you want to visit a friend, get on a plane, or go see a movie, there is no highly accurate, instant test that can tell you right then and there whether or not you have a SARS-CoV-2 infection. But new research from Lawrence Berkeley National Laboratory (Berkeley Lab) could help get reliable instant tests on the market. A study led by Michal Hammel and Curtis D. Hodge suggests that a highly sensitive lateral flow assay - the same type of device used in home pregnancy tests - could be developed using pairs of rigid antibodies that bind to the SARS-CoV-2 nucleocapsid protein. Such a test would only require a small drop of mucus or saliva, could give results ...

The first-ever discovery of an extraterrestrial radioactive isotope on Earth has scientists rethinking the origins of the elements on our planet. The tiny traces of plutonium-244 were found in ocean crust alongside radioactive iron-60. The two isotopes are evidence of violent cosmic events in the vicinity of Earth millions of years ago. Star explosions, or supernovae create many of the heavy elements in the periodic table, including those vital for human life, such as iron, potassium and iodine. To form even heavier elements, such as gold, uranium and plutonium it was thought that a more violent event may be needed, such as two neutron stars merging. However, a study led by Professor Anton Wallner from The Australian National University (ANU) suggests ...

A rigorous meta-analysis of randomized clinical trials (RCTs) that compared the effects of medical therapies alone with medical therapies plus revascularization in patients with stable ischemic heart disease (SIHD) was presented at EuroPCR on May 18, 2021. The study concluded that adding revascularization was associated with a statistically important reduction in cardiovascular death associated with a statistically important reduction in spontaneous myocardial infarction (MI), providing a biologically plausible explanation for the observed benefit. An international group of investigators performed a meta-analysis of RCTs conducted between 1979 and 2020. Strict entry criteria were established to assure the analysis was restricted to studies involving elective, ...

When it comes sharing recipes on social media, what users post, and what they cook may be two entirely different things. That's the conclusion of a END ...

An international team of scientists from the Menzies Health Institute Queensland (MHIQ) at Griffith University and from City of Hope, a research and treatment center for cancer, diabetes and other life-threatening diseases in the U.S., have developed an experimental direct-acting antiviral therapy to treat COVID-19. Traditional antivirals reduce symptoms and help people recover earlier. Examples include Tamiflu®, zanamivir and remdesivir. This next-generation antiviral approach used gene-silencing RNA technology called siRNA (small-interfering RNA) to attack the virus' genome directly, which stops ...

ATLANTA - MAY 18, 2021 - A new study finds breast cancer survivors in general have higher risk of new cancer diagnosis compared to healthy individuals. The article, which appears in CANCER, states that compared to the general population in the United States, the risk of new cancer diagnoses among survivors was 20% higher for those with hormone receptor (HR) positive cancers and 44% higher for those with HR-negative cancers. Breast cancer is the most commonly diagnosed and prevalent cancer among women in the U.S., with over 3.9 million living breast cancer survivors as of 2019. The number of survivors is expected to increase with the aging population and advances in breast cancer treatment. Subsequent primary cancer (SPC) after breast cancer is a well-known late effect, but the ...