A novel system of chilled panels that can replace air conditioning can also help reduce the risk of indoor disease transmission, suggests new analysis from the University of British Columbia, University of Pennsylvania and Princeton University. The researchers computed air conditioning requirements in 60 of the world's most populous cities--with the additional ventilation required due to COVID-19. Then, they compared the energy costs with their cooling method, using the chilled panels and natural ventilation. The results, published in the COVID-19 edition of Applied Energy, showed that the alternative solution can save up to 45 per cent of the required energy, while ensuring building occupants are comfortable ...

Nearly three-quarters of Earth's land had been transformed by humans by 10,000BC, but new research shows it largely wasn't at the expense of the natural world. A study involving University of Queensland researchers combined global maps of population and land use over the past 12,000 years with current biodiversity data, demonstrating the effective environmental stewardship of Indigenous and traditional peoples. UQ's Professor James Watson said the findings challenged the modern assumption that human 'development' inevitably led to environmental destruction. "There's a paradigm among natural scientists, conservationists and policymakers that ...

Unless you've studied chemistry in college, it's unlikely you've come across the name aziridine. An organic compound with the molecular formula, C2H4NH, aziridines are well-known among medicinal chemists, who make use of the compound to prepare pharmaceutical drugs such as Mitomycin C, a chemotherapeutic agent known for its anti-tumor activity. Specifically, aziridines are what chemists call "enantiomers"--molecules that are mirror images of each other and cannot be superposed on one another. A peculiarity with enantiomers is that the biological activity ...

A team headed by Dr. Phillip M. Maffettone (currently at National Synchrotron Light Source II in Upton, USA) and Professor Andrew Cooper from the Department of Chemistry and Materials Innovation Factory at the University of Liverpool joined forces with the Bochum-based group headed by Lars Banko and Professor Alfred Ludwig from the Chair of Materials Discovery and Interfaces and Yury Lysogorskiy from the Interdisciplinary Centre for Advanced Materials Simulation. The international team published their report in the journal Nature Computational Science from 19 April 2021. Previously manual, time-consuming, error-prone Efficient analysis of X-ray diffraction data (XRD) plays a crucial role in the discovery of new materials, for example for the energy ...

A new study at Tel Aviv University found that the British variant (termed: B.1.1.7) of Covid-19 is 45% more contagious than the original virus. The researchers relied on data from about 300,000 PCR tests for Covid-19 obtained from the COVID-19 testing lab, which was established in collaboration with the Electra Group. The new study was conducted by Prof. Ariel Munitz and Prof. Moti Gerlitz of the Department of Clinical Microbiology and Immunology at the Sackler Faculty of Medicine, together with Dr. Dan Yamin and PhD student Matan Yechezkel from the Laboratory for Epidemic Modeling and Analysis (LEMA) at the Department of Industrial Engineering, all at Tel Aviv University. The study's results were published in the prominent scientific ...

Musty, moldy, smoky or horse dung-like smelling cocoa is not suitable for chocolate production. As part of a larger research project, a team of scientists led by Martin Steinhaus from the Leibniz Institute for Food Systems Biology at the Technical University of Munich has identified the odorants responsible for such off-flavors. The food industry can now use these results to objectively assess the sensory quality of fermented cocoa based on odorant concentrations. The research team published the data in the Journal of Agricultural and Food Chemistry. Who likes chocolate ...

An international group of scientific experts co-directed by CNRS oceanographer Jean-Pierre Gattuso* has stated the requirements for coral reef survival in an article published in Biological Conservation. Over 500 million people rely on coral reefs for the protection they confer against submersion, the fishing resources they offer, and the tourism they help attract. Yet these ecosystems are among the most threatened by global warming: since the 1980s, there has been a rise in the number of bleaching episodes, during which corals expel the microscopic algae that keep them alive. While these events are reversible if the temperature change is only ...

The largest study of its type in the UK has identified differences in the immune response to COVID-19, between people with no symptoms, compared to those suffering a more serious reaction to the virus. Researchers from the Wellcome Sanger Institute, Newcastle University, University College London, University of Cambridge, EMBL's European Bioinformatics Institute (EMBL-EBI) and their collaborators within the Human Cell Atlas initiative, found raised levels of specific immune cells in asymptomatic people. They also showed people with more serious symptoms had lost these protective cell types, but gained inflammatory cells. These differences in the immune response could help explain serious lung inflammation and blood clotting symptoms, and could be used to identify potential ...

Scientists have developed a new biomaterial that regrows blood vessels and bone, potentially providing a single-stage approach when repairing large bone defects. The study, led by researchers from RCSI University of Medicine and Health Sciences and SFI AMBER Centre, is published in the Journal of Controlled Release. Previous RCSI-led research had found that activating a mechanosensitive gene, called placental growth factor (PGF), at different doses promoted bone regeneration and grew new blood vessels. Using this knowledge, the researchers developed a biomaterial that delivers PGF at different concentrations. Inspired by the natural way in ...

ROCHESTER, Minn. -- A new Mayo Clinic study bolsters evidence that colorectal cancer is often imprinted in family genes and passed on from one generation to the next. In the study, published in Clinical Gastroenterology and Hepatology, researchers within the Mayo Clinic Center for Individualized Medicine found 1 in 6 patients with colorectal cancer had an inherited cancer-related gene mutation, which likely predisposed them to the disease. In addition, the researchers discovered that 60% of these cases would not have been detected if relying on a standard guideline-based approach. "We found that 15.5% of the 361 patients with colorectal cancer had an inherited mutation in a gene associated with the development of their cancer," says Niloy Jewel Samadder, M.D., a Mayo ...

Nearly a decade ago, global news outlets reported vast ice melt in the Arctic as sapphire lakes glimmered across the previously frozen Greenland Ice Sheet, one of the most important contributors to sea-level rise. Now researchers have revealed the long-term impact of that extreme melt. Using a new approach to ice-penetrating radar data, Stanford University scientists show that this melting left behind a contiguous layer of refrozen ice inside the snowpack, including near the middle of the ice sheet where surface melting is usually minimal. Most importantly, the formation of the melt layer changed the ice sheet's behavior by reducing its ability to store future meltwater. The research appears in Nature Communications ...

PHILADELPHIA-- Researchers at Penn Medicine have identified more genetic mutations that strongly predispose younger, otherwise healthy women to peripartum cardiomyopathy (PPCM), a rare condition characterized by weakness of the heart muscle that begins sometime during the final month of pregnancy through five months after delivery. PPCM can cause severe heart failure and often leads to lifelong heart failure and even death. The study is published today in Circulation. PPCM affects women in one out of every 2,000 deliveries worldwide, with about a third of those women developing heart failure for life, and about five percent of them ...

A myriad of genetic factors can influence the onset of diseases like high blood pressure, heart diseases, and type 2 diabetes. If we were to know how the DNA influences the risk of developing such diseases, we, we could shift from reactive to more preventive care, not only improving patients' quality of living but also saving money in the health system. However, tracing the connections between the DNA and disease onset requires solid statistical models that reliably work on very large datasets of several hundred thousand patients. Matthew Robinson, Assistant Professor at the Institute ...

Our guts may not provide long-lasting systemic immunity from COVID-19, which is where immune cells circulate through the body to provide protection to other organs, finds a new study published in Frontiers in Immunology. An analysis of blood samples from patients infected with SARS-CoV-2 revealed that immune cells circulating in the blood, which were triggered by the gut's response to infection, were limited in number when compared to immune cells that had been triggered elsewhere in the body. "Although the gut is considered an important portal of entry for the virus, the immune response in the blood of COVID-19 patients is dominated by ...

Philadelphia, April 20, 2021 - American artisan cheese has become increasingly popular over the past few decades. Understanding spoilage concerns and the financial consequences of defects can improve quality, profitability, and sustainability in the American artisan cheesemaking industry. In an article appearing in the END ...

Some Himalayan glaciers are more resilient to global warming than previously predicted, new research suggests. Rock glaciers are similar to "true" ice glaciers in that they are mixtures of ice and rock that move downhill by gravity - but the enhanced insulation provided by surface rock debris means rock glaciers will melt more slowly as temperatures rise. Rock glaciers have generally been overlooked in studies about the future of Himalayan ice. The new study, led by Dr Darren Jones at the University of Exeter, shows rock glaciers already account for about one twenty-fifth of Himalayan ...

A new mathematical model for the interaction of bacteria in the gut could help design new probiotics and specially tailored diets to prevent diseases. The research, from Chalmers University of Technology in Sweden, was recently published in the journal PNAS. "Intestinal bacteria have an important role to play in health and the development of diseases, and our new mathematical model could be extremely helpful in these areas," says Jens Nielsen, Professor of Systems Biology at Chalmers, who led the research. The new paper describes how the mathematical model performed when making predictions ...

Newly published research contained in the Special Issue of the Journal of Marketing features fourteen global author teams focused on the topic of Better Marketing for a Better World. Edited by Rajesh Chandy (London Business School), Gita Johar (Columbia University), Christine Moorman (Duke University), and John Roberts (University of New South Wales), this Special Issue brings together wide-ranging research to assess, illuminate, and debate whether, when, and how marketing contributes to a better world. The Special Issue is built on the thesis that marketing has the power to improve lives, sustain livelihoods, strengthen societies, and benefit the world at large. It calls for a renewed ...

PORTLAND, Ore. - Policies designed to prevent the misuse of opioids may have the unintended side effect of limiting access to the pain-relieving drugs by terminally ill patients nearing the end of their life, new research led by the Oregon State University College of Pharmacy suggests. A study of more than 2,500 hospital patients discharged to hospice care over a nine-year period showed a decreasing trend of opioid prescriptions as well as an increase in the prescribing of less powerful, non-opioid analgesics, meaning some of those patients might have been undertreated for their pain compared to similar patients in prior years. The findings, published in the Journal of Pain and Symptom Management, are an important step toward optimizing ...

Philadelphia, April 20, 2021 - A collaborative study from the Center for Injury Research and Prevention (CIRP) and the Center for Autism Research (CAR) at Children's Hospital of Philadelphia (CHOP) identified clear strengths and a series of specific challenges autistic adolescents experience while learning to drive. The findings were recently published by the American Journal of Occupational Therapy. Researchers conducted in-depth interviews with 17 specialized driving instructors who were trained as occupational therapists, driving rehabilitation specialists, or licensed driving instructors and who had completed additional training related ...

Flushing a toilet can generate large quantities of microbe-containing aerosols depending on the design, water pressure or flushing power of the toilet. A variety of pathogens are usually found in stagnant water as well as in urine, feces and vomit. When dispersed widely through aerosolization, these pathogens can cause Ebola, norovirus that results in violent food poisoning, as well as COVID-19 caused by SARS-CoV-2. Respiratory droplets are the most prominent source of transmission for COVID-19, however, alternative routes may exist given the discovery of small numbers of viable viruses in urine and stool samples. Public restrooms are especially cause for concern for transmitting COVID-19 because they are ...

A new UCLA study finds that the proportion of physicians who are Black in the U.S. has increased by only 4 percentage points over the past 120 years, and that the share of doctors who are Black men remains unchanged since 1940. The research also spotlights a significant income gap between white and Black male physicians -- a disparity, the researcher writes, that could reflect a combination of pay discrimination and unequal access for physicians to pursue careers in more lucrative specialties. The paper will be published April 19 in the peer-reviewed Journal of General Internal Medicine. "These findings demonstrate how slow progress has been, and how far and fast we have to go, if we care about the diversity of the physician workforce and the health benefits such diversity brings ...

COLUMBUS, Ohio - A high daily dose of an omega-3 supplement may help slow the effects of aging by suppressing damage and boosting protection at the cellular level during and after a stressful event, new research suggests. Researchers at The Ohio State University found that daily supplements that contained 2.5 grams of omega-3 polyunsaturated fatty acids, the highest dose tested, were the best at helping the body resist the damaging effects of stress. Compared to the placebo group, participants taking omega-3 supplements produced less of the stress hormone cortisol and lower levels of a pro-inflammatory protein during a stressful event in the lab. And while levels of protective compounds sharply declined in the placebo group after the stressor, there were ...

A Monash University study has uncovered for the first time a way to prevent and reverse damage caused by broken-heart syndrome, also known as Takotsubo cardiomyopathy. Using mouse models, the pre-clinical study published in the acclaimed journal Signal Transduction and Targeted Therapy, has shown the cardioprotective benefit of a drug called Suberanilohydroxamic acid, or SAHA, dramatically improved cardiac health and reversed the broken-heart. The landmark study used SAHA to target genes and is a world first for Takotsubo cardiomyopathy. SAHA, currently used for cancer treatment, is approved by the US Food and Drug Administration (FDA) and Australian Therapeutic Goods Administration (TGA), works by providing a protective benefit to genes and ...

For the first time, a study has shown a clear link between the frequency and duration of unconscious wakefulness during night-time sleep and an increased risk of dying from diseases of the heart and blood vessels, and death from any cause, particularly in women. The study of 8001 men and women, which is published today (Tuesday) in the European Heart Journal [1], found that women who experienced unconscious wakefulness most often and for longer periods of time had nearly double the risk of dying from cardiovascular disease during an average of between 6 and 11 years' ...