WASHINGTON (Sept. 14, 2015) -- According to initial results of a multi-site landmark study, led by Dominic Raj, M.D., at the George Washington University (GW) site, cardiovascular disease morbidity is significantly reduced through intensive management of high blood pressure. By targeting a blood pressure of 120 millimeters of mercury (mm Hg), lower than current guidelines, researchers found that adults 50 years and older also significantly reduced their rates of cardiovascular disease and cardiovascular events, such as heart attack and heart failure, as well as stroke, ...

Humans are extremely choosy when it comes to mating, only settling down and having kids after a long screening process involving nervous flirtations, set-ups by friends, online matchmaking sites, awkward dates, humiliating rejections, hasty retreats and the occasional lucky strike. In the end, we "fall in love" and "live happily ever after." But evolution is an unforgiving force - isn't this choosiness rather a costly waste of time and energy when we should just be "going forth and multiplying?" What, if anything, is the evolutionary point of it all? A new study may have ...

MRSA is bad news. If you've never heard of it, here's what you need to know: It's pronounced MER-suh, it's a nasty bacterial infection and it can cause serious disease and death. Senior molecular biology major Jacob Hatch knows MRSA as the infection that took his dad's leg. Hatch was thousands of miles away on an LDS (Mormon) mission when Methicillin-Resistant Staphylococcus aureus decalcified the bones in his dad's foot and lower leg, leading to an emergency amputation just below the knee. "It was really hard to hear the news--you never expect to hear someone in ...

Irvine, Calif., Sept. 14, 2015 -- University of California, Irvine researchers with the School of Medicine have identified the mechanism by which valproic acid controls epileptic seizures, and by doing so, also revealed an underlying factor of seizures. Valproic acid is widely used to treat various types of seizure disorders, but to this point, the cellular mechanism affected by its anticonvulsant properties were not well understood. Dr. Naoto Hoshi, an associate professor of pharmacology and physiology & biophysics, and colleagues discovered that valproic acid preserved ...

Athens, Ga. - Microbiology researchers at the University of Georgia studying a soil bacterium have identified a potential mechanism for neurodegenerative diseases. A role for the protein HSD10 had been suspected in patients with Alzheimer's disease and Parkinson's disease, but no direct connection had previously been established. This new breakthrough suggests that HSD10 reduces oxidative stress, promotes cell repair and prevents cellular death. The authors first discovered that an enzyme related to HSD10, CsgA, produces energy during sporulation in the bacterium ...

A new review has produced the most conclusive evidence to date that people consume more food or non-alcoholic drinks when offered larger sized portions or when they use larger items of tableware. The research, carried out by the University of Cambridge and published in the Cochrane Database of Systematic Reviews, suggests that eliminating larger-sized portions from the diet completely could reduce energy intake by up to 16% among UK adults or 29% among US adults. Overeating increases the risks of heart disease, diabetes, and many cancers, which are among the leading causes ...

Single grandparents raising grandchildren are more vulnerable to poor physical and mental health than are single parents, according to a study recently published in Current Gerontology and Geriatrics Research. These caregivers may be at greater risk for diminished physical capacity and heightened prevalence of depression, researchers found. Researchers at Georgia State University and the University of Toronto found that solo grandparents caring for grandchildren fare worse than single parents across four critical health areas: physical health, mental health, functional ...

SAN FRANCISCO--After analyzing the seismic waves produced by small underground chemical explosions at a test site in Vermont, scientists say that some features of seismic waves could be affected by the amount of gas produced in the explosion. This unexpected finding may have implications for how scientists use these types of chemical explosions to indirectly study the seismic signal of nuclear detonations. Researchers use chemical blasts to learn more about the specific seismic signatures produced by explosions--which differ from those produced by earthquakes--to help ...

A new guideline that aims to prevent fractures in residents of long-term care facilities is targeted at frail seniors and their families as well as health care workers. The guideline, published in CMAJ (Canadian Medical Association Journal), was developed with input from residents of long-term care facilities and their families, as well as researchers and health care professionals. Seniors living in long-term care homes have a two- to four-fold risk of sustaining a fracture such as a hip or spinal fracture, compared with adults of similar age living in the community. ...

Scientists have identified a gene - FOXC1 - that, if switched on, causes more aggressive cancer in a fifth of acute myeloid leukaemia (AML) patients, according to a Cancer Research UK study* published in the journal Cancer Cell, today. The FOXC1 gene is normally switched on during embryonic development and is needed to turn cells into specialised tissues, like the eyes, kidney, brain and bone. But this new research found that in certain patients with AML - a type of blood cancer that affects white blood cells and the bone marrow - this gene was wrongly switched on inside ...

(BOSTON) - Stem cell therapies are often limited by low survival of transplanted stem cells and the lack of precise control over their differentiation into the terminal cell types needed to repair or replace injured tissues. Now, a team led by Wyss Institute Core Faculty member David Mooney, Ph.D., has developed a new strategy - embedding stem cells into porous, transplantable hydrogels - that has experimentally improved bone repair by boosting the survival rate of transplanted stem cells and influencing their cell differentiation. Mooney - who is also the Robert P. Pinkas ...

(Boston)--A panel of experts and researchers have developed a new classification system for gout, the most common form of inflammatory arthritis. This new system standardizes the classification of this condition using a variety of evidence-based criteria. Led by a researchers at Boston University School of Medicine (BUSM) and institutions from around the world, the study is a joint publication appearing in two journals simultaneously, Annals of Rheumatologic Disease and Arthritis & Rheumatology. Gout is characterized by the deposition of a specific type of crystal in ...

GAINESVILLE, Fla. -- Larger and private colleges and universities seem to attract hookah cafes and lounges, but smoke-free policies decrease these odds, according to findings published in the American Journal of Preventive Medicine this month. That may bode well for the long-term health of college-age students. Waterpipe smoking, more commonly known as hookah, boasts enticing flavors and a healthier reputation, increasing its popularity among college students. It is estimated that more than 10 percent of U.S. college students are current users. However, recent evidence ...

MADISON, Wis. -- Hydrogen could be the ideal fuel: Whether used to make electricity in a fuel cell or burned to make heat, the only byproduct is water; there is no climate-altering carbon dioxide. Like gasoline, hydrogen could also be used to store energy. Hydrogen is usually produced by separating water with electrical power. And although the water supply is essentially limitless, a major roadblock to a future "hydrogen economy" is the need for platinum or other expensive noble metals in the water-splitting devices. Noble metals resist oxidation and include many ...

Societies are failing women, children and adolescents, particularly in the poorest communities around the world, and urgent action is needed to save lives and improve health, say global health experts. In a special supplement published today by The BMJ, public health experts from around the globe highlight the critical actions and investments that will have the greatest impact on the health and well-being of women, children and adolescents. The 15 papers in this special supplement outline the current evidence, identify successes as well as critical gaps in progress, ...

Montreal, September 14, 2015 - Using extensive genetic data compiled by the UK10K project, an international team of researchers led by Dr. Brent Richards of the Lady Davis Institute at the Jewish General Hospital has identified a genetic variant near the gene EN1 as having the strongest effect on bone mineral density (BMD) and fracture identified to date. The findings are published in the forthcoming issue of the prestigious journal Nature. "EN1 has never before been linked to osteoporosis in humans, so this opens up a brand new pathway to pursue in developing drugs to ...

BLOOMINGTON, Ind. -- A study three years ago sparked a medical mystery when it revealed a part of the brain not found in any present-day anatomy textbooks. Recently, Indiana University computational neuroscientist Franco Pestilli and an international research team published an article in the journal Cerebral Cortex that suggests this missing part of the brain may play an important role in how we understand the world -- despite getting "lost" for more than a century. A long flat bundle of nerves called the vertical occipital fasciculus, or VOF, the structure appeared ...

Researchers at Cardiff University have devised a way of increasing the yield of biodiesel by using the waste left over from its production process. Using simple catalysis, the researchers have been able to recycle a non-desired by-product produced when biodiesel is formed from vegetable oil, and convert this into an ingredient to produce even more biodiesel. It is believed this new process will have significant environmental benefits by improving the yield of biodiesel in a sustainable way that doesn't require the use of additional fossil fuels, and could potentially ...

PROVIDENCE, R.I. [Brown University] -- Terahertz radiation could one day provide the backbone for wireless systems that can deliver data up to one hundred times faster than today's cellular or Wi-Fi networks. But there remain many technical challenges to be solved before terahertz wireless is ready for prime time. Researchers from Brown University have taken a major step toward addressing one of those challenges. They've developed what they believe to be the first system for multiplexing terahertz waves. Multiplexers are devices that enable separate streams of data to ...

(SACRAMENTO, Calif.) -- Vitamin D insufficiency among the elderly is highly correlated with accelerated cognitive decline and impaired performance, particularly in domains such as memory loss that are associated with Alzheimer's disease and dementia, researchers with the UC Davis Alzheimer's Disease Center and Rutgers University have found. The effect is "substantial," with individuals with low vitamin D declining at a rate three times faster than those with adequate vitamin D levels. The researchers said their findings amplify the importance of identifying vitamin D ...

Vitamin D insufficiency was associated with faster decline in cognitive functions among a group of ethnically diverse older adults, according to an article published online by JAMA Neurology. In addition to promoting calcium absorption and bone health, vitamin D may influence all organ systems. Both the vitamin D receptor and the enzyme that converts 25-hydroxyvitamin D (25-OHD) to the active form of the vitamin are expressed in all human organs, including the brain. Thus, research has increasingly examined the association between vitamin D status and a variety of health ...

To encourage hospitals to improve quality of care, Medicare penalizes those with higher than expected rates of readmission within 30 days of discharge. The logic behind the penalties is that if patients receive high quality care, including proper discharge planning, they should be less likely to end up back in the hospital. This seems straightforward, but it turns out that the social and clinical characteristics of a hospital's patient population that are not included in Medicare's calculation explain nearly half of the difference in readmission rates between the best- ...

Black children were less likely to receive any pain medication for moderate pain and less likely to receive opioids for severe pain than white children in a study of racial disparities in the pain management of children with appendicitis in emergency departments, according to an article published online by JAMA Pediatrics. Racial and ethnic differences in the emergency department (ED) management of pain have been described, with lower rates of opioid prescription for black and Hispanic patients than for white patients. However, there are fewer studies in children. Appendicitis ...

The largest population genome sequencing effort to date is published today in Nature. A series of papers describing resources and application of the data is published at the same time in Nature, Nature Genetics, Bioinformatics and Nature Communications. Rare genetic variants are changes in DNA that are carried only by relatively few people in a population. The UK10K study was designed to explore the contribution of these rare genetic variants to human disease and its risk factors. "The project has made important new contributions towards describing the role of rare ...

This news release is available in Spanish. Final OS and subgroup analysis of the pivotal study SAR-3007 First interim results of the Y-IMAGE prospective study showing real-world data for trabectedin in advanced soft tissue sarcoma (STS) Clinical data of trabectedin in translocated-related sarcomas, and in advanced leiomyosarcomas and liposarcomas Early clinical studies of PM1183 in combination with paclitaxel or cisplatin show a synergistic activity Madrid, September 14, 2015: PharmaMar announces that it will show new data from clinical pivotal ...