COLUMBUS, Ohio - Research led by The Ohio State University Wexner Medical Center and College of Medicine identified a new compound that might serve as a basis for developing a new class of drugs for diabetes. Study findings are published online in the journal Nature Chemical Biology. The adenosine monophosphate-activated protein kinase (Ampk) is a crucial enzyme involved in sensing the body's energy stores in cells. Impaired energy metabolism is seen in obesity, which is a risk factor for diabetes. Some medications used to treat diabetes, such as metformin, work by increasing the activity of Ampk. "In ...

African trypanosomiasis (also known as sleeping sickness) is a disease transmitted by tsetse flies and is fatal to humans and other animals; however, there is currently no vaccine, this disease is mainly controlled by reducing insect populations and patient treatment. A study published in the open access journal PLOS Biology by Alvaro Acosta-Serrano at Liverpool School of Tropical Medicine and an international team of researchers suggests that the approved drug nitisinone could be repurposed to kill tsetse flies without harming important pollinator insects. Currently, the most effective method of controlling the transmission of African trypanosomiasis is by employing insecticide-based vector control campaigns (traps, targets, ...

The COHERENT particle physics experiment at the Department of Energy's Oak Ridge National Laboratory has firmly established the existence of a new kind of neutrino interaction. Because neutrinos are electrically neutral and interact only weakly with matter, the quest to observe this interaction drove advances in detector technology and has added new information to theories aiming to explain mysteries of the cosmos. "The neutrino is thought to be at the heart of many open questions about the nature of the universe," said Indiana University physics professor Rex Tayloe. He led the installation, operation and data analysis of a cryogenic liquid argon ...

A Brazilian study published in the journal Molecular Human Reproduction helps understand why obese mothers tend to have children with a propensity to develop metabolic disease during their lifetime, as suggested by previous research. According to the authors, "transgenerational transmission of metabolic diseases" may be associated with Mfn2 deficiency in the mother's oocytes (immature eggs). Mfn2 refers to mitofusin-2, a protein involved in the regulation of vascular smooth muscle cell proliferation. It is normally found in the outer membrane of mitochondria, ...

Incidence rates of skin cancer (cutaneous malignant melanoma) have increased more than 550% in males and 250% in females since the early 1980s in England - according to a new study by Brighton and Sussex Medical School (BSMS). Published in the new Lancet journal, The Lancet Regional Health - Europe, the study analysed data on more than 265,000 individuals diagnosed with skin cancer in England over the 38-year period, 1981-2018. Skin cancer is the fifth most common cancer in the UK, with about 16,200 new cases each year. Excessive exposure to UV radiation from the sun (or sunlight) is the main environmental risk factor for developing skin cancer. It is estimated that about 86% of all skin cancers in the UK are ...

Since the founding of the United Nations Convention on Biological Diversity (CBD) in Rio de Janeiro in 1992, member states have regularly agreed on global strategies to bring the increasingly rapid loss of biodiversity to a halt. In 2002, the heads of state adopted the so-called 2010 biodiversity targets. Eight years later, little progress had been made and 20 new, even more ambitious goals were set for the next ten years. Last year, it became clear that this target had been missed, too. The loss of biodiversity continues unabated. This year, new targets are being negotiated again - this time for 2030. The decisions are to be made at the Conference of the Parties (COP15) in Kunming, China. To ...

UNIVERSITY PARK, Pa. -- The actions that older adults take on Facebook may be more important to their user experience and well-being than their overall use of the site, according to researchers. In a study conducted by a team that included researchers from Penn State, older adults experienced different levels of competence, relatedness and autonomy on Facebook based on the types of their activities on the site. Specifically, older adults who posted more pictures to Facebook felt more competent, which led to significantly higher levels of well-being in general, ...

Researchers from North Carolina State University have created a trifunctional contraceptive gel that contains spermicidal, anti-viral and libido-enhancing agents in one formulation. When tested in a rat model, the gel both enhanced male libido and prevented pregnancy in 100% of cases, as compared to an average 87% effective rate with a commercially available contraceptive gel. "We are using three pharmacological agents in a new formulation," says Ke Cheng, Randall B. Terry, Jr. Distinguished Professor in Regenerative Medicine at NC State's College of Veterinary Medicine, professor in the NC State/UNC Joint Department of Biomedical Engineering and corresponding author of a paper describing the work. "Our hope ...

PHOENIX, Ariz. -- Jan. 26, 2021 -- Breast cancer, even at its initial stages, could be detected earlier and more accurately than current techniques using blood samples and a unique proteomics-based technology, according to findings of a study led by the Translational Genomics Research Institute (TGen), an affiliate of City of Hope. Patrick Pirrotte, Ph.D., an Assistant Professor and Director of TGen's Collaborative Center for Translational Mass Spectrometry, and an international team of researchers developed a test that can detect infinitesimally small breast cancer biomarkers that are shed into the bloodstream from cells surrounding cancer known as extracellular matrix (ECM), according to the findings of their study recently published in the scientific journal Breast Cancer Research. For ...

Since stem cells can continually self-regenerate, making more stem cells, and differentiate into many different specialized cell types, they play an important role in our development and health. But there can also be a dark side -- stem cells can sometimes become cancer stem cells, proliferating out of control and leading to blood cancers, such as leukemia and multiple myeloma. The self-renewing nature of cancer stem cells makes them particularly hard to eradicate, and they're often the reason a blood cancer reoccurs. Researchers at UC San Diego Health and University of California San Diego School of Medicine are ...

Amsterdam, NL, January 26, 2021 - With medicinal cannabis now legalized in many parts of the world, there is growing interest in its use to alleviate symptoms of many illnesses including Parkinson's disease (PD). According to results of a survey of PD patients in Germany in the Journal of Parkinson's Disease, over 8% of patients with PD reported using cannabis products and more than half of those users (54%) reported a beneficial clinical effect. Cannabis products containing THC (tetrahydrocannabinol, the main psychoactive compound of cannabis) can be prescribed in Germany when previous therapies are unsuccessful or not tolerated, and where cannabis can be expected with not a very unlikely ...

COLUMBUS, Ohio - Research led by The Ohio State University Wexner Medical Center and College of Medicine found that the widely prescribed pain-relief drug gabapentin can prevent harmful structural changes in the injured spinal cords of mice, and also block cardiovascular changes and immune suppression caused by spinal cord injury. "Gabapentin is often prescribed as a treatment for pain, but if it is given early after injury - before symptoms develop - it can also limit structural changes in nerve cells. We show that these benefits remain even one month after stopping gabapentin treatment in spinal injured mice. We believe that gabapentin could be repurposed as a prophylactic therapy that can prevent autonomic dysfunction in ...

Nanoparticle is first therapy to trigger this novel way to kill lymphoma cells Drug is being developed for clinical trials Drug selectively attacks cancer cells, leaves normal cells unharmed CHICAGO --- Scientists at Northwestern Medicine have developed a novel therapy to trick cancer cells into gobbling up what they think is their favorite food - cholesterol - which actually triggers their destruction. What appears to them as a cholesterol-loaded particle is actually a synthetic nanoparticle that binds to the cancer cells and starves them to death. ...

A study performed by the Universitat Oberta de Catalunya (UOC) provided eight recommendations for improving the online technology to help with the treatment and diagnosis of neglected tropical diseases (NTDs). The analysis, presented in a recent open-access publication, was performed by UOC researchers Carme Carrion and Marta Aymerich from the eHealth Lab and Noemí Robles from the eHealth Center, together with José Antonio Ruiz Postigo from the World Health Organization and Oriol Solà de Morales from the Health Innovation Technology Transfer Foundation. In the study, the authors looked at the context of the existing apps and identified their weaknesses. The ...

Announcing a new publication for BIO Integration journal. In this opinion article the authors Tianhong Yao, Huirong Lin, Jingsong Mao, Shuaidong Huo and Gang Liu from Xiamen University, Xiamen, China discuss CT imaging features of patients infected with 2019 novel coronavirus. Novel coronavirus pneumonia is an acute, infectious pneumonia caused by a novel coronavirus infection. Computed tomographic (CT) imaging is one of the main methods to screen and diagnose patients with this disease. In this article the authors discuss the importance and clinical value of chest ...

Damage to the brain gray matter plays an important role in the progression of multiple sclerosis. This study now shows that such damage can be caused by inflammatory reactions that lead to loss of synapses, which impairs neural activity. Multiple sclerosis (MS) is a chronic inflammatory disease that affects the central nervous system, in which nerve cells are attacked by the patient's own immune system. In many cases, the disease develops into a progressive form, which is characterized by a shift of pathology from the white matter to the gray matter, ...

Every year, more than 400,000 people die from malaria, the majority are children under the age of five years old, who die from a disease which affects more than 200 million people a year. The most serious form of the disease is cerebral malaria which may cause severe neurological consequences and, in the worst-case scenario, result in death. The precise mechanism behind cerebral malaria has remained a mystery - until now, says a research group from the Department of Immunology and Microbiology at the University of Copenhagen. 'In our study, we show that a certain type of the malaria parasite can cross the blood-brain barrier by utilising ...

Mangrove ecosystems are at particular risk of being polluted by plastic carried from rivers to the sea. Fifty-four per cent of mangrove habitat is within 20 km of a river that discharges more than a tonne of plastic waste a year into the ocean, according to a new paper published in the journal Science of the Total Environment. Mangroves in southeast Asia are especially threatened by river-borne plastic pollution, the researchers found. The paper, written by scientists at GRID-Arendal and the University of Bergen, is the first global assessment of coastal environments' exposure to river-borne plastic pollution. The majority of plastic waste carried to sea by rivers ends up trapped along coastlines, but some types ...

FORT LAUDERDALE/DAVIE, Fla. - Global warming or climate change. It doesn't matter what you call it. What matters is that right now it is having a direct and dramatic effect on marine environments across our planet. "More immediately pressing than future climate change is the increasing frequency and severity of extreme 'underwater heatwaves' that we are already seeing around the world today," Lauren Nadler, Ph.D., who is an assistant professor in Nova Southeastern University's (NSU) Halmos College of Arts and Sciences . "This phenomenon is what we wanted to both simulate and understand." Nadler is a co-author of a new study on this topic, which you can find published online ...

Scientists have designed a single-dose universal vaccine that could protect against the many forms of leptospirosis bacteria, according to a study published today in eLife. An effective vaccine would help prevent the life-threatening conditions caused by leptospirosis, such as Weil's disease and lung haemorrhage, which are fatal in 10% and 50% of cases, respectively. Leptospirosis is caused by a diverse group of spirochetes called leptospires. A broad range of mammals, including rats, harbour the bacteria in their kidneys and release them into the environment through their urine. Humans and animals can then get infected after coming into contact with contaminated water or soil. In addition to having a major impact on the health of vulnerable human populations, ...

Syracuse, N.Y. - As President Joe Biden seeks to raise the federal minimum wage, a new study published recently by researchers from Syracuse University shows that a higher minimum wage will reduce infant deaths. In the study, "Effects of US state preemption laws on infant mortality," Syracuse University professors found that each additional dollar of minimum wage reduces infant deaths by up to 1.8 percent annually in large U.S. cities. The study was published recently by Preventive Medicine. The federal minimum wage has not been increased since 2009, and Biden's $1.9 trillion American Rescue Plan to aid those hit hardest by the COVID-19 pandemic calls for Congress to raise the minimum wage from $7.25 ...

CAMBRIDGE, MD (January 26, 2021)--The Chesapeake Bay has a long history of nutrient pollution resulting in degraded water quality. However, scientists from the University of Maryland Center for Environmental Science are reporting some improvements in the Choptank River on Maryland's Eastern Shore. The Choptank is a tributary of Chesapeake Bay, and its watershed lies primarily in the state of Maryland, with a portion in Delaware. There are strong similarities between the Choptank basin and the Chesapeake as a whole, which enables the Choptank to be used as a model for progress in the Bay. The Chesapeake Bay is an estuary which has undergone considerable ...

Researchers from McGill University have discovered, for the first time, one of the possible mechanisms that contributes to the ability of lysergic acid diethylamide (LSD) to increase social interaction. The findings, which could help unlock potential therapeutic applications in treating certain psychiatric diseases, including anxiety and alcohol use disorders, are published in the journal PNAS. Psychedelic drugs, including LSD, were popular in the 1970s and have been gaining popularity over the past decade, with reports of young professionals claiming to regularly take small non-hallucinogenic micro-doses of ...

Black holes are considered amongst the most mysterious objects in the universe. Part of their intrigue arises from the fact that they are actually amongst the simplest solutions to Einstein's field equations of general relativity. In fact, black holes can be fully characterized by only three physical quantities: their mass, spin and charge. Since they have no additional "hairy" attributes to distinguish them, black holes are said to have "no hair": Black holes of the same mass, spin, and charge are exactly identical to each other. Dr. Lior Burko of Theiss Research in collaboration with Professor Gaurav Khanna of the University of Massachusetts Dartmouth and the University ...

Landslides caused by the collapse of unstable volcanoes are one of the major dangers of volcanic eruptions. A method to detect long-term movements of these mountains using satellite images could help identify previously overlooked instability at some volcanoes, according to Penn State scientists. "Whenever there is a large volcanic eruption, there is a chance that if a flank of the volcano is unstable there could be a collapse," said Judit Gonzalez-Santana, a doctoral student in the Department of Geosciences. "To better explore this hazard, we applied an increasingly popular and more sensitive time-series method to look at these movements, or surface ...