In a study spanning four decades, researchers from the University of Hong Kong's Research Division for Ecology & Biodiversity (HKU) in the Faculty of Science, and Toho University's Department of Biology (Toho), Japan, have discovered that predation by snakes is pushing lizards to be active at warmer body temperatures on islands where snakes are present, in comparison to islands free from snakes. Their work also detected significant climatic warming throughout the years and found lizard body temperatures to have also increased accordingly. The findings show that lizard thermal biology is highly dependent on predation pressures ...

Geneva, Switzerland, 7 January 2021 - 'Mini-brains' are pin-head sized collections of several different types of human brain cell. They are used as a tool, allowing scientists to learn about how the brain develops, study disease and test new medicines. Personalized 'mini-brains' can be grown from stem cells generated from a sample of human hair or skin and could shed light on how brain disease progresses in an individual and how this person may respond to drugs. Research published today by a team of scientists and engineers from HEPIA and the Wyss Center for Bio and Neuroengineering, in the journal Frontiers in Bioengineering and Biotechnology, has revealed ...

Until now, the reason why the drug levodopa (L-Dopa), which reduces the motor symptoms of Parkinson's disease, declines in efficacy after a few years' use has been unknown. A side effect that then often occur is involuntary movements. A Swedish-French collaboration, led from Uppsala University, has now been able to connect the problems with defective metabolism of L-Dopa in the brain. The study is published in Science Advances. "The findings may lead to new strategies for treating advanced Parkinson's," says Professor Per Andrén of the Department of Pharmaceutical Biosciences at Uppsala University. He and Dr Erwan Bézard of the University of Bordeaux, France, headed ...

The coastline of Israel is one of the warmest areas in the Mediterranean Sea. Here, most marine species have been at the limits of their tolerance to high temperatures for a long time - and now they are already beyond those limits. Global warming has led to an increase in sea temperatures beyond those temperatures that Mediterranean species can sustain. Consequently, many of them are going locally extinct. Paolo Albano's team quantified this local extinction for marine molluscs, an invertebrate group encompassing snails, clams and mussels. They thoroughly surveyed the Israeli coastline and ...

Sweden kept preschools, primary and lower secondary schools open during the spring of 2020. So far, little research has been done on the risk of children being seriously affected by COVID-19 when the schools were open. A study from Karolinska Institutet in Sweden has now shown that one child in 130,000 was treated in an intensive care unit on account of COVID-19 during March-June. The study has been published in New England Journal of Medicine. So far, more than 80 million people have become ill with COVID-19 and globally, almost two million people have died from the disease. Many countries have closed down parts of society in order to reduce the spread of infection. One such measure has been to close schools. ...

Men and women aged over 50 can reap similar relative benefits from resistance training, a new study led by UNSW Sydney shows. While men are likely to gain more absolute muscle size, the gains relative to body size are on par to women's. The findings, recently published in END ...

Social media misinformation can negatively influence people's attitudes about vaccine safety and effectiveness, but credible organizations -- such as research universities and health institutions -- can play a pivotal role in debunking myths with simple tags that link to factual information, University of California, Davis, researchers, suggest in a new study. Researchers found that fact-check tags located immediately below or near a post can generate more positive attitudes toward vaccines than misinformation alone, and perceived source expertise makes a difference. "In fact, fact-checking labels ...

An international team of researchers led by Swinburne University of Technology has demonstrated the world's fastest and most powerful optical neuromorphic processor for artificial intelligence (AI), which operates faster than 10 trillion operations per second (TeraOPs/s) and is capable of processing ultra-large scale data. Published in the prestigious journal Nature, this breakthrough represents an enormous leap forward for neural networks and neuromorphic processing in general. Artificial neural networks, a key form of AI, can 'learn' and perform complex operations with wide applications to computer vision, natural language processing, facial recognition, speech translation, ...

El Niño events have long been perceived as a driver for low rainfall in the winter and spring in Hawai'i, creating a six-month wet-season drought. However, a recent study by researchers in the University of Hawai'i at Mānoa School of Ocean and Earth Science and Technology (SOEST) revealed the connection between Hawai'i winter rainfall and El Niño is not as straightforward as previously thought. Studies in the past decade suggested that there are at least two types of El Niño: the Eastern Pacific and Central Pacific, when the warmest pool of water is located in the eastern or central portions of the ocean basin, respectively. El Niño events usually ...

WASHINGTON--Black and Hispanic people with COVID-19 and diabetes are more likely than Caucasians to die or have serious complications, according to a new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism. ...

With an estimated lifespan between 25 to 40 years, the queen conch (Strombus gigas) is a prized delicacy long harvested for food and is revered for its beautiful shell. Second only to the spiny lobster, it is one of the most important benthic fisheries in the Caribbean region. Unfortunately, the species faces a challenge of survival: how to endure and thrive, as populations are in a steady state of decline from overfishing, habitat degradation and hurricane damage. In some places, the conch populations have dwindled so low that the remaining conch cannot find breeding partners. This dire situation is urgent in ecological and economic terms. To preserve this most significant molluscan fishery in the Caribbean, ...

Osaka, Japan - Medical professionals all want to be able to quickly and correctly diagnose diseases. Their future ability to do so will depend on identifying what biochemicals are present in tissue sections, where the biomolecules are, and at what concentrations. For this purpose, mass spectrometry imaging--which can identify multiple biochemicals in a single experiment--will be useful. However, the stability of biomolecular sampling needs improvement to obtain the chemical distribution information with high spatial resolution. In the recent study published in Analytical Chemistry, researchers from Osaka University used mass spectrometry to image the distribution of ...

A scalpel-free alternative to brain surgery has the potential to benefit people with Parkinson's disease symptoms that are much more severe on one side of the body, new research suggests. More testing is needed, but the approach, which uses a technology called focused ultrasound, could offer a new option for patients whose symptoms are poorly controlled by medications and those who cannot or do not wish to undergo traditional brain surgery. "This small brain region, the subthalamic nucleus, had a very strong and potent effect on parkinsonian symptoms when we targeted it with precise, focused ultrasound energy," ...

The invention of optical fibers has revolutionized not only telecommunications but also sensing technology. Optical fiber sensors can measure strain, temperature, pressure, and many other physical parameters along the fibers, but they are currently immune to electromagnetic noise -- interference from other external electric or magnetic interactions. It is a desirable trait, until the effect of the electromagnetic field on the fibers needs to be measured. Now, an international team of researchers has used what was previously considered a 'damaged' part of an optical fiber to develop such a magnetic field sensor. They published details of their approach on Nov. 5 in Advanced Photonics Research. "This nature of immunity ...

Methylcyclopentadiene (MCPD) is an important monomer in the production of RJ-4 fuel, a high-energy-density rocket fuel, and various valuable products. Currently, MCPD is mainly obtained from the by-products of petroleum cracking tar at a very low yield of ~ 0.7 kg ton-1 and high price of ~10,000 USD ton-1. The exploration of highly efficient processes to convert renewable biomass to MCPD is stimulated by the energy and environment problems. Recently, a group led by Prof. LI Ning and Prof. ZHANG Tao from the Dalian Institute of Chemical Physics (DICP) of the Chinese Academy of Sciences (CAS) synthesized bio-based MCPD via direct hydrodeoxygenation of 3-methylcyclopent-2-enone (MCP) derived from cellulose. Their study was published in Nature Communications on Jan. 4. The researchers ...

By comparing thousands of bacterial genomes, scientists in Gothenburg, Sweden have traced back the evolutionary history of antibiotic resistance genes. In almost all cases where an origin could be determined, the gene started to spread from bacteria that, themselves, can cause disease. While human DNA is only passed down from parent to child, bacteria also have the habit of sharing some of their genes across species. This often applies to genes that make the bacteria resistant to antibiotics. The use and overuse of antibiotics provide an advantage to those bacteria that have acquired resistance genes, thus further promoting the spread of resistance and making it more difficult to treat infections. This development threatens large parts of modern healthcare. The rapid advances in DNA ...

Tokyo, Japan - Guillain-Barré syndrome is an infamous autoimmune neuropathy, yet genetic variants predisposing individuals to this disease have yet to be described. In a new study, researchers from Tokyo Medical and Dental University (TMDU) discovered two novel genetic variants in a protein made by antibody-forming immune cells, providing a mechanism for the development of the disease. The body's immune system is supposed to fight off invaders; however, in autoimmune diseases this defense goes rogue and attacks the host instead through the production of autoantibodies. Guillain-Barré syndrome (GBS) is an acutely developing, autoimmune peripheral neuropathy that leads to muscle ...

Using synchrotron radiation at SPring-8 - a large-scale synchrotron radiation facility - Tohoku University, Toshiba Corporation, and the Japan Synchrotron Radiation Research Institute (JASRI) have successfully imaged the magnetization dynamics of a hard disk drive (HDD) write head for the first time, with a precision of one ten-billionth of a second. The method makes possible precise analysis of write head operations, accelerating the development of the next-generation write heads and further increasing HDD capacity. Details of the research were published in the Journal of Applied Physics on October 6 and presented at the 44th Annual Conference on Magnetics in Japan, on December 14. International Data Corporation predicts a five-fold increase ...

The genomes of egg-laying monotreme mammals, platypus and echidna, have been published in the prestigious journal Nature, providing a valuable public resource for research in mammalian biology and evolution, with applications for their conservation and health. Monotremes display a unique mix of mammalian and reptilian features and form the most distantly related, and least understood, group of living mammals. Their genetic blueprint provides fundamental insights into their unique biology and into the evolution of all mammals. "The platypus and ...

The perception of our own voice depends on sound transmission through air (air-conducted) as well as through the skull bone (bone-conducted or BC). The transmission properties of BC speech are, however, not well understood. Now, scientists from Japan Advanced Institute of Science and Technology report their latest findings on BC transmission under the influence of oral cavity sound pressure, which can boost BC-based technology and basic research on hearing loss and speech impairment. Ever wondered why your voice sounds different in a recording compared to how you perceive it as you speak? You are not alone. The ...

Infectious diseases are caused by pathogenic viruses, bacteria, fungi or parasites. The treatment of bacterial and fungal infections relies particularly on antimicrobial drugs, while the focus in treating viral infections is the alleviation of symptoms. Initial therapy for infection is often empiric and guided by clinical presentation. Its efficacy on the pathogen is, however, only seldom understood at therapy initiation. Although methods for assessing treatment responses exist, the effectiveness is mainly determined through monitoring symptoms and signs of infections. Advances in sequencing technology have made characterization of genomes and gene expression products increasingly practical. The technology has also made it possible ...

Combining electronic structure calculations and machine learning (ML) techniques has become a common approach in the atomistic modelling of matter. Using the two techniques together has allowed researchers, for instance, to create models that use atomic coordinates as the only inputs to inexpensively predict any property that can be computed by the first-principles calculations that had been used to train them. While the earliest and by now most advanced efforts have focused on using predictions of total energies and atomic forces to construct interatomic potentials, more recent efforts have targeted additional properties of crystals and molecules such as ionization energies, NMR chemical shieldings, dielectric response properties and charge density. In the paper "Learning ...

It is during rare merging events that galaxies undergo dramatic changes in their appearance and in their stellar content. These systems are excellent laboratories to trace the formation of star clusters under extreme physical conditions. The Milky Way typically forms star clusters with masses that are 10 thousand times the mass of our Sun. This doesn't compare to the masses of the star clusters forming in colliding galaxies, which can reach millions of times the mass of our Sun. These dense stellar systems are also very luminous. Even after the collision, when the resulting galactic system begins to fade into a more quiescent phase, these very massive star clusters will shine throughout their host galaxy, as long-lasting witnesses of past merging events. By studying the six galaxy ...

Autoimmune diseases are diseases of "mistaken identity", where the immune system - which is supposed to protect us against infectious diseases and neoplasias - mistakenly attacks and destroys components of our own body. The incidence of autoimmune diseases is increasing on a worldwide basis, and these diseases - including type 1 diabetes (T1D), systemic lupus erythematosus (SLE), multiple sclerosis (MS) and rheumatoid arthritis (RA) - now affect up to 5% of the population in different regions. There is no cure for autoimmune diseases, and while the immune target of T1D, SLE, MS, and RA are distinct, they share several similar elements, including up to 50% common genetic risk, chronic local inflammation and mechanisms ...

Researchers at the University of Gothenburg now suggest a possible cure for children with hard-to-treat forms of neuroblastoma using a new combination of drugs. In a new study in the journal Cancer Research, they describe how a two small molecule-based drug combination likely inhibit the tumor's growth. Neuroblastoma is the most common form of childhood cancer, derived from the peripheral nervous system, i.e., the part of the nervous system that is not the brain or spinal cord. The disease can occur in the chest, neck, abdomen and adrenal glands and can also spread to the spine. Symptoms include general aches, anemia and skeletal pain. The ...