The tobacco industry and regulatory authorities should support more relevant and less costly in vitro toxicology testing methods over unreliable animal testing, according to a review of research advances published this week in the comment pages of the peer-reviewed scientific journal Alternatives to Laboratory Animals The article by researchers from People for the Ethical Treatment of Animals (PETA) and the Physicians Committee for Responsible Medicine (PCRM) comes as the Food and Drug Administration's (FDA) Tobacco Products Scientific Advisory Committee prepares to evaluate ...

Philadelphia, PA, April 1, 2015 - The rapid rise in popularity of energy drinks (EDs), particularly among adolescents (aged 10-19 years) and young adults, has serious implications for cardiac health. In an article published in the Canadian Journal of Cardiology, researchers focus on the pharmacology of EDs, adverse reactions to them, and how the marketing of these drinks as a means to relieve fatigue and improve physical and cognitive performance may be ignoring real dangers. An international research team led by Fabian Sanchis-Gomar, PhD, MD, of the Research Institute ...

While research shows that nearly all coral reef locations in the Caribbean and Gulf of Mexico will experience bleaching by mid-century, a new study showing in detail when and where bleaching will occur shows great variety in the timing and location of these harmful effects. The new research published today in Global Change Biology by NOAA scientists and colleagues provides the first fine-scale projections of coral bleaching, an important planning tool for managers. "Our new local-scale projections will help resource managers better understand and plan for the effects ...

A new genomic analysis of tissue from patients with prostate cancer has added more evidence that cells within metastases from such tumors can migrate to other body parts and form new sites of spread on their own. Results of the analysis undermine anew long-held beliefs that cells with metastatic potential originate solely from the original or primary site of a cancer, according to the scientists who performed the study. "The idea that metastatic tumors can seed and establish other metastatic tumors in patients is different from traditional theories that the primary ...

As part of an effort to understand how an experimental drug for atherosclerosis causes the build-up of fat in the liver, scientists have developed a computer model that can predict how the rate at which liver stores fat in response to various situations. Being able to model liver fat storage gives researchers a way to predict the side effects of drugs and environmental factors at much earlier stages in the research and drug development process, possibly reducing the number of experiments involving animal models. Additionally, this computer simulation helps describe all ...

While testosterone replacement therapies may be controversial in males, new research in The FASEB Journal may extend this controversy to females too. That's because research involving mice, appearing in the April 2015 issue, suggests that there is an association between low levels of androgens (which includes testosterone), and atherosclerosis and obesity in females. "We hope that our study will contribute to intensified research efforts on the definition of androgen deficiency in women (e.g. which levels of androgens in the blood should be considered too low?), the ...

Jacksonville, Fla. (April 1, 2015) - Training pediatric primary care providers to screen and assess depression and suicide risk in adolescent patients improved providers' confidence and knowledge of these conditions and increased frequency of screenings for this critical patient population. The study, published in the May/June issue of Academic Pediatrics, demonstrates an effective tool for improving recognition of adolescent depression. "Adolescent depression is woefully underrecognized and undertreated," said Elise Fallucco, MD, a lead author of the study and child ...

The name sounds like something Marvin the Martian might have built, but the "nanomechanical plasmonic phase modulator" is not a doomsday device. Developed by a team of government and university researchers, including physicists from the National Institute of Standards and Technology (NIST), the innovation harnesses tiny electron waves called plasmons. It's a step towards enabling computers to process information hundreds of times faster than today's machines. Computers currently shuttle information around using electricity traveling down nanoscale metal wires. Although ...

Annapolis, Md -- New research published today in Nature Communications provides insight into how large-scale deforestation could impact global food production by triggering changes in local climate. In the study, researchers from the United States and China zero in on albedo (the amount of the sun's radiation reflected from Earth's surface) and evapotranspiration (the transport of water into the atmosphere from soil, vegetation, and other surfaces) as the primary drivers of changes in local temperature. The research is the first global analysis of the effects of forest ...

If you want the benefits of medical marijuana without the "unwanted side effects" of cannabis, new research should leave you on a high note. According to a research report appearing in the April 2015 issue of The FASEB Journal, fenofibrate, also known by the brand name Tricor®, may benefit a wide range of health issues, such as pain, appetite stimulation, nausea, as well as immune and various psychiatric and neurological conditions. This suggests that fenofibrate may be the starting point for a new class of cannabis-like drugs to treat these types of conditions. "By ...

The Pacific Northwest is dotted by small, low-lying, coastal cities where populations tend to cluster. These communities can be isolated and are susceptible to devastation from major storms that bring substantial wind, waves and storm surge. With climate change, it is anticipated that storms will only become more frequent and intense, signifying a need to understand how the areas will be affected. David Hill, a researcher at Oregon State University, is focused on the hydrology and hydrodynamics in coastal areas, which represent the boundary between terrestrial and marine ...

PHILADELPHIA-- Penn Medicine researchers are continuing their work in trying to understand the mechanisms through which anesthetics work to elicit the response that puts millions of Americans to sleep for surgeries each day. Their most recent study looked at ketamine, an anesthetic discovered in the 1960s and more recently prescribed as an anti-depressant at low doses. Through collaboration with the University of Pennsylvania's department of Chemistry and scientists at the Duke University Medical Center, researchers at Penn's Perelman School of Medicine have identified ...

ALEXANDRIA, VA -- An updated clinical practice guideline from the American Academy of Otolaryngology--Head and Neck Surgery Foundation published today in Otolaryngology-Head and Neck Surgery identifies quality improvement opportunities and explicit actionable recommendations for clinicians managing adult sinusitis, including a greater focus on patient education and patient preference. "More than ever before, there is a prominent role for shared decision-making between patients and clinicians when managing adult sinusitis--especially in deciding whether to use antibiotics ...

In 2006 construction began on a new shopping centre in Tulln. The works unearthed various archaeologically valuable objects that were salvaged during rescue excavations. Among these objects was also the complete skeleton of a large mammal. Large mammal uncovered during excavations in Tulln "The partly excavated skeleton was at first suspected to be a large horse or cattle," says archaeozoologist Alfred Galik from the Institute for Anatomy, Histology and Embryology at the University of Veterinary Medicine Vienna. "But one look at the cervical vertebrae, the lower jaw ...

Therapeutic agents intended to reduce dental plaque and prevent tooth decay are often removed by saliva and the act of swallowing before they can take effect. But a team of researchers has developed a way to keep the drugs from being washed away. Dental plaque is made up of bacteria enmeshed in a sticky matrix of polymers--a polymeric matrix--that is firmly attached to teeth. The researchers, led by Danielle Benoit at the University of Rochester and Hyun Koo at the University of Pennsylvania's School of Dental Medicine, found a new way to deliver an antibacterial agent ...

People who apply eyeliner on the inner eyelid run the risk of contaminating the eye and causing vision trouble, according to research by a scientist at the University of Waterloo. This is the first study to prove that particles from pencil eyeliner move into the eye. Dr. Alison Ng, at the Centre for Contact Lens Research at Waterloo, directed the study when she was at Cardiff University in Wales. The team's findings appear in Eye and Contact Lens Science and Clinical Practice, the official peer-reviewed journal of the Contact Lens Association of Ophthalmologists. Dr. ...

If you are trying to have a baby, a good night's sleep is more important than ever. A new research report appearing in The FASEB Journal shows that the womb has its own "body clock" that needs to synchronize with the mother's body clock to ensure optimal conditions for fetal growth and development. The inability of a mother's body clock to synchronize with the womb's clock may be at least part of the reason why some women have difficulty carrying a pregnancy to full term. Specifically, the failed synchronization switches off body clock genes in cells lining the womb, which ...

ANCHORAGE, Alaska -- A team of scientists led by the U.S. Geological Survey found that polar bears, increasingly forced on shore due to sea ice loss, may be eating terrestrial foods including berries, birds and eggs, but any nutritional gains are limited to a few individuals and likely cannot compensate for lost opportunities to consume their traditional, lipid-rich prey -- ice seals. "Although some polar bears may eat terrestrial foods, there is no evidence the behavior is widespread," said Dr. Karyn Rode, lead author of the study and scientist with the USGS. "In the ...

Washington, DC--Night owls are more likely to develop diabetes, metabolic syndrome and sarcopenia than early risers, even when they get the same amount of sleep, according to a new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism. The study examined the difference between night and morning chronotypes, or a person's natural sleep-wake cycle. Staying awake later at night is likely to cause sleep loss, poor sleep quality, and eating at inappropriate times, which might eventually lead to metabolic change. "Regardless of lifestyle, ...

Washington, DC--Exposure to the endocrine-disrupting chemical bisphenol A during pregnancy may raise a mother's susceptibility to weight gain and diabetes later in life, according to a new animal study published in the Endocrine Society's journal Endocrinology. A chemical used to manufacture plastics and epoxy resins, bisphenol A (BPA) is found in a variety of consumer products, including plastic bottles, food cans and cash register receipts. The U.S. Centers for Disease Control and Prevention have estimated that more than 96 percent of Americans have BPA in their bodies. BPA ...

Cambridge, Mass. April 1, 2015-- A collaborative study between researchers from the Broad Institute of MIT and Harvard, Massachusetts Institute of Technology, and the National Center for Biotechnology Information of the National Institutes of Health (NIH-NCBI) has identified a highly efficient Cas9 nuclease that overcomes one of the primary challenges to in vivo genome editing. This finding, published today in Nature, is expected to help make the CRISPR toolbox accessible for in vivo experimental and therapeutic applications. Originally discovered in bacteria, the CRISPR-Cas9 ...

Many microbes cannot be cultivated in a laboratory setting, hindering attempts to understand Earth's microbial diversity. Since microbes are heavily involved in, and critically important to environmental processes from nutrient recycling, to carbon processing, to the fertility of topsoils, to the health and growth of plants and forests, accurately characterizing them, as a basis for understanding their activities, is a major goal of the Department of Energy (DOE). One approach has been to study collected DNA extracted from the complex microbial community, or the metagenome, ...

NEW YORK (April 1, 2015) - Hospitals and health systems preparing for and treating patients with Ebola Virus Disease (EVD) in the fall of 2015 faced unexpected challenges for ensuring safety of staff, patients and the community. The experiences are detailed in two studies published online in Infection Control & Hospital Epidemiology, the journal of the Society for Healthcare Epidemiology of America (SHEA). In a case study of the care of two patients with confirmed or suspected EVD at the National Institutes of Health (NIH) Clinical Center's Special Clinical Studies Unit, ...

Mammals are good at figuring out which direction a sound is coming from, whether it's a rabbit with a predator breathing down its neck or a baby crying for its mother. But how we judge how far away that sound is was a mystery until now. Researchers from UConn Health report in the 1 April issue of the Journal of Neuroscience that echoes and fluctuations in volume (amplitude modulation) are the cues we use to figure the distance between us and the source of a noise. "This opens up a new horizon," says Duck O. Kim, a neuroscientist at UConn Health. Researchers have long ...

Don't throw away those bouncing batteries. Researchers at Princeton University have found that common test of bouncing a household battery is not actually an effective way to check a battery's charge. "The bounce does not tell you whether the battery is dead or not, it just tells you whether the battery is fresh," said Daniel Steingart, an assistant professor of mechanical and aerospace engineering and of the Andlinger Center for Energy and the Environment. The battery bounce test, popularized in online videos, shows that fully charged batteries bounce very little ...