Ribosome formation is viewed as a promising potential target for new antibacterial agents. Researchers from Charité - Universitätsmedizin Berlin have gained new insights into this multifaceted process. The formation of ribosomal components involves multiple helper proteins which, much like instruments in an orchestra, interact in a coordinated way. One of these helper proteins - protein ObgE - acts as the conductor, guiding the entire process. The research, which produced the first-ever image-based reconstruction of this process, has been published in Molecular Cell*. Ribosomes are an essential component of all living cells. Frequently referred to as 'molecular protein factories', they translate genetic information into chains of linked-up ...

What can you see on this picture (next to thearticle)? Say what comes to your mind immediately! If you said „star", you focus rather on the details, if you said „sun", then rather on the global pattern. People can be different in whether they typically see the forest or the trees, but the dominant attentional mode is focusing first on the whole, and then on the details. This is the same with children. Or so it has been until now! Children of the Alpha Generation (who has been born after 2010) typically grow up with mobile devices in their hands which seems to change how they perceive the world, as Hungarian researchers showed. The Alpha Generation Lab of Diagnostics and Therapy Excellence Programme at Eötvös Loránd University (Budapest) studies ...

Materials - Quantum building blocks Oak Ridge National Laboratory scientists demonstrated that an electron microscope can be used to selectively remove carbon atoms from graphene's atomically thin lattice and stitch transition-metal dopant atoms in their place. This method could open the door to making quantum building blocks that can interact to produce exotic electronic, magnetic and topological properties. This is the first precision positioning of transition-metal dopants in graphene. The produced graphene-dopant complexes can exhibit atomic-like behavior, inducing desired properties in the graphene. "What could ...

Collaborating with the University of Oxford, Professor Ho Yin Edwin Chan's research team from the School of Life Sciences of The Chinese University of Hong Kong (CUHK) recently unveiled the counteracting relationship between pre-mRNA-processing factor 19 (Prpf19) and exocyst complex component 7 (Exoc7) in controlling the degradation of disease protein and neurodegeneration of the rare hereditary ataxia. The research findings have been published in the prestigious scientific journal, Cell Death & Disease. Protein misfolding contributes to the pathogenesis of SCA3 Proteins play a significant role in every single cell development in the human body, including neurons. Numerous studies have proved that misfolds and aggregation of ...

A new paper by Dr. Miki Ben-Dor and Prof. Ran Barkai from the Jacob M. Alkow Department of Archaeology at Tel Aviv University proposes an original unifying explanation for the physiological, behavioral and cultural evolution of the human species, from its first appearance about two million years ago, to the agricultural revolution (around 10,000 BCE). According to the paper, humans developed as hunters of large animals, causing their ultimate extinction. As they adapted to hunting small, swift prey animals, humans developed higher cognitive abilities, evidenced by the most obvious evolutionary change - the growth of brain volume from ...

A study carried out by researchers from the Institute of Genomics, University of Tartu revealed that human gut microbiome can be used to predict changes in Type 2 diabetes related glucose regulation up to four years ahead. Type 2 diabetes is a metabolic disease characterized by elevated blood glucose levels that contributes to millions of deaths worldwide each year and its prevalence is rapidly increasing. Type 2 diabetes is preceded by "prediabetes" - a condition when the glucose levels have started to rise, but the progression of the disease ...

Takeaway coffees - they're a convenient start for millions of people each day, but while the caffeine perks us up, the disposable cups drag us down, with nearly 300 billion ending up in landfill each year. While most coffee drinkers are happy to make a switch to sustainable practices, new research from the University of South Australia shows that an absence of infrastructure and a general 'throwaway' culture is severely delaying sustainable change. It's a timely finding, particularly given the new bans on single-use plastics coming into effect in South Australia today, and the likelihood of takeaway coffee cups taking ...

Tsukuba, Japan - Single-celled algae and animal sperm cells are widely separated in evolution but both swim in the same way, by waving their protruding hairs, called cilia or flagella. Motion is driven by molecular motors, complex assemblies of proteins that exert a force when changing shape. The motor proteins are connected to the cell's internal skeleton of microtubules; the moving force from the motor causes microtubules to slide, moving the flagella and propelling the cell. Now a team led by Professor Kazuo Inaba of the University of Tsukuba in collaboration with scientists from Osaka University, Tokyo Institute of Technology and Paul Scherrer Institute has described a new protein that is closely ...

While many people believe misinformation on Facebook and Twitter from time to time, people with lower education or health literacy levels, a tendency to use alternative medicine or a distrust of the health care system are more likely to believe inaccurate medical postings than others, according to research published by the American Psychological Association. "Inaccurate information is a barrier to good health care because it can discourage people from taking preventive measures to head off illness and make them hesitant to seek care when they get sick," said lead author Laura D. Scherer, PhD, with the University of Colorado School of Medicine. "Identifying who is most susceptible to misinformation ...

Electric scooters or "e-scooters" are taking over cities worldwide and have broad appeal with tourists. Although e-scooter use declined during the COVID-19 pandemic, its popularity could rebound rapidly, especially if travelers start to substitute scooters for transit on some shorter trips. Shared e-scooters in particular, are a rapidly emerging mode of transportation, but present a host of regulatory challenges from equitable distribution to parking infrastructure to pedestrian safety, among others. Understanding travel demand patterns of shared ...

An associate professor from RUDN University found out the effect of the number and size of pores on the permeability of bone implants by biological fluids. The results of the study could help choose the optimal physical parameters of implants. The results of the study were published in the International Journal of Engineering. For an implant to survive in the body and to take the place of bone tissue, it should be made of a non-toxic, biologically inert, and wearproof material. However, at the same time, it should be light, porous, and permeable by biological liquids. If an implant does not interfere with the transfer of oxygen, minerals, and nutrients, new bone tissue and blood vessels start to grow around it, and a patient's ...

Osaka, Japan - Osaka University researchers employed machine learning to design new polymers for use in photovoltaic devices. After virtually screening over 200,000 candidate materials, they synthesized one of the most promising and found its properties were consistent with their predictions. This work may lead to a revolution in the way functional materials are discovered. Machine learning is a powerful tool that allows computers to make predictions about even complex situations, as long as the algorithms are supplied with sufficient example data. This is especially useful for complicated ...

With their exuberant colours, fiery personalities and captivating courtship displays, the fairy wrasses are one of the most beloved coral reef fish. Despite this, the evolutionary history of its genus was not well understood - until now. Fairy wrasses diverged in form and colour after repeated sea level rises and falls during the last ice age, finds a new study. Published in top journal Systematic Biology, it employed a novel genome-wide dataset to make this discovery. Lead author, ichthyologist and PhD candidate at the University of Sydney, Mr Yi-Kai (Kai) Tea, says ...

Osaka, Japan - Nature is full of diversity, but underneath the differences are often shared features. Researchers from Japan investigating diversity in plant features have discovered that plant root tips commonly converged to a particular shape because of physical restrictions on their growth. In a study published in February in Development, researchers from Osaka University, Nara Institute of Science and Technology, and Kobe University have revealed that plant root tips are constrained to a dome-shaped outline because of restrictions on their tissue growth. This study is one of the papers selected as a Research Highlight published in this issue of Development ...

Raspberry muffins are in our future. Washington State University scientists have figured out a way to treat raspberries before they're frozen so that they maintain their structure when thawed. The tart little berries are very delicate and freezing damages their cells. They turn to mush when baked and leak juice into the surrounding baked product, making them unattractive and diluted in flavor. As a result, frozen raspberries are rarely used in baking, whether at home or in commercial bakeries. But that's about to change. In a recent article published in Food and Bioprocess ...

Making cheese leaves a lot to chance as a batch could be ripened for months or even years before a problem is discovered, which could send a prized batch of cheddar to be sold off cheap as an ingredient for processed cheese. It's part of why cheese is so complex and expensive to make - a factory could invest lots of time and money into what they think will be a top-graded batch, only to discover it's a flop when it's too late to fix. But new research from RMIT University in Melbourne, Australia allows quality to be checked much earlier and more precisely in the process, giving manufacturers a better chance to react to issues with the ripening process. Dr ...

Researchers from Tokyo Medical and Dental University (TMDU) observe underdeveloped jaw cartilage in newborn rats exposed to periods of low oxygen Tokyo, Japan - Breathing in adequate amounts of oxygen is critical for human life. However, certain disorders can cause individuals to go through periods where they are exposed to periodical low levels of oxygen, called intermittent hypoxia (IH). This is common in people who suffer from some sleep disorders like obstructive sleep apnea. Although we know IH can cause neurological development issues, it is not clear how it affects cartilage. Now, researchers at Tokyo Medical and Dental University (TMDU) have shown that IH can result in underdeveloped jaw cartilage in rats. In an article published in Scientific Reports, researchers ...

HIV infections are treated with antiviral drugs which effectively prevent the disease from developing. While pharmacological HIV therapy has advanced considerably, the virus cannot be entirely eliminated from the body with currently available drugs. However, in roughly one-fifth of HIV patients the immune system does not recover as expected: the quantity of CD4 T cells, reflecting the status of the immune system, remains low even when the quantity of HI viruses in blood is suppressed to very low levels or below the measurement threshold. In such patients, indications of chronic immune activation, which erodes the immune system, can be detected. In cooperation with the University of Erlangen-Nuremberg in Germany, researchers at the University of Helsinki have ...

Wildlife tourism including white shark cage-diving is growing in popularity, but these industries remain highly contentious amongst tourists, conservationists, and scientists alike. Many voice concerns about possible negative impacts - especially when it targets potentially dangerous animals - while proponents cite the socio-economic benefits to justify wildlife tourism activities. In reality, wildlife tourism is complex, requiring managers to balance the benefits and drawbacks to determine what is acceptable for such industries. To help solve this question of "is wildlife tourism good or bad?", a tool to help managers assess these industries has been created ...

A painful tradeoff between a number of infected and negative economic impact must be considered before deciding on the lockdown strategy within a city. As national economies continue to crumble, citizens wonder whether their governments did a good job at regulating the lockdown measures. Russian city of St. Petersburg is at the frontlines of this ongoing war with Covid-19. To combat this situation effectively, Russian government allocated significant funds for the research. Results followed. Scientists from Peter the Great St.Petersburg Polytechnic University (SPbPU) modified the existing SIR class pandemic prediction model. Now it is better. But why? What is the nature ...

Breast cancer is the commonest fatal cancer in women. Early detection increases a woman's chances of recovery. Magnetic Resonance Imaging (MRI) is an accurate technique for detecting and classifying tumours in breast tissue. However, it sometimes causes "false alarms", thus requiring further investigation (biopsy) and in some cases even resulting in so-called overtreatment, that is to say unnecessary surgery. For the first time, a research team from MedUni Vienna has now confirmed a threshold value for a non-invasive imaging biomarker. This can be incorporated into short standard MRI scans ...

Without electronics and photonics, there would be no computers, smartphones, sensors, or information and communication technologies. In the coming years, the new field of phononics may further expand these options. That field is concerned with understanding and controlling lattice vibrations (phonons) in solids. In order to realize phononic devices, however, lattice vibrations have to be controlled as precisely as commonly realized in the case of electrons or photons. Phononic cyrstals The key building block for such a device is a phononic ...

Tohoku University scientists and their colleagues in Germany have revealed that a first-time exposure to only a brief period of brain hyperactivity resulted in an acute breakdown of the inter-cellular network of glial cells. Pharmacological intervention of the glial plasticity may provide a new preventative strategy for fighting epilepsy. The findings were detailed in the Journal of Neuroscience. Epilepsy is a disorder characterized by neuronal hyper-excitation and a progression of seizures with each episode. Anti-epileptic drugs are mostly aimed at suppressing hyperactivity, ...

Results of a 2018 multirocket launch at Poker Flat Research Range north of Fairbanks, Alaska, will help scientists better understand the impact of more water vapor accumulating near the fringe of the Earth's atmosphere. "This is the first time anyone has experimentally demonstrated that cloud formation in the mesosphere is directly linked to cooling by water vapor itself," said Irfan Azeem, space physicist at Astra LLC in Louisville, Colorado, and principal investigator of the Super Soaker mission. The NASA-funded project, named Super Soaker, ...

In recent years, European forests have suffered greatly from extreme climate conditions and their impacts. More than half of Europe's forests are potentially at risk from windthrow, forest fire, insect attacks or a combination of these. This is the main result of a study by an international team of scientists with the participation of Henrik Hartmann from the Max Planck Institute for Biogeochemistry in Jena, Germany. Using satellite data and artificial intelligence, the scientists studied vulnerability to disturbances in the period between 1979 and 2018. In the light of ongoing climate change, their findings are very important for improving mitigation and adaptation strategies ...