What The Study Did: This study combined the results of 12 studies with 1.8 million participants to examine the association between attention-deficit/hyperactivity disorder (ADHD) in childhood and adolescence and the subsequent risk of developing a psychotic disorder. Authors: Mikaïl Nourredine, M.D., M.Sc., of the Hospices Civils de Lyon in Lyon, France, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (10.1001/jamapsychiatry.2020.4799) Editor's Note: The article includes conflict of interest disclosures. Please see the article for additional information, including other authors, author contributions and ...

BOSTON (February 24, 2021) - Results of a study published today in JAMA Surgery reveal the impact post-operative delirium has on health care costs in the U.S. Data from the study shows that if delirium were prevented or made less severe for patients, it could reduce health care costs by $33 billion per year, that is, $44,300 per patient per year. Severe delirium resulted in an additional $56,500 per patient per year, as compared to routine health care costs for older post-operative patients. Tammy Hshieh, M.D., M.P.H., Adjunct Scientist, and Ray Yun Gou, M.A., Data Scientist II, both with the Aging Brain Center in the Hinda and Arthur Marcus Institute for Aging Research at Hebrew SeniorLife, are co-first authors. Sharon K. Inouye, M.D., M.P.H., Director ...

CHAPEL HILL, N.C.--For the last decade, the U.S. Food and Drug Administration has required tobacco manufacturers and importers to report the levels of harmful and potentially harmful chemicals found in their tobacco products and tobacco smoke. The idea was to educate the public and ultimately to decrease tobacco use, but little research has demonstrated if such information can impact on people's decisions to quit smoking. A new study from the University of North Carolina at Chapel Hill has found that smokers who saw messages about tobacco chemicals with associated ...

The stem cells in our brain generate new neurons throughout life, for example in the hippocampus. This region of the brain plays a key role for a range of memory processes. With increasing age, and in patients suffering from Alzheimer's disease, the hippocampus' ability to create new neurons declines steadily - and with it, its memory functions. Distribution of age-dependent cell damage A study conducted by the research group of Sebastian Jessberger, a professor at the Brain Research Institute of the University of Zurich, shows how the formation of new neurons is impaired with advancing age. Protein structures in the nuclei of neural stem cells make sure that harmful proteins accumulating ...

The most modern light sources for research are based on particle accelerators. These are large facilities in which electrons are accelerated to almost the speed of light, and then emit light pulses of a special character. In storage-ring-based synchrotron radiation sources, the electron bunches travel in the ring for billions of revolutions, then generate a rapid succession of very bright light pulses in the deflecting magnets. In contrast, the electron bunches in free-electron lasers (FELs) are accelerated linearly and then emit a single super-bright flash of ...

Researchers have mapped the physical organization of the brain of a microscopic soil-living nematode worm called Caenorhabditis elegans, creating a new model for the architecture of the animal's brain and how it processes information. In a surprise twist, they found a large degree of variation in the structure of some neural circuits or pathways in individual worms which complemented a core set of neural circuits common to different animals. The scientists say the worms' brains might have a lot more in common with larger animals than previously thought. Created by neuroscientists at the University of Leeds in collaboration with researchers in New York's Albert Einstein College of Medicine, the brain map reveals that ...

Scientists at the Children's Medical Center Research Institute at UT Southwestern (CRI) have identified the specialized environment, known as a niche, in the bone marrow where new bone and immune cells are produced. The study, published in Nature, also shows that movement-induced stimulation is required for the maintenance of this niche, as well as the bone and immune-forming cells that it contains. Together, these findings identify a new way that exercise strengthens bones and immune function. Researchers from the Morrison laboratory discovered that forces created from walking or running are transmitted from bone surfaces along arteriolar blood vessels into the marrow inside bones. Bone-forming ...

A study of spatial learning in mice shows that exposure to new experiences dampens established representations in the brain's hippocampus and prefrontal cortex, allowing the mice to learn new navigation strategies. The study, published in Nature, was supported by the National Institutes of Health. "The ability to flexibly learn in new situations makes it possible to adapt to an ever-changing world," noted Joshua A. Gordon, M.D., Ph.D., a senior author on the study and director of the National Institute of Mental Health, part of NIH. "Understanding the neural basis of this flexible learning in animals gives us insight into ...

Asymmetry in the proton confounds physicists, but a new discovery may bring back old theories to explain it. Symmetry -- displayed in areas ranging from mathematics and art, to living organisms and galaxies -- is an important underlying structure in nature. It characterizes our universe and enables it to be studied and understood. Because symmetry is such a pervasive theme in nature, physicists are especially intrigued when an object seems like it should be symmetric, but it isn't. When scientists are confronted with these broken symmetries, it's as if they've found an object with a strange reflection in the mirror. "Nature is leading the way for concepts in older models of the proton to get a second look." -- ...

UCLA materials scientists and their colleagues have developed a new method to make synthetic biomaterials that mimic the internal structure, stretchiness, strength and durability of tendons and other biological tissues. The researchers developed a two-pronged process to enhance the strength of existing hydrogels that could be used to create artificial tendons, ligaments, cartilage that are 10 times tougher than the natural tissues. Although the hydrogels contain mostly water with little solid content (about 10% polymer), they are more durable than Kevlar and rubber, which are both 100% polymer. This kind of breakthrough has never been achieved in water-laden polymers until this study, which was recently published in Nature. ...

With the hope of contributing to the fight against cancer, researchers in Sweden have published a new molecular mapping of proteins that regulate the cell division process - identifying 300 such proteins. The release of the data, which was published today in the scientific journal, Nature, is significant because it helps bring medical research closer to the point of being able to target specific proteins to treat cancer. Identifying and understanding what characterizes these proteins is important, says co-author Emma Lundberg, a professor at KTH Royal Institute of Technology whose research group at Science ...

What The Study Did: National COVID-19 registry data are used in this study to describe the epidemiology, clinical characteristics, complications, and hospital and postdischarge outcomes of pediatric patients with multisystem inflammatory syndrome in children (MIS-C) and to compare each in patients with severe COVID-19. Authors: Adrienne G. Randolph, M.D., of Boston Children's Hospital, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jama.2021.2091) Editor's Note: The article includes conflict of ...

What The Study Did: This randomized clinical trial compares the effects of once-weekly subcutaneous semaglutide versussplacebo for weight management as an adjunct to intensive behavioral therapy with initial low-calorie diet in adults with overweight or obesity. Authors: Thomas A. Wadden, Ph.D., of the University of Pennsylvania in Philadelphia, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jama.2021.1831) Editor's Note: The article includes conflict of interest and funding/support disclosures. Please see the article for additional information, including other authors, author contributions ...

Many genetic variants have been found to have a linkage with genetic diseases, but the understanding of their functional roles in causing diseases are still limited. An international research team, including a biomedical scientist from City University of Hong Kong (CityU), has developed a high-throughput biological assay technique which enabled them to conduct a systematic analysis on the impact of nearly 100,000 genetic variants on the binding of transcription factors to DNA. Their findings provided valuable data for finding key biomarkers of type 2 diabetes for diagnostics and treatments. And they ...

Long-term use of a medication used to treat kidney transplant patients may not be necessary in individuals with low-to-moderate risk of organ rejection, according to the results of a study led by a University of Cincinnati transplant researcher. The randomized clinical trial of 385 patients on immunosuppressive drugs tacrolimus and mycophenolate examined whether use of these medicines called corticosteroids could be eliminated at seven days after kidney transplantation. The study shows that 15 years after transplantation no difference in kidney transplant survival or patient survival rates were found between patients who received long-term corticosteroids versus those who had corticosteroid eliminated early, explains E. Steve Woodle, MD, the William ...

MEMPHIS, TN, FEBRUARY 24, 2021:- Early diagnosis of Alzheimer's disease has been shown to reduce cost and improve patient outcomes, but current diagnostic approaches can be invasive and costly. A recent study, published in the Journal of Alzheimer's Disease, has found a novel way to identify a high potential for developing Alzheimer's disease before symptoms occur. Ray Romano, Ph.D., RN, completed the research as part of his Ph.D. in the Nursing Science Program at the University of Tennessee Health Science Center (UTHSC) College of Graduate Health Sciences. Dr. Romano conducted the research through the joint laboratory ...

Plants and animals can rapidly respond to changes in their environment, such as a Venus flytrap snapping shut when a fly touches it. However, replicating similar actions in soft robots requires complex mechanics and sensors. Now, researchers reporting in ACS Applied Materials & Interfaces have printed liquid metal circuits onto a single piece of soft polymer, creating an intelligent material that curls under pressure or mechanical strain. Watch a video of the smart material here. Ideally, soft robots could mimic intelligent and autonomous behaviors ...

What The Article Says: This JAMA Insights review from Centers for Disease Control and Prevention COVID-19 Response team members presents data on the number of long-term care facilities and the numbers of residents and staff of those facilities who received first-dose vaccination through mid-January under the agency's public-private partnership with CVS, Walgreens and Managed Health Care Associates. Authors: Radhika Gharpure, D.V.M., M.P.H., of the COVID-19 Response at the CDC, is the corresponding author. To access the embargoed study: Visit ...

Coprolites, or fossilized dog feces, are often used to understand the dietary preferences of ancient civilizations. However, the samples are often contaminated, making the analysis difficult. A new study, published in END ...

PHILADELPHIA -- A second study of the injectable anti-obesity medication, semaglutide, has confirmed the large weight losses reported in a study earlier this month, establishing the reliability and robustness of this new drug. With obesity affecting more than 40 percent of American adults, the findings could have a major impact on weight management in primary care and other settings. The END ...

To become climate neutral by 2050, the European Union launched two ambitious programmes: "Green Deal" and "DigitalStrategy". As a key component of their successful implementation, climate scientists and computer scientists launched the "Destination Earth" initiative, which will start in mid-?2021 and is expected to run for up to ten years. During this period, a highly accurate digital model of the Earth is to be created, a digital twin of the Earth, to map climate development and extreme events as accurately as possible in space and time. Observational data will be continuously incorporated into the digital ...

SAN ANTONIO -- Feb. 24, 2021 -- A Southwest Research Institute® (SwRI®) scientist examined 11 Mars years of image data to understand the seasonal processes that create linear gullies on the slopes of the megadune in the Russell crater on Mars. In early spring images, captured by two different cameras on the Mars Reconnaissance Orbiter, SwRI's Dr. Cynthia Dinwiddie noticed airborne plumes of dusty material associated with the linear dune gullies on the sand dune's downwind slope. These clues point to active processes involving chunks of frozen CO2, or dry ice, sliding down the sand dune, kicking up sand and dust along the way. Russell crater, on Mars, ...

Meat alternatives are officially mainstream. To wit, Burger King added the plant-based Impossible Burger to its menu nationwide in 2019, and McDonald's plans to unveil its own McPlant in 2021. Alongside these vegetarian options, many companies are also working to culture meat outside of animals grown from cell lines. Proponents highlight a range of potential environmental and health benefits offered by this emerging industry, and several companies believe that these benefits could also play out with seafood. A multidisciplinary team of researchers has taken a good, hard look at what it would take for cell-based seafood to deliver conservation benefits. They have ...

Immunologists at St. Jude Children's Research Hospital have discovered that tumors use a unique mechanism to switch on regulatory T cells to protect themselves from attack by the immune system. Surprisingly, the mechanism does not affect regulatory T cell function outside the tumor and may therefore limit the immune-associated toxicities of targeting regulatory T cells. The finding offers the promise of drug treatment to selectively shut down regulatory T cells in a tumor, rendering the tumor vulnerable to cancer immunotherapies that activate the immune ...

BROOKLYN, New York, Wednesday, February 24, 2021 -The Governance Lab (The GovLab) at the NYU Tandon School of Engineering released a report, "The Power of Virtual Communities," which examines the role online groups play in creating opportunities for people to build new kinds of meaningful communities they often could not form in real space. This first-of-its-kind research was built on interviews with 50 Facebook community leaders in 17 countries, 26 global experts from academia and industry, unique access to Facebook's underlying research and an original global survey conducted by YouGov of 15,000 people in 15 countries who are currently members of online and ...