ROCKVILLE, MD - Coronaviruses exploit our cells so they can make copies of themselves inside us. After they enter our cells, they use our cell machinery to make unique tools of their own that help them generate these copies. By understanding the molecular tools that are shared across coronaviruses, there is potential to develop treatments that can not only work in the current COVID-19 pandemic, but in future coronavirus outbreaks as well. Rockefeller University researchers in the labs of Tarun Kapoor and Shixin Liu, including postdoctoral associate ...

ROCKVILLE, MD - A tenth of all intensive care unit patients worldwide, and many critical patients with COVID-19, have acute respiratory distress syndrome (ARDS). Therapeutic hypothermia, an intentional cooling of the body, has been suggested as a way to improve ARDS. New research by Chiara Autilio and colleagues in the lab of Jesus Perez-Gil at the Complutense University of Madrid shows not only how therapeutic hypothermia works in the lungs at the molecular level, but also why it could be successfully applied to ARDS. Autilio and her colleagues' work was published in Nature Scientific Reports in January 2021 and will be presented ...

ROCKVILLE, MD - The remarkable genetic scissors called CRISPR/Cas9, the discovery that won the 2020 Nobel Prize in Chemistry, sometimes cut in places that they are not designed to target. Though CRISPR has completely changed the pace of basic research by allowing scientists to quickly edit genetic sequences, it works so fast that it is hard for scientists to see what sometimes goes wrong and figure out how to improve it. Julene Madariaga Marcos, a Humboldt postdoctoral fellow, and colleagues in the lab of Professor Ralf Seidel at Leipzig University in Germany, found a way to analyze the ultra-fast movements of CRISPR enzymes, which will help researchers understand how they recognize their target sequences in hopes of improving the specificity. Madariaga Marcos will present ...

New compound targets neurons that initiate voluntary movement After 60 days of treatment, diseased brain cells look like healthy cells More research needed before clinical trial can be initiated CHICAGO and EVANSTON--- Northwestern University scientists have identified the first compound that eliminates the ongoing degeneration of upper motor neurons that become diseased and are a key contributor to ALS (amyotrophic lateral sclerosis), a swift and fatal neurodegenerative disease that paralyzes its victims. In addition to ALS, upper motor neuron degeneration also results in other motor neuron diseases, such as hereditary spastic paraplegia (HSP) and primary lateral sclerosis (PLS). In ALS, movement-initiating nerve cells in the brain (upper motor neurons) and muscle-controlling ...

According to a 2017 UCLA study, students with ADHD make up about 6% of the college student population and represent the most common type of disability supported by college disability offices. But are these students receiving enough academic support from their institutions? Despite ADHD being prevalent among college students, there has been little research focused on how having ADHD impacts the transition to college and ongoing academic success. Until now. New research from George DuPaul, professor of school psychology and associate dean for research in Lehigh University's College of Education, and colleagues confirms students with ADHD face consequential challenges in succeeding and completing ...

DURHAM, N.C. -- Younger, smaller trees that comprise much of North America's eastern forests have increased their seed production under climate change, but older, larger trees that dominate forests in much of the West have been less responsive, a new Duke University-led study finds. Declines in these trees' seed production, or fecundity, could limit western forests' ability to regenerate following the large-scale diebacks linked to rising temperatures and intensifying droughts that are now occurring in many states and provinces. This continental divide, reported for the ...

In recent years, researchers have discovered ways to remove specific fears from the brain, increase one's own confidence, or even change people's preferences, by using a combination of artificial intelligence and brain scanning technology. Their technique could lead to new treatments for patients with conditions such as post-traumatic stress disorder (PTSD), phobias or anxiety disorders. But while this technique is extremely promising, in some individuals it remains unsuccessful. Why are there such differences in outcome? Better understanding how the brain can self-regulate its own activity patterns would go a long way toward establishing the technique for clinical use. The researchers who spearheaded this technique have thus released a unique dataset ...

Peer review/Experimental study/Animals Propranolol, a drug that is efficacious against infantile haemangiomas ("strawberry naevi", resembling birthmarks), can also be used to treat cerebral cavernous malformations, a condition characterised by misshapen blood vessels in the brain and elsewhere. This has been shown by researchers at Uppsala University in a new study published in the scientific journal Stroke. "Up to now, there's been no drug treatment for these patients, so our results may become hugely important for them," says Peetra Magnusson of the University's Department of Immunology, Genetics and Pathology, who headed the study. Cerebral cavernous malformations (CCMs, also called cavernous angiomas or cavernomas) are vascular lesions ...

DALLAS, Feb. 23, 2021 — Women face many female-specific risks for heart disease and stroke, including pregnancy, physical and emotional stress, sleep patterns and many physiological factors, according to multiple studies highlighted in this year’s Go Red for Women® special issue of the Journal of the American Heart Association, published online today. “Although cardiovascular disease is the leading cause of death in men and women, women are less likely to be diagnosed and receive preventive care and aggressive treatment compared to men,” said Journal of the American Heart Association Editor-in-Chief Barry London, M.D., Ph.D., Ph.D., the Potter Lambert Chair in Internal Medicine, director of the division ...

Using an innovative computational approach to analyze vast brain cell gene expression datasets, researchers at MIT and Sorbonne Université have found that Huntington's disease may progress to advanced stages more because of a degradation of the cells' health maintenance systems than because of increased damage from the disease pathology itself. The analysis yielded a trove of specific gene networks governing molecular pathways that disease researchers may now be able to target to better sustain brain cell health amid the devastating neurodegenerative ...

The use of the polymeric flame retardant PolyFR in "eco-friendly" foam plastic building insulation may be harmful to human health and the environment, according to a new commentary in Environmental Science & Technology. The authors' analysis identifies several points during the lifecycle of foam insulation that may expose workers, communities, and ecosystems to PolyFR and its potentially toxic breakdown products. With the climate crisis fueling demand for energy-efficient insulation, the production of PolyFR is increasing rapidly. That's because this flame retardant is added to all foam plastic building insulation in North America to comply with flammability codes, replacing the flame retardant ...

HSE University researchers have become the first in the world to discover genetic predisposition to severe COVID-19. The results of the study were published in the journal Frontiers in Immunology. T-cell immunity is one of the key mechanisms used by the human body to fight virus infections. The staging ground for cell immunity development is the presentation of virus peptides on the surface of infected cells. This is followed by activation of T lymphocytes, which start to kill the infected cells. The ability to successfully present virus peptides is largely determined by genetics. In human cells, human leukocyte antigen class I (HLA-I) molecules are responsible for this presentation. The set of six such molecules is unique in every ...

Young novice drivers who speak into hand-held smartphones while driving are also likely to drive while under the influence of drink or drugs, according to researchers at Lero, the Science Foundation Ireland Research Centre for Software. The study "Smartphone Use While Driving: An Investigation of Young Novice Driver (YND) Behaviour," also found that speaking on a hand-held phone is strongly correlated with high-risk driving behaviours such as overtaking on the inside of the car ahead, speeding, driving without a valid licence and driving while intoxicated. Lero researchers, surveyed 700 German Young Novice Drivers ...

COVID-19 infection in pregnancy is not associated with stillbirth or early neonatal death, according to a new study. However the research, from over 4000 pregnant women with suspected or confirmed COVID-19, also found women who had a positive test were more likely to have a premature birth. The research, led by scientists from Imperial College London and published in the journal Ultrasound in Obstetrics and Gynecology, used data from the UK and the USA. The study team looked at data from 4004 pregnant women who had suspected or confirmed COVID-19. Of these women, ...

ITHACA, N.Y. - Critics claim environmental regulations hurt productivity and profits, but the reality is more nuanced, according to an analysis of environmental policies in China by a pair of Cornell economists. The analysis found that, contrary to conventional wisdom, market-based or incentive-based policies may actually benefit regulated firms in the traditional and "green" energy sectors, by spurring innovation and improvements in production processes. Policies that mandate environmental standards and technologies, on the other hand, may broadly harm output and profits. "The conventional wisdom is not entirely ...

As electronic devices saturate all corners of public and personal life, engineers are scrambling to find lightweight, mechanically stable, flexible, and easily manufactured materials that can shield humans from excessive electromagnetic radiation as well as prevent electronic devices from interfering with each other. In a breakthrough report published in Advanced Materials--the top journal in the field-- engineers at the University of California, Riverside describe a flexible film using a quasi-one-dimensional nanomaterial filler that combines excellent electromagnetic shielding with ease of manufacture. "These novel films are promising for high-frequency communication technologies, which require electromagnetic ...

A federally approved heart medication shows significant effectiveness in interfering with SARS-CoV-2 entry into the human cell host, according to a new study by a research team from Texas A&M University and The University of Texas Medical Branch (UTMB). The medication bepridil, which goes by the trade name Vascor, is currently approved by the U.S. Food and Drug Administration (FDA) to treat angina, a heart condition. The team's leaders are College of Science professor Wenshe Ray Liu, professor and holder of the Gradipore Chair in the Department of Chemistry at Texas A&M, and Chien-Te Kent Tseng, professor ...

Climate change impacts are broad and far reaching. A new study by University of Oklahoma researchers from the Institute for Environmental Genomics explores the impacts of climate warming on microbial network complexity and stability, providing critical insights to ecosystem management and for projecting ecological consequences of future climate warming. "Global climate change is one of the most profound anthropogenic disturbances to our planet," said Jizhong Zhou, IEG's director, a George Lynn Cross Research Professor in the College of Arts and Sciences and an adjunct professor in the Gallogly College of Engineering. "Climate warming can alter soil microbial community diversity, structure and activities, but it remains uncertain whether and how it impacts network complexity and its relationships ...

COLUMBUS, Ohio - If depression is making it more difficult for some unemployed people to land a job, one type of therapy may help, research suggests. In a new study, 41% of unemployed or underemployed people undergoing cognitive behavioral therapy (CBT) found a new job or went from part- to full-time work by the end of the 16-week treatment for depression. Those who had a job but found it difficult to focus on and accomplish work tasks because of depression said the treatment helped to significantly reduce these problems. "For the most part, researchers have focused on showing ...

Just when you thought you could head indoors to be safe from the air pollution that plagues the Salt Lake Valley, new research shows that elevated air pollution events, like horror movie villains, claw their way into indoor spaces. The research, conducted in conjunction with the Utah Division of Facilities Construction and Management, is published in Science of the Total Environment. In a long-term study in a Salt Lake-area building, researchers found that the amount of air pollution that comes indoors depends on the type of outdoor pollution. Wildfires, fireworks and wintertime inversions all affect indoor air to different degrees, ...

Researchers Learn that Pregnant Women Pass Along Protective COVID Antibodies to their Babies Antibodies that guard against COVID-19 can transfer from mothers to babies while in the womb, according to a new study from Weill Cornell Medicine and NewYork-Presbyterian researchers published in the American Journal of Obstetrics and Gynecology. This discovery, published Jan. 22, adds to growing evidence that suggests that pregnant women who generate protective antibodies after contracting the coronavirus often convey some of that natural immunity to their fetuses. The findings also lend support to the idea that vaccinating mothers-to-be may also have benefits for their newborns. "Since we can now say that the antibodies pregnant women make against COVID-19 ...

The U.S. pulp and paper industry uses large quantities of water to produce cellulose pulp from trees. The water leaving the pulping process contains a number of organic byproducts and inorganic chemicals. To reuse the water and the chemicals, paper mills rely on steam-fed evaporators that boil up the water and separate it from the chemicals. Water separation by evaporators is effective but uses large amounts of energy. That's significant given that the United States currently is the world's second-largest producer of paper and paperboard. The country's approximately 100 paper mills are estimated to use about 0.2 quads (a quad is a quadrillion BTUs) of energy per year for water recycling, making it one of the most energy-intensive chemical processes. All industrial ...

Large galaxies are known to strip the gas that occupies the space between the stars of smaller satellite galaxies. In research published today, astronomers have discovered that these small satellite galaxies also contain less 'molecular' gas at their centres. Molecular gas is found in giant clouds in the centres of galaxies and is the building material for new stars. Large galaxies are therefore stealing the material that their smaller counterparts need to form new stars. Lead author Dr Adam Stevens is an astrophysicist based at UWA working for the International Centre for Radio Astronomy Research (ICRAR) and affiliated to the ARC Centre of Excellence in All Sky Astrophysics in 3 Dimensions (ASTRO 3D). Dr Stevens ...

FAYETTEVILLE, Ark. - Cold temperatures, prevalent during glacial periods, had a significant impact on past and modern unglaciated landscapes across much of North America, according to a recent study by University of Arkansas geologist Jill A. Marshall. Marshall, assistant professor of geosciences, is the first author of the study, published in the journal Geophysical Research Letters. The findings help shape understanding of the earth's "Critical Zone," the relatively thin layer of the planet that extends from where vegetation meets the atmosphere to the lowermost extent of weathered bedrock. "Climate and ecosystems determine how quickly bedrock ...

DALLAS - Feb. 22, 2021 - Three decades-old antibiotics administered together can block a type of pain triggered by nerve damage in an animal model, UT Southwestern researchers report. The finding, published online today in PNAS, could offer an alternative to opioid-based painkillers, addictive prescription medications that are responsible for an epidemic of abuse in the U.S. Over 100 million Americans are affected by chronic pain, and a quarter of these experience pain on a daily basis, a burden that costs an estimated $600 billion in lost wages and medical expenses ...