Researchers at the Lady Davis Institute (LDI) at the Jewish General Hospital have discovered that increased levels of the protein OAS1 are associated with reduced mortality and less severe disease requiring ventilation among patients with COVID-19. Using drugs that boost OAS1 levels could be explored to try to improve these outcomes. The findings are published today in Nature Medicine. "Our analysis shows evidence that OAS1 has a protective effect against COVID-19 susceptibility and severity," explains Dr. Brent Richards, a senior investigator at the LDI's Centre for Clinical Epidemiology and Professor of Medicine, Human Genetics, Epidemiology and Biostatistics at McGill University. "This is a very ...

A new study using leading edge technology has shed surprising light on the ancient habitat where some of the first dinosaurs roamed in the UK around 200 million years ago. The research, led by the University of Bristol, examined hundreds of pieces of old and new data including historic literature vividly describing the landscape as a "landscape of limestone islands like the Florida Everglades" swept by storms powerful enough to "scatter pebbles, roll fragments of marl, break bones and teeth." The evidence was carefully compiled and digitised so it could be used to generate for the first time ...

NEW YORK, NY (Feb. 26, 2021)--People who took statins to lower cholesterol were approximately 50% less likely to die if hospitalized for COVID-19, a study by physicians at Columbia University Vagelos College of Physicians and Surgeons and NewYork-Presbyterian has found. "Our study is one of the larger studies confirming this hypothesis and the data lay the groundwork for future randomized clinical trials that are needed to confirm the benefit of statins in COVID-19," says Aakriti Gupta, MD, a cardiologist at NewYork-Presbyterian/Columbia University Irving Medical Center and one of the co-lead authors of the study. "If their beneficial effect bears out in randomized clinical trials, statins could potentially prove to be a low-cost and effective therapeutic ...

Ithaca, NY--Famous for their uncanny ability to imitate other birds and even mechanical devices, researchers find that Australia's Superb Lyrebird also uses that skill in a totally unexpected way. Lyrebirds imitate the panicked alarm calls of a mixed-species flock of birds while males are courting and even while mating with a female. These findings are published in the journal Current Biology. "The male Superb Lyrebird creates a remarkable acoustic illusion," says Anastasia Dalziell, currently a Cornell Lab of Ornithology Associate and recent Cornell Lab Rose Postdoctoral Fellow, now at the University of Wollongong, Australia. "Birds gather in mobbing flocks and the ruckus they make is a potent cue of a predator nearby. The ...

A common barnacle could be used to help trace missing persons lost at sea, according to research by UNSW Science. Researchers from the Centre for Marine Science and Innovation have developed an equation that can estimate the minimum time an object has spent drifting at sea by counting the number of Lepas anserifera attached to the object. They also developed an equation which can help plot possible drift paths of a missing boat. "We saw this opportunity that Lepas could possibly fill in this gap in that marine forensic process and possibly contribute (to finding missing people)," study lead author Thomas ...

February 26, 2021 - Kawasaki, Japan: The Innovation Center of NanoMedicine (Director General: Prof. Kazunori Kataoka, Location: Kawasaki in Japan, Abbreviation: iCONM) reported in ACS Nano (Impact Factor: 14.588 in 2019) together with the group of Prof. Yu Matsumoto of Otorhinolaryngology and Head and Neck Surgery (Prof. Tatsuya Yamasoba) and the group of Prof. Horacio Cabral of the Department of Bioengineering (Prof. Ryo Miyake) in the University of Tokyo that the efficacy of polymeric nano-micelles with different drug activation profile depends on the expression level of c-Myc, one of the major proto-oncogene, has been developed. See: https://pubs.acs.org/doi/10.1021/acsnano.1c00364 It ...

Preterm labor comprises 12.7% of all pregnancies. Although the overall rate of pregnancy is decreasing, the occurrence of premature birth due to preterm labor in south korea has been increasing over the past 7 years. Not only is preterm birth accountable for about a half of all neonatal mortality cases, the neurological deficits in surviving premature infants often lead to problems later in life, such as developmental disorders and respiratory complications. Currently, preterm labor is detected only when expecting mothers experience abnormal symptoms, or when they undergo a routine test like abdominal ultrasound or a laboratory test for ...

Researchers at Oregon Health & Science University have demonstrated a new method of quickly mapping the genome of single cells, while also clarifying the spatial position of the cells within the body. The discovery, published in the journal Nature Communications, builds upon previous advances by OHSU scientists in single-cell genome sequencing. The study represents another milestone in the field of precision medicine. "It gives us a lot more precision," said senior author Andrew Adey, Ph.D., associate professor of molecular and medical genetics in the OHSU School of Medicine. "The single-cell aspect gives us the ability to track the molecular changes within each cell type. Our new study also allows the capture of where those ...

If you've ever watched Planet Earth, you know the ocean is a wild place to live. The water is teaming with different ecosystems and organisms varying in complexity from an erudite octopus to a sea star. Unexpectedly, it is the sea star, a simple organism characterized by a decentralized nervous system, that offers insights into advanced adaptation to hydrodynamic forces--the forces created by water pressure and flow. Researchers from the USC Viterbi School of Engineering found that sea stars effectively stay attached to surfaces under extreme hydrodynamic loads by altering their shape. The researchers, including the Henry Salvatori Early Career Chair in Aerospace and Mechanical Engineering Mitul Luhar and doctoral ...

Epilepsy is one of the most common neurological conditions, affecting more than 65 million worldwide. For those dealing with epilepsy, the advent of a seizure can feel like a ticking time bomb. It could happen at any time or any place, potentially posing a fatal risk when a seizure strikes during risky situations, such as while driving. A research team at USC Viterbi School of Engineering and Keck Medicine of USC is tackling this dangerous problem with a powerful new seizure predicting mathematical model that will give epilepsy patients an accurate warning five minutes to one hour before they are likely to experience a seizure, offering enhanced freedom for the patient and cutting the need for medical intervention. The research, ...

New York, NY (February 26, 2020) - Molecules called microRNAs (miRNAs) that are measurable in urine have been identified by researchers at Mount Sinai as predictors of both heart and kidney health in children without disease. The epidemiological study of Mexican children was published in February in the journal Epigenomics. "For the first time, we measured in healthy children the associations between urinary miRNAs and cardiorenal outcomes, including blood pressure, urinary sodium and potassium levels, and eGFR [estimated glomerular filtration rate, a measure of how well the kidneys are filtering or cleaning the blood]," says lead author Yuri Levin-Schwartz, ...

Living in a group has clear benefits. As a member of a societal group, one can share resources with the others, seek protection from predators, and forage in an efficient manner. In a 2020 paper published in Science Advances, the neuroscientist Jee Hyun Choi and her student Jisoo Kim of the Brain Science Institute in the Korea Institute of Science and Technology (KIST) argue that there are much more stories about the advantages of group living and social behaviors to the mammalian brain yet to be discovered. Their research was conducted using CBRAIN (Collective Brain Research Aided by Illuminating Neural activity), a unique neuro-telemetric device equipped with LED lights, which enables the ...

Curcumin is a polyphenol compound produced by plants of the Curcuma longa species and has been reported to have many physiological activities, which include anti-oxidation, anti-inflammatory, anti-cancer, and anti-amyloid properties. However, the mechanism and network of action are not completely clear. Amyloidosis is a group of diseases characterized by abnormal aggregates of proteins, known as amyloid fibrils, and subsequent deposition in various tissues and organs, such as Alzheimer's disease, immunoglobulin light chain amyloidosis. In previous studies, curcumin has been ...

Tohoku University researchers have produced cellulose nanofiber (CNF) synthesized silk naturally through a simple tweak to silkworms' diet. Mixing CNF with commercially available food and feeding the silkworms resulted in a stronger and more tensile silk. The results of their research were published in the journal Materials and Design on February 1, 2021. "The idea for our research came to us when we realized the flow-focusing method by which silkworms produce silk is optimal for the nanofibril alignment of CNF," said Tohoku University materials engineer Fumio Narita and co-author of the study. Silk is usually associated with clothes. But its usage is incredibly diverse thanks to its strength and elastic properties. Its biocompatibility makes it even safe to ...

An open-source platform, OpenEP co-developed by researchers from the School of Biomedical Engineering & Imaging Sciences at King's College London has been made available to advance research on atrial fibrillation, a condition characterised by an irregular and often fast heartbeat. It can cause significant symptoms such as breathlessness, palpitations and fatigue, as well as being a major contributor to stroke and heart failure. Current research into the condition involves the interpretation of large amounts of clinical patient data using software written by individual ...

The centre is part of the German Federal Institute for Risk Assessment (BfR). With the help of microscopy and artificial intelligence, the "E-Morph" test reliably identifies substances that can have oestrogen-like or even opposing effects, according to the research team's report in the specialist journal "Environment International". "E-Morph is a milestone on the way to, one day, replacing animal experiments currently required to detect hormone-like effects," says BfR President Prof. Dr. Dr. Andreas Hensel. Link to the specialist publication (ScienceDirect): https://www.sciencedirect.com/science/article/pii/S0160412021000350 Link ...

A number of brain areas change their activity before we execute a planned voluntary movement. A new study by Umeå University identifies a novel function of this preparatory neural activity, highlighting another mechanism the nervous system can use to achieve its goals. Voluntary movements are prepared before they are executed. For example, such 'preparation' occurs in the period between seeing a coffee cup and starting to reach for it. Neurons in many areas of the brain change their activity during movement preparation in ways that reflect different aspects of ...

Eminent scientists warn that key ecosystems around Australia and Antarctica are collapsing, and propose a three-step framework to combat irreversible global damage. Their report, authored by 38 Australian, UK and US scientists from universities and government agencies, is published today in the international journal Global Change Biology. Researchers say I heralds a stark warning for ecosystem collapse worldwide, if action if not taken urgently. Lead author, Dr Dana Bergstrom from the Australian Antarctic Division, said that the project emerged from a conference inspired by her ecological research in polar environments. "I was seeing unbelievably rapid, widespread dieback in the alpine tundra of World Heritage-listed Macquarie Island and started wondering if this ...

Converting both nitrogen (N2) and carbon dioxide (CO2) into value-added urea molecules via C-N coupling reaction is a promising method to solve the problem of excessive CO2 emissions. Compared with huge energy consumption industrial processes, the electrochemical urea synthesis provides an appealing route under mild conditions. However, it still faces challenges of low catalytic activity and selectivity. A research team led by Prof. ZHANG Guangjin from the Institute of Process Engineering (IPE) of the Chinese Academy of Sciences fabricated Bi-BiVO4 Mott-Schottky heterostructure catalysts for efficient urea synthesis at ambient conditions. This work was published in Angewandte Chemie International ...

The Korea Institute of Machinery and Materials (KIMM) successfully developed all-round gripper* technology, enabling robots to hold objects of various shapes and stiffnesses. With the new technology, a single gripper can be used to handle different objects such as screwdrivers, bulbs, and coffee pots, and even food with delicate surfaces such as tofu, strawberries, and raw chicken. It is expected to expand applications in contact-free services such as household chores, cooking, serving, packaging, and manufacturing. *Gripper: A device that enables robots to hold and handle objects, ...

Memphis, Tenn. (February 25, 2021) - Early diagnosis of Alzheimer's disease has been shown to reduce cost and improve patient outcomes, but current diagnostic approaches can be invasive and costly. A recent study, published in the Journal of Alzheimer's Disease, has found a novel way to identify a high potential for developing Alzheimer's disease before symptoms occur. Ray Romano, PhD, RN, completed the research as part of his PhD in the Nursing Science Program at the University of Tennessee Health Science Center College of Graduate Health Sciences. Dr. Romano conducted the research through the joint laboratory of Associate ...

DETROIT (February 25, 2021) - Researchers at Henry Ford Health System, as part of a national asthma collaborative, have identified a gene variant associated with childhood asthma that underscores the importance of including diverse patient populations in research studies. The study is published in the print version of the American Journal of Respiratory and Critical Care Medicine. For 14 years researchers have known that a casual variant for early onset asthma resides on chromosome 17, which holds one of the most highly replicated and significant genetic associations with asthma. Henry Ford researchers acknowledged they would not have identified it in this study ...

ROCKVILLE, MD - Scientists are still a long way from being able to treat Alzheimer's Disease, in part because the protein aggregates that can become brain plaques, a hallmark of the disease, are hard to study. The plaques are caused by the amyloid beta protein, which gets misshapen and tangled in the brain. To study these protein aggregates in tissue samples, researchers often have to use techniques that can further disrupt them, making it difficult to figure out what's going on. But new research by Vrinda Sant, a graduate student, and Madhura Som, a recent PhD graduate, in the lab of Ratnesh Lal at the University of California, San Diego, provides a new technique for studying amyloid beta and could be useful in future Alzheimer's treatments. Sant and her colleagues will present their research ...

Our use of social media, specifically our efforts to maximize "likes," follows a pattern of "reward learning," concludes a new study by an international team of scientists. Its findings, which appear in the journal Nature Communications, reveal parallels with the behavior of animals, such as rats, in seeking food rewards. "These results establish that social media engagement follows basic, cross-species principles of reward learning," explains David Amodio, a professor at New York University and the University of Amsterdam and one of the paper's authors. "These findings may help us understand why social media comes to dominate daily life for many people and provide clues, borrowed from research on reward learning and addiction, to how troubling online engagement may ...

Chemical engineering researchers have developed a new catalyst that significantly increases yield in styrene manufacturing, while simultaneously reducing energy use and greenhouse gas emissions. "Styrene is a synthetic chemical that is used to make a variety of plastics, resins and other materials," says Fanxing Li, corresponding author of the work and Alcoa Professor of Chemical Engineering at North Carolina State University. "Because it is in such widespread use, we are pleased that we could develop a technology that is cost effective and will reduce the environmental impact of styrene manufacturing." Industry estimates ...