Standardised mortality ratios (SMRs) for hospitals do not provide an accurate picture of how many deaths could have been avoided, according to a new study by researchers at the London School of Hygiene & Tropical Medicine and Imperial College London published in the BMJ. The authors say the widely used hospital-wide standardised mortality ratios, such as HSMR (Hospital Standardised Mortality Ratio) and SHMI (Summary Hospital level Mortality Indicator), should not be used to benchmark hospitals' quality of care. Hospital-wide SMRs compare the number of deaths in a hospital ...

The first comprehensive genome analyses of 7 melon varieties was completed by a research team led by Josep Casacuberta, Jordi Garcia-Mas and Sebastian Ramos-Onsins, providing breeders new knowledge important for understanding phenotypic variability and helping increasing plant quality yields by selective breeding. The findings were published in the advanced online edition of Molecular Biology and Evolution. The researchers sought to bridge the gap between expanding the genetic knowledge of melons and understanding important traits such as flavor, size and water use. The ...

Disruptions in a key brain region can explain the varied outcomes after a traumatic brain injury (TBI) in children and adolescents, according to research published July 15 in The Journal of Neuroscience. Post-injury outcomes vary widely, and injury severity can only explain some of this variance. Combining data from brain imaging and recording, researchers at the University of Southern California and UCLA found that disruptions in the structure and function of a brain region called the corpus callosum could explain the variance in cognitive outcomes. TBI is the leading ...

Why do some youngsters bounce back quickly from a traumatic brain injury, while others suffer devastating side effects for years? New UCLA/USC research suggests that damage to the fatty sheaths around the brain's nerve fibers--not injury severity-- may explain the difference. Published in the July 15 edition of the Journal of Neuroscience, the finding identifies possible biomarkers that physicians could use to predict higher-risk patients who require closer monitoring. The study is the first to combine imaging scans with recording of the brain's electrical activity ...

WASHINGTON, DC, July 14, 2015 -- When a sound wave hits an obstacle and is scattered, the signal may be lost or degraded. But what if you could guide the signal around that obstacle, as if the interfering barrier didn't even exist? Recently, researchers at Nanjing University in China created a material from polyethylene membranes that does exactly that. Their final product, described this week in the Journal of Applied Physics, from AIP Publishing, was an acoustical "metamaterial" with an effective density near zero (DNZ). This work could help to endow a transmission ...

A quick biological test may be able to identify children who have literacy challenges or learning disabilities long before they learn to read, according to new research from Northwestern University. The study, publishing in the Open Access journal PLOS Biology on July 14th, centers on the child's ability to decipher speech -- specifically consonants -- in a chaotic, noisy environment. Preliterate children whose brains inefficiently process speech against a background of noise are more likely than their peers to have trouble with reading and language development when ...

A yearlong study of more than 300 patients found that the investigational drug patiromer can reduce elevated blood-potassium levels--a common side effect of drugs essential in the treatment of chronic diabetic kidney disease. The drug, given in this trial at one of four doses based on disease severity, returned blood potassium levels to normal when measured at four weeks and kept them under control for one year, the length of the trial. By quickly bringing potassium levels back to normal and keeping them there, patiromer can prevent life-threatening adverse events. The ...

The new guidelines for determining whether patients should begin taking statins to prevent cardiovascular disease issued in 2013 by the American College of Cardiology (ACC) and the American Heart Association (AHA) are more accurate and more efficient than an earlier set of guidelines in assigning treatment to adults at increased risk for cardiovascular events - including heart attacks and strokes - and identifying those whose low risk rules out the need to take statins. In their paper appearing in the July 15 issue of JAMA, a team led by Massachusetts General Hospital (MGH) ...

An examination of the 2013 guidelines for determining statin eligibility, compared to guidelines from 2004, indicates that they are associated with greater accuracy and efficiency in identifying increased risk of cardiovascular disease (CVD) events and presence of subclinical coronary artery disease, particularly in individuals at intermediate risk, according to a study in the July 14 issue of JAMA. The 2013 American College of Cardiology/American Heart Association (ACC/AHA) guidelines for the management of blood cholesterol represent a shift in the treatment approach ...

A microsimulation model-based analyses suggests that the health benefits associated with the 10-year atherosclerotic cardiovascular disease risk threshold of 7.5 percent or higher used in the 2013 ACC-AHA cholesterol guidelines are worth the additional costs required to achieve these health gains, and that a more lenient threshold might also be cost-effective, according to a study in the July 14 issue of JAMA. In November 2013 the American College of Cardiology and the American Heart Association (ACC/AHA) released new recommendations to guide statin treatment initiation ...

Among patients with diabetic kidney disease and hyperkalemia (elevated potassium levels in the blood), a potentially life-threatening condition, those who received the new drug patiromer, twice daily for four weeks, had significant decreases in potassium levels which lasted through one year, according to a study in the July 14 issue of JAMA. Patients at the highest risk for hyperkalemia are those taking renin-angiotensin-aldosterone system (RAAS) inhibitors with stage 3 or greater chronic kidney disease (CKD) who also have diabetes mellitus, heart failure, or both. Because ...

An examination of state vaccination requirements for adolescents finds that the human papillomavirus (HPV) vaccine is currently required in only two states, many fewer than another vaccine associated with sexual transmission (hepatitis B) and another primarily recommended for adolescents (meningococcal conjugate), according to a study in the July 14 issue of JAMA. Eight years after HPV vaccines were first recommended in the United States, vaccination coverage is substantially below the Healthy People 2020 target of 80 percent. Data from the U.S. Centers for Disease Control ...

Berkeley -- Researchers at the University of California, Berkeley, in collaboration with scientists at the Gladstone Institutes, have developed a template for growing beating cardiac tissue from stem cells, creating a system that could serve as a model for early heart development and a drug-screening tool to make pregnancies safer. In experiments to be published Tuesday, July 14, in the journal Nature Communications, the researchers used biochemical and biophysical cues to prompt stem cells to differentiate and self-organize into micron-scale cardiac tissue, including ...

Boston, MA - A new study from Harvard T.H. Chan School of Public Health researchers has found that it would be cost-effective to treat 48-67% of all adults aged 40-75 in the U.S. with cholesterol-lowering statins. By expanding the current recommended treatment guidelines and boosting the percentage of adults taking statins, an additional 161,560 cardiovascular-related events could be averted, according to the researchers. "The new cholesterol treatment guidelines have been controversial, so our goal for this study was to use the best available evidence to quantify the ...

WASHINGTON, DC --July 14, 2015--Multiple species of bacteria working together in healthy guts are responsible for keeping out nasty bacterial invader, Clostridium difficile, a hospital-acquired culprit responsible for 15,000 deaths each year. The study, published this week in mBio, the online open-access journal of the American Society for Microbiology, could lead to tests to predict which hospital patients are at highest risk of infection and better management of infections. "Hospital-acquired C. difficile infections have bloomed as a problem in the last 10-15 years, ...

High-fat feeding can cause impairments in the functioning of the mesolimbic dopamine system, says Stephanie Fulton of the University of Montreal and the CHUM Research Centre (CRCHUM.) This system is a critical brain pathway controlling motivation. Fulton's findings, published today in Neuropsychopharmacology, may have great health implications. "Our research shows that independent of weight gain and obesity, high-fat feeding can cause impairments in the functioning of the brain circuitry profoundly implicated in mood disorders, drug addiction, and overeating - several states ...

Despite modern chemoradiation therapy it is still very difficult to give reliable prognoses for malignant gliomas. Surgical removal of the glioma is still the preferred method of treatment. Doctors at Universitätsklinikum Erlangen's Department of Neurosurgery have now developed a new procedure for analysing radiological imaging scans which makes it possible to predict the course of a disease relatively precisely. Their findings have now been published in the journal 'Scientific Reports'.* The Friedlein Grading A/B (FGA/B) classification system - named after the physician ...

HOUSTON - (July 14, 2015) - After Amazon announced plans last week for a day of online retail discounts July 15 comparable to Black Friday, Wal-Mart is launching a rival sale online the same day. Who will win the e-commerce battle? Winning is a matter of consistent superior e-service quality -- not just on one particular day of the year, according to new research from Rice University's Jones Graduate School of Business. "Increased e-service quality is associated with increased customer satisfaction, which then leads to higher repurchase intentions," said Vikas Mittal, ...

Putnam Valley, NY. (July 14, 2015) - Systemic lupus erythematosus (SLE) is an autoimmune disease that produces autoantibodies and subsequent immune reactions that can lead to a variety of symptoms, including inflammation of the kidneys, or nephritis. When researchers transplanted mesenchymal stem cells (MSCs) derived from human bone marrow into mice modeled with SLE, they found that inflammation was reduced and nephritis "attenuated." They suggested that their study revealed a "novel mechanism" by which the MSCs can regulate the progression of autoimmune diseases such as ...

HOUSTON - (July 14, 2015) - From 2004 to 2010 in Texas, mental illness was the most common reason for the hospitalization of children ages 10-14 while pregnancy/birth was the most common reason for the hospitalization of adolescents ages 15-17, according to researchers at The University of Texas Health Science Center at Houston (UTHealth) Medical School. The results were published in the July issue of Hospital Pediatrics, a journal of the American Academy of Pediatrics. "We were surprised by those two findings and the related costs in millions of dollars," said Bethanie ...

WEST LAFAYETTE, Ind. - New research is revealing details about how the exoskeleton of a certain type of deep-sea shrimp allows the animal to survive scalding hot waters in hydrothermal vents thousands of feet under water. "A biological species surviving in that kind of extreme environment is a big deal," said Vikas Tomar, an associate professor in Purdue University's School of Aeronautics and Astronautics. "And shrimp are a great test case for evolution because you can find different species all over the world living at various depths and with a range of adaptation requirements." He ...

DURHAM, N.C. -- Hypervigilance to hostility in others triggers aggressive behavior in children, says a new Duke University-led study. The four-year longitudinal study involving 1,299 children and their parents finds the pattern holds true in 12 different cultural groups from nine countries across the globe. This pattern is more common in some cultures than others, which helps explain why some cultures have more aggressive behavior problems in children than other cultures, according to the study. The findings, published online Monday in Proceedings of the National ...

MADISON, Wis. -- A diet that starves triple-negative breast cancer cells of an essential nutrient primes the cancer cells to be more easily killed by a targeted antibody treatment, UW Carbone Cancer Center scientists report in a recent publication. The study's senior author, Vincent Cryns, professor of medicine at the University of Wisconsin School of Medicine and Public Health, says the study lays the foundation for a clinical trial to see if a low-methionine diet will help improve outcomes in women with "triple-negative" breast cancer. Methionine is an essential amino ...

Scientists have designed nanoparticles that release drugs in the presence of a class of proteins that enable cancers to metastasize. That is, they have engineered a drug delivery system so that the very enzymes that make cancers dangerous could instead guide their destruction. "We can start with a small molecule and build that into a nanoscale carrier that can seek out a tumor and deliver a payload of drug," said Cassandra Callmann, a graduate student in chemistry and biochemistry at the University of California, San Diego, and first author of the report published in ...

NEW YORK, NY (July 14, 2015) - A plan to ensure that evidence-based psychosocial interventions are routinely used in clinical practice and made a part of clinical training for mental health professionals was released today by the National Academy of Medicine (NAM). The NAM report, titled, "Psychosocial Interventions for Mental and Substance Use Disorders," points to a strong need to strengthen evidence on the effectiveness of psychosocial interventions, and to develop guidelines and quality measures for implementing these interventions in professional practice. Though ...