While the world has its eyes on vaccines to stop the spread of coronavirus, therapeutics are still necessary to treat hospitalized patients. One of these treatments, remdesivir, is the first and only antiviral agent of its kind that the U.S. Food and Drug Administration (FDA) has approved so far for COVID-19. Research at the University of Cincinnati, however, contends that this antiviral drug is being used too indiscriminately when treating patients hospitalized with the virus. The study is published in the journal Fundamental & Clinical Pharmacology. The FDA approved remdesivir, marketed as Veklury, for emergency use authorization in May 2020 to treat COVID-19 and granted full approval ...

Mobile apps have revolutionised the way people meet in Switzerland and elsewhere in recent years. Unlike traditional dating sites, these apps do not feature detailed user profiles but are largely based on rating photos using a swipe review system. As dating apps escalated in popularity, so has criticism about them encouraging casual dating only, threatening the existence of long-term commitment, and possibly damaging the quality of intimacy. There is no scientific evidence, however, to validate these claims. A study by the University of Geneva (UNIGE), Switzerland, provides a wealth of information about couples who met through dating apps, drawing on data from a 2018 Swiss survey. The results, ...

Very low birthweight infants often need blood transfusions to survive. A National Institutes of Health-funded study suggests that providing a higher threshold of red cells within accepted limits offers no advantage in survival or reduction in neurological impairment over a lower threshold. The research was conducted by Haresh Kirpalani, B.M., of the University of Pennsylvania, Philadelphia, and colleagues and was funded by the NIH's Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Heart, Lung, and Blood Institute, and National Center for Advancing Translational Sciences. The study appears in The ...

Women awaiting liver transplants in the United States are known to be about one-third more likely than men to become too ill to undergo surgery or die before receiving a liver. Now a study headed by UC San Francisco and Columbia University highlights the role that frailty plays in this gender gap. The study followed 1,405 patients with cirrhosis, of whom 41 percent were women, awaiting liver transplantation at nine transplant centers in the United States. The men, whose ages ranged from 49 to 63, were more likely to have chronic hepatitis C and alcoholic liver disease (27 percent versus 22, and 33 percent versus 19 percent). The women, whose ages ranged ...

In an in-depth study of how COVID-19 affects a patient's brain, National Institutes of Health researchers consistently spotted hallmarks of damage caused by thinning and leaky brain blood vessels in tissue samples from patients who died shortly after contracting the disease. In addition, they saw no signs of SARS-CoV-2 in the tissue samples, suggesting the damage was not caused by a direct viral attack on the brain. The results were published as a correspondence in the New England Journal of Medicine. "We found that the brains of patients who contract infection from SARS-CoV-2 may be susceptible to microvascular blood vessel damage. Our results ...

The U.S. Department of Energy's (DOE) Princeton Plasma Physics Laboratory (PPPL) is collaborating with private industry on cutting-edge fusion research aimed at achieving commercial fusion energy. This work, enabled through a public-private DOE grant program, supports efforts to develop high-performance fusion grade plasmas. In one such project PPPL is working in coordination with MIT's Plasma Science and Fusion Center (PSFC) and Commonwealth Fusion Systems, a start-up spun out of MIT that is developing ...

In a first-of-its-kind study within cycad horticulture literature, University of Guam researchers have found that the use of anti-transpirants neither help nor hinder successful propagation of cycad stem cuttings. The Guam-based study, published Oct. 22 in the journal Tropical Conservation Science, investigated whether retaining leaves during the propagation of cycad stem cuttings conferred any benefit to propagation success. Additionally, two anti-transpirant products were utilized to investigate their efficacy during the propagation process. Leaves perform a variety of critical functions for plants, including ...

813 years of annual river discharge at 62 stations, 41 rivers in 16 countries, from 1200 to 2012. That is what researchers at the Singapore University of Technology and Design (SUTD) produced after two years of research in order to better understand past climate patterns of the Asian Monsoon region. Home to many populous river basins, including ten of the world's biggest rivers (Figure 1), the Asian Monsoon region provides water, energy, and food for more than three billion people. This makes it crucial for us to understand past climate patterns so that we can better predict long term changes in ...

COLUMBUS, Ohio - The introduction of computer simulation to the identification of symptoms in children with attention deficit/hyperactivity disorder (ADHD) has potential to provide an additional objective tool to gauge the presence and severity of behavioral problems, Ohio State University researchers suggest in a new publication. Most mental health disorders are diagnosed and treated based on clinical interviews and questionnaires - and, for about a century, data from cognitive tests has been ...

Kraków, 30 December 2020 The map of nuclear deformation takes the form of a mountain landscape Until recently, scientists believed that only very massive nuclei could have excited zero-spin states of increased stability with a significantly deformed shape. Meanwhile, an international team of researchers from Romania, France, Italy, the USA and Poland showed in their latest article that such states also exist in much lighter nickel nuclei. Positive verification of the theoretical model used in these experiments allows describing the properties of nuclei unavailable in Earth laboratories. More than ...

New Orleans, LA - Research conducted at LSU Health New Orleans Neuroscience Center of Excellence reports that a combination of an LSU Health-patented drug and selected DHA derivatives is more effective in protecting brain cells and increasing recovery after stroke than a single drug. The findings are published in Brain Circulation, available here. Nicolas Bazan, MD, PhD, Boyd Professor, Professor of Neurology and Director of the Neuroscience Center of Excellence at LSU Health New Orleans School of Medicine, and Ludmila ...

In some cases, immune cells in the lungs can contribute to worsening a virus attack. In a new study, researchers at Karolinska Institutet in Sweden describe how different kinds of immune cells, called macrophages, develop in the lungs and which of them may be behind severe lung diseases. The study, which was published in Immunity, may contribute to future treatments for COVID-19, among other diseases. The structure of the lungs exposes them to viruses and bacteria from both the air and the blood. Macrophages are immune cells that, among other things, protect the lungs from such attacks. ...

East Hanover, NJ. December 30, 2020. A team of rehabilitation researchers has studied processing speed deficits in individuals with spinal cord injury (SCI), comparing their brain activation patterns with those of healthy age-matched controls, and older healthy individuals. They found that the SCI group and older controls had similar activation patterns, but the SCI group differed significantly from their age-matched controls. The article, "The neural mechanisms underlying processing speed deficits in individuals who have sustained a spinal cord injury: A pilot study" (doi: 10.1007/s10548-020-00798-x) was ...

BOSTON -- A peer-reviewed paper published in The New England Journal of Medicine provides data from the much-anticipated COVE study, which evaluated mRNA-1273, a vaccine candidate against COVID-19 manufactured by Moderna, Inc. Results from the primary analysis of the study, which will continue for two years, provide evidence that the vaccine can prevent symptomatic infection. Among the more than 30,000 participants randomized to receive the vaccine or a placebo, 11 of those in the vaccine group developed symptomatic COVID-19 compared to 185 participants who received the placebo, demonstrating 94.1 percent efficacy in preventing symptomatic COVID-19. Cases ...

December 30, 2020 - As the COVID-19 pandemic emerged, trauma centers faced unprecedented obstacles to providing care for injured patients. A look at steps taken by trauma centers in response to COVID-19 is provided by a survey in the January/February Journal for Healthcare Quality (JHQ), the peer-reviewed journal of the National Association for Healthcare Quality (NAHQ). The journal is published in the Lippincott portfolio by Wolters Kluwer. Trauma centers introduced new processes to optimize use of personal protective equipment (PPE), ICU beds, ventilators, and other limited resources, according to the report by David Bar-Or, MD, of ION Research, Englewood, Colo., ...

WHAT: The investigational vaccine known as mRNA-1273 was 94.1% efficacious in preventing symptomatic coronavirus disease 2019 (COVID-19), according to preliminary results from a Phase 3 clinical trial reported in the New England Journal of Medicine. The vaccine also demonstrated efficacy in preventing severe COVID-19. Investigators identified no safety concerns and no evidence of vaccine-associated enhanced respiratory disease (VAERD). The vaccine was co-developed by Moderna, Inc., a biotechnology company based in Cambridge, Massachusetts, and the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes ...

"Today's computer applications generate a large amount of data that needs to be processed by machine learning algorithms," says Yeseong Kim of Daegu Gyeongbuk Institute of Science and Technology (DGIST), who led the effort. Powerful 'unsupervised' machine learning involves training an algorithm to recognize patterns in large datasets without providing labelled examples for comparison. One popular approach is a clustering algorithm, which groups similar data into different classes. These algorithms are used for a wide variety of data analyses, such as identifying fake news on social media, filtering spam in our e-mails, and detecting ...

DALLAS - Dec. 30, 2020 - When fat cells in the body are stuffed with excess fat, the surrounding tissue becomes inflamed. That chronic, low-level inflammation is one of the driving factors behind many of the diseases associated with obesity. Now, UT Southwestern scientists have discovered a type of cell responsible, at least in mice, for triggering this inflammation in fat tissue. Their findings, published in Nature Metabolism, could eventually lead to new ways to treat obesity. "The inflammation of fat cells in obese individuals is linked to many of the ...

Lithium is an energy-critical element that is considered to be a geopolitically significant resource. However, the supply of lithium may not be enough to meet continuously increasing demand. As a result, scientists are looking for new ways to extract lithium ions. Ion selective membranes have already been used extensively for water treatment and ion sieving in electrodialysis technology. However, conventional membranes exhibit low and useless Li+ selectivity, making them insufficient for meeting industry requirements. Chinese scientists have recently made progress in the preparation and application of a bioinspired ...

Arctic sea ice has been rapidly declining in recent decades, and changes in arctic sea ice can have a significant impact on global weather and climate through interactions with the atmosphere and oceans. In addition, the Arctic shipping routes are a shortcut to connect the major countries in the Northern Hemisphere. The Arctic region is also rich in natural resources and biological resources. Simulation of the Arctic sea ice could provide valuable information for Arctic shipping as well as climate studies, and it is therefore urgent to evaluate the ability to simulate Arctic sea ice and diagnose the sources of simulation errors. To address the issue of error source identification, ...

Experts in optical physics have developed a new way to see inside living cells in greater detail using existing microscopy technology and without needing to add stains or fluorescent dyes. Since individual cells are almost translucent, microscope cameras must detect extremely subtle differences in the light passing through parts of the cell. Those differences are known as the phase of the light. Camera image sensors are limited by what amount of light phase difference they can detect, referred to as dynamic range. "To see greater detail using the same image sensor, we must expand the dynamic range so that we can ...

Activating an immune signaling pathway best known for fighting viral and bacterial infections can boost the ability of genetically engineered T cells to eradicate breast cancer in mice, according to a new study by researchers at the University of North Carolina. The study, to be published December 31 in the Journal of Experimental Medicine (JEM), suggests that CAR T cells, which are already used to treat certain blood cancers in humans, may also be successful against solid tumors if combined with other immunotherapeutic approaches. Chimeric antigen receptor (CAR) T cells are a type of white blood cell that have been genetically engineered to recognize ...

The Asian tiger mosquito does not pose a major risk for Zika virus epidemics, according to a study published December 31 in the open-access journal PLOS Pathogens by Albin Fontaine of the Institut de Recherche Biomédicale des Armées, and colleagues. Zika virus has triggered large outbreaks in human populations, in some cases causing congenital deformities, fetal loss, or neurological problems in adults. While the yellow fever mosquito Aedes aegypti is considered the primary vector of Zika ...

A novel computational drug screening strategy combined with lab experiments suggest that pralatrexate, a chemotherapy medication originally developed to treat lymphoma, could potentially be repurposed to treat Covid-19. Haiping Zhang of the Shenzhen Institutes of Advanced Technology in Shenzhen, China, and colleagues present these findings in the open-access journal PLOS Computational Biology. With the Covid-19 pandemic causing illness and death worldwide, better treatments are urgently needed. One shortcut could be to repurpose existing drugs that were originally developed to ...

Multiple bouts of blood feeding by mosquitoes shorten the incubation period for malaria parasites and increase malaria transmission potential, according to a study published December 31 in the open-access journal PLOS Pathogens by Lauren Childs of Virginia Tech, Flaminia Catteruccia of the Harvard T.H. Chan School of Public Health, and colleagues. Given that mosquitoes feed on blood multiple times in natural settings, the results suggest that malaria elimination may be substantially more challenging than suggested by previous experiments, which typically involve a single blood meal. Malaria ...